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VTDGSADAPSQAKRPGRRANGSTDPADTREYSERLATLARFTLRHKALVIGVWLGAAVVLALLFPQLETV VRQQSVDLIPRDAPSLQTVDRMSAAFGEEGSKTMVFVAMEDPTGLTPTARQRYGELVRRLQAEGDHVLLV QDLLADPITEAQAVSADRKAWYLPVGVTGTLGDPTAAESLNAVRDIAAEVFTGSTTTVQVTGPPATFSDM IASAEHDLLLISIATAGVIALILLIVYRSVFTALLPLLVIGLSLAVGRGVLSALGEMGMPVSQFTVAFMT AILLGAGTDYTVFLISRYHEQRRAQVPADQAIIHATASIGRVILASAATVALAFLAMVFARLSVFAALGP ACAIAVLFGFLATVTLLPPVLSLAAKRGIGEPKPDRTRRYWNSVAVAVVRRPVPLLIVSLVILLALSAAA ATIKISYDDRKGQPDTTASNQGYHLLDRHFRKDVVISEFLVVENPTDMRTGKGLADLDEMASRVSQIPGV TKVSGVTRPTGERLDQAELAWQNGQIGDKMAGAVAEGNSRKDDLAKLTGGADQLADGLAQLDSTVRTALT PLAGILTQAQSAGTQVNQFRPGLLRAFRTADFAGIMPRAVNSCIRCGLHAACGSPTRSEVCADYRTVRYS GQYQLLLSSASDTPCGAHVHFSGLQRMILRARYPNIFRSAPARLSYQGRRF
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_4632 | - | - | 100% (681) | MMPL domain-containing protein |
| M. gilvum PYR-GCK | Mflv_0403 | - | e-110 | 41.18% (544) | transport protein |
| M. gilvum PYR-GCK | Mflv_2705 | - | 9e-75 | 31.79% (541) | transport protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3853c | mmpL8 | 1e-111 | 39.13% (529) | integral membrane transport protein |
| M. tuberculosis H37Rv | Rv3823c | mmpL8 | 1e-110 | 38.94% (529) | integral membrane transport protein |
| M. leprae Br4923 | MLBr_01231 | mmpL10 | 2e-99 | 34.98% (626) | hypothetical protein MLBr_01231 |
| M. abscessus ATCC 19977 | MAB_0855 | - | 1e-121 | 40.63% (539) | MmpL family protein |
| M. marinum M | MMAR_4836 | - | 0.0 | 75.39% (577) | MmpL family transport protein |
| M. avium 104 | MAV_1761 | - | 1e-106 | 38.68% (574) | MmpL10 protein |
| M. smegmatis MC2 155 | MSMEG_4741 | - | 1e-115 | 38.85% (610) | MmpL protein |
| M. thermoresistible (build 8) | TH_3450 | - | 0.0 | 83.21% (560) | PUTATIVE MMPL domain protein |
| M. ulcerans Agy99 | MUL_3688 | mmpL4_1 | 6e-72 | 31.89% (555) | transmembrane transport protein MmpL4_1 |
| M. vanbaalenii PYR-1 | Mvan_0312 | - | 0.0 | 95.76% (590) | MMPL domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_4632|M.gilvum_PYR-GCK -MTDGSADAPSQAKRPGRRANGSTDPADTREYSERLATLARFTLR-HKAL
Mvan_0312|M.vanbaalenii_PYR-1 -MTDGTADSPSQATRSGRGANGSPDPADTREYSERLAALARFTLR-HKAL
MMAR_4836|M.marinum_M MADYGWVSSGVATLSRPVRERLQKVAAGEGAYSDRLARLAGFSIR-HKVL
TH_3450|M.thermoresistible__bu ------------------------------------------------VL
MLBr_01231|M.leprae_Br4923 -------------------------------------------------M
MAV_1761|M.avium_104 -----------------------MSPTAPAGDEVEMRRIADFVVR-WPWL
Mb3853c|M.bovis_AF2122/97 ----MCDVLMQPVRTPRPSTNLRSKPLRPTGDGGVFPRLGRLIVR-RPWV
Rv3823c|M.tuberculosis_H37Rv ----MCDVLMQPVRTPRPSTNLRSKPLRPTGDGGVFPRLGRLIVR-RPWV
MAB_0855|M.abscessus_ATCC_1997 ----------------------------MAENTGGIYGLIAQIVRRAPVI
MSMEG_4741|M.smegmatis_MC2_155 ------------------------------MSRVGFSGLGRFIVR-HPLV
MUL_3688|M.ulcerans_Agy99 --MSESNSGASISTEDTGPIEIGAATGGAPNRERGHRPVIPHTIRILAVP
Mflv_4632|M.gilvum_PYR-GCK VIGVWLGAAVVLALLFPQLETVVRQQSVDLIPRDAPSLQTVDRMSAAFGE
Mvan_0312|M.vanbaalenii_PYR-1 VIGVWLGAAVVLALLFPQLETVVRQQSVDLIPRDAPSLQTVDRMSAAFGE
MMAR_4836|M.marinum_M IIGMWVVTAAALAVLFPQLETVVRQQSVNLIPRDAPSLQTVDRMGAAFGE
TH_3450|M.thermoresistible__bu VIGTWLAVAVVLALLFPQLETVVRQQSVDLIPRDVPSFQTLDRMSAAFGE
MLBr_01231|M.leprae_Br4923 VIGCWTLLALMLPMTVPSLTELTQRHPVVILPVDAPSSVAAKKISQAFHE
MAV_1761|M.avium_104 VIGFWAALAVALPLAFPSLAEMAQKHPLAILPGNAPSNVAARQMTEAFHE
Mb3853c|M.bovis_AF2122/97 VIAFWVALAGLLAPTVPSLDAISQRHPVAILPSDAPVLVSTRQMTAAFRE
Rv3823c|M.tuberculosis_H37Rv VIAFWVALAGLLAPTVPSLDAISQRHPVAILPSDAPVLVSTRQMTAAFRE
MAB_0855|M.abscessus_ATCC_1997 VIGLWIGLAAVLALTAPSLQKAIEDHPVDLLPKDAPVMETTRQMVESFQE
MSMEG_4741|M.smegmatis_MC2_155 VIASWLAVAGVLLAAVPSLPAVAERNPPGFLPADSEVFAAGNAMQEAFNE
MUL_3688|M.ulcerans_Agy99 IILGWVLLTVLVNVVVPSLEVVSEQHSAPMTPMDAPSMKAMMRLGHNFRE
:* * : : *.* . :. : * : : : * *
Mflv_4632|M.gilvum_PYR-GCK EGSKTMVFVAMEDPTGLTPTARQRYGELVRRLQAEGDHVLLVQDLLADPI
Mvan_0312|M.vanbaalenii_PYR-1 EGSKTMVFVAMEDPNGLTPTARQRYGELVSRLQSEGDHVLLVQDLLADPI
MMAR_4836|M.marinum_M QGSKTTIFVAMEDPAGLTAPVRQRYNTMISRLRADSEHVRLVQDLLADPV
TH_3450|M.thermoresistible__bu QGSKTTVFVAMEDPAGLTPAARDRYEAMVSRLRADTDHVLLVQDLLADPV
MLBr_01231|M.leprae_Br4923 VDSENVLIVLLTDDKGLGPADETVYRTLVDRLRNDTKDVVVLQDFLSTPP
MAV_1761|M.avium_104 SGSDDLLLVALTDEKGLGPADEAVYRRLVDALRRDTRDVVMVQDFISAPP
Mb3853c|M.bovis_AF2122/97 AGLQSVAVVVLSDAKGLGAADERSYKELVDALRRDTRDVVMLQDFVTTPP
Rv3823c|M.tuberculosis_H37Rv AGLQSVAVVVLSDAKGLGAADERSYKELVDALRRDTRDVVMLQDFVTTPP
MAB_0855|M.abscessus_ATCC_1997 SGAQNILLIVLTNENGLTPADEQTYRILAARMREDTRDVSMVQDFITKPP
MSMEG_4741|M.smegmatis_MC2_155 TGGGNVAIAILSNENGLTPADEETYRALVDKLRADTEYVLSTQDFVTIPE
MUL_3688|M.ulcerans_Agy99 FDSNSTVMIVLEGQHKLGDDAHQYYDSLIRQLRQDPEHIQHIQDFWGDRL
. . : . * . * : :: : : **:
Mflv_4632|M.gilvum_PYR-GCK TEAQAVSADRKAWYLPVGVTGTLGDPTAAESLNAVRDIAAEVFTGS----
Mvan_0312|M.vanbaalenii_PYR-1 TEAQAVSVDRKAWYLPVGVAGTLGDPTAAESVNAVRDIAAEVFTGS----
MMAR_4836|M.marinum_M TASQAVSQDGKAWYVPVGVAGTLGDVKAAESVQAVRTIAAQAFSGS----
TH_3450|M.thermoresistible__bu TATQAVSQDGKAWYLPVGVAGTLGDPTAAESVQAVRALAAEAFADS----
MLBr_01231|M.leprae_Br4923 LHELLVSKDGKAWILPIVLAGELGTSASYQAYAGVAGIVKQTLEST----
MAV_1761|M.avium_104 LRSAVTSKDRKAWVLPVGIAGELGTPQSYAAFNRIAGIVKQTLEKHENGP
Mb3853c|M.bovis_AF2122/97 LRELMTSKDNQAWILPVGLPGDLGSTQSKQAYARVADIVEHQVAGS----
Rv3823c|M.tuberculosis_H37Rv LRELMTSKDNQAWILPVGLPGDLGSTQSKQAYARVADIVEHQVAGS----
MAB_0855|M.abscessus_ATCC_1997 LREMMSSTDGKAWYLPVGLQGELATPESGKAYVGALKIIKDATQGT----
MSMEG_4741|M.smegmatis_MC2_155 LRQVMTSEDNKAWQLPISAAGTMGTAEGQNAYRQIVDTVKSSTANT----
MUL_3688|M.ulcerans_Agy99 TAAGAQSADGKSAYVMVNLAGNQGTTLANESVEAVRDVINRTHEPAG---
* * :: : : * . . :
Mflv_4632|M.gilvum_PYR-GCK ---TTTVQVTGPPATFSDMIASAEHDLLLISIATAGVIALILLIVYRSVF
Mvan_0312|M.vanbaalenii_PYR-1 ---TTTVHVTGPPATFSDMIASAEHDLLLISIATAGVIALILLIVYRSVF
MMAR_4836|M.marinum_M ---PTNVRVTGPPATFHDQIASAEEDLVVISIATAGLIAMILLVVYRSVF
TH_3450|M.thermoresistible__bu ---STTVRVTGPPATFSDQIGSAEHDLVLISIATAGLIALILLIVYRSVF
MLBr_01231|M.leprae_Br4923 AGSSLKANLTGPASTVADLTDAGARDRTSIELVIAVLLLTILMIIYRNPI
MAV_1761|M.avium_104 AATSLTVSLTGPAATVADLTVAGERDRLPIELAIAVLVLVVLLVVYRSAV
Mb3853c|M.bovis_AF2122/97 ---TLTANLTGPAATVADLNLTGQRDRSRIEFAITILLLVILLIIYRNPI
Rv3823c|M.tuberculosis_H37Rv ---TLTANLTGPAATVADLNLTGQRDRSRIEFAITILLLVILLIIYGNPI
MAB_0855|M.abscessus_ATCC_1997 ---SLKAFTTGPTATVGDLTVVGERDLHKVEITTAALVLLILLIVYRNPV
MSMEG_4741|M.smegmatis_MC2_155 ---SLSAEVIGPAATFEDVVKIGERDQHVIEIATVLIVLMILIIVYRNLV
MUL_3688|M.ulcerans_Agy99 ----VKAYVTGPAALSDDMHLIGNASLATITMFTLGAIAVMLLLVYRSIV
.. **.: * . . : : : :*:::* . .
Mflv_4632|M.gilvum_PYR-GCK TALLPLLVIGLSLAVGRGVLSALGEMGMP-VSQFTVAFMTAILLGAGTDY
Mvan_0312|M.vanbaalenii_PYR-1 TALLPLLVIGLSLAVGRGVLSALGEMGMP-VSQFTVAFMTAILLGAGTDY
MMAR_4836|M.marinum_M TALLPLLVIGVSLAVGRGVLSALGESGMP-VSQFTIAFMTVILLGAGTDY
TH_3450|M.thermoresistible__bu TALLPLLVIGVSLAVGRGVLSALGEMGMP-VSQFTVAFMTAILLGAGTDY
MLBr_01231|M.leprae_Br4923 TMLLPLITIGASLMTAQAVVSGVSVLAGLAVSNQMIVLLSAMIAGAGTDY
MAV_1761|M.avium_104 TMLLPLVTILLSLVIAQAAVAGYSQLTGSGVSNQSIVFLSAIMAGAGTDY
Mb3853c|M.bovis_AF2122/97 TMVLPLITIGMSVVVAQRLVA-IAGLAGLGIANQSIIFMSGMMVGAGTDY
Rv3823c|M.tuberculosis_H37Rv TMVLPLITIGMSVVVAQRLVA-IAGLAGLGIANQSIIFMSGMMVGAGTDY
MAB_0855|M.abscessus_ATCC_1997 TMMLPLIVVGVSLGIAQAAVGGLAQMGLS-ISNQTLTFMTAMMMGAGVDY
MSMEG_4741|M.smegmatis_MC2_155 AMLLPLLMIGMALVVAEQSVAGLGAIHLIGLGPQTLMLMTAMMMGAGTDY
MUL_3688|M.ulcerans_Agy99 TTVIQLFMTGIALASSRGVVAVLGYHNVFGLTTFAANILTMLAIAAGTDY
: :: *. :: .. :. . : ::: : .**.**
Mflv_4632|M.gilvum_PYR-GCK TVFLISRYHEQRRAQ----VPADQAIIHATASIGRVILASAATVALAFLA
Mvan_0312|M.vanbaalenii_PYR-1 TVFLISRYHEQRRAQ----VPADQAIIHATASIGRVILASAATVALAFLA
MMAR_4836|M.marinum_M SVFLISRYHEQRRQN----VPPDLSVINATATIGRVILASAATVAFAFLA
TH_3450|M.thermoresistible__bu TVFLISRYHEQRRAQ----VAPEQAAIYATASIGRVILASAATVAFAFLA
MLBr_01231|M.leprae_Br4923 AVFLISRYHDYIRMGSGSAQDAGCAVRQALISLGKVIAASAATVGITFLG
MAV_1761|M.avium_104 AVFLISRYHDFLRRG----DDFDQAVRKALISIGKVITASASTVGITFLL
Mb3853c|M.bovis_AF2122/97 AVFLISRYHDYLRQG----ADSDQAVKKALTSIGKVIAASAATVAITFLG
Rv3823c|M.tuberculosis_H37Rv AVFLISRYHDYLRQG----ADSDQAVKKALTSIGKVIAASAATVAITFLG
MAB_0855|M.abscessus_ATCC_1997 AVFLISRYHEYIKQG----LASDDAVAAALESIGKVVAASAATVAVTFLG
MSMEG_4741|M.smegmatis_MC2_155 AIFLFSRYHECVRSG----LSSDDAVVEALDSIGKVIAGSAGTVAITFMG
MUL_3688|M.ulcerans_Agy99 GIFLVGRYQEARQAG----EDRQDAYYTTFRGVAPVVLGSGLTIAGATYC
:**..**:: : : : :. *: .*. *:. :
Mflv_4632|M.gilvum_PYR-GCK MVFARLSVFAALGPACAIAVLFGFLATVTLLPPVLSLAAKRGIGEPKPDR
Mvan_0312|M.vanbaalenii_PYR-1 MVFARLSVFAALGPACAIAVLFGFLATVTLLPPVLSLAAERGIGEPKSDR
MMAR_4836|M.marinum_M MVFAKLSVFAALGPACAIAVFVGFAATVTLFPPVLALAAKRGIGEPKADR
TH_3450|M.thermoresistible__bu MVFARLSVFAALGPACAIAVLFGFLATVTLLPPVLALAAKRGIGDPKPDR
MLBr_01231|M.leprae_Br4923 MSFTKIRVFSTVGPALAIGIAVAFLAAVTLMPALLVLAGTRGWVAPRRDR
MAV_1761|M.avium_104 IGFARMGVFKTVGISSAIGIGVAFLAAVTLLPAIMVLAGPRGWIRPRREL
Mb3853c|M.bovis_AF2122/97 MVFTQLGILKTVGPMLGISVAVVFFAAVTLLPALMVLTGRRGWIAPRRDL
Rv3823c|M.tuberculosis_H37Rv MVFTQLGILKTVGPMLGISVAVVFFAAVTLLPALMVLTGRRGWIAPRRDL
MAB_0855|M.abscessus_ATCC_1997 MGFTKLGILSTVGPALSVSILIAFVASVTFLPAVLVLVGRRGWITPRKAY
MSMEG_4741|M.smegmatis_MC2_155 LAFTDLGVFSTVGPALSVTIGFGFVASVTLLPAMVVLAGRRGWVKPRKDL
MUL_3688|M.ulcerans_Agy99 LSFARLPWFNTMGAPVAIGMLVVVLAGLTLGPAVVFVGSRFHPFESKRAA
: *: : : ::* .: : . . * :*: *.:: : . .:
Mflv_4632|M.gilvum_PYR-GCK TR-RYWNSVAVAVVRRPVPLLIVSLVILLALSAAAATIKISYDDRKGQPD
Mvan_0312|M.vanbaalenii_PYR-1 TR-RYWNSVAVAVVRRPVPLLIVSLVILLALSAAAATIKISYDDRKGQPA
MMAR_4836|M.marinum_M TR-RYWNWIAVAVVRRPVPLLVASLALVLGLAAVALTMHISYDDRRGQPA
TH_3450|M.thermoresistible__bu TR-RYWNSVAVAVVRRPVTLLTISLAVLLALSAVAVTINISYDDRKGQPA
MLBr_01231|M.leprae_Br4923 AG-AFWRRTGVRIVRRPVAYLSASMVILIVLALCASLVRFNYDDRKQIPA
MAV_1761|M.avium_104 TT-GLWRRSGIRIVRRPRAHLVASVLVLIILASCAGLVRYNYDDRKALRP
Mb3853c|M.bovis_AF2122/97 TR-RFWRSSGVHIVRRPKTHLLASALVLVILAGCAGLARYNYDDRKTLPA
Rv3823c|M.tuberculosis_H37Rv TR-RFWRSSGVHIVRRPKTHLLASALVLVILAGCAGLARYNYDDRKTLPA
MAB_0855|M.abscessus_ATCC_1997 AN-KIWHRSGINIVKRPGAHLAVSLVVLVILATCGAMVKFGYDDRKNLPP
MSMEG_4741|M.smegmatis_MC2_155 TG-RIWRRSGVHIVRKPVIHLVASLTVLLALAGCAMLVNFNYDDRKNLPD
MUL_3688|M.ulcerans_Agy99 NRGRLWRRVGTAVVRWPAPILALSGAIVLVGMVALPGFKTSYNDRYYLPA
*. . :*: * * * ::: . .*:**
Mflv_4632|M.gilvum_PYR-GCK TTASNQGYHLLDRHFRKDVVISEFLVVENPTDMRTGKGLADLDEMASRVS
Mvan_0312|M.vanbaalenii_PYR-1 TTASNQGYHLLDRHFRKDVVITEFLVVENPTDMRTGKGLADLDEMASRVS
MMAR_4836|M.marinum_M TTASNEGYRLLDRHFRKDAIVTEFMVVESPTDMRTSKALADLDEMASRVS
TH_3450|M.thermoresistible__bu DTASNQGYQLLDRHFRKDVVFTEFLVVENPTDMRTGKGLADLDEMASRVA
MLBr_01231|M.leprae_Br4923 SDESSVGYAALESHFPVGQAIPEYLLIQSPHDLRTPRALADMAELAQRVS
MAV_1761|M.avium_104 SAPSSVGYAALERHFPVNQSIPEYILIRSPHDLRTPQALADLEQLADRVS
Mb3853c|M.bovis_AF2122/97 SVESSIGYAALDKHFPSNLIIPEYLFIQSSTDLRTPKALADLEQMVQRVS
Rv3823c|M.tuberculosis_H37Rv SVESSIGYAALDKHFPSNLIIPEYLFIQSSTDLRTPKALADLEQMVQRVS
MAB_0855|M.abscessus_ATCC_1997 WADSNQGYAAIEKHFPVNSTLPQYLYIKSPHDLRTPRGLADLEQMAARVS
MSMEG_4741|M.smegmatis_MC2_155 DAHSNMGYAALDKHFPVSSTVQQFILIQSPHDLRSPKALADMEQMAQRVS
MUL_3688|M.ulcerans_Agy99 SAPSNLGEAAADRHFSHARMNPDMLMVEAEHDMRNPADMLVLDKVAKNVI
*. * : ** : : :. *:*. : : ::. .*
Mflv_4632|M.gilvum_PYR-GCK QIPGVTKVSGVTRPTGERLDQAELAWQNGQIGDKMAGAVAEGNSRKDDLA
Mvan_0312|M.vanbaalenii_PYR-1 QIPGVTKVSGVTRPTGERLDQAELAWQNGQIGDKMAGAVAEGNSRKDDLA
MMAR_4836|M.marinum_M QLPGVTKVSGVTRPTGARLDQAQLSWQNGEIGDKMAGAVAKGDAHKDDLA
TH_3450|M.thermoresistible__bu QIPGVTKVSGVTRPTGERLDQAKLAWQNQQIGDKMADAVADGNARKADLA
MLBr_01231|M.leprae_Br4923 QIPGIALVRGVTRPTGKPLEETSATYQAGMVGKQLGSASHLIGESTGDLN
MAV_1761|M.avium_104 QLPNVSVVSGITRPTGNVPEQFRATYQAGAIGSMLAGGSTMINDQTDDLN
Mb3853c|M.bovis_AF2122/97 QVPGVAMVRGITRPAGRSLEQARTSWQAGEVGSKLDEGSKQIAAHTGDID
Rv3823c|M.tuberculosis_H37Rv QVPGVAMVRGITRPAGRSLEQARTSWQAGEVGSKLDEGSKQIAVHTGDID
MAB_0855|M.abscessus_ATCC_1997 QVPGVDKVRGITRPTGEPLEEAKLSYQAGEVGGKLGDASNLIDARTRDLD
MSMEG_4741|M.smegmatis_MC2_155 QLPDIEMVRGVTRPTGEMLQEARATWQAGEVGGKLNDASTLIDANDANLS
MUL_3688|M.ulcerans_Agy99 RTVGIAMIQDITRPLGIPIQHSSIPFQNSMQSQTMMQNMAFLKERMADMT
: .: : .:*** * :. .:* . : ::
Mflv_4632|M.gilvum_PYR-GCK KLTGGADQLADGLAQLDSTVRTALTPLAGILTQAQSAGTQVNQFRPGLLR
Mvan_0312|M.vanbaalenii_PYR-1 KLTGGADQLADGLAQLDSTVRTALTPLAEILTQAQSAGTQVNQFRPLLQQ
MMAR_4836|M.marinum_M KLTHGADQLAGGLAQLDTTLRTALTPLTGLLTQAQSSGSQVQRFRPLLQQ
TH_3450|M.thermoresistible__bu KLTNGADQLAAGLAQLDTTLRTALAPLSGILSQAQSAGTQMQQFRPLLQQ
MLBr_01231|M.leprae_Br4923 RLASGAGLLADKLGDVRIQVGQAVAGISGLLDNLAFAQKMFGDSK-TLGE
MAV_1761|M.avium_104 RLARGAGTLADNLGDVRGQVNQLAASVRELENAFSSTKNQYSGDA-LVNQ
Mb3853c|M.bovis_AF2122/97 KLAGGANLMASKLGDVRAQVNRAISTVGGLIDALAYLQDLLGGNR-VLGE
Rv3823c|M.tuberculosis_H37Rv KLAGGANLMASKLGDVRAQVNRAISTVGGLIDALAYLQDLLGGNR-VLGE
MAB_0855|M.abscessus_ATCC_1997 KLAAGGHTLADKLGQVRDSVKNSLGTARALVEVLAQLRGS-GRTG-TLAD
MSMEG_4741|M.smegmatis_MC2_155 TLSGGAHKLADVLGQISTQVTNALVTVRPLAGALADMETKYGGEK-TLDQ
MUL_3688|M.ulcerans_Agy99 KMADEMQVLIDTTERMYAVMRELDTTTTDMARVTAETSTITDELRDHLAE
:: : : : : :
Mflv_4632|M.gilvum_PYR-GCK AFRTADFAGIMPR------------------------AVNSCIRCGLHAA
Mvan_0312|M.vanbaalenii_PYR-1 LSATAPAVDQAIQSSPGLRPLANQAQNAISQLDPLVGALNTSPWCATTPQ
MMAR_4836|M.marinum_M LSATAPAVDQAIRTGPGLRQQADQAQNAIAAIDPLVGALNTSPWCATTPE
TH_3450|M.thermoresistible__bu LSATAPAVDQAIQAGPGLRPWADQAAHAIAILDPLVGALNTAPWCATTPQ
MLBr_01231|M.leprae_Br4923 IDTAGKLVSSMRALGNMFGINFSTTMNDINWVGAVVIALDSSVLCDTNPI
MAV_1761|M.avium_104 VDIAARLVDHVNSLSNAMGWNFTAAKNMFAWIGPVLAALQGNPVCDADSS
Mb3853c|M.bovis_AF2122/97 LEGAEKLIGSMRALGDTIDADASFVANNTEWASPVLGALDSSPMCTADPA
Rv3823c|M.tuberculosis_H37Rv LEGAEKLIGSMRALGDTIDADASFVANNTEWASPVLGALDSSPMCTADPA
MAB_0855|M.abscessus_ATCC_1997 LDSVDKLVTSMHSLGDAIEANAQGASEVYGWIEPVARVLVGNPACDMDPG
MSMEG_4741|M.smegmatis_MC2_155 IDQSAELVANMRSLGRAMGVNLARITDVYDWSAPMVRALNVSPECNLDPA
MUL_3688|M.ulcerans_Agy99 FDDFWRPMR---------------------------SYFYWEKHCFDVPI
. * .
Mflv_4632|M.gilvum_PYR-GCK CG-----------------------------SPTR-SEVCADYRTVR---
Mvan_0312|M.vanbaalenii_PYR-1 CAQIRDQVKILVTLRDSGFFTQIADLGDRYDPATN-ATVGGTLANVQNAV
MMAR_4836|M.marinum_M CTQLRDQVQILVTLRHTGFFNQLANLGDLYQPGS--DTAAGTVADVQNTI
TH_3450|M.thermoresistible__bu CAQIRDQVQVLVTLRNSGFFNQVADLGDRYNPATG-ATVAETLADIRNAV
MLBr_01231|M.leprae_Br4923 CADARAQFHKLLTASEDGTLDNIAHLWKQLGSTQSSQTIGATVSGLEKTL
MAV_1761|M.avium_104 CSATRATFEQLVGPRGQADLDAIDDLSHQLQAYPDKRALKASTDRLRNAF
Mb3853c|M.bovis_AF2122/97 CASARTELQRLVTARDDGTLAKISELARQLQATRAVQTLAATVSGLRGAL
Rv3823c|M.tuberculosis_H37Rv CASARTELQRLVTARDDGTLAKISELARQLQATRAVQTLAATVSGLRGAL
MAB_0855|M.abscessus_ATCC_1997 CRSSRDEMNKFLETKQDGTRDKIVELGRELKSVDNDKQISSTIARLRTAL
MSMEG_4741|M.smegmatis_MC2_155 CAASRSDLQRIVEAKDNGNLDKFAELGRQLESTEGDETLDEAVSGLQQSI
MUL_3688|M.ulcerans_Agy99 CWSFRS----------------------LFDSLDGIDKLSEKFSELTEDI
* . :
Mflv_4632|M.gilvum_PYR-GCK -----------------YSGQYQLLLSSASDTPCGAHVHFSGLQRMILR-
Mvan_0312|M.vanbaalenii_PYR-1 ASLDKAFGAL--GDPADLATNLRRLQDGIGQLASGAQALATGVRTLADSN
MMAR_4836|M.marinum_M TSLDKTFGAL--GDPADLAGNIRRLQSGISQLASGAQALATGVHTLADSN
TH_3450|M.thermoresistible__bu TAMDKAFGAL--GDPADLAGNIGRLQDGISQLASGAQALATGVHTLVDSN
MLBr_01231|M.leprae_Br4923 TAVNTSLRSLGLDNPNVMRSKMIGLQNGVNDLASAGRRIADGVAVLVDQT
MAV_1761|M.avium_104 AKLNDVLRAMGMDRPGGLQSNLTTLQNGADQFAGGSRQVADAVAQLVDKV
Mb3853c|M.bovis_AF2122/97 ATVIRAMGSLGMSSPGGVRSKINLVNKGVNDLADGSRQLAEGVQLLVDQV
Rv3823c|M.tuberculosis_H37Rv ATVIRAMGSLGMSSPGGVRSKINLVNKGVNDLADGSRQLAEGVQLLVDQV
MAB_0855|M.abscessus_ATCC_1997 NSIDTNLRRLGLSDSYGIQKRFTEVLTGVNSLADGSAQLAEGVQMLVDQT
MSMEG_4741|M.smegmatis_MC2_155 KEATAAARELGLEDASSVKRQLDQLEQGVNLLADSSHQLAQGVQLLVDQT
MUL_3688|M.ulcerans_Agy99 QR---------------TAGLTSQMLTLIPPMIATMKTTKALTLTMQSTF
: :
Mflv_4632|M.gilvum_PYR-GCK -----------ARYPNIFRSAPARLS----------YQ------------
Mvan_0312|M.vanbaalenii_PYR-1 IEMLSGMSQIATQLQNSSRAAADSDSSSGFYLPANAFE------------
MMAR_4836|M.marinum_M IEMLSGMSQIATQLQNSARTTAGSDNASGFYLPTNAFE------------
TH_3450|M.thermoresistible__bu LEMLSGMSQIATQLQNSARASADSDSSSGFYLPPNTFE------------
MLBr_01231|M.leprae_Br4923 RTMGTSLARASAFLMEMGQDAS-QPSMAGFNVPPQLLN------------
MAV_1761|M.avium_104 KQLGAGLSESAAFLLSLKHDAA-HPAMAGFNIPAQLLR------------
Mb3853c|M.bovis_AF2122/97 KKMGFGLGEASAFLLAMKDTAT-TPAMAGFYIPPELLSYATGESVKAETM
Rv3823c|M.tuberculosis_H37Rv KKMGFGLGEASAFLLAMKDTAT-TPAMAGFYIPPELLSYATGESVKAETM
MAB_0855|M.abscessus_ATCC_1997 KQMGGQLGDASTLLVAAKRDAA-PGSMSGFYIPQQVLT------------
MSMEG_4741|M.smegmatis_MC2_155 RNMGQGLDQASQFLLAMKRDAS-DPQMSGFYIPPQILT------------
MUL_3688|M.ulcerans_Agy99 SAMLDQMDELSNTAIVMGQSFDASKNDDFFYLPPEAFD------------
Mflv_4632|M.gilvum_PYR-GCK ------------GRRF----------------------------------
Mvan_0312|M.vanbaalenii_PYR-1 ------------NRQFTDVAEQFLSPDGKTARFMIESSHDPYSVEAMDLA
MMAR_4836|M.marinum_M ------------NRQFADVAKHFLSPDGKTARFAIESSYDPYSSDAMNLA
TH_3450|M.thermoresistible__bu ------------NRQFADVAKQFLSPDGKTARFAIESSHDPYSVDAMNLA
MLBr_01231|M.leprae_Br4923 ------------TEDFKKLVQAFISPDGHSVRYFIQTDLNPFSSAAMDQV
MAV_1761|M.avium_104 ------------LPQFQEAAKVFISPDGHSVRYLVQSKLSPFSTQAMDQV
Mb3853c|M.bovis_AF2122/97 PSEYRDLLGGLNVDQLKKVAAAFISPDGHSIRYLIQTDLNPFSTAAMDQI
Rv3823c|M.tuberculosis_H37Rv PSEYRDLLGGLNVDQLKKVAAAFISPDGHSIRYLIQTDLNPFSTAAMDQI
MAB_0855|M.abscessus_ATCC_1997 ------------QDSFKTAAAAFVSADGHAVRYLVQSNLNPFSPEAMDQV
MSMEG_4741|M.smegmatis_MC2_155 ------------QEEFNKAAALFVSPDGRSVRYLVQTALDPFGTAAMDQV
MUL_3688|M.ulcerans_Agy99 ------------NPDFQTGLRMFLSPDGKSARFFITHQGDPMTPEGISRV
:
Mflv_4632|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0312|M.vanbaalenii_PYR-1 SRITDTANTARPNTSLADATVSVAGFPAVNSDIQRLLWADFAQLAIATII
MMAR_4836|M.marinum_M HKITEVADAARPNTSLANATVSMAGFPAVNSDIQRLLSADFHQLAFATLV
TH_3450|M.thermoresistible__bu HTITDVADAARPNTSLAHATVSVAGFPAVNSDIARLLWADFAQLAIATIV
MLBr_01231|M.leprae_Br4923 NTILNVATGAQPNTTLSDASIYLSGYTVTLRDTRDYYDRDLQLIVIVTMI
MAV_1761|M.avium_104 DAITATARGAQPNTALADAEVSMAGYTVGLKDTRDYYQHDIKFIIAVTLL
Mb3853c|M.bovis_AF2122/97 DAITAAARGAQPNTALADAKVSVVGLPVVLKDTRDYSDHDLRLIIAMTVC
Rv3823c|M.tuberculosis_H37Rv DAITAAARGAQPNTALADAKVSVVGLPVVLKDTRDYSDHDLRLIIAMTVC
MAB_0855|M.abscessus_ATCC_1997 RAIQEAARSAQPNTTLSDASISMAGLSAMYNDIRNYYNHDLRFIIVLTVI
MSMEG_4741|M.smegmatis_MC2_155 KDIVKTAESARPNTSLTDAKISLVGFSSIQNEMRNYYDGDLRFIITVTLI
MUL_3688|M.ulcerans_Agy99 DAERTAAQEGLKQSSLSDAKVYLGGTAATFKDMADGEKYDLMIAVVSALT
Mflv_4632|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0312|M.vanbaalenii_PYR-1 IVGVILVLLLRALLAPLYLLGTVVLNYLASLGIGVVVFQWGLGHEIAWPV
MMAR_4836|M.marinum_M IVGLILVVLLRALVAPLYLLGTVVLNYGAALGLGTLVFQYGLGKEIAWPV
TH_3450|M.thermoresistible__bu IVGLILVLLLRALLAPIYLLGTVVLNYLASLGIGVLVFQYLLGHEIAWPV
MLBr_01231|M.leprae_Br4923 VVLLILMALLRSIVAPIYLVGSVIVSYLSALGLCVLVFQVLLRQQLHWSV
MAV_1761|M.avium_104 VVLLTLMALLRAIVAPLYLVATVVISYLSAVGVGVLVFQFLLGQQLHWSV
Mb3853c|M.bovis_AF2122/97 IVLLILIVLLRAIVAPLYLIGSVIVSYLAALGIGVIVFQFLLGQEMHWSI
Rv3823c|M.tuberculosis_H37Rv IVLLILIVLLRAIVAPLYLIGSVIVSYLAALGIGVIVFQFLLGQEMHWSI
MAB_0855|M.abscessus_ATCC_1997 VVLLILVALLRAIVAPLYLIGSVIISYASAVGIGVIAFQFIGGQPLSWSV
MSMEG_4741|M.smegmatis_MC2_155 VVFLILAALLRSIIAPIYLVLSVVLSYMSALGIGVVFFQFILGKEIVWTV
MUL_3688|M.ulcerans_Agy99 LIFLIMLLLTRSVVAALVIVGTAASSIAASFGLSVLIWQDLFGIKIHWIV
Mflv_4632|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0312|M.vanbaalenii_PYR-1 PLLAFIILVAVGADYNMLLVSRLREESGTNIRVGVLRTVANTGAVITSAG
MMAR_4836|M.marinum_M PLLAFIILVAVGADYNMLLISRLREESAHNIRVGVLRTVANTGSVITSAG
TH_3450|M.thermoresistible__bu PLLAFIILVAVGADYNMLLVSRLREESGTNIRVGVLRTVANTGSVITSAG
MLBr_01231|M.leprae_Br4923 PGLAFVVLVAVGADYNMLLASRLRDESSHGLRASVIRTVRSTGGVITAAG
MAV_1761|M.avium_104 PPLAFVVLVAVGADYNMLLVSRMRDESPHSMRYGIIRTLSSTGGVITAAG
Mb3853c|M.bovis_AF2122/97 PGLTFVILVAVGADYNMLLISRLREEAVLGVRSGVIRTVASTGGVITAAG
Rv3823c|M.tuberculosis_H37Rv PGLTFVILVAVGADYNMLLISRLREEAVLGVRSGVIRTVASTGGVITAAG
MAB_0855|M.abscessus_ATCC_1997 PGMAFIVLVAVGADYNLLFISRIRDESPDGIRSGVIKTVKSTGGVITSAG
MSMEG_4741|M.smegmatis_MC2_155 PGMAFLVLVAVGADYNLLLISRIRDEAAHGMRTAVIRTIGATGGVITSAG
MUL_3688|M.ulcerans_Agy99 AALSVIILLAVGSDYNLLLVSRFREEIHAGLKTGIIRSMAGTGGVVTAAG
Mflv_4632|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0312|M.vanbaalenii_PYR-1 LIFAASMFGLMVGSVAIMIQAGLIIGFGLLLDTFLVRTLTVPAIATLLRE
MMAR_4836|M.marinum_M LIFAASMFGLIAGSIAIMIQAGFIIGCGLLLDTFVVRTLTVPAIATLLRE
TH_3450|M.thermoresistible__bu VIFAASMFGLMFGSIAIMIQAGFIVGCGLLLDTFLVRTLTVPAIATLLRE
MLBr_01231|M.leprae_Br4923 LIFAASMFGLLLSSIATVVQAGFVLGSGILLDTFIVRTITVPAVAALLRR
MAV_1761|M.avium_104 LIFAASMSGLLFSSIGTVVQGGVVIGVGILLDTFLVRTVTVPAIAALAGR
Mb3853c|M.bovis_AF2122/97 LIMAASMYGLVFASLGSVVQGAFVLGTGLLLDTFLVRTVTVPAIAVLVGQ
Rv3823c|M.tuberculosis_H37Rv LIMAASMYGLVFASLGSVVQGAFVLGTGLLLDTFLVRTVTVPAIAVLVGQ
MAB_0855|M.abscessus_ATCC_1997 VIFAASMFGLLIGNLQSMVEAGFIIGMGLLLDTFLVRTITIPALVVLCGQ
MSMEG_4741|M.smegmatis_MC2_155 LIFAASMFGLTFSSLLAAVQIGFIIGVGLLLDTFLVRTITVPAAAVLIGK
MUL_3688|M.ulcerans_Agy99 LVFAFTMASMLGSDLRVLGQFGSTVCIGLLLDTLIVRTLLMPSIATLLGR
Mflv_4632|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0312|M.vanbaalenii_PYR-1 ASWWP-------------TKATNPRRGDPKQKA-----------------
MMAR_4836|M.marinum_M ASWWP-------------QRKPLTHNG-----------------------
TH_3450|M.thermoresistible__bu ASWWP-------------QPNRAR--------------------------
MLBr_01231|M.leprae_Br4923 ASWWP------------ARPWGNNA-------------------------
MAV_1761|M.avium_104 ANWWP------------SRIAVRRNPVSGQP-------------------
Mb3853c|M.bovis_AF2122/97 ANWWLPSSWRPATWWPLGRRRGRAQRTKRKPLLPKEEEEQSPPDDDDLIG
Rv3823c|M.tuberculosis_H37Rv ANWWLPSSWRPATWWPLGRRRGRAQRTKRKPLLPKEEEEQSPPDDDDLIG
MAB_0855|M.abscessus_ATCC_1997 ANWWPSASVESWFRQRFSRSKPDAQEGDCAVSDDPEAASGESSPEEPLIS
MSMEG_4741|M.smegmatis_MC2_155 LSWWP--------------TKPPAP---------------EPAPTEPTVA
MUL_3688|M.ulcerans_Agy99 WFWWP------------QVVHPRGDNARPRVAAPTH--------------
Mflv_4632|M.gilvum_PYR-GCK -----------
Mvan_0312|M.vanbaalenii_PYR-1 -----------
MMAR_4836|M.marinum_M -----------
TH_3450|M.thermoresistible__bu -----------
MLBr_01231|M.leprae_Br4923 -----------
MAV_1761|M.avium_104 -----------
Mb3853c|M.bovis_AF2122/97 LWLHDGLRL--
Rv3823c|M.tuberculosis_H37Rv LWLHDGLRL--
MAB_0855|M.abscessus_ATCC_1997 ASREVELAGRR
MSMEG_4741|M.smegmatis_MC2_155 PAAQA------
MUL_3688|M.ulcerans_Agy99 -----------