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M. bovis AF2122 / 97 Mb2743c (fadE20)

annotation: acyl-CoA dehydrogenase FADE20
coordinates: 2992767 - 2993927
length: 386

MGSATKYQRTLFEPEHELFRESYRAFLDRHVAAYHDEWEKTKIVDRGVWLEAGKQGFLGMAVPEEYGGGG
NADFRYNTVITEETCAGRYSGIGFGLHNDIVAPYLLALATEEQKRRWFPNFCTGELTTAIAMTEPGTGSD
LQGITTRAVKHGDHYVLNGSKTFITNGINSDLVIVVAQTDPEKGAQGFSLLVVERGMAGFERGRQLDKIG
LDAQDTAELSFTDVAVPAENLLGQEGMGFIYLMQNLPQERISIAIMAAAGMESVLEQTLQYAKERKAFGR
SIGSFQNSRFLLAELATEATVVRIMVDEFIKLHLAGKLTAEQAAMAKWYATEKQVYLNDRCLQLHGGYGY
MREYPVARAYLDSRVQTIYGGTTEIMKEIIGRGLGV
Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb2743cfadE20-100% (386)acyl-CoA dehydrogenase FADE20
M. bovis AF2122 / 97Mb1000cfadE132e-5938.60% (342) acyl-CoA dehydrogenase FADE13
M. bovis AF2122 / 97Mb2528cfadE191e-5536.47% (340) acyl-CoA dehydrogenase

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. gilvum PYR-GCKMflv_2118-1e-12656.99% (379) acyl-CoA dehydrogenase domain-containing protein
M. tuberculosis H37RvRv2724cfadE200.099.48% (386) acyl-CoA dehydrogenase FADE20
M. leprae Br4923MLBr_00737fadE255e-4830.42% (378) putative acyl-CoA dehydrogenase
M. abscessus ATCC 19977MAB_3040c-1e-17776.82% (384) acyl-CoA dehydrogenase
M. marinum MMMAR_1989fadE200.091.19% (386) acyl-CoA dehydrogenase FadE20
M. avium 104MAV_3616-0.090.67% (386) long-chain specific acyl-CoA dehydrogenase
M. smegmatis MC2 155MSMEG_5197-1e-12857.52% (379) long-chain specific acyl-CoA dehydrogenase
M. thermoresistible (build 8)TH_2583-1e-17577.02% (383) PUTATIVE peptidase S1 and S6, chymotrypsin/Hap
M. ulcerans Agy99MUL_3367fadE200.090.41% (386) acyl-CoA dehydrogenase FadE20
M. vanbaalenii PYR-1Mvan_2439-0.084.21% (380) long-chain-acyl-CoA dehydrogenase

CLUSTAL 2.0.9 multiple sequence alignment


Mflv_2118|M.gilvum_PYR-GCK          -----------MKRTIYDAEHEAFRDTVKEYIERELVPNSEKWETERIVD
MSMEG_5197|M.smegmatis_MC2_155      -----------MKRLIYNEEHEAFRQTVKEYIERELVPHSEKWEAERIVD
Mb2743c|M.bovis_AF2122/97           MGS-----ATKYQRTLFEPEHELFRESYRAFLDRHVAAYHDEWEKTKIVD
Rv2724c|M.tuberculosis_H37Rv        MGS-----ATKYQRTLFEPEHELFRESYRAFLDRHVAPYHDEWEKTKIVD
MMAR_1989|M.marinum_M               MGS-----AIKYQRTLFEPEHDLFRESYRGFLERHVAPYHDEWEKAKIVD
MUL_3367|M.ulcerans_Agy99           MGS-----AIKYQRTLFEPEHDLFRESYRGFLERHVALYHDEWEKAKIVD
MAV_3616|M.avium_104                MSS-----AIKYQRTLFESEHELFRESYRAFLDRHVAPYHDEWEKAKIVD
Mvan_2439|M.vanbaalenii_PYR-1       MGASEAKPVIAYERTLFEPEHDMFRESFRAFLDRHVAPHHEEWEKNKLVD
MAB_3040c|M.abscessus_ATCC_199      MAG-----AVKFKRTIFEPEHELFRESFKTFLDRHAEPYKEEWEKNKIVD
TH_2583|M.thermoresistible__bu      MSGIDTGRAVFYDRTLFEPEHEMFRDSYRTFLKRSVAPYHQQWEIDGIVD
MLBr_00737|M.leprae_Br4923          MVG--WSGNPLFDLFKLPEEHNELRATIRALAEKEIAPHAADVDQRARFP
                                                .      **: :* : :   .:       . :    . 

Mflv_2118|M.gilvum_PYR-GCK          RSAYTAAGKYGLIGFNMPEEFGGGGTDDFRFNAIIDEEIAKAGVHGPALS
MSMEG_5197|M.smegmatis_MC2_155      RSAYTAAGKYGLIGFNMPEEFGGGGSDDFRFNAIIDEEIAKSGVHGPALS
Mb2743c|M.bovis_AF2122/97           RGVWLEAGKQGFLGMAVPEEYGGGGNADFRYNTVITEETCAGRYSGIGFG
Rv2724c|M.tuberculosis_H37Rv        RGVWLEAGKQGFLGMAVPEEYGGGGNADFRYNTVITEETCAGRYSGIGFG
MMAR_1989|M.marinum_M               RGVWLEAGKQGFLGMAVPEEYGGGGNPDFRYNTIITEETSAGRYSGIGFG
MUL_3367|M.ulcerans_Agy99           RGVWLEAGKQGFLGMAVPEEYGGGGNPDFRYNTIITEETSAGRYSGIGFG
MAV_3616|M.avium_104                RGVWLEAGKQGFLGMAVPEEYGGGGNPDFRYNTIITEETTRGRYSGIGFG
Mvan_2439|M.vanbaalenii_PYR-1       RDVWLEAGKQGFLGMAVPEEYGGGGVDDFRYNTIVTEEVTAGRYTGLGFS
MAB_3040c|M.abscessus_ATCC_199      RALWVEAGKQGFLGTDMPEEFGGGGLIDFRYNTIITEEVTKGRHTGVGFS
TH_2583|M.thermoresistible__bu      RGVWLEAGKQGFLGMGVPEEHGGGGVADFRYNAIVTEETTAAGFSGLGFA
MLBr_00737|M.leprae_Br4923          EEALAALNASGFNAIHVPEEYGGQG-ADSVAACIVIEEVARVDASASLIP
                                    .      .  *: .  :***.** *  *     :: **       .  : 

Mflv_2118|M.gilvum_PYR-GCK          LHNDVVGPYFKDLTNDEQKKRWLPGVTSGETIIAVAMTEPGAGSDLAGIR
MSMEG_5197|M.smegmatis_MC2_155      LHNDVVGPYFKELANDEQRRRWLPGITSGELIIAIAMTEPGAGSDLAGIR
Mb2743c|M.bovis_AF2122/97           LHNDIVAPYLLALATEEQKRRWFPNFCTGELTTAIAMTEPGTGSDLQGIT
Rv2724c|M.tuberculosis_H37Rv        LHNDIVAPYLLALATEEQKRRWFPNFCTGELITAIAMTEPGTGSDLQGIT
MMAR_1989|M.marinum_M               LHNDIVAPYLLALATEEQKQRWLPKFCTGEFITAIAMTEPGTGSDLQGIK
MUL_3367|M.ulcerans_Agy99           LHNEIVAPYLLALATEEQKQRRLPKFCTGEFITAIAMTEPGTGSDLQGIK
MAV_3616|M.avium_104                LHNDIVAPYLLALATEEQKQRWLPKFCTGELITAIAMTEPGTGSDLQGIK
Mvan_2439|M.vanbaalenii_PYR-1       LHNDVAAPYLIRLATEEQKQRWLPKFCSGEIISAIAMTEPGTGSDLQGIK
MAB_3040c|M.abscessus_ATCC_199      LHNDVAGPYFRDLANDEQKARWFPGFCSGELISAIAMTEPGTGSDLQGIK
TH_2583|M.thermoresistible__bu      LHNDMVAPYLLRLATAEQKQRWLPRFCSGECITALAMTEPGAGSDLQGIR
MLBr_00737|M.leprae_Br4923          AVNKLGTMGLILRGSEELKKQVLPSLAAEGAMASYALSEREAGSDAASMR
                                      *.:    :    . * : : :* . :     : *::*  :***  .: 

Mflv_2118|M.gilvum_PYR-GCK          TSAVRDGDDWIINGSKTFISSGINCDLCVVVARTDPEAGHKGFSLFVVER
MSMEG_5197|M.smegmatis_MC2_155      TSAVRDGDDWIINGSKTFISSGINCDLCVVVARTDPEAGHKGFSLFVVER
Mb2743c|M.bovis_AF2122/97           TRAVKHGDHYVLNGSKTFITNGINSDLVIVVAQTDPEKGAQGFSLLVVER
Rv2724c|M.tuberculosis_H37Rv        TRAVKHGDHYVLNGSKTFITNGINSDLVIVVAQTDPEKGAQGFSLLVVER
MMAR_1989|M.marinum_M               TRAVKQGDHYLLNGSKTFITNGINADLVIVVAQTDPEKGAQGFSLLVVER
MUL_3367|M.ulcerans_Agy99           TRAVKQGDHYLLNGSKTFITNGINADLVIVVAQTDPEKGAQGFSLLVVER
MAV_3616|M.avium_104                TRAVKQGDHYVLNGSKTFITNGINSDLVIVVAQTDPDKGAQGFSLLVVER
Mvan_2439|M.vanbaalenii_PYR-1       TRAVRDGDHYVLNGAKTFITNGIHSDLVIVVAQTDPDKGALGFSLLVVER
MAB_3040c|M.abscessus_ATCC_199      TRAVKDGDHYILNGAKTFITNGINADLVIVVAQTDPEKGALGFSLIVVER
TH_2583|M.thermoresistible__bu      TRAVRDGDGWVLNGSKTFITNGINADLVIVFAQTDPDKGSMGYSLLVVER
MLBr_00737|M.leprae_Br4923          TRAKADGDDWILNGFKCWITNGGKSTWYTVMAVTDPDKGANGISAFIVHK
                                    * *  .** :::** * :*:.* :.    *.* ***: *  * * ::*.:

Mflv_2118|M.gilvum_PYR-GCK          DMEGFTRGRKLDKMGLHSQDTSELHFENVRVPNANLLGKEGRGFYHLMTN
MSMEG_5197|M.smegmatis_MC2_155      GMEGFTRGRKLDKMGLHSQDTSELHFENVRVPHANLLGKEGRGFYHLMTN
Mb2743c|M.bovis_AF2122/97           GMAGFERGRQLDKIGLDAQDTAELSFTDVAVPAENLLGQEGMGFIYLMQN
Rv2724c|M.tuberculosis_H37Rv        GMAGFERGRQLDKIGLDAQDTAELSFTDVAVPAENLLGQEGMGFIYLMQN
MMAR_1989|M.marinum_M               GMEGFERGRHLDKIGLDAQDTAELSFSDVQVPVENLLGQEGMGFIYLMQN
MUL_3367|M.ulcerans_Agy99           GMEGFERGRHLDKIGLDAQDTAELSFSDVQVPVENLLGQEGMGFIYLMQN
MAV_3616|M.avium_104                GMEGFERGRHLDKIGLDAQDTAELSFTDVHVPAENLLGQEGMGFIYLMQN
Mvan_2439|M.vanbaalenii_PYR-1       GMAGFERGRKLDKIGLDAQDTAELSFTDVKVPVENLLGEEGQGFIYLMQN
MAB_3040c|M.abscessus_ATCC_199      GMEGFERGRKLDKVGLDAQDTAELSFTDVRVPAANLLGEEGQGFIYLMKN
TH_2583|M.thermoresistible__bu      GMAGFERGRRLDKIGMTGQDTAELSFTDVRVPAENLLGKVGKGLLYLMQN
MLBr_00737|M.leprae_Br4923          DDEGFSIGPKEKKLGIKGSPTTELYFDKCRIPGDRIIGEPGTGFKTALAT
                                    .  **  * : .*:*: .. *:** * .  :*  .::*: * *:   : .

Mflv_2118|M.gilvum_PYR-GCK          LPSERLSIAISAIAGARAVFDETLQYSKDRKAFGQSIGSFQHNRFLLAEM
MSMEG_5197|M.smegmatis_MC2_155      LPSERLSIAISAIAGARAVFDETLQYCKDRKAFGQPIGSFQHNRFLLAEM
Mb2743c|M.bovis_AF2122/97           LPQERISIAIMAAAGMESVLEQTLQYAKERKAFGRSIGSFQNSRFLLAEL
Rv2724c|M.tuberculosis_H37Rv        LPQERISIAIMAAAGMESVLEQTLQYAKERKAFGRSIGSFQNSRFLLAEL
MMAR_1989|M.marinum_M               LPQERISIAIMAAAGMESVLDQTLQYTKERKAFGRSIGNFQNSRFVLAEL
MUL_3367|M.ulcerans_Agy99           LPQERISIAIMAAAGMESVLDQTLQYTKERKAFGRSIGNFQNSRFVLAEL
MAV_3616|M.avium_104                LPQERISIAVMAAAAMEQVLEQTLEYTKERKAFGKSIGSFQNSRFVLAEL
Mvan_2439|M.vanbaalenii_PYR-1       LPQERISIAIMAAAAMEAVLDVTLQYTKERKAFGRPIGSQQNSRFLLAEL
MAB_3040c|M.abscessus_ATCC_199      LPQERMSIAVMAAAAMESVLEETIAYTTERKAFGKPIKSFQNSRFLLAEL
TH_2583|M.thermoresistible__bu      LPQERLSIAVMSAAAMAATLESTLEYVQQRKAFGRPIGSFQNSRFVLAEL
MLBr_00737|M.leprae_Br4923          LDHTRPTIGAQAVGIAQGALDAAIVYTKDRKQFGESISTFQSIQFMLADM
                                    *   * :*.  : .    .:: :: *  :** **..* . *  :*:**::

Mflv_2118|M.gilvum_PYR-GCK          ETELEVTETYIDRCLQGVVDGE-LTAVEAAKAKWWATEVAKKVVDQCVQL
MSMEG_5197|M.smegmatis_MC2_155      ETELEVTENYIDRCLQGVVDGE-LTAVEAAKAKWWATETAKKIVDNCVQL
Mb2743c|M.bovis_AF2122/97           ATEATVVRIMVDEFIKLHLAGK-LTAEQAAMAKWYATEKQVYLNDRCLQL
Rv2724c|M.tuberculosis_H37Rv        ATEATVVRIMVDEFIKLHLAGK-LTAEQAAMAKWYATEKQVYLNDRCLQL
MMAR_1989|M.marinum_M               ATEATMVRIMVDEFIELHLDGK-LTAEQAAMAKWYSTEKQVSLNDRCLQL
MUL_3367|M.ulcerans_Agy99           ATEATMVRIMVDESIELHLDGK-LTAEQAAMAKWYSTEKQVSLNDRCLQL
MAV_3616|M.avium_104                ATEATVVRMMVDEFVRLHLDHK-LTAEQAAMAKWYSTEKQVHLIDRCLQL
Mvan_2439|M.vanbaalenii_PYR-1       STEATVVRMMVDEFIKLHLQDK-LTVEQAAMAKWYSTEKQVHLIDRCLQL
MAB_3040c|M.abscessus_ATCC_199      ATDATVIRVMVDEFISLLNKEE-LSVEQAAMAKWYSTEKQVHLIDRCLQL
TH_2583|M.thermoresistible__bu      ATEATAIRIMVDEFVRLHDAGK-LTAEQAAMAKWFATEAFVRLADRCLQL
MLBr_00737|M.leprae_Br4923          AMKVEAARLIVYAAAARAERGEPDLGFISAASKCFASDIAMEVTTDAVQL
                                      .    .  :          :      :* :* ::::    :   .:**

Mflv_2118|M.gilvum_PYR-GCK          HGGYGYMLEYRVARAYVDGRIQTIFGGTTEIMKEIIGRELGV
MSMEG_5197|M.smegmatis_MC2_155      HGGYGYMMEYRVARAYVDGRIQTIFGGTTEIMKEIIGRDLGV
Mb2743c|M.bovis_AF2122/97           HGGYGYMREYPVARAYLDSRVQTIYGGTTEIMKEIIGRGLGV
Rv2724c|M.tuberculosis_H37Rv        HGGYGYMREYPVARAYLDSRVQTIYGGTTEIMKEIIGRGLGV
MMAR_1989|M.marinum_M               HGGYGYMREYPVARAYLDSRVQTIYGGTTEIMKEIIGRSLGI
MUL_3367|M.ulcerans_Agy99           HGGYGYMREYPVARAYLDSRVQTIYGGTTEIMKEIIGRSLGI
MAV_3616|M.avium_104                HGGYGYMREYPVARAYLDARVQTIYGGTTEIMKEIIGRSLGV
Mvan_2439|M.vanbaalenii_PYR-1       HGGYGYMREYDVARAYLDARVQTIYGGTTEIMKEIIGRSLGV
MAB_3040c|M.abscessus_ATCC_199      HGGYGFMREYPVARAYMDSRIQTIYGGTTEIMKEIIGRSL--
TH_2583|M.thermoresistible__bu      HGGYGYMREYPIAKSYLDARVQTIYGGTTEIMKEIIGRRLCT
MLBr_00737|M.leprae_Br4923          FGGAGYTSDFPVERFMRDAKITQIYEGTNQIQRVVMSRALLR
                                    .** *:  :: : :   *.::  *: **.:* : ::.* *