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SPTAPAGDEVEMRRIADFVVRWPWLVIGFWAALAVALPLAFPSLAEMAQKHPLAILPGNAPSNVAARQMT EAFHESGSDDLLLVALTDEKGLGPADEAVYRRLVDALRRDTRDVVMVQDFISAPPLRSAVTSKDRKAWVL PVGIAGELGTPQSYAAFNRIAGIVKQTLEKHENGPAATSLTVSLTGPAATVADLTVAGERDRLPIELAIA VLVLVVLLVVYRSAVTMLLPLVTILLSLVIAQAAVAGYSQLTGSGVSNQSIVFLSAIMAGAGTDYAVFLI SRYHDFLRRGDDFDQAVRKALISIGKVITASASTVGITFLLIGFARMGVFKTVGISSAIGIGVAFLAAVT LLPAIMVLAGPRGWIRPRRELTTGLWRRSGIRIVRRPRAHLVASVLVLIILASCAGLVRYNYDDRKALRP SAPSSVGYAALERHFPVNQSIPEYILIRSPHDLRTPQALADLEQLADRVSQLPNVSVVSGITRPTGNVPE QFRATYQAGAIGSMLAGGSTMINDQTDDLNRLARGAGTLADNLGDVRGQVNQLAASVRELENAFSSTKNQ YSGDALVNQVDIAARLVDHVNSLSNAMGWNFTAAKNMFAWIGPVLAALQGNPVCDADSSCSATRATFEQL VGPRGQADLDAIDDLSHQLQAYPDKRALKASTDRLRNAFAKLNDVLRAMGMDRPGGLQSNLTTLQNGADQ FAGGSRQVADAVAQLVDKVKQLGAGLSESAAFLLSLKHDAAHPAMAGFNIPAQLLRLPQFQEAAKVFISP DGHSVRYLVQSKLSPFSTQAMDQVDAITATARGAQPNTALADAEVSMAGYTVGLKDTRDYYQHDIKFIIA VTLLVVLLTLMALLRAIVAPLYLVATVVISYLSAVGVGVLVFQFLLGQQLHWSVPPLAFVVLVAVGADYN MLLVSRMRDESPHSMRYGIIRTLSSTGGVITAAGLIFAASMSGLLFSSIGTVVQGGVVIGVGILLDTFLV RTVTVPAIAALAGRANWWPSRIAVRRNPVSGQP*
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. avium 104 | MAV_1761 | - | - | 100% (1014) | MmpL10 protein |
M. avium 104 | MAV_5284 | - | e-138 | 33.77% (986) | membrane protein, MmpL family protein |
M. avium 104 | MAV_3863 | - | e-124 | 30.22% (1006) | MmpL4 protein |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb1215 | mmpL10 | 0.0 | 60.18% (987) | transmembrane transport protein MmpL10 |
M. gilvum PYR-GCK | Mflv_0403 | - | 0.0 | 66.43% (992) | transport protein |
M. tuberculosis H37Rv | Rv1183 | mmpL10 | 0.0 | 60.18% (987) | transmembrane transport protein MmpL10 |
M. leprae Br4923 | MLBr_01231 | mmpL10 | 0.0 | 57.29% (981) | hypothetical protein MLBr_01231 |
M. abscessus ATCC 19977 | MAB_0937c | - | 0.0 | 67.87% (996) | MmpL family protein |
M. marinum M | MMAR_2342 | - | 0.0 | 49.80% (1008) | MmpL family transport protein |
M. smegmatis MC2 155 | MSMEG_0410 | - | 0.0 | 66.90% (991) | MmpL protein |
M. thermoresistible (build 8) | TH_2203 | mmpL8 | 0.0 | 54.80% (989) | PROBABLE CONSERVED INTEGRAL MEMBRANE TRANSPORT PROTEIN MMPL8 |
M. ulcerans Agy99 | MUL_0757 | mmpL5 | 1e-108 | 28.34% (988) | transmembrane transport protein, MmpL5 |
M. vanbaalenii PYR-1 | Mvan_0271 | - | 0.0 | 66.60% (991) | transport protein |
CLUSTAL 2.0.9 multiple sequence alignment MMAR_2342|M.marinum_M --------MSDSEAARAGGFFDKLSRFVIQKPFVVIAIWISLAAIPALMF TH_2203|M.thermoresistible__bu --------MGGTETPTGRGFFGRLGDFVIRFPLIVIGLWVGLAVVLVATV Mb1215|M.bovis_AF2122/97 ----------------------------------MVGCWVALALVLPMAV Rv1183|M.tuberculosis_H37Rv ----------------------------------MVGCWVALALVLPMAV MLBr_01231|M.leprae_Br4923 ---------------------------------MVIGCWTLLALMLPMTV Mflv_0403|M.gilvum_PYR-GCK --------------------MRRLADVVVRWPWAVIGVWIALAVALPLSF Mvan_0271|M.vanbaalenii_PYR-1 --------------------MRRLADLVVRWPWAVIAVWVAMAVALPLSF MSMEG_0410|M.smegmatis_MC2_155 --------------------MRKLADLVVRWPLVVIGVWLAMAVALPLSF MAB_0937c|M.abscessus_ATCC_199 --------------------MRRLADLVVRWPWVVIGAWVALAIALPLTF MAV_1761|M.avium_104 --------MSPTAPAGDEVEMRRIADFVVRWPWLVIGFWAALAVALPLAF MUL_0757|M.ulcerans_Agy99 MTATTTDTPTDVVPPAEHPPRPFIPRMIRTFAVPLILGWVLLIAVLNSVV :: * : . MMAR_2342|M.marinum_M PPLMEAAAGKNNSAALPDDAPTMVASKEMAKTFEGKSNKKDAKAKPGSKP TH_2203|M.thermoresistible__bu PPLAEVAAR-NPVSVLPEDAPVMVTSREMSEAFD---------------- Mb1215|M.bovis_AF2122/97 PSLAEMAQR-HPVAVLPADAPSSVAVRQMAEAFH---------------- Rv1183|M.tuberculosis_H37Rv PSLAEMAQR-HPVAVLPADAPSSVAVRQMAEAFH---------------- MLBr_01231|M.leprae_Br4923 PSLTELTQR-HPVVILPVDAPSSVAAKKISQAFH---------------- Mflv_0403|M.gilvum_PYR-GCK PSLGQMAAK-NPLQILPADAPSSVTAQKMAEAFD---------------- Mvan_0271|M.vanbaalenii_PYR-1 PSLGEMAQK-HPLVILPSDAPSSVTAAKMAEAFQ---------------- MSMEG_0410|M.smegmatis_MC2_155 PSLGEMAEK-HPLQVLPAEAPSSVTAAKMAEAFQ---------------- MAB_0937c|M.abscessus_ATCC_199 PSLTEMAEK-HPLAILPADAPSSVTAKKMTEAFH---------------- MAV_1761|M.avium_104 PSLAEMAQK-HPLAILPGNAPSNVAARQMTEAFH---------------- MUL_0757|M.ulcerans_Agy99 PQLEVVGQM-QAVSMSPDAAPSMISMKHIGKVFR---------------- * * : * ** :: .: :.* MMAR_2342|M.marinum_M KEDPSDGSQLLVILTDENGLGPGDLAAYTKLVEKLRAEKYS----VQDFI TH_2203|M.thermoresistible__bu --DSGGDNLLLVVMTDEEGLGPEDEKAYQKLVAALRAEPNGDIMMMQDFI Mb1215|M.bovis_AF2122/97 --ESGSENILVVLLTDEKGLGAADENVYHTLVDRLRNDAKD-VVMLQDFL Rv1183|M.tuberculosis_H37Rv --ESGSENILVVLLTDEKGLGAADENVYHTLVDRLRNDAKD-VVMLQDFL MLBr_01231|M.leprae_Br4923 --EVDSENVLIVLLTDDKGLGPADETVYRTLVDRLRNDTKD-VVVLQDFL Mflv_0403|M.gilvum_PYR-GCK --EPGSDNLLVVAFINESGLVPEDELTYRNVVDALRDDVAD-VVSVQDFL Mvan_0271|M.vanbaalenii_PYR-1 --ETSNDNLLLVAFINETGLEPADEATYRKVVDALRDDVTD-VVSVQDFV MSMEG_0410|M.smegmatis_MC2_155 --ESGNDDLMLVALINDKGLTPDDEAVYRKIVDALRGDLIN-VVSVQDFI MAB_0937c|M.abscessus_ATCC_199 --ESSNDDLLLVVFINENGLGKDDADSYRKVVDALRHDLTN-VVSVQDFI MAV_1761|M.avium_104 --ESGSDDLLLVALTDEKGLGPADEAVYRRLVDALRRDTRD-VVMVQDFI MUL_0757|M.ulcerans_Agy99 --EGDSDSAAMIVLEGQEPLGAAAHKFYDKMITKLRADTKH-VQSVQDFW : .. . :: : .: * * :: ** : :*** MMAR_2342|M.marinum_M SNPPLREVLASKDNKAWNLPVMFKTSQDDPATQSAYKKIKELVKEALAGS TH_2203|M.thermoresistible__bu TTPQLREVVASEDGKAWYLPINLAGAWSTPEGGGAFTRVAEIVREATADA Mb1215|M.bovis_AF2122/97 TTPPLREVLGSKDGKAWILPIGLAGDLGTPKSYHAYTDVERIVKR---TV Rv1183|M.tuberculosis_H37Rv TTPPLREVLGSKDGKAWILPIGLAGDLGTPKSYHAYTDVERIVKR---TV MLBr_01231|M.leprae_Br4923 STPPLHELLVSKDGKAWILPIVLAGELGTSASYQAYAGVAGIVKQTLEST Mflv_0403|M.gilvum_PYR-GCK GTPQLRQFLTSEDKTTWVLPVSLVGELGTPRAYESFNRVADVIRHEVPDA Mvan_0271|M.vanbaalenii_PYR-1 STPQLRQFLTSEDKTTWVLPVSLEGELGTPRAFDSFNRVSDVVKHHLGDG MSMEG_0410|M.smegmatis_MC2_155 GTPQLRPFLTSQDKTTWVLPVSLEGELGTPRAFESFNRVSEIVEHTVDQN MAB_0937c|M.abscessus_ATCC_199 GTPELRKFLTSQDNKTWVLPVGLAGELGTPKAFESYNRVTSLIQHSIDGS MAV_1761|M.avium_104 SAPPLRSAVTSKDRKAWVLPVGIAGELGTPQSYAAFNRIAGIVKQTLEKH MUL_0757|M.ulcerans_Agy99 GDPLTATGAQSGDGKAAYVQVKLAGNQGESLANESVEAVKTIVDSLQAPP * * * .: : : : . . : : :: MMAR_2342|M.marinum_M -------TLTAHYAGAVATVADLVTIGQEDTHIIEIGTAVSVLVILLMVY TH_2203|M.thermoresistible__bu -------PMTVHLTGPAATIADVTAVGQRDIHVIEIATVVMVLTILLIVY Mb1215|M.bovis_AF2122/97 AGT----TLTANVTGPAATVADLTDAGARDRASIELAIAVMLLVILMVIY Rv1183|M.tuberculosis_H37Rv AGT----TLTANVTGPAATVADLTDAGARDRASIELAIAVMLLVILMVIY MLBr_01231|M.leprae_Br4923 AGS----SLKANLTGPASTVADLTDAGARDRTSIELVIAVLLLTILMIIY Mflv_0403|M.gilvum_PYR-GCK GTG--GSSLTVHVTGPAATVADLTVAGEQDRLPIEIAIAVLVLGVLLLVY Mvan_0271|M.vanbaalenii_PYR-1 -------PLQVYLTGPAATVADLTVAGEQDRLPIEIAIAVLVLGVLLLVY MSMEG_0410|M.smegmatis_MC2_155 AAD--G-ALQVHITGPAATVADLTVAGQQDRLPIEIAIAVLVLGVLLLVY MAB_0937c|M.abscessus_ATCC_199 -------PTTVHITGPAATVADLTVAGQQDRLPIEIAIAVLVLAVLLLVY MAV_1761|M.avium_104 ENGPAATSLTVSLTGPAATVADLTVAGERDRLPIELAIAVLVLVVLLVVY MUL_0757|M.ulcerans_Agy99 -------GVKVYVTGSAALVADQQLAGDRSLQLIEMVTFTVIIVMLLLVY . :*..: :** * .. **: . :: :*:::* MMAR_2342|M.marinum_M RNIVTMLVPLATIGLSLATAQGVLSGLSKIG-LDVQMQTIVFMTAVMIGA TH_2203|M.thermoresistible__bu RNVVTMLMPLVTIGVAFVTAQGLVGALAPLG-LGVSDQTIVLMTGIMVGA Mb1215|M.bovis_AF2122/97 RNPVTMLLPLVTIGASLMTAQALVAGVSLVGGLAVSNQAIVLLSAMIAGA Rv1183|M.tuberculosis_H37Rv RNPVTMLLPLVTIGASLMTAQALVAGVSLVGGLAVSNQAIVLLSAMIAGA MLBr_01231|M.leprae_Br4923 RNPITMLLPLITIGASLMTAQAVVSGVSVLAGLAVSNQMIVLLSAMIAGA Mflv_0403|M.gilvum_PYR-GCK RNPVTMLLPLLTIGASVLIAQGVVAGYSELTGAGVSNQSIVFLSAILAGA Mvan_0271|M.vanbaalenii_PYR-1 RSAVTMLLPLVTIGSSLVIAQAVVAGYSQLSGSGVSNQSIVFLSAIMAGA MSMEG_0410|M.smegmatis_MC2_155 RNVVTMLLPLVTIGSSLIIAQSVVAGYSELTGSGVSNQSMVFLSAIMAGA MAB_0937c|M.abscessus_ATCC_199 RSALTMMLPLVTIGSSLVIAQSVVAAYSQLTGAGVSNQSIVFLSAILAGA MAV_1761|M.avium_104 RSAVTMLLPLVTILLSLVIAQAAVAGYSQLTGSGVSNQSIVFLSAIMAGA MUL_0757|M.ulcerans_Agy99 RSIITAAIMLTMVVLGLLATRGGVAFLGYHRIIGLSTFATNLLVVLAIAA *. :* : * : .. ::. :. . :. :: : .* MMAR_2342|M.marinum_M GTDYAVFLISRYHDYVRKG----QDSDLAVKNAMMSIGKVIAASAATVAV TH_2203|M.thermoresistible__bu GVDYAVFLISRYHDFVRRG----VEHRAAIRQAMGSIGKVIGASAATVAV Mb1215|M.bovis_AF2122/97 GTDYAVFLISRYHEYVRLG----EHPERAVQRAMMSVGKVIAASAATVGI Rv1183|M.tuberculosis_H37Rv GTDYAVFLISRYHEYVRLG----EHPERAVQRAMMSVGKVIAASAATVGI MLBr_01231|M.leprae_Br4923 GTDYAVFLISRYHDYIRMGSGSAQDAGCAVRQALISLGKVIAASAATVGI Mflv_0403|M.gilvum_PYR-GCK GTDYAVFLISRYHDYLRRG----AEAGEAVRAAMASIGKVITASASTVGI Mvan_0271|M.vanbaalenii_PYR-1 GTDYAVFLISRYHDYLRSG----ADFDDAVRAAMISIGKVITASAATVGV MSMEG_0410|M.smegmatis_MC2_155 GTDYAVFLISRYHDFLRSG----HGYDEAVRAAMISIGKVIAASATTVGL MAB_0937c|M.abscessus_ATCC_199 GTDYAVFLISRYHDYLRSG----KNYDQAVRAAMMSIGKVITASATTVGI MAV_1761|M.avium_104 GTDYAVFLISRYHDFLRRG----DDFDQAVRKALISIGKVITASASTVGI MUL_0757|M.ulcerans_Agy99 ATDYAIFLIGRYQEARGLG----QDRESAYYTMFGGTAHVVLGSGLTIAG ..***:***.**:: * * : . .:*: .*. *:. MMAR_2342|M.marinum_M TFLAMVFSKLAIFASIGPAISISIIIAFVAAITLLPSILVLIGRRG-WIK TH_2203|M.thermoresistible__bu TFFAMVFTTLSVFQTVGPAMALAIFVCFLAAVTFLPAMIVLAGPRG-WIS Mb1215|M.bovis_AF2122/97 TFLGMRFAKLGVFSTVGPALAIGIAVSFLAAVTLLPAILVLASPRG-WVA Rv1183|M.tuberculosis_H37Rv TFLGMRFAKLGVFSTVGPALAIGIAVSFLAAVTLLPAILVLASPRG-WVA MLBr_01231|M.leprae_Br4923 TFLGMSFTKIRVFSTVGPALAIGIAVAFLAAVTLMPALLVLAGTRG-WVA Mflv_0403|M.gilvum_PYR-GCK TFLAMSFAEMGVFRTIGVSAAIGIGVAYLAGVTLLPAILVLAGPRG-WIK Mvan_0271|M.vanbaalenii_PYR-1 TFLVMSFAQMGVFRTIGVSSAIGIGVAFLAGMTLLPAILVLAGPRG-WVK MSMEG_0410|M.smegmatis_MC2_155 TFLLLSFAKMGVFRTVGVAAAIGIAVAFLAGVTLLPAILVLAGPRG-WVK MAB_0937c|M.abscessus_ATCC_199 TFLLLSFAKMGVFQTVGVSSAIGIGVAYLSGMTLLPAILVLAGPRG-WVK MAV_1761|M.avium_104 TFLLIGFARMGVFKTVGISSAIGIGVAFLAAVTLLPAIMVLAGPRG-WIR MUL_0757|M.ulcerans_Agy99 ATFCLSFTRLPYFQTLGVPLAIGMVIVVATALTLGPALIAVMSRFGKLLE : : : *: : * ::* . ::.: : :.:*: *:::.: . * : MMAR_2342|M.marinum_M PRRDLTHRFWRILGTRIVRRPRVHLIGSLIVLAILASSTLLVRFNYDDLK TH_2203|M.thermoresistible__bu PRRDLTTRFWRRSGIRIVRAPKAHLAVSLIILLGLAGCALTVQFNYDDRK Mb1215|M.bovis_AF2122/97 PRGERMATFWRRAGTRIVRRPKAYLGASLIGLVALASCASLAHFNYDDRK Rv1183|M.tuberculosis_H37Rv PRGERMATFWRRAGTRIVRRPKAYLGASLIGLVALASCASLAHFNYDDRK MLBr_01231|M.leprae_Br4923 PRRDRAGAFWRRTGVRIVRRPVAYLSASMVILIVLALCASLVRFNYDDRK Mflv_0403|M.gilvum_PYR-GCK PRRELTAQFWRRSGIRIVRRPVPHLVASALVLALLAGFAIVADFNYDDRK Mvan_0271|M.vanbaalenii_PYR-1 PRRELTARFWRRSGIRIVRRPVPHLVASVLVLILLAGCAAFATFNYDDRK MSMEG_0410|M.smegmatis_MC2_155 PRRELTTRFWRRSGIRIVRRPVPHLVGSVLVLALLGGFTLVAHYNYDDRK MAB_0937c|M.abscessus_ATCC_199 PRRELTAQFWRRSGIRIVRRPIPHLVASVLVLALLGSCALLARYNYDDRK MAV_1761|M.avium_104 PRRELTTGLWRRSGIRIVRRPRAHLVASVLVLIILASCAGLVRYNYDDRK MUL_0757|M.ulcerans_Agy99 PKRMARVRGWRKIGAAIVRWPGPILIGAVALALVGLLTLPGYKTNYNDRN *: ** * *** * * : **:* : MMAR_2342|M.marinum_M ALPEDVDSVAGYNAMDRHFPQNMMTPMMLFIKSPHDLRSPTALADLELMV TH_2203|M.thermoresistible__bu TLPQSVESAAGYAAMERHYPVNSNLPQYLFINSPRDLRSPEALADLEEMA Mb1215|M.bovis_AF2122/97 QLPPSDPSSVGYAAMEHHFSVNQTIPEYLIIHSAHDLRTPRGLADLEQLA Rv1183|M.tuberculosis_H37Rv QLPPSDPSSVGYAAMEHHFSVNQTIPEYLIIHSAHDLRTPRGLADLEQLA MLBr_01231|M.leprae_Br4923 QIPASDESSVGYAALESHFPVGQAIPEYLLIQSPHDLRTPRALADMAELA Mflv_0403|M.gilvum_PYR-GCK AVDAAAPSSVGYAALERHFPISQSIPQYILIQSPKDLRNPQALADLEQMA Mvan_0271|M.vanbaalenii_PYR-1 AVAASAPSSVGYAALERHFPISQSIPQYILVQSPRDLRSPQALADLEQMA MSMEG_0410|M.smegmatis_MC2_155 VVSPDASSSIGYAALEQHFPISQSIPEYIFIQSPHDLRNPRALADLEQLA MAB_0937c|M.abscessus_ATCC_199 AVSPSAPSSVGYAALERHFPLSQSIPEYILIQSPRDLRTPQALADLEQMA MAV_1761|M.avium_104 ALRPSAPSSVGYAALERHFPVNQSIPEYILIRSPHDLRTPQALADLEQLA MUL_0757|M.ulcerans_Agy99 YLPADLPANEGYSAAERHFSQARMNPEVLMVESDHDMRNSSDFLVINKIA : : ** * : *:. * :::.* :*:*.. : : :. MMAR_2342|M.marinum_M SRVSQLPNIIAIRGLTRPNGEPLEQTKVSYQAGEVGSKLDEASSAIEDHG TH_2203|M.thermoresistible__bu RRVSQLPEVDTVRGITRPTGEPLEQAALSYQAGEVGIRLDDASKQITDHT Mb1215|M.bovis_AF2122/97 QRVSQIPGVAMVRGVTRPNGETLEQARATYQAGQVGNRLGGASRMIDERT Rv1183|M.tuberculosis_H37Rv QRVSQIPGVAMVRGVTRPNGETLEQARATYQAGQVGNRLGGASRMIDERT MLBr_01231|M.leprae_Br4923 QRVSQIPGIALVRGVTRPTGKPLEETSATYQAGMVGKQLGSASHLIGEST Mflv_0403|M.gilvum_PYR-GCK SRIAQLPDVSLVSGVTRPLGEVPAEFRATFQAGIVGDRLAAGSAQIGERS Mvan_0271|M.vanbaalenii_PYR-1 SRIAQLPDISLVSGVTRPLGEVPREFRATFQAGLVGDRLAAGSAQIGARD MSMEG_0410|M.smegmatis_MC2_155 SRVAQLPDVGLVSGITRPLGEVPPEFRATFQAGIVGDRLADGSTQIDQRT MAB_0937c|M.abscessus_ATCC_199 SRIAQLPDVGLVSGVTRPLGEVPPEFRATYQAGLVGTRLADGSNQINQRS MAV_1761|M.avium_104 DRVSQLPNVSVVSGITRPTGNVPEQFRATYQAGAIGSMLAGGSTMINDQT MUL_0757|M.ulcerans_Agy99 KAIFGVEGISRVQAITRPDGKPIEHTSIPFLISMQGTSQKLTEKYNQDLT : : : : .:*** *: . .: . * . MMAR_2342|M.marinum_M GELDQLADGSNQLADALAGVRDEVTESVANAGALVDLLVTMKKLIGGDKT TH_2203|M.thermoresistible__bu GDLDMLADGADQLADALGDVRGQVFQTVATTKALVDALSTLQERFGGDRT Mb1215|M.bovis_AF2122/97 GDLNRLASGANLLADNLGDVRGQVSRAVAGVRSLVDALAYIQNQFGGNKT Rv1183|M.tuberculosis_H37Rv GDLNRLASGANLLADNLGDVRGQVSRAVAGVRSLVDALAYIQNQFGGNKT MLBr_01231|M.leprae_Br4923 GDLNRLASGAGLLADKLGDVRIQVGQAVAGISGLLDNLAFAQKMFGDSKT Mflv_0403|M.gilvum_PYR-GCK GDLTTLADGATTLADSLGDVRSQVNEIAPSLKGIIDTFSSVRTEYGGDKL Mvan_0271|M.vanbaalenii_PYR-1 DDLDELTTGADTLADTLVDVRAQVNKIAPSLQTLLDAVTRVRVEYGGDRL MSMEG_0410|M.smegmatis_MC2_155 SDLNRLTSGAKTLADSLADVRSQINQIAPSIQSLVDTFSSVRTEYGGDKL MAB_0937c|M.abscessus_ATCC_199 SDLNRLTSGANTLAGSLTDLRNQLNKITPGLQSLLEASNSLKTKSGGDEL MAV_1761|M.avium_104 DDLNRLARGAGTLADNLGDVRGQVNQLAASVRELENAFSSTKNQYSGDAL MUL_0757|M.ulcerans_Agy99 TSMLQQVNDIQTNIDQMERMHDLTQQMAD--------------------- .: . . . : :: . . MMAR_2342|M.marinum_M LNALDQTAKLVGRMRALGDALTSNMVDVSNVVAWVGPIVSALNASPQCNA TH_2203|M.thermoresistible__bu LDDIDNAARLVSGMRELGDAIGVNVANVAGNLEWAVPVLTALDTSPVCAA Mb1215|M.bovis_AF2122/97 FNEIDNAARLVSNIHALGDALQVNFDGIANSFDWLDSVVAALDTSPVCDS Rv1183|M.tuberculosis_H37Rv FNEIDNAARLVSNIHALGDALQVNFDGIANSFDWLDSVVAALDTSPVCDS MLBr_01231|M.leprae_Br4923 LGEIDTAGKLVSSMRALGNMFGINFSTTMNDINWVGAVVIALDSSVLCDT Mflv_0403|M.gilvum_PYR-GCK VRDVATAAKLVDSVNKLGLSMGINFRAVRDMFAWIGPVLTALQGNRVCDA Mvan_0271|M.vanbaalenii_PYR-1 VRDVETAAKLVQSVNELGLSMGISFAAVRDMFGWIGPVLAALHGNAVCDA MSMEG_0410|M.smegmatis_MC2_155 VRDVDTAAKLVASVNALGNAMGINLAAVKDMFAWIGPVLAALQGNPVCDA MAB_0937c|M.abscessus_ATCC_199 VRNVDNAAKLVDEINALANDMGWNFSAAKDMFGWINPVLAALQGNPICDA MAV_1761|M.avium_104 VNQVDIAARLVDHVNSLSNAMGWNFTAAKNMFAWIGPVLAALQGNPVCDA MUL_0757|M.ulcerans_Agy99 -----VTHQMVIQMKGMVVDVEELRNHIADFDDFFRPIRSYFYWEKHCFD : ::* :. : . . : .: : . * MMAR_2342|M.marinum_M DPACAAARSQLQALVAAQTSGSLSSITALGRTLQQ-TQEFQTVAQTIAKL TH_2203|M.thermoresistible__bu DPRCVSAREELRQLTVAGRQGVLDRIAALGRQLEE-TRGGQTIDQTLATL Mb1215|M.bovis_AF2122/97 NPMCGNARVQFHKLQTARDNGTLDKVVGLARQLQS-TRSPQTVSAVVNDL Rv1183|M.tuberculosis_H37Rv NPMCGNARVQFHKLQTARDNGTLDKVVGLARQLQS-TRSPQTVSAVVNDL MLBr_01231|M.leprae_Br4923 NPICADARAQFHKLLTASEDGTLDNIAHLWKQLGS-TQSSQTIGATVSGL Mflv_0403|M.gilvum_PYR-GCK NPSCVDTRMQFEKLVSAREDGRVDEINQLAGQLQG-VDDRQSLTATVNQL Mvan_0271|M.vanbaalenii_PYR-1 NPSCVNTRMQFERLMDARADGRLERINTLAGELEG-LDDTQSLNSTVKTL MSMEG_0410|M.smegmatis_MC2_155 NPSCSATRAQFERVLDPSNEGNLNQINQLAQEFQG-VEDRETLNSAVKKL MAB_0937c|M.abscessus_ATCC_199 DTSCSNTRGQFERLVGERNSGRLDEIERLAHQLGNSPGNKATLSTTVTKL MAV_1761|M.avium_104 DSSCSATRATFEQLVGPRGQADLDAIDDLSHQLQA-YPDKRALKASTDRL MUL_0757|M.ulcerans_Agy99 IPVCWSLRSVFDTLDG---------VDLMTEDINNLLPLMERLDTLMPQM . * * : : : : : : : MMAR_2342|M.marinum_M ETNLNQAVKLLRSIDG-----MQNQLNQMQQGASALAQGSRAIAQGVNEL TH_2203|M.thermoresistible__bu TGTLTDATAALRAAGLDKPGSLQAKIATMQEGADALADASRKLADGVQLL Mb1215|M.bovis_AF2122/97 GRSLNSVVRSLKSLGLDNPDAARARLISMQNGANDLASAGRQVADGVQML Rv1183|M.tuberculosis_H37Rv GRSLNSVVRSLKSLGLDNPDAARARLISMQNGANDLASAGRQVADGVQML MLBr_01231|M.leprae_Br4923 EKTLTAVNTSLRSLGLDNPNVMRSKMIGLQNGVNDLASAGRRIADGVAVL Mflv_0403|M.gilvum_PYR-GCK NGALAQVTKAISAMGLDTPAGARAGLDDLQDGADRLADGSRQVAGGVDQL Mvan_0271|M.vanbaalenii_PYR-1 NAAMTNIVKAVDELGLDSPGGAQTSLRDIRQGTDRLASGSRQVAGGVDQL MSMEG_0410|M.smegmatis_MC2_155 NAAMANVAKAVDAMGLDKPGGTQKGLKDLQQGASRLAGGSREVAGGVDEL MAB_0937c|M.abscessus_ATCC_199 NASLLSVVNGLHAMGLDKPGGPQAGLNQLRQGADRLAGGSQQVAGGVDQL MAV_1761|M.avium_104 RNAFAKLNDVLRAMGMDRPGGLQSNLTTLQNGADQFAGGSRQVADAVAQL MUL_0757|M.ulcerans_Agy99 TAMMPEMIQTMK---------------SMKAQMLSMHSTQQGLQDQMAAM : : :: : : : : : MMAR_2342|M.marinum_M VKQTKRMGTGLDEASDFLLQMKHDANKPSMAGFNIPPEALAKDEFKKAAQ TH_2203|M.thermoresistible__bu VNQTKEMGSGLGEASSFLLAMKRDATTPAMAGFYIPPEVLTQEEFAKAAE Mb1215|M.bovis_AF2122/97 VDQTKNMGIGLNQASAFLMAMGNDASQPSMAGFNVPPQVLKSEEFKKVAQ Rv1183|M.tuberculosis_H37Rv VDQTKNMGIGLNQASAFLMAMGNDASQPSMAGFNVPPQVLKSEEFKKVAQ MLBr_01231|M.leprae_Br4923 VDQTRTMGTSLARASAFLMEMGQDASQPSMAGFNVPPQLLNTEDFKKLVQ Mflv_0403|M.gilvum_PYR-GCK VEQIKVMAAGLDQAAAFLLTMRNDASSSNMAGFSIPAEVLGAVEFQKASE Mvan_0271|M.vanbaalenii_PYR-1 VEQVRVMADGLNQAAAFLLTMRHDAASANMAGFSIPAEVLNAVEFQKAAE MSMEG_0410|M.smegmatis_MC2_155 VKQVKVIAAGLNEASTFLLTMRNNAADPSQAGFNIPPEVFGLEDFKKASA MAB_0937c|M.abscessus_ATCC_199 VGQIKVIVNGLNQASNFLLTMKTNAADPSQAGFNIPAEVLNNPDFQRAAK MAV_1761|M.avium_104 VDKVKQLGAGLSESAAFLLSLKHDAAHPAMAGFNIPAQLLRLPQFQEAAK MUL_0757|M.ulcerans_Agy99 QEDSSAMGEAFDSS-------------RNDDSFYLPPEVFNNPDFKRGLE . : .: : .* :*.: : :* . MMAR_2342|M.marinum_M IFISPDGHGARYLVQSALNPFTTAAMDQVDEILDVAHDAQPNSELSDATI TH_2203|M.thermoresistible__bu IFVSPDGHGVRYLVTTTLNPFSTEAMDLVNEITETARGARANTELAEADI Mb1215|M.bovis_AF2122/97 AFISPDGHTVRYFIQTDLNPFSTAAMDQVNTIIDTAKGAQPNTSLADASI Rv1183|M.tuberculosis_H37Rv AFISPDGHTVRYFIQTDLNPFSTAAMDQVNTIIDTAKGAQPNTSLADASI MLBr_01231|M.leprae_Br4923 AFISPDGHSVRYFIQTDLNPFSSAAMDQVNTILNVATGAQPNTTLSDASI Mflv_0403|M.gilvum_PYR-GCK AFVSPDGHSVRYLVQTKLNPFSSEAMDQVNTISDIARGAQPNTMLSDASI Mvan_0271|M.vanbaalenii_PYR-1 AFISPDGHSVRYLVQTRLNPFSPEAMDQVNVINDIARGAQPNTSLADASI MSMEG_0410|M.smegmatis_MC2_155 AYISPDGHSVRYLVQTKLNPFSAEAMDQVNQIGDIARGAQPNTTLADAEI MAB_0937c|M.abscessus_ATCC_199 AFISPDGHSVRYLVQTKLNPFSPEAMDQVNQISDVAKGAQPNTTLADATI MAV_1761|M.avium_104 VFISPDGHSVRYLVQSKLSPFSTQAMDQVDAITATARGAQPNTALADAEV MUL_0757|M.ulcerans_Agy99 QFLSPDGHAVRFIISHEGDPMSQAGINHIDKIKTAAKEAIKGTPLEGSTI ::***** .*::: .*:: .:: :: * * * .: * : : MMAR_2342|M.marinum_M SMVGIPTGLSDTRDYYNHDIQFIVFATILIVFLILVILLRAIVAPLYLIG TH_2203|M.thermoresistible__bu SMAGFTTTLRDTRDYYNNDFRLITTLTVVIVFLILVALLRAIVAPLYLIA Mb1215|M.bovis_AF2122/97 SMSGYPVMLRDIRDYYERDMRLIVAVTVVVVILILMALLRAIVAPLYLVG Rv1183|M.tuberculosis_H37Rv SMSGYPVMLRDIRDYYERDMRLIVAVTVVVVILILMALLRAIVAPLYLVG MLBr_01231|M.leprae_Br4923 YLSGYTVTLRDTRDYYDRDLQLIVIVTMIVVLLILMALLRSIVAPIYLVG Mflv_0403|M.gilvum_PYR-GCK SMGGFPAALRDTRDYYERDIRFIIVVTLVIVMLVLMLLLRSLIAPLYLVG Mvan_0271|M.vanbaalenii_PYR-1 SMGGFPAALRDTRDYYERDIRFIIIAALIVVLVTLSVLLRSLVAPLYLVG MSMEG_0410|M.smegmatis_MC2_155 SMGGFPVALRDTRDYYQQDIRFIIIATLIVVLLTLTVLLRTVIAPLYLVG MAB_0937c|M.abscessus_ATCC_199 SMGGFPTALRDTRDYYQHDIQFIIAATLIVVLLTLMVLLRAIVAPLYLVG MAV_1761|M.avium_104 SMAGYTVGLKDTRDYYQHDIKFIIAVTLLVVLLTLMALLRAIVAPLYLVA MUL_0757|M.ulcerans_Agy99 YLGGTVAMFKDLSDGNTFDLMIAGISALCLIFIIMLIITRSVVAAAVIVG : * . : * * *: : :: :::: : : *:::*. ::. MMAR_2342|M.marinum_M SVLVSFLSALGLGVIVFQLILGKDLHWSLPGLSFILLVAVGADYNMLLIS TH_2203|M.thermoresistible__bu SVVISYLSALGLGVILFQYILGQELSWSVPGLTFIVLVAVGADYNMLLIS Mb1215|M.bovis_AF2122/97 SVVISYMSAIGLGVVVFQVFLGQELHWSVPGLAFVVLVAVGADYNMLLAS Rv1183|M.tuberculosis_H37Rv SVVISYMSAIGLGVVVFQVFLGQELHWSVPGLAFVVLVAVGADYNMLLAS MLBr_01231|M.leprae_Br4923 SVIVSYLSALGLCVLVFQVLLRQQLHWSVPGLAFVVLVAVGADYNMLLAS Mflv_0403|M.gilvum_PYR-GCK SVVVSYFAAIGIGVLVFQLLLGQQLHWSVPPLAFVVLVAVGADYNMLFVS Mvan_0271|M.vanbaalenii_PYR-1 SVVVSYFAAIGIGVLTFQLLLGQQLHWSVPPLAFVVLVAVGADYNMLFVS MSMEG_0410|M.smegmatis_MC2_155 SVVVSYFAAIGLGVLMFQVVLGQQLHWSVPPLAFVVLVAVGADYNMLFVS MAB_0937c|M.abscessus_ATCC_199 SVVLSYFAAIGIGVLTFQYLLGEQLHWTVPPLAFVVLVAVGADYNMLFVS MAV_1761|M.avium_104 TVVISYLSAVGVGVLVFQFLLGQQLHWSVPPLAFVVLVAVGADYNMLLVS MUL_0757|M.ulcerans_Agy99 TVVLSLGASFGLSVLIWQHVLGIELHWLVLAMAVIILLAVGADYNLLLVA :*::* ::.*: *: :* .* :* * : ::.::*:*******:*: : MMAR_2342|M.marinum_M RIRDESPHGVRVGVIRTVGSTGGVITSAGLIFAASMFGLLAASITTMVEA TH_2203|M.thermoresistible__bu RIREESPHGIRSGIIRTVGHTGGVITSAGLIFAASMFGLVFASITTMIQA Mb1215|M.bovis_AF2122/97 RLRDESALGVRSSVIRTVRCTGGVITAAGLIFAASMSGLLFSSIGTVVQG Rv1183|M.tuberculosis_H37Rv RLRDESALGVRSSVIRTVRCTGGVITAAGLIFAASMSGLLFSSIGTVVQG MLBr_01231|M.leprae_Br4923 RLRDESSHGLRASVIRTVRSTGGVITAAGLIFAASMFGLLLSSIATVVQA Mflv_0403|M.gilvum_PYR-GCK RMRDESPHSVRFGIIRTLGSTGGVITAAGLIFAASMAGLLFSSIGIVVQG Mvan_0271|M.vanbaalenii_PYR-1 RLRDESPHSVRYGVIRTLGSTGGVITAAGLIFAASMAGLLFSSIGIVVQG MSMEG_0410|M.smegmatis_MC2_155 RLRDESPHSVRYGVIRTLGSTGGVITAAGLIFAASMAGLLFSSIGLVVQG MAB_0937c|M.abscessus_ATCC_199 RMRDESASSVRYGIIRALNSTGGVITAAGLIFAASVGGLLFSSIGIVVQG MAV_1761|M.avium_104 RMRDESPHSMRYGIIRTLSSTGGVITAAGLIFAASMSGLLFSSIGTVVQG MUL_0757|M.ulcerans_Agy99 RLKEEIHAGINTGIIRAMGGSGSVVTAAGLVFAFTMMSFAVSELTVMAQV *:::* .:. .:**:: :*.*:*:***:** :: .: :.: : : MMAR_2342|M.marinum_M GFIIGSGILIDTFLVRSVTVPAMAAMLGQANWWPSKIGASSTRRRVYQRA TH_2203|M.thermoresistible__bu GFILGVGLLLDTFLVRTITVPATAVLVGRANWWPAKPPHDG--------- Mb1215|M.bovis_AF2122/97 GFIIGVGILIDTFVVRTITVPAMATLLGRASWWPGHPWQRCAPEEGQMSA Rv1183|M.tuberculosis_H37Rv GFIIGVGILIDTFVVRTITVPAMATLLGRASWWPGHPWQRCAPEEGQMSA MLBr_01231|M.leprae_Br4923 GFVLGSGILLDTFIVRTITVPAVAALLRRASWWPARPWGNNA-------- Mflv_0403|M.gilvum_PYR-GCK GFVIGVGILLDTFVVRTITVPAIATLLGRANWWPSRVA---APARERVSA Mvan_0271|M.vanbaalenii_PYR-1 GFVIGVGILLDTFVVRTITVPAIAALVGRANWWPSKVGPQQAAPRAVESA MSMEG_0410|M.smegmatis_MC2_155 GFVIGVGILLDTFVVRTITVPAIASLVGRANWWPGQIG--TSPSNSRAPA MAB_0937c|M.abscessus_ATCC_199 GFVIGVGILLDTFVVRTITVPAIAALVGKANWWPSQVNARQTSSAKPSAA MAV_1761|M.avium_104 GVVIGVGILLDTFLVRTVTVPAIAALAGRANWWPSRIA----VRRNPVSG MUL_0757|M.ulcerans_Agy99 GTTIGMGLLFDTLIVRSFMTPSIAALLGKWFWWPQVVRQRPAPQPWPTPA * :* *:*:**::**:. .*: * : : *** MMAR_2342|M.marinum_M GSRKPNLLDRIKSLGPAKQRAAVTAKASTTTTKRPSTAVKKRGELVSKPG TH_2203|M.thermoresistible__bu -------------------------------------------------- Mb1215|M.bovis_AF2122/97 RMSARTKTVFQAVADGSKR------------------------------- Rv1183|M.tuberculosis_H37Rv RMSARTKTVFQAVADGSKR------------------------------- MLBr_01231|M.leprae_Br4923 -------------------------------------------------- Mflv_0403|M.gilvum_PYR-GCK DT------------------------------------------------ Mvan_0271|M.vanbaalenii_PYR-1 GSG----------------------------------------------- MSMEG_0410|M.smegmatis_MC2_155 EVT----------------------------------------------- MAB_0937c|M.abscessus_ATCC_199 APAG---------------------------------------------- MAV_1761|M.avium_104 QP------------------------------------------------ MUL_0757|M.ulcerans_Agy99 PTPPPATTSV---------------------------------------- MMAR_2342|M.marinum_M TRKRVRKPAWPDIPITNDDYESLQEHALPLFGSIRLPRELTPIDPALHNG TH_2203|M.thermoresistible__bu -------------------------------------------------- Mb1215|M.bovis_AF2122/97 -------------------------------------------------- Rv1183|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_01231|M.leprae_Br4923 -------------------------------------------------- Mflv_0403|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_0271|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_0410|M.smegmatis_MC2_155 -------------------------------------------------- MAB_0937c|M.abscessus_ATCC_199 -------------------------------------------------- MAV_1761|M.avium_104 -------------------------------------------------- MUL_0757|M.ulcerans_Agy99 -------------------------------------------------- MMAR_2342|M.marinum_M DGATSNGDGTTNGSGADCKQLQLIGLGDTTEFRVPNGTTNGNGNGNGHTN TH_2203|M.thermoresistible__bu -------------------------------------------------- Mb1215|M.bovis_AF2122/97 -------------------------------------------------- Rv1183|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_01231|M.leprae_Br4923 -------------------------------------------------- Mflv_0403|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_0271|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_0410|M.smegmatis_MC2_155 -------------------------------------------------- MAB_0937c|M.abscessus_ATCC_199 -------------------------------------------------- MAV_1761|M.avium_104 -------------------------------------------------- MUL_0757|M.ulcerans_Agy99 -------------------------------------------------- MMAR_2342|M.marinum_M GNGHTNGNGHTNGNGHTNGTNGHGTNGATNGNGHTNGTNGTNGHGTNGAT TH_2203|M.thermoresistible__bu -------------------------------------------------- Mb1215|M.bovis_AF2122/97 -------------------------------------------------- Rv1183|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_01231|M.leprae_Br4923 -------------------------------------------------- Mflv_0403|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_0271|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_0410|M.smegmatis_MC2_155 -------------------------------------------------- MAB_0937c|M.abscessus_ATCC_199 -------------------------------------------------- MAV_1761|M.avium_104 -------------------------------------------------- MUL_0757|M.ulcerans_Agy99 -------------------------------------------------- MMAR_2342|M.marinum_M NGHTNGTNGNGHTNGTNGHGTNGATNGNGHTNGTNGTNGHGTNGATNGHT TH_2203|M.thermoresistible__bu -------------------------------------------------- Mb1215|M.bovis_AF2122/97 -------------------------------------------------- Rv1183|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_01231|M.leprae_Br4923 -------------------------------------------------- Mflv_0403|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_0271|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_0410|M.smegmatis_MC2_155 -------------------------------------------------- MAB_0937c|M.abscessus_ATCC_199 -------------------------------------------------- MAV_1761|M.avium_104 -------------------------------------------------- MUL_0757|M.ulcerans_Agy99 -------------------------------------------------- MMAR_2342|M.marinum_M NGNGNGTNGNGNGTNGHGTNGHTNGNGTNGATNGASNGATNGTNGHTNGN TH_2203|M.thermoresistible__bu -------------------------------------------------- Mb1215|M.bovis_AF2122/97 -------------------------------------------------- Rv1183|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_01231|M.leprae_Br4923 -------------------------------------------------- Mflv_0403|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_0271|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_0410|M.smegmatis_MC2_155 -------------------------------------------------- MAB_0937c|M.abscessus_ATCC_199 -------------------------------------------------- MAV_1761|M.avium_104 -------------------------------------------------- MUL_0757|M.ulcerans_Agy99 -------------------------------------------------- MMAR_2342|M.marinum_M GNGNGTNGHTSGNGNGTNGATNGASNGATNGTNGHTNGNGNGTNGATNGH TH_2203|M.thermoresistible__bu -------------------------------------------------- Mb1215|M.bovis_AF2122/97 -------------------------------------------------- Rv1183|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_01231|M.leprae_Br4923 -------------------------------------------------- Mflv_0403|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_0271|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_0410|M.smegmatis_MC2_155 -------------------------------------------------- MAB_0937c|M.abscessus_ATCC_199 -------------------------------------------------- MAV_1761|M.avium_104 -------------------------------------------------- MUL_0757|M.ulcerans_Agy99 -------------------------------------------------- MMAR_2342|M.marinum_M TNGNGNGTNGHTSGNGNGTNGATNGASNGATNGTNGHTNGNGNGNGTNGA TH_2203|M.thermoresistible__bu -------------------------------------------------- Mb1215|M.bovis_AF2122/97 -------------------------------------------------- Rv1183|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_01231|M.leprae_Br4923 -------------------------------------------------- Mflv_0403|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_0271|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_0410|M.smegmatis_MC2_155 -------------------------------------------------- MAB_0937c|M.abscessus_ATCC_199 -------------------------------------------------- MAV_1761|M.avium_104 -------------------------------------------------- MUL_0757|M.ulcerans_Agy99 -------------------------------------------------- MMAR_2342|M.marinum_M TNEHGTNGSTNGDIDDADEGHALPLFGPSNQRDLLIKR TH_2203|M.thermoresistible__bu -------------------------------------- Mb1215|M.bovis_AF2122/97 -------------------------------------- Rv1183|M.tuberculosis_H37Rv -------------------------------------- MLBr_01231|M.leprae_Br4923 -------------------------------------- Mflv_0403|M.gilvum_PYR-GCK -------------------------------------- Mvan_0271|M.vanbaalenii_PYR-1 -------------------------------------- MSMEG_0410|M.smegmatis_MC2_155 -------------------------------------- MAB_0937c|M.abscessus_ATCC_199 -------------------------------------- MAV_1761|M.avium_104 -------------------------------------- MUL_0757|M.ulcerans_Agy99 --------------------------------------