For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
MADYGWVSSGVATLSRPVRERLQKVAAGEGAYSDRLARLAGFSIRHKVLIIGMWVVTAAALAVLFPQLET VVRQQSVNLIPRDAPSLQTVDRMGAAFGEQGSKTTIFVAMEDPAGLTAPVRQRYNTMISRLRADSEHVRL VQDLLADPVTASQAVSQDGKAWYVPVGVAGTLGDVKAAESVQAVRTIAAQAFSGSPTNVRVTGPPATFHD QIASAEEDLVVISIATAGLIAMILLVVYRSVFTALLPLLVIGVSLAVGRGVLSALGESGMPVSQFTIAFM TVILLGAGTDYSVFLISRYHEQRRQNVPPDLSVINATATIGRVILASAATVAFAFLAMVFAKLSVFAALG PACAIAVFVGFAATVTLFPPVLALAAKRGIGEPKADRTRRYWNWIAVAVVRRPVPLLVASLALVLGLAAV ALTMHISYDDRRGQPATTASNEGYRLLDRHFRKDAIVTEFMVVESPTDMRTSKALADLDEMASRVSQLPG VTKVSGVTRPTGARLDQAQLSWQNGEIGDKMAGAVAKGDAHKDDLAKLTHGADQLAGGLAQLDTTLRTAL TPLTGLLTQAQSSGSQVQRFRPLLQQLSATAPAVDQAIRTGPGLRQQADQAQNAIAAIDPLVGALNTSPW CATTPECTQLRDQVQILVTLRHTGFFNQLANLGDLYQPGSDTAAGTVADVQNTITSLDKTFGALGDPADL AGNIRRLQSGISQLASGAQALATGVHTLADSNIEMLSGMSQIATQLQNSARTTAGSDNASGFYLPTNAFE NRQFADVAKHFLSPDGKTARFAIESSYDPYSSDAMNLAHKITEVADAARPNTSLANATVSMAGFPAVNSD IQRLLSADFHQLAFATLVIVGLILVVLLRALVAPLYLLGTVVLNYGAALGLGTLVFQYGLGKEIAWPVPL LAFIILVAVGADYNMLLISRLREESAHNIRVGVLRTVANTGSVITSAGLIFAASMFGLIAGSIAIMIQAG FIIGCGLLLDTFVVRTLTVPAIATLLREASWWPQRKPLTHNG
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. marinum M | MMAR_4836 | - | - | 100% (1022) | MmpL family transport protein |
M. marinum M | MMAR_2342 | - | 0.0 | 39.56% (1011) | MmpL family transport protein |
M. marinum M | MMAR_4975 | - | e-137 | 31.88% (985) | MmpL family transport protein |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb1549c | mmpL12 | 0.0 | 40.61% (980) | transmembrane transport protein MmpL12 |
M. gilvum PYR-GCK | Mflv_4632 | - | 0.0 | 75.39% (577) | MMPL domain-containing protein |
M. tuberculosis H37Rv | Rv1522c | mmpL12 | 0.0 | 40.71% (980) | transmembrane transport protein MmpL12 |
M. leprae Br4923 | MLBr_01231 | mmpL10 | 0.0 | 38.00% (979) | hypothetical protein MLBr_01231 |
M. abscessus ATCC 19977 | MAB_0855 | - | 0.0 | 38.83% (976) | MmpL family protein |
M. avium 104 | MAV_1761 | - | 0.0 | 38.68% (998) | MmpL10 protein |
M. smegmatis MC2 155 | MSMEG_4741 | - | 0.0 | 38.80% (987) | MmpL protein |
M. thermoresistible (build 8) | TH_3450 | - | 0.0 | 81.51% (968) | PUTATIVE MMPL domain protein |
M. ulcerans Agy99 | MUL_0757 | mmpL5 | 1e-125 | 30.97% (972) | transmembrane transport protein, MmpL5 |
M. vanbaalenii PYR-1 | Mvan_0312 | - | 0.0 | 78.78% (985) | MMPL domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment MMAR_4836|M.marinum_M MADYGWVSSGVATLSRPVRERLQKVAAGEGAYSDRLARLAGFSIR-HKVL TH_3450|M.thermoresistible__bu ------------------------------------------------VL Mflv_4632|M.gilvum_PYR-GCK -MTDGSADAPSQAKRPGRRANGSTDPADTREYSERLATLARFTLR-HKAL Mvan_0312|M.vanbaalenii_PYR-1 -MTDGTADSPSQATRSGRGANGSPDPADTREYSERLAALARFTLR-HKAL MAB_0855|M.abscessus_ATCC_1997 ----------------------------MAENTGGIYGLIAQIVRRAPVI MSMEG_4741|M.smegmatis_MC2_155 ------------------------------MSRVGFSGLGRFIVR-HPLV MLBr_01231|M.leprae_Br4923 -------------------------------------------------M MAV_1761|M.avium_104 -----------------------MSPTAPAGDEVEMRRIADFVVR-WPWL Mb1549c|M.bovis_AF2122/97 -----------------------MARHDEAKAGGLFDRIGNFVVR-WPLI Rv1522c|M.tuberculosis_H37Rv -----------------------MARHDEAKAGGLFDRIGNFVVR-WPLI MUL_0757|M.ulcerans_Agy99 ----------------MTATTTDTPTDVVPPAEHPPRPFIPRMIRTFAVP MMAR_4836|M.marinum_M IIGMWVVTAAALAVLFPQLETVVRQQSVNLIPRDAPSLQTVDRMGAAFGE TH_3450|M.thermoresistible__bu VIGTWLAVAVVLALLFPQLETVVRQQSVDLIPRDVPSFQTLDRMSAAFGE Mflv_4632|M.gilvum_PYR-GCK VIGVWLGAAVVLALLFPQLETVVRQQSVDLIPRDAPSLQTVDRMSAAFGE Mvan_0312|M.vanbaalenii_PYR-1 VIGVWLGAAVVLALLFPQLETVVRQQSVDLIPRDAPSLQTVDRMSAAFGE MAB_0855|M.abscessus_ATCC_1997 VIGLWIGLAAVLALTAPSLQKAIEDHPVDLLPKDAPVMETTRQMVESFQE MSMEG_4741|M.smegmatis_MC2_155 VIASWLAVAGVLLAAVPSLPAVAERNPPGFLPADSEVFAAGNAMQEAFNE MLBr_01231|M.leprae_Br4923 VIGCWTLLALMLPMTVPSLTELTQRHPVVILPVDAPSSVAAKKISQAFHE MAV_1761|M.avium_104 VIGFWAALAVALPLAFPSLAEMAQKHPLAILPGNAPSNVAARQMTEAFHE Mb1549c|M.bovis_AF2122/97 VIGCWIAVAAALTLLLPTLQAQAAKREQAPLPPGAPSMVLQKEMSAAFQE Rv1522c|M.tuberculosis_H37Rv VIGCWIAVAAALTLLLPTLQAQAAKREQAPLPPGAPSMVLQKEMSAAFQE MUL_0757|M.ulcerans_Agy99 LILGWVLLIAVLNSVVPQLEVVGQMQAVSMSPDAAPSMISMKHIGKVFRE :* * * * * . * : * * MMAR_4836|M.marinum_M -QGSKTTIFVAMEDPAGLTAPVRQRYNTMISRLRADSEHVRLVQDLLADP TH_3450|M.thermoresistible__bu -QGSKTTVFVAMEDPAGLTPAARDRYEAMVSRLRADTDHVLLVQDLLADP Mflv_4632|M.gilvum_PYR-GCK -EGSKTMVFVAMEDPTGLTPTARQRYGELVRRLQAEGDHVLLVQDLLADP Mvan_0312|M.vanbaalenii_PYR-1 -EGSKTMVFVAMEDPNGLTPTARQRYGELVSRLQSEGDHVLLVQDLLADP MAB_0855|M.abscessus_ATCC_1997 -SGAQNILLIVLTNENGLTPADEQTYRILAARMREDTRDVSMVQDFITKP MSMEG_4741|M.smegmatis_MC2_155 -TGGGNVAIAILSNENGLTPADEETYRALVDKLRADTEYVLSTQDFVTIP MLBr_01231|M.leprae_Br4923 -VDSENVLIVLLTDDKGLGPADETVYRTLVDRLRNDTKDVVVLQDFLSTP MAV_1761|M.avium_104 -SGSDDLLLVALTDEKGLGPADEAVYRRLVDALRRDTRDVVMVQDFISAP Mb1549c|M.bovis_AF2122/97 KIETSALLLVLLTNENGLGPADEAVYRKLIENLRADTQDKISVQDFLAVP Rv1522c|M.tuberculosis_H37Rv KIETSALLLVLLTNENGLGPADEAVYRKLIENLRADTQDKISVQDFLAVP MUL_0757|M.ulcerans_Agy99 -GDSDSAAMIVLEGQEPLGAAAHKFYDKMITKLRADTKHVQSVQDFWGDP : : . * .. . * : :: : **: * MMAR_4836|M.marinum_M VTASQAVSQDGKAWYVPVGVAGTLGDVKAAESVQAVRTIAAQAFSGS--- TH_3450|M.thermoresistible__bu VTATQAVSQDGKAWYLPVGVAGTLGDPTAAESVQAVRALAAEAFADS--- Mflv_4632|M.gilvum_PYR-GCK ITEAQAVSADRKAWYLPVGVTGTLGDPTAAESLNAVRDIAAEVFTGS--- Mvan_0312|M.vanbaalenii_PYR-1 ITEAQAVSVDRKAWYLPVGVAGTLGDPTAAESVNAVRDIAAEVFTGS--- MAB_0855|M.abscessus_ATCC_1997 PLREMMSSTDGKAWYLPVGLQGELATPESGKAYVGALKIIKDATQGT--- MSMEG_4741|M.smegmatis_MC2_155 ELRQVMTSEDNKAWQLPISAAGTMGTAEGQNAYRQIVDTVKSSTANT--- MLBr_01231|M.leprae_Br4923 PLHELLVSKDGKAWILPIVLAGELGTSASYQAYAGVAGIVKQTLEST--- MAV_1761|M.avium_104 PLRSAVTSKDRKAWVLPVGIAGELGTPQSYAAFNRIAGIVKQTLEKHENG Mb1549c|M.bovis_AF2122/97 EMKELLASKDNKAWNLPITFAGDAASPETQAAFKRVAAIVKQTVAGT--- Rv1522c|M.tuberculosis_H37Rv EMKELLASKDNKAWNLPITFAGDAASPETQAAFKRVAAIVKQTVAGT--- MUL_0757|M.ulcerans_Agy99 LTATGAQSGDGKAAYVQVKLAGNQGESLANESVEAVKTIVDSLQAPP--- * * ** : : * . : . MMAR_4836|M.marinum_M ----PTNVRVTGPPATFHDQIASAEEDLVVISIATAGLIAMILLVVYRSV TH_3450|M.thermoresistible__bu ----STTVRVTGPPATFSDQIGSAEHDLVLISIATAGLIALILLIVYRSV Mflv_4632|M.gilvum_PYR-GCK ----TTTVQVTGPPATFSDMIASAEHDLLLISIATAGVIALILLIVYRSV Mvan_0312|M.vanbaalenii_PYR-1 ----TTTVHVTGPPATFSDMIASAEHDLLLISIATAGVIALILLIVYRSV MAB_0855|M.abscessus_ATCC_1997 ----SLKAFTTGPTATVGDLTVVGERDLHKVEITTAALVLLILLIVYRNP MSMEG_4741|M.smegmatis_MC2_155 ----SLSAEVIGPAATFEDVVKIGERDQHVIEIATVLIVLMILIIVYRNL MLBr_01231|M.leprae_Br4923 -AGSSLKANLTGPASTVADLTDAGARDRTSIELVIAVLLLTILMIIYRNP MAV_1761|M.avium_104 PAATSLTVSLTGPAATVADLTVAGERDRLPIELAIAVLVLVVLLVVYRSA Mb1549c|M.bovis_AF2122/97 ----SLTVHLSGPIATVADLTELGEKDVRIIEIGAAVSVLIILILVYRNL Rv1522c|M.tuberculosis_H37Rv ----SLTVHLSGPIATVADLTELGEKDVRIIEIGTAVSVLIILILVYRNL MUL_0757|M.ulcerans_Agy99 ----GVKVYVTGSAALVADQQLAGDRSLQLIEMVTFTVIIVMLLLVYRSI .. *. : . * . .. :.: : :*:::**. MMAR_4836|M.marinum_M FTALLPLLVIGVSLAVGRGVLSALGESGMP-VSQFTIAFMTVILLGAGTD TH_3450|M.thermoresistible__bu FTALLPLLVIGVSLAVGRGVLSALGEMGMP-VSQFTVAFMTAILLGAGTD Mflv_4632|M.gilvum_PYR-GCK FTALLPLLVIGLSLAVGRGVLSALGEMGMP-VSQFTVAFMTAILLGAGTD Mvan_0312|M.vanbaalenii_PYR-1 FTALLPLLVIGLSLAVGRGVLSALGEMGMP-VSQFTVAFMTAILLGAGTD MAB_0855|M.abscessus_ATCC_1997 VTMMLPLIVVGVSLGIAQAAVGGLAQMGLS-ISNQTLTFMTAMMMGAGVD MSMEG_4741|M.smegmatis_MC2_155 VAMLLPLLMIGMALVVAEQSVAGLGAIHLIGLGPQTLMLMTAMMMGAGTD MLBr_01231|M.leprae_Br4923 ITMLLPLITIGASLMTAQAVVSGVSVLAGLAVSNQMIVLLSAMIAGAGTD MAV_1761|M.avium_104 VTMLLPLVTILLSLVIAQAAVAGYSQLTGSGVSNQSIVFLSAIMAGAGTD Mb1549c|M.bovis_AF2122/97 VTMLVPLATIGASVVTAQGTLSGLAEFGLA-VNMQAIVFMSAVMIGAGTD Rv1522c|M.tuberculosis_H37Rv VTMLVPLATIGASVVTAQGTLSGLAEFGLA-VNMQAIVFMSAVMIGAGTD MUL_0757|M.ulcerans_Agy99 ITAAIMLTMVVLGLLATRGGVAFLGYHRIIGLSTFATNLLVVLAIAAATD .: : * : .: . :. . :. :: .: .*..* MMAR_4836|M.marinum_M YSVFLISRYHEQRRQN----VPPDLSVINATATIGRVILASAATVAFAFL TH_3450|M.thermoresistible__bu YTVFLISRYHEQRRAQ----VAPEQAAIYATASIGRVILASAATVAFAFL Mflv_4632|M.gilvum_PYR-GCK YTVFLISRYHEQRRAQ----VPADQAIIHATASIGRVILASAATVALAFL Mvan_0312|M.vanbaalenii_PYR-1 YTVFLISRYHEQRRAQ----VPADQAIIHATASIGRVILASAATVALAFL MAB_0855|M.abscessus_ATCC_1997 YAVFLISRYHEYIKQG----LASDDAVAAALESIGKVVAASAATVAVTFL MSMEG_4741|M.smegmatis_MC2_155 YAIFLFSRYHECVRSG----LSSDDAVVEALDSIGKVIAGSAGTVAITFM MLBr_01231|M.leprae_Br4923 YAVFLISRYHDYIRMGSGSAQDAGCAVRQALISLGKVIAASAATVGITFL MAV_1761|M.avium_104 YAVFLISRYHDFLRRG----DDFDQAVRKALISIGKVITASASTVGITFL Mb1549c|M.bovis_AF2122/97 YAVFLISRYHDYVRHG----EKSDMAVKKALMSIGKVITASAATVAVTFL Rv1522c|M.tuberculosis_H37Rv YAVFLISRYHDYVRHG----EKSDMAVKKALMSIGKVITASAATVAVTFL MUL_0757|M.ulcerans_Agy99 YAIFLIGRYQEARGLG----QDRESAYYTMFGGTAHVVLGSGLTIAGATF *::**:.**:: : .:*: .*. *:. : : MMAR_4836|M.marinum_M AMVFAKLSVFAALGPACAIAVFVGFAATVTLFPPVLALAAKRG-IGEPKA TH_3450|M.thermoresistible__bu AMVFARLSVFAALGPACAIAVLFGFLATVTLLPPVLALAAKRG-IGDPKP Mflv_4632|M.gilvum_PYR-GCK AMVFARLSVFAALGPACAIAVLFGFLATVTLLPPVLSLAAKRG-IGEPKP Mvan_0312|M.vanbaalenii_PYR-1 AMVFARLSVFAALGPACAIAVLFGFLATVTLLPPVLSLAAERG-IGEPKS MAB_0855|M.abscessus_ATCC_1997 GMGFTKLGILSTVGPALSVSILIAFVASVTFLPAVLVLVGRRG-WITPRK MSMEG_4741|M.smegmatis_MC2_155 GLAFTDLGVFSTVGPALSVTIGFGFVASVTLLPAMVVLAGRRG-WVKPRK MLBr_01231|M.leprae_Br4923 GMSFTKIRVFSTVGPALAIGIAVAFLAAVTLMPALLVLAGTRG-WVAPRR MAV_1761|M.avium_104 LIGFARMGVFKTVGISSAIGIGVAFLAAVTLLPAIMVLAGPRG-WIRPRR Mb1549c|M.bovis_AF2122/97 AMVFTKLEVFSAVGPAIAVAITVSLLGAVTLLPAILTLTGRRG-WIKPRR Rv1522c|M.tuberculosis_H37Rv AMVFTKLEVFSAVGPAIAVAITVSLLGAVTLLPAILTLTGRRG-WIKPRR MUL_0757|M.ulcerans_Agy99 CLSFTRLPYFQTLGVPLAIGMVIVVATALTLGPALIAVMSRFGKLLEPKR : *: : : ::* . :: : . . ::*: *.:: : . * *: MMAR_4836|M.marinum_M DRTRRYWNWIAVAVVRRPVPLLVASLALVLGLAAVALTMHISYDDRRGQP TH_3450|M.thermoresistible__bu DRTRRYWNSVAVAVVRRPVTLLTISLAVLLALSAVAVTINISYDDRKGQP Mflv_4632|M.gilvum_PYR-GCK DRTRRYWNSVAVAVVRRPVPLLIVSLVILLALSAAAATIKISYDDRKGQP Mvan_0312|M.vanbaalenii_PYR-1 DRTRRYWNSVAVAVVRRPVPLLIVSLVILLALSAAAATIKISYDDRKGQP MAB_0855|M.abscessus_ATCC_1997 AYANKIWHRSGINIVKRPGAHLAVSLVVLVILATCGAMVKFGYDDRKNLP MSMEG_4741|M.smegmatis_MC2_155 DLTGRIWRRSGVHIVRKPVIHLVASLTVLLALAGCAMLVNFNYDDRKNLP MLBr_01231|M.leprae_Br4923 DRAGAFWRRTGVRIVRRPVAYLSASMVILIVLALCASLVRFNYDDRKQIP MAV_1761|M.avium_104 ELTTGLWRRSGIRIVRRPRAHLVASVLVLIILASCAGLVRYNYDDRKALR Mb1549c|M.bovis_AF2122/97 DLTSRMWRRSGVRIVRRPTIHLVGSLIVLVALAGCTLLIRFNYDDLKTVP Rv1522c|M.tuberculosis_H37Rv DLTSRMWRRSGVRIVRRSTIHLVGSLIVLVALAGCTLLIRFNYDDLKTVP MUL_0757|M.ulcerans_Agy99 MARVRGWRKIGAAIVRWPGPILIGAVALALVGLLTLPGYKTNYNDRNYLP *. . :*: . * :: : : . .*:* . MMAR_4836|M.marinum_M ATTASNEGYRLLDRHFRKDAIVTEFMVVESPTDMRTSKALADLDEMASRV TH_3450|M.thermoresistible__bu ADTASNQGYQLLDRHFRKDVVFTEFLVVENPTDMRTGKGLADLDEMASRV Mflv_4632|M.gilvum_PYR-GCK DTTASNQGYHLLDRHFRKDVVISEFLVVENPTDMRTGKGLADLDEMASRV Mvan_0312|M.vanbaalenii_PYR-1 ATTASNQGYHLLDRHFRKDVVITEFLVVENPTDMRTGKGLADLDEMASRV MAB_0855|M.abscessus_ATCC_1997 PWADSNQGYAAIEKHFPVNSTLPQYLYIKSPHDLRTPRGLADLEQMAARV MSMEG_4741|M.smegmatis_MC2_155 DDAHSNMGYAALDKHFPVSSTVQQFILIQSPHDLRSPKALADMEQMAQRV MLBr_01231|M.leprae_Br4923 ASDESSVGYAALESHFPVGQAIPEYLLIQSPHDLRTPRALADMAELAQRV MAV_1761|M.avium_104 PSAPSSVGYAALERHFPVNQSIPEYILIRSPHDLRTPQALADLEQLADRV Mb1549c|M.bovis_AF2122/97 QHVESVKGYEAMNRHFPMNAMTPMVLFIKSPRDLRTPGALADIEMMSREI Rv1522c|M.tuberculosis_H37Rv QHVESVKGYEAMNRHFPMNAMTPMVLFIKSPRDLRTPGALADIEMMSREI MUL_0757|M.ulcerans_Agy99 ADLPANEGYSAAERHFSQARMNPEVLMVESDHDMRNSSDFLVINKIAKAI : ** : ** : :.. *:*. : : :: : MMAR_4836|M.marinum_M SQLPGVTKVSGVTRPTGARLDQAQLSWQNGEIGDKMAGAVAKGDAHKDDL TH_3450|M.thermoresistible__bu AQIPGVTKVSGVTRPTGERLDQAKLAWQNQQIGDKMADAVADGNARKADL Mflv_4632|M.gilvum_PYR-GCK SQIPGVTKVSGVTRPTGERLDQAELAWQNGQIGDKMAGAVAEGNSRKDDL Mvan_0312|M.vanbaalenii_PYR-1 SQIPGVTKVSGVTRPTGERLDQAELAWQNGQIGDKMAGAVAEGNSRKDDL MAB_0855|M.abscessus_ATCC_1997 SQVPGVDKVRGITRPTGEPLEEAKLSYQAGEVGGKLGDASNLIDARTRDL MSMEG_4741|M.smegmatis_MC2_155 SQLPDIEMVRGVTRPTGEMLQEARATWQAGEVGGKLNDASTLIDANDANL MLBr_01231|M.leprae_Br4923 SQIPGIALVRGVTRPTGKPLEETSATYQAGMVGKQLGSASHLIGESTGDL MAV_1761|M.avium_104 SQLPNVSVVSGITRPTGNVPEQFRATYQAGAIGSMLAGGSTMINDQTDDL Mb1549c|M.bovis_AF2122/97 AELPNIVMVRGLTRPNGEPLKETKVSFQAGEVGGKLDEATTLLEEHGGEL Rv1522c|M.tuberculosis_H37Rv AELPNIVMVRGLTRPNGEPLKETKVSFQAGEVGGKLDEATTLLEEHGGEL MUL_0757|M.ulcerans_Agy99 FGVEGISRVQAITRPDGKPIEHTSIPFLISMQGTSQKLTEKYNQDLTTSM : .: * .:*** * .. .: * .: MMAR_4836|M.marinum_M AKLTHGADQLAGGLAQLDTTLRTALTPLTGLLTQAQSSGSQVQRFRPLLQ TH_3450|M.thermoresistible__bu AKLTNGADQLAAGLAQLDTTLRTALAPLSGILSQAQSAGTQMQQFRPLLQ Mflv_4632|M.gilvum_PYR-GCK AKLTGGADQLADGLAQLDSTVRTALTPLAGILTQAQSAGTQVNQFRPGLL Mvan_0312|M.vanbaalenii_PYR-1 AKLTGGADQLADGLAQLDSTVRTALTPLAEILTQAQSAGTQVNQFRPLLQ MAB_0855|M.abscessus_ATCC_1997 DKLAAGGHTLADKLGQVRDSVKNSLGTARALVEVLAQLRGS-GRTGT-LA MSMEG_4741|M.smegmatis_MC2_155 STLSGGAHKLADVLGQISTQVTNALVTVRPLAGALADMETKYGGEKT-LD MLBr_01231|M.leprae_Br4923 NRLASGAGLLADKLGDVRIQVGQAVAGISGLLDNLAFAQKMFGDSKT-LG MAV_1761|M.avium_104 NRLARGAGTLADNLGDVRGQVNQLAASVRELENAFSSTKNQYSGDAL-VN Mb1549c|M.bovis_AF2122/97 DQLTGGAHQLADALAQIRNEINGAVASSSGIVNTLQAMMDLMGGDKT-IR Rv1522c|M.tuberculosis_H37Rv DQLTGGAHQLADALAQIRNEINGAVASSSGIVNTLQAMMDLMGGDKT-IR MUL_0757|M.ulcerans_Agy99 LQQVNDIQTNIDQMERMHDLTQQMADVTHQMVIQMKGMVVDVEELRNHIA . : : : : MMAR_4836|M.marinum_M QLSATAPAVDQAIRTGPGLRQQADQAQNAIAAIDPLVGALNTSPWCATTP TH_3450|M.thermoresistible__bu QLSATAPAVDQAIQAGPGLRPWADQAAHAIAILDPLVGALNTAPWCATTP Mflv_4632|M.gilvum_PYR-GCK RAFRTADFAGIMPR------------------------AVNSCIRCGLHA Mvan_0312|M.vanbaalenii_PYR-1 QLSATAPAVDQAIQSSPGLRPLANQAQNAISQLDPLVGALNTSPWCATTP MAB_0855|M.abscessus_ATCC_1997 DLDSVDKLVTSMHSLGDAIEANAQGASEVYGWIEPVARVLVGNPACDMDP MSMEG_4741|M.smegmatis_MC2_155 QIDQSAELVANMRSLGRAMGVNLARITDVYDWSAPMVRALNVSPECNLDP MLBr_01231|M.leprae_Br4923 EIDTAGKLVSSMRALGNMFGINFSTTMNDINWVGAVVIALDSSVLCDTNP MAV_1761|M.avium_104 QVDIAARLVDHVNSLSNAMGWNFTAAKNMFAWIGPVLAALQGNPVCDADS Mb1549c|M.bovis_AF2122/97 QLENASQYVGRMRALGDNLSGTVTDAEQIATWASPMVNALNSSPVCNSDP Rv1522c|M.tuberculosis_H37Rv QLENASQYVGRMRALGDNLSGTVTDAEQIATWASPMVNALNSSPVCNSDP MUL_0757|M.ulcerans_Agy99 DFDDFFRPIR---------------------------SYFYWEKHCFDIP . * . MMAR_4836|M.marinum_M ECTQLRDQVQILVTLRHTGFFNQLANLGDLYQPGS--DTAAGTVADVQNT TH_3450|M.thermoresistible__bu QCAQIRDQVQVLVTLRNSGFFNQVADLGDRYNPATG-ATVAETLADIRNA Mflv_4632|M.gilvum_PYR-GCK ACG-----------------------------SPTR-SEVCADYRTVR-- Mvan_0312|M.vanbaalenii_PYR-1 QCAQIRDQVKILVTLRDSGFFTQIADLGDRYDPATN-ATVGGTLANVQNA MAB_0855|M.abscessus_ATCC_1997 GCRSSRDEMNKFLETKQDGTRDKIVELGRELKSVDNDKQISSTIARLRTA MSMEG_4741|M.smegmatis_MC2_155 ACAASRSDLQRIVEAKDNGNLDKFAELGRQLESTEGDETLDEAVSGLQQS MLBr_01231|M.leprae_Br4923 ICADARAQFHKLLTASEDGTLDNIAHLWKQLGSTQSSQTIGATVSGLEKT MAV_1761|M.avium_104 SCSATRATFEQLVGPRGQADLDAIDDLSHQLQAYPDKRALKASTDRLRNA Mb1549c|M.bovis_AF2122/97 ACRTSRAQLAAIVQAQDDGLLRSIRALAVTLQQTQEYQTLARTVSTLDGQ Rv1522c|M.tuberculosis_H37Rv ACRTSRAQLAAIVQAQDDGLLRSIRALAVTLQQTQEYQTLARTVSTLDGQ MUL_0757|M.ulcerans_Agy99 VCWSLRS----------------------VFDTLDGVDLMTEDINNLLPL * : MMAR_4836|M.marinum_M ITSLDKTFGALG--DPADLAGNIRRLQSGISQLASGAQALATGVHTLADS TH_3450|M.thermoresistible__bu VTAMDKAFGALG--DPADLAGNIGRLQDGISQLASGAQALATGVHTLVDS Mflv_4632|M.gilvum_PYR-GCK ------------------YSGQYQLLLSSASDTPCGAHVHFSGLQRMILR Mvan_0312|M.vanbaalenii_PYR-1 VASLDKAFGALG--DPADLATNLRRLQDGIGQLASGAQALATGVRTLADS MAB_0855|M.abscessus_ATCC_1997 LNSIDTNLRRLGLSDSYGIQKRFTEVLTGVNSLADGSAQLAEGVQMLVDQ MSMEG_4741|M.smegmatis_MC2_155 IKEATAAARELGLEDASSVKRQLDQLEQGVNLLADSSHQLAQGVQLLVDQ MLBr_01231|M.leprae_Br4923 LTAVNTSLRSLGLDNPNVMRSKMIGLQNGVNDLASAGRRIADGVAVLVDQ MAV_1761|M.avium_104 FAKLNDVLRAMGMDRPGGLQSNLTTLQNGADQFAGGSRQVADAVAQLVDK Mb1549c|M.bovis_AF2122/97 LKQVVSTLKAV-----DGLPTKLAQMQQGANALADGSAALAAGVQELVDQ Rv1522c|M.tuberculosis_H37Rv LKQVVSTLKAV-----DGLPTKLAQMQQGANALADGSAALAAGVQELVDQ MUL_0757|M.ulcerans_Agy99 MERLDTLMPQMT--------AMMPEMIQTMKSMKAQMLSMHSTQQGLQDQ : : MMAR_4836|M.marinum_M NIEMLSGMSQIATQLQNSARTTAGSDNASGFYLPTNAFENRQFADVAKHF TH_3450|M.thermoresistible__bu NLEMLSGMSQIATQLQNSARASADSDSSSGFYLPPNTFENRQFADVAKQF Mflv_4632|M.gilvum_PYR-GCK ------------ARYPNIFRSAPARLS----------YQGRRF------- Mvan_0312|M.vanbaalenii_PYR-1 NIEMLSGMSQIATQLQNSSRAAADSDSSSGFYLPANAFENRQFTDVAEQF MAB_0855|M.abscessus_ATCC_1997 TKQMGGQLGDASTLLVAAKRDAA-PGSMSGFYIPQQVLTQDSFKTAAAAF MSMEG_4741|M.smegmatis_MC2_155 TRNMGQGLDQASQFLLAMKRDAS-DPQMSGFYIPPQILTQEEFNKAAALF MLBr_01231|M.leprae_Br4923 TRTMGTSLARASAFLMEMGQDAS-QPSMAGFNVPPQLLNTEDFKKLVQAF MAV_1761|M.avium_104 VKQLGAGLSESAAFLLSLKHDAA-HPAMAGFNIPAQLLRLPQFQEAAKVF Mb1549c|M.bovis_AF2122/97 VKKMGSGLNEAADFLLGIKRDAD-KPSMAGFNIPPQIFSRDEFKKGAQIF Rv1522c|M.tuberculosis_H37Rv VKKMGSGLNEAADFLLGIKRDAD-KPSMAGFNIPPQIFSRDEFKKGAQIF MUL_0757|M.ulcerans_Agy99 MAAMQEDSSAMGEAFDSSRNDDS-------FYLPPEVFNNPDFKRGLEQF . * MMAR_4836|M.marinum_M LSPDGKTARFAIESSYDPYSSDAMNLAHKITEVADAARPNTSLANATVSM TH_3450|M.thermoresistible__bu LSPDGKTARFAIESSHDPYSVDAMNLAHTITDVADAARPNTSLAHATVSV Mflv_4632|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_0312|M.vanbaalenii_PYR-1 LSPDGKTARFMIESSHDPYSVEAMDLASRITDTANTARPNTSLADATVSV MAB_0855|M.abscessus_ATCC_1997 VSADGHAVRYLVQSNLNPFSPEAMDQVRAIQEAARSAQPNTTLSDASISM MSMEG_4741|M.smegmatis_MC2_155 VSPDGRSVRYLVQTALDPFGTAAMDQVKDIVKTAESARPNTSLTDAKISL MLBr_01231|M.leprae_Br4923 ISPDGHSVRYFIQTDLNPFSSAAMDQVNTILNVATGAQPNTTLSDASIYL MAV_1761|M.avium_104 ISPDGHSVRYLVQSKLSPFSTQAMDQVDAITATARGAQPNTALADAEVSM Mb1549c|M.bovis_AF2122/97 LSADGHAARYFVQSALNPATTEAMDQVNDILRVADSARPNTELEDATIGL Rv1522c|M.tuberculosis_H37Rv LSADGHAARYFVQSALNPATTEAMDQVNDILRVADSARPNTELEDATIGL MUL_0757|M.ulcerans_Agy99 LSPDGHAVRFIISHEGDPMSQAGINHIDKIKTAAKEAIKGTPLEGSTIYL MMAR_4836|M.marinum_M AGFPAVNSDIQRLLSADFHQLAFATLVIVGLILVVLLRALVAPLYLLGTV TH_3450|M.thermoresistible__bu AGFPAVNSDIARLLWADFAQLAIATIVIVGLILVLLLRALLAPIYLLGTV Mflv_4632|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_0312|M.vanbaalenii_PYR-1 AGFPAVNSDIQRLLWADFAQLAIATIIIVGVILVLLLRALLAPLYLLGTV MAB_0855|M.abscessus_ATCC_1997 AGLSAMYNDIRNYYNHDLRFIIVLTVIVVLLILVALLRAIVAPLYLIGSV MSMEG_4741|M.smegmatis_MC2_155 VGFSSIQNEMRNYYDGDLRFIITVTLIVVFLILAALLRSIIAPIYLVLSV MLBr_01231|M.leprae_Br4923 SGYTVTLRDTRDYYDRDLQLIVIVTMIVVLLILMALLRSIVAPIYLVGSV MAV_1761|M.avium_104 AGYTVGLKDTRDYYQHDIKFIIAVTLLVVLLTLMALLRAIVAPLYLVATV Mb1549c|M.bovis_AF2122/97 AGVPTALRDIRDYYNSDMKFIVIATIVIVFLILVILLRALVAPIYLIGSV Rv1522c|M.tuberculosis_H37Rv AGVPTALRDIRDYYNSDMKFIVIATIVIVFLILVILLRALVAPIYLIGSV MUL_0757|M.ulcerans_Agy99 GGTVAMFKDLSDGNTFDLMIAGISALCLIFIIMLIITRSVVAAAVIVGTV MMAR_4836|M.marinum_M VLNYGAALGLGTLVFQYGLGKEIAWPVPLLAFIILVAVGADYNMLLISRL TH_3450|M.thermoresistible__bu VLNYLASLGIGVLVFQYLLGHEIAWPVPLLAFIILVAVGADYNMLLVSRL Mflv_4632|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_0312|M.vanbaalenii_PYR-1 VLNYLASLGIGVVVFQWGLGHEIAWPVPLLAFIILVAVGADYNMLLVSRL MAB_0855|M.abscessus_ATCC_1997 IISYASAVGIGVIAFQFIGGQPLSWSVPGMAFIVLVAVGADYNLLFISRI MSMEG_4741|M.smegmatis_MC2_155 VLSYMSALGIGVVFFQFILGKEIVWTVPGMAFLVLVAVGADYNLLLISRI MLBr_01231|M.leprae_Br4923 IVSYLSALGLCVLVFQVLLRQQLHWSVPGLAFVVLVAVGADYNMLLASRL MAV_1761|M.avium_104 VISYLSAVGVGVLVFQFLLGQQLHWSVPPLAFVVLVAVGADYNMLLVSRM Mb1549c|M.bovis_AF2122/97 LISYLSALGIGTLVFQLILGQEMHWSLPGLSFILLVAIGADYNMLLISRI Rv1522c|M.tuberculosis_H37Rv LISYLSALGIGTLVFQLILGQEMHWSLPGLSFILLVAIGADYNMLLISRI MUL_0757|M.ulcerans_Agy99 VLSLGASFGLSVLIWQHVLGIELHWLVLAMAVIILLAVGADYNLLLVARL MMAR_4836|M.marinum_M REESAHNIRVGVLRTVANTGSVITSAGLIFAASMFGLIAGSIAIMIQAGF TH_3450|M.thermoresistible__bu REESGTNIRVGVLRTVANTGSVITSAGVIFAASMFGLMFGSIAIMIQAGF Mflv_4632|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_0312|M.vanbaalenii_PYR-1 REESGTNIRVGVLRTVANTGAVITSAGLIFAASMFGLMVGSVAIMIQAGL MAB_0855|M.abscessus_ATCC_1997 RDESPDGIRSGVIKTVKSTGGVITSAGVIFAASMFGLLIGNLQSMVEAGF MSMEG_4741|M.smegmatis_MC2_155 RDEAAHGMRTAVIRTIGATGGVITSAGLIFAASMFGLTFSSLLAAVQIGF MLBr_01231|M.leprae_Br4923 RDESSHGLRASVIRTVRSTGGVITAAGLIFAASMFGLLLSSIATVVQAGF MAV_1761|M.avium_104 RDESPHSMRYGIIRTLSSTGGVITAAGLIFAASMSGLLFSSIGTVVQGGV Mb1549c|M.bovis_AF2122/97 RDESPHGIRIGVIRTVGSTGGVITSAGLIFAASMFGLVGANINTMAQAGF Rv1522c|M.tuberculosis_H37Rv RDESPHGIRIGVIRTVGSTGGVITSAGLIFAASMFGLVGASINTMAQAGF MUL_0757|M.ulcerans_Agy99 KEEIHAGINTGIIRAMGGSGSVVTAAGLVFAFTMMSFAVSELTVMAQVGT MMAR_4836|M.marinum_M IIGCGLLLDTFVVRTLTVPAIATLLREASWWP------------------ TH_3450|M.thermoresistible__bu IVGCGLLLDTFLVRTLTVPAIATLLREASWWP------------------ Mflv_4632|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_0312|M.vanbaalenii_PYR-1 IIGFGLLLDTFLVRTLTVPAIATLLREASWWP------------------ MAB_0855|M.abscessus_ATCC_1997 IIGMGLLLDTFLVRTITIPALVVLCGQANWWPSASVES------------ MSMEG_4741|M.smegmatis_MC2_155 IIGVGLLLDTFLVRTITVPAAAVLIGKLSWWP------------------ MLBr_01231|M.leprae_Br4923 VLGSGILLDTFIVRTITVPAVAALLRRASWWP------------------ MAV_1761|M.avium_104 VIGVGILLDTFLVRTVTVPAIAALAGRANWWP------------------ Mb1549c|M.bovis_AF2122/97 TIGIGIVLDTFLVRTVTVPALTTMIGRANWWPSELGRDPSTPPTKADRWL Rv1522c|M.tuberculosis_H37Rv TIGIGIVLDTFLVRTVTVPALTTMIGRANWWPSELGRDPSTPPTKADRWL MUL_0757|M.ulcerans_Agy99 TIGMGLLFDTLIVRSFMTPSIAALLGKWFWWPQVVRQRP----------- MMAR_4836|M.marinum_M -----------------------------QRKPLTHNG------------ TH_3450|M.thermoresistible__bu -----------------------------QPNRAR--------------- Mflv_4632|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_0312|M.vanbaalenii_PYR-1 -----------------------------TKATNPRRGDPKQKA------ MAB_0855|M.abscessus_ATCC_1997 WFRQRFSRSKPDAQEGDCAVSDDPEAASGESSPEEPLISASREVELAGRR MSMEG_4741|M.smegmatis_MC2_155 --------TKPPAP---------------EPAPTEPTVAPAAQA------ MLBr_01231|M.leprae_Br4923 ------------------------------ARPWGNNA------------ MAV_1761|M.avium_104 ------------------------------SRIAVRRNPVSGQP------ Mb1549c|M.bovis_AF2122/97 RRVKGHRRKAPIPAPKPPHTKVVRNTNGHASKAATKSVPNGKPADLAEGN Rv1522c|M.tuberculosis_H37Rv RRVKGHRRKAPIPAPKPPHTKVVRNTNGHASKAATKSVPNGKPADLAEGN MUL_0757|M.ulcerans_Agy99 -----------------------------APQPWPTPAPTPPPATTSV-- MMAR_4836|M.marinum_M -------------------------------------------------- TH_3450|M.thermoresistible__bu -------------------------------------------------- Mflv_4632|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_0312|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_0855|M.abscessus_ATCC_1997 -------------------------------------------------- MSMEG_4741|M.smegmatis_MC2_155 -------------------------------------------------- MLBr_01231|M.leprae_Br4923 -------------------------------------------------- MAV_1761|M.avium_104 -------------------------------------------------- Mb1549c|M.bovis_AF2122/97 GEYLIDHLRRHSLPLFGYAAMPAYDVVDGVSKPNGDGAHIGKEPVDHLLG Rv1522c|M.tuberculosis_H37Rv GEYLIDHLRRHSLPLFGYAAMPAYDVVDGVSKPNGDGAHIGKEPVDHLLG MUL_0757|M.ulcerans_Agy99 -------------------------------------------------- MMAR_4836|M.marinum_M ---------------------------------------- TH_3450|M.thermoresistible__bu ---------------------------------------- Mflv_4632|M.gilvum_PYR-GCK ---------------------------------------- Mvan_0312|M.vanbaalenii_PYR-1 ---------------------------------------- MAB_0855|M.abscessus_ATCC_1997 ---------------------------------------- MSMEG_4741|M.smegmatis_MC2_155 ---------------------------------------- MLBr_01231|M.leprae_Br4923 ---------------------------------------- MAV_1761|M.avium_104 ---------------------------------------- Mb1549c|M.bovis_AF2122/97 H--------------------------------------- Rv1522c|M.tuberculosis_H37Rv HSLPLFGLAGLPSYDRWDDTSIGEPAVGHAGSKPDAKLST MUL_0757|M.ulcerans_Agy99 ----------------------------------------