For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
GSATKYQRTLFEPEHELFRESYRAFLDRHVAPYHDEWEKTKIVDRGVWLEAGKQGFLGMAVPEEYGGGGN ADFRYNTVITEETCAGRYSGIGFGLHNDIVAPYLLALATEEQKRRWFPNFCTGELITAIAMTEPGTGSDL QGITTRAVKHGDHYVLNGSKTFITNGINSDLVIVVAQTDPEKGAQGFSLLVVERGMAGFERGRQLDKIGL DAQDTAELSFTDVAVPAENLLGQEGMGFIYLMQNLPQERISIAIMAAAGMESVLEQTLQYAKERKAFGRS IGSFQNSRFLLAELATEATVVRIMVDEFIKLHLAGKLTAEQAAMAKWYATEKQVYLNDRCLQLHGGYGYM REYPVARAYLDSRVQTIYGGTTEIMKEIIGRGLGV*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv2724c | fadE20 | - | 100% (386) | PROBABLE ACYL-CoA DEHYDROGENASE FADE20 |
| M. tuberculosis H37Rv | Rv0975c | fadE13 | 6e-68 | 39.57% (374) | acyl-CoA dehydrogenase FADE13 |
| M. tuberculosis H37Rv | Rv2500c | fadE19 | 8e-57 | 34.39% (378) | acyl-CoA dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2743c | fadE20 | 0.0 | 99.48% (386) | acyl-CoA dehydrogenase FADE20 |
| M. gilvum PYR-GCK | Mflv_2118 | - | 1e-128 | 57.52% (379) | acyl-CoA dehydrogenase domain-containing protein |
| M. leprae Br4923 | MLBr_00737 | fadE25 | 3e-49 | 30.69% (378) | putative acyl-CoA dehydrogenase |
| M. abscessus ATCC 19977 | MAB_3040c | - | 1e-179 | 77.34% (384) | acyl-CoA dehydrogenase |
| M. marinum M | MMAR_1989 | fadE20 | 0.0 | 91.71% (386) | acyl-CoA dehydrogenase FadE20 |
| M. avium 104 | MAV_3616 | - | 0.0 | 91.19% (386) | long-chain specific acyl-CoA dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_5197 | - | 1e-129 | 58.05% (379) | long-chain specific acyl-CoA dehydrogenase |
| M. thermoresistible (build 8) | TH_2583 | - | 1e-176 | 77.55% (383) | PUTATIVE peptidase S1 and S6, chymotrypsin/Hap |
| M. ulcerans Agy99 | MUL_3367 | fadE20 | 0.0 | 90.67% (386) | acyl-CoA dehydrogenase FadE20 |
| M. vanbaalenii PYR-1 | Mvan_2439 | - | 0.0 | 84.74% (380) | long-chain-acyl-CoA dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_2118|M.gilvum_PYR-GCK -----------MKRTIYDAEHEAFRDTVKEYIERELVPNSEKWETERIVD
MSMEG_5197|M.smegmatis_MC2_155 -----------MKRLIYNEEHEAFRQTVKEYIERELVPHSEKWEAERIVD
Rv2724c|M.tuberculosis_H37Rv MGS-----ATKYQRTLFEPEHELFRESYRAFLDRHVAPYHDEWEKTKIVD
Mb2743c|M.bovis_AF2122/97 MGS-----ATKYQRTLFEPEHELFRESYRAFLDRHVAAYHDEWEKTKIVD
MMAR_1989|M.marinum_M MGS-----AIKYQRTLFEPEHDLFRESYRGFLERHVAPYHDEWEKAKIVD
MUL_3367|M.ulcerans_Agy99 MGS-----AIKYQRTLFEPEHDLFRESYRGFLERHVALYHDEWEKAKIVD
MAV_3616|M.avium_104 MSS-----AIKYQRTLFESEHELFRESYRAFLDRHVAPYHDEWEKAKIVD
Mvan_2439|M.vanbaalenii_PYR-1 MGASEAKPVIAYERTLFEPEHDMFRESFRAFLDRHVAPHHEEWEKNKLVD
MAB_3040c|M.abscessus_ATCC_199 MAG-----AVKFKRTIFEPEHELFRESFKTFLDRHAEPYKEEWEKNKIVD
TH_2583|M.thermoresistible__bu MSGIDTGRAVFYDRTLFEPEHEMFRDSYRTFLKRSVAPYHQQWEIDGIVD
MLBr_00737|M.leprae_Br4923 MVG--WSGNPLFDLFKLPEEHNELRATIRALAEKEIAPHAADVDQRARFP
. **: :* : : .: . : .
Mflv_2118|M.gilvum_PYR-GCK RSAYTAAGKYGLIGFNMPEEFGGGGTDDFRFNAIIDEEIAKAGVHGPALS
MSMEG_5197|M.smegmatis_MC2_155 RSAYTAAGKYGLIGFNMPEEFGGGGSDDFRFNAIIDEEIAKSGVHGPALS
Rv2724c|M.tuberculosis_H37Rv RGVWLEAGKQGFLGMAVPEEYGGGGNADFRYNTVITEETCAGRYSGIGFG
Mb2743c|M.bovis_AF2122/97 RGVWLEAGKQGFLGMAVPEEYGGGGNADFRYNTVITEETCAGRYSGIGFG
MMAR_1989|M.marinum_M RGVWLEAGKQGFLGMAVPEEYGGGGNPDFRYNTIITEETSAGRYSGIGFG
MUL_3367|M.ulcerans_Agy99 RGVWLEAGKQGFLGMAVPEEYGGGGNPDFRYNTIITEETSAGRYSGIGFG
MAV_3616|M.avium_104 RGVWLEAGKQGFLGMAVPEEYGGGGNPDFRYNTIITEETTRGRYSGIGFG
Mvan_2439|M.vanbaalenii_PYR-1 RDVWLEAGKQGFLGMAVPEEYGGGGVDDFRYNTIVTEEVTAGRYTGLGFS
MAB_3040c|M.abscessus_ATCC_199 RALWVEAGKQGFLGTDMPEEFGGGGLIDFRYNTIITEEVTKGRHTGVGFS
TH_2583|M.thermoresistible__bu RGVWLEAGKQGFLGMGVPEEHGGGGVADFRYNAIVTEETTAAGFSGLGFA
MLBr_00737|M.leprae_Br4923 EEALAALNASGFNAIHVPEEYGGQG-ADSVAACIVIEEVARVDASASLIP
. . *: . :***.** * * :: ** . :
Mflv_2118|M.gilvum_PYR-GCK LHNDVVGPYFKDLTNDEQKKRWLPGVTSGETIIAVAMTEPGAGSDLAGIR
MSMEG_5197|M.smegmatis_MC2_155 LHNDVVGPYFKELANDEQRRRWLPGITSGELIIAIAMTEPGAGSDLAGIR
Rv2724c|M.tuberculosis_H37Rv LHNDIVAPYLLALATEEQKRRWFPNFCTGELITAIAMTEPGTGSDLQGIT
Mb2743c|M.bovis_AF2122/97 LHNDIVAPYLLALATEEQKRRWFPNFCTGELTTAIAMTEPGTGSDLQGIT
MMAR_1989|M.marinum_M LHNDIVAPYLLALATEEQKQRWLPKFCTGEFITAIAMTEPGTGSDLQGIK
MUL_3367|M.ulcerans_Agy99 LHNEIVAPYLLALATEEQKQRRLPKFCTGEFITAIAMTEPGTGSDLQGIK
MAV_3616|M.avium_104 LHNDIVAPYLLALATEEQKQRWLPKFCTGELITAIAMTEPGTGSDLQGIK
Mvan_2439|M.vanbaalenii_PYR-1 LHNDVAAPYLIRLATEEQKQRWLPKFCSGEIISAIAMTEPGTGSDLQGIK
MAB_3040c|M.abscessus_ATCC_199 LHNDVAGPYFRDLANDEQKARWFPGFCSGELISAIAMTEPGTGSDLQGIK
TH_2583|M.thermoresistible__bu LHNDMVAPYLLRLATAEQKQRWLPRFCSGECITALAMTEPGAGSDLQGIR
MLBr_00737|M.leprae_Br4923 AVNKLGTMGLILRGSEELKKQVLPSLAAEGAMASYALSEREAGSDAASMR
*.: : . * : : :* . : : *::* :*** .:
Mflv_2118|M.gilvum_PYR-GCK TSAVRDGDDWIINGSKTFISSGINCDLCVVVARTDPEAGHKGFSLFVVER
MSMEG_5197|M.smegmatis_MC2_155 TSAVRDGDDWIINGSKTFISSGINCDLCVVVARTDPEAGHKGFSLFVVER
Rv2724c|M.tuberculosis_H37Rv TRAVKHGDHYVLNGSKTFITNGINSDLVIVVAQTDPEKGAQGFSLLVVER
Mb2743c|M.bovis_AF2122/97 TRAVKHGDHYVLNGSKTFITNGINSDLVIVVAQTDPEKGAQGFSLLVVER
MMAR_1989|M.marinum_M TRAVKQGDHYLLNGSKTFITNGINADLVIVVAQTDPEKGAQGFSLLVVER
MUL_3367|M.ulcerans_Agy99 TRAVKQGDHYLLNGSKTFITNGINADLVIVVAQTDPEKGAQGFSLLVVER
MAV_3616|M.avium_104 TRAVKQGDHYVLNGSKTFITNGINSDLVIVVAQTDPDKGAQGFSLLVVER
Mvan_2439|M.vanbaalenii_PYR-1 TRAVRDGDHYVLNGAKTFITNGIHSDLVIVVAQTDPDKGALGFSLLVVER
MAB_3040c|M.abscessus_ATCC_199 TRAVKDGDHYILNGAKTFITNGINADLVIVVAQTDPEKGALGFSLIVVER
TH_2583|M.thermoresistible__bu TRAVRDGDGWVLNGSKTFITNGINADLVIVFAQTDPDKGSMGYSLLVVER
MLBr_00737|M.leprae_Br4923 TRAKADGDDWILNGFKCWITNGGKSTWYTVMAVTDPDKGANGISAFIVHK
* * .** :::** * :*:.* :. *.* ***: * * * ::*.:
Mflv_2118|M.gilvum_PYR-GCK DMEGFTRGRKLDKMGLHSQDTSELHFENVRVPNANLLGKEGRGFYHLMTN
MSMEG_5197|M.smegmatis_MC2_155 GMEGFTRGRKLDKMGLHSQDTSELHFENVRVPHANLLGKEGRGFYHLMTN
Rv2724c|M.tuberculosis_H37Rv GMAGFERGRQLDKIGLDAQDTAELSFTDVAVPAENLLGQEGMGFIYLMQN
Mb2743c|M.bovis_AF2122/97 GMAGFERGRQLDKIGLDAQDTAELSFTDVAVPAENLLGQEGMGFIYLMQN
MMAR_1989|M.marinum_M GMEGFERGRHLDKIGLDAQDTAELSFSDVQVPVENLLGQEGMGFIYLMQN
MUL_3367|M.ulcerans_Agy99 GMEGFERGRHLDKIGLDAQDTAELSFSDVQVPVENLLGQEGMGFIYLMQN
MAV_3616|M.avium_104 GMEGFERGRHLDKIGLDAQDTAELSFTDVHVPAENLLGQEGMGFIYLMQN
Mvan_2439|M.vanbaalenii_PYR-1 GMAGFERGRKLDKIGLDAQDTAELSFTDVKVPVENLLGEEGQGFIYLMQN
MAB_3040c|M.abscessus_ATCC_199 GMEGFERGRKLDKVGLDAQDTAELSFTDVRVPAANLLGEEGQGFIYLMKN
TH_2583|M.thermoresistible__bu GMAGFERGRRLDKIGMTGQDTAELSFTDVRVPAENLLGKVGKGLLYLMQN
MLBr_00737|M.leprae_Br4923 DDEGFSIGPKEKKLGIKGSPTTELYFDKCRIPGDRIIGEPGTGFKTALAT
. ** * : .*:*: .. *:** * . :* .::*: * *: : .
Mflv_2118|M.gilvum_PYR-GCK LPSERLSIAISAIAGARAVFDETLQYSKDRKAFGQSIGSFQHNRFLLAEM
MSMEG_5197|M.smegmatis_MC2_155 LPSERLSIAISAIAGARAVFDETLQYCKDRKAFGQPIGSFQHNRFLLAEM
Rv2724c|M.tuberculosis_H37Rv LPQERISIAIMAAAGMESVLEQTLQYAKERKAFGRSIGSFQNSRFLLAEL
Mb2743c|M.bovis_AF2122/97 LPQERISIAIMAAAGMESVLEQTLQYAKERKAFGRSIGSFQNSRFLLAEL
MMAR_1989|M.marinum_M LPQERISIAIMAAAGMESVLDQTLQYTKERKAFGRSIGNFQNSRFVLAEL
MUL_3367|M.ulcerans_Agy99 LPQERISIAIMAAAGMESVLDQTLQYTKERKAFGRSIGNFQNSRFVLAEL
MAV_3616|M.avium_104 LPQERISIAVMAAAAMEQVLEQTLEYTKERKAFGKSIGSFQNSRFVLAEL
Mvan_2439|M.vanbaalenii_PYR-1 LPQERISIAIMAAAAMEAVLDVTLQYTKERKAFGRPIGSQQNSRFLLAEL
MAB_3040c|M.abscessus_ATCC_199 LPQERMSIAVMAAAAMESVLEETIAYTTERKAFGKPIKSFQNSRFLLAEL
TH_2583|M.thermoresistible__bu LPQERLSIAVMSAAAMAATLESTLEYVQQRKAFGRPIGSFQNSRFVLAEL
MLBr_00737|M.leprae_Br4923 LDHTRPTIGAQAVGIAQGALDAAIVYTKDRKQFGESISTFQSIQFMLADM
* * :*. : . .:: :: * :** **..* . * :*:**::
Mflv_2118|M.gilvum_PYR-GCK ETELEVTETYIDRCLQGVVDGE-LTAVEAAKAKWWATEVAKKVVDQCVQL
MSMEG_5197|M.smegmatis_MC2_155 ETELEVTENYIDRCLQGVVDGE-LTAVEAAKAKWWATETAKKIVDNCVQL
Rv2724c|M.tuberculosis_H37Rv ATEATVVRIMVDEFIKLHLAGK-LTAEQAAMAKWYATEKQVYLNDRCLQL
Mb2743c|M.bovis_AF2122/97 ATEATVVRIMVDEFIKLHLAGK-LTAEQAAMAKWYATEKQVYLNDRCLQL
MMAR_1989|M.marinum_M ATEATMVRIMVDEFIELHLDGK-LTAEQAAMAKWYSTEKQVSLNDRCLQL
MUL_3367|M.ulcerans_Agy99 ATEATMVRIMVDESIELHLDGK-LTAEQAAMAKWYSTEKQVSLNDRCLQL
MAV_3616|M.avium_104 ATEATVVRMMVDEFVRLHLDHK-LTAEQAAMAKWYSTEKQVHLIDRCLQL
Mvan_2439|M.vanbaalenii_PYR-1 STEATVVRMMVDEFIKLHLQDK-LTVEQAAMAKWYSTEKQVHLIDRCLQL
MAB_3040c|M.abscessus_ATCC_199 ATDATVIRVMVDEFISLLNKEE-LSVEQAAMAKWYSTEKQVHLIDRCLQL
TH_2583|M.thermoresistible__bu ATEATAIRIMVDEFVRLHDAGK-LTAEQAAMAKWFATEAFVRLADRCLQL
MLBr_00737|M.leprae_Br4923 AMKVEAARLIVYAAAARAERGEPDLGFISAASKCFASDIAMEVTTDAVQL
. . : : :* :* :::: : .:**
Mflv_2118|M.gilvum_PYR-GCK HGGYGYMLEYRVARAYVDGRIQTIFGGTTEIMKEIIGRELGV
MSMEG_5197|M.smegmatis_MC2_155 HGGYGYMMEYRVARAYVDGRIQTIFGGTTEIMKEIIGRDLGV
Rv2724c|M.tuberculosis_H37Rv HGGYGYMREYPVARAYLDSRVQTIYGGTTEIMKEIIGRGLGV
Mb2743c|M.bovis_AF2122/97 HGGYGYMREYPVARAYLDSRVQTIYGGTTEIMKEIIGRGLGV
MMAR_1989|M.marinum_M HGGYGYMREYPVARAYLDSRVQTIYGGTTEIMKEIIGRSLGI
MUL_3367|M.ulcerans_Agy99 HGGYGYMREYPVARAYLDSRVQTIYGGTTEIMKEIIGRSLGI
MAV_3616|M.avium_104 HGGYGYMREYPVARAYLDARVQTIYGGTTEIMKEIIGRSLGV
Mvan_2439|M.vanbaalenii_PYR-1 HGGYGYMREYDVARAYLDARVQTIYGGTTEIMKEIIGRSLGV
MAB_3040c|M.abscessus_ATCC_199 HGGYGFMREYPVARAYMDSRIQTIYGGTTEIMKEIIGRSL--
TH_2583|M.thermoresistible__bu HGGYGYMREYPIAKSYLDARVQTIYGGTTEIMKEIIGRRLCT
MLBr_00737|M.leprae_Br4923 FGGAGYTSDFPVERFMRDAKITQIYEGTNQIQRVVMSRALLR
.** *: :: : : *.:: *: **.:* : ::.* *