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TASISPWMSAELLELRDLAAKFFSTELAPHAQRFADQHQVDRELWHKAGELGLLCMSIPEEYGGGGGTFA HEAVVLEEQARVGDSSWGAGLHSGIVAHYILQYAAEELRRQWLPKMASGEMIGAIAMTEPGTGSDLQSVK TKAILDGDEYVITGAKTFITNGQQADLIIVVAKTDPSQGAAGISLIVAEADRPGFRRGKVLDKIGQRGQD TSELFFDDVRVPRSHLLGETEGQGFIQLMTQLPQERLIVAVGAVAAMELAVEQTLKYTREREAFGRPVFG FQNTKFILAEAATETRIARVFLDYCIDLHLAGQLDVQTVAMAKWWTTERAMKVLDDCLQLHGGYGYMTEY PISRLWVDQRVQKIYAGTNEVMKEIISRSL*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_3132 | - | - | 100% (381) | acyl-CoA dehydrogenase |
| M. marinum M | MMAR_1989 | fadE20 | e-110 | 54.44% (360) | acyl-CoA dehydrogenase FadE20 |
| M. marinum M | MMAR_0697 | - | 5e-95 | 47.62% (378) | acyl-CoA dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2743c | fadE20 | 1e-108 | 53.01% (366) | acyl-CoA dehydrogenase FADE20 |
| M. gilvum PYR-GCK | Mflv_4601 | - | 1e-164 | 71.39% (381) | acyl-CoA dehydrogenase domain-containing protein |
| M. tuberculosis H37Rv | Rv2724c | fadE20 | 1e-109 | 53.55% (366) | acyl-CoA dehydrogenase FADE20 |
| M. leprae Br4923 | MLBr_00737 | fadE25 | 1e-55 | 32.61% (368) | putative acyl-CoA dehydrogenase |
| M. abscessus ATCC 19977 | MAB_2081 | - | 0.0 | 93.96% (381) | acyl CoA dehydrogenase |
| M. avium 104 | MAV_2703 | - | 1e-119 | 56.91% (376) | putative acyl-CoA dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_5197 | - | 1e-99 | 47.27% (366) | long-chain specific acyl-CoA dehydrogenase |
| M. thermoresistible (build 8) | TH_3180 | - | 1e-125 | 55.50% (382) | PUTATIVE acyl-CoA dehydrogenase domain protein |
| M. ulcerans Agy99 | MUL_3367 | fadE20 | 1e-108 | 53.39% (369) | acyl-CoA dehydrogenase FadE20 |
| M. vanbaalenii PYR-1 | Mvan_2439 | - | 1e-111 | 53.83% (366) | long-chain-acyl-CoA dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2743c|M.bovis_AF2122/97 MGS-----ATKYQRTLFEPEHELFRESYRAFLDRHVAAYHDEWEKTKIVD
Rv2724c|M.tuberculosis_H37Rv MGS-----ATKYQRTLFEPEHELFRESYRAFLDRHVAPYHDEWEKTKIVD
MUL_3367|M.ulcerans_Agy99 MGS-----AIKYQRTLFEPEHDLFRESYRGFLERHVALYHDEWEKAKIVD
Mvan_2439|M.vanbaalenii_PYR-1 MGASEAKPVIAYERTLFEPEHDMFRESFRAFLDRHVAPHHEEWEKNKLVD
MSMEG_5197|M.smegmatis_MC2_155 -----------MKRLIYNEEHEAFRQTVKEYIERELVPHSEKWEAERIVD
MMAR_3132|M.marinum_M --------MTASISPWMSAELLELRDLAAKFFSTELAPHAQRFADQHQVD
MAB_2081|M.abscessus_ATCC_1997 --------MSSPISPWMNAELLELRDLAAKFFSAELAPHANRFADQHHVD
Mflv_4601|M.gilvum_PYR-GCK --------MAANRSSWMDDDLDALRDLARTFCEKEVAPHSARFIEQHHVD
TH_3180|M.thermoresistible__bu -------MITKRMSPWFDDEVRALYDLAREFFEREVVAHVDTWDAQRHID
MAV_2703|M.avium_104 ----MSELFPDYRPSWETDQHRELRKHAAEFFRKEATPNQERWAAQHAVD
MLBr_00737|M.leprae_Br4923 --MVGWSGNPLFDLFKLPEEHNELRATIRALAEKEIAPHAADVDQRARFP
: : . . .
Mb2743c|M.bovis_AF2122/97 RGVWLEAGKQGFLGMAVPEEYGGGGNADFRYNTVITEETCAGRYSGIGFG
Rv2724c|M.tuberculosis_H37Rv RGVWLEAGKQGFLGMAVPEEYGGGGNADFRYNTVITEETCAGRYSGIGFG
MUL_3367|M.ulcerans_Agy99 RGVWLEAGKQGFLGMAVPEEYGGGGNPDFRYNTIITEETSAGRYSGIGFG
Mvan_2439|M.vanbaalenii_PYR-1 RDVWLEAGKQGFLGMAVPEEYGGGGVDDFRYNTIVTEEVTAGRYTGLGFS
MSMEG_5197|M.smegmatis_MC2_155 RSAYTAAGKYGLIGFNMPEEFGGGGSDDFRFNAIIDEEIAKSGVHGPALS
MMAR_3132|M.marinum_M RELWHKAGELGLLCMSIPEEYGGGG-GTFAHEAVVLEEQARVGDSSWGAG
MAB_2081|M.abscessus_ATCC_1997 RELWNRAGELGLLCMSIPEEYGGGG-GTFAHEAVVLEEQARIGDSSWGAG
Mflv_4601|M.gilvum_PYR-GCK RDLWTRAGDLGLLCMSIPEQYGGGG-GTFAHEAVLIEEQARIGDSAWGAP
TH_3180|M.thermoresistible__bu RQVWLEAGKLGLLLCSVPEEYGGGG-GTFAHDVAVFDAQGYSGDLSLGIA
MAV_2703|M.avium_104 REFWNKAGDAGLLGLDLPEEYGGAG-GDFAMNVVVQEELAYAYDQGFGFA
MLBr_00737|M.leprae_Br4923 EEALAALNASGFNAIHVPEEYGGQG-ADSVAACIVIEEVARVDASASLIP
. . *: :**::** * : : .
Mb2743c|M.bovis_AF2122/97 LHNDIVAPYLLALATEEQKRRWFPNFCTGELTTAIAMTEPGTGSDLQGIT
Rv2724c|M.tuberculosis_H37Rv LHNDIVAPYLLALATEEQKRRWFPNFCTGELITAIAMTEPGTGSDLQGIT
MUL_3367|M.ulcerans_Agy99 LHNEIVAPYLLALATEEQKQRRLPKFCTGEFITAIAMTEPGTGSDLQGIK
Mvan_2439|M.vanbaalenii_PYR-1 LHNDVAAPYLIRLATEEQKQRWLPKFCSGEIISAIAMTEPGTGSDLQGIK
MSMEG_5197|M.smegmatis_MC2_155 LHNDVVGPYFKELANDEQRRRWLPGITSGELIIAIAMTEPGAGSDLAGIR
MMAR_3132|M.marinum_M LHSGIVAHYILQYAAEELRRQWLPKMASGEMIGAIAMTEPGTGSDLQSVK
MAB_2081|M.abscessus_ATCC_1997 LHSGIVAHYILQYATEELRAQWLPKMASGEMIGAIAMTEPGTGSDLQSVK
Mflv_4601|M.gilvum_PYR-GCK LHSGIVAHYLLEYGTDEQKERFLPRLATGEMVGAIAMTEPGTGSDLQSVT
TH_3180|M.thermoresistible__bu VHSGIVPHYIVKYGSEEQKRQWLPPMATGEVLSAIGMTEPGAGSDLKAIR
MAV_2703|M.avium_104 VHSPIVAHYIWAYGSDEQRRRWLPKIISGEAVLAIAMTEPGTGSDLQSVK
MLBr_00737|M.leprae_Br4923 AVNKLGTMGLILRGSEELKKQVLPSLAAEGAMASYALSEREAGSDAASMR
. : : . :* : : :* : : : .::* :*** .:
Mb2743c|M.bovis_AF2122/97 TRAVKHGDHYVLNGSKTFITNGINSDLVIVVAQTDPEKGAQGFSLLVVER
Rv2724c|M.tuberculosis_H37Rv TRAVKHGDHYVLNGSKTFITNGINSDLVIVVAQTDPEKGAQGFSLLVVER
MUL_3367|M.ulcerans_Agy99 TRAVKQGDHYLLNGSKTFITNGINADLVIVVAQTDPEKGAQGFSLLVVER
Mvan_2439|M.vanbaalenii_PYR-1 TRAVRDGDHYVLNGAKTFITNGIHSDLVIVVAQTDPDKGALGFSLLVVER
MSMEG_5197|M.smegmatis_MC2_155 TSAVRDGDDWIINGSKTFISSGINCDLCVVVARTDPEAGHKGFSLFVVER
MMAR_3132|M.marinum_M TKAILDGDEYVITGAKTFITNGQQADLIIVVAKTDPSQGAAGISLIVAEA
MAB_2081|M.abscessus_ATCC_1997 TKALLDGDEYVITGSKTFITNGQQADLIIVVAKTDPSQGAAGISLIVVEA
Mflv_4601|M.gilvum_PYR-GCK TKASRVGDEYVVNGSKTFITNGAQADLIIVVAKTDPSAGANGISLVLVEG
TH_3180|M.thermoresistible__bu TTAVRDGDEYIVNGSKTFITNGGSADMILLAVKTDPKAGARGISLLIVDL
MAV_2703|M.avium_104 TTARRDGDFYVINGSKTFISNGTHCDLLVIVAKTDPSKGAAGVSLIVAET
MLBr_00737|M.leprae_Br4923 TRAKADGDDWILNGFKCWITNGGKSTWYTVMAVTDPDKGANGISAFIVHK
* * ** :::.* * :*:.* . : . ***. * *.* .:..
Mb2743c|M.bovis_AF2122/97 --GMAGFERGRQLDKIGLDAQDTAELSFTDVAVPAENLLGQ-EGMGFIYL
Rv2724c|M.tuberculosis_H37Rv --GMAGFERGRQLDKIGLDAQDTAELSFTDVAVPAENLLGQ-EGMGFIYL
MUL_3367|M.ulcerans_Agy99 --GMEGFERGRHLDKIGLDAQDTAELSFSDVQVPVENLLGQ-EGMGFIYL
Mvan_2439|M.vanbaalenii_PYR-1 --GMAGFERGRKLDKIGLDAQDTAELSFTDVKVPVENLLGE-EGQGFIYL
MSMEG_5197|M.smegmatis_MC2_155 --GMEGFTRGRKLDKMGLHSQDTSELHFENVRVPHANLLGK-EGRGFYHL
MMAR_3132|M.marinum_M --DRPGFRRGKVLDKIGQRGQDTSELFFDDVRVPRSHLLGETEGQGFIQL
MAB_2081|M.abscessus_ATCC_1997 --DRAGFRRGKVLDKIGQRGQDTSELFFDEVRVPRSHLLGQAEGQGFIQL
Mflv_4601|M.gilvum_PYR-GCK --DRPGFRRGRVLDKVGQRGQDTSELYFEDVHIPVENLLGTTEGQGFIQL
TH_3180|M.thermoresistible__bu R-DCDGYQVTRVLDKVGQHGADTAELSFTDVRVPVANLLGAEEGKGFGQM
MAV_2703|M.avium_104 DENLAGFERGRVLAKMGQHAQDTRELFFSDMRVPVANLLGAQEGLGFYQL
MLBr_00737|M.leprae_Br4923 --DDEGFSIGPKEKKLGIKGSPTTELYFDKCRIPGDRIIGE-PGTGFKTA
. *: *:* . * ** * . :* .::* * **
Mb2743c|M.bovis_AF2122/97 MQNLPQERISIAIMAAAGMESVLEQTLQYAKERKAFGRSIGSFQNSRFLL
Rv2724c|M.tuberculosis_H37Rv MQNLPQERISIAIMAAAGMESVLEQTLQYAKERKAFGRSIGSFQNSRFLL
MUL_3367|M.ulcerans_Agy99 MQNLPQERISIAIMAAAGMESVLDQTLQYTKERKAFGRSIGNFQNSRFVL
Mvan_2439|M.vanbaalenii_PYR-1 MQNLPQERISIAIMAAAAMEAVLDVTLQYTKERKAFGRPIGSQQNSRFLL
MSMEG_5197|M.smegmatis_MC2_155 MTNLPSERLSIAISAIAGARAVFDETLQYCKDRKAFGQPIGSFQHNRFLL
MMAR_3132|M.marinum_M MTQLPQERLIVAVGAVAAMELAVEQTLKYTREREAFGRPVFGFQNTKFIL
MAB_2081|M.abscessus_ATCC_1997 MTQLPQERLIVAVGAVAAMELALEQTLKYTREREAFGRPVFGFQNTKFTL
Mflv_4601|M.gilvum_PYR-GCK MQQLPQERLILALGAVTVLETALEFTVEYTKDRHAFGKPVFAFQNTKFKL
TH_3180|M.thermoresistible__bu IDQLAQERLAVAAQAMGGMERAVDDTVAYTKSREAFGQSIFDFQNTAFEL
MAV_2703|M.avium_104 MEQLARERLIIATICAALAEVAVLEAIKYSREREAFGRPIGKFQHTKFVL
MLBr_00737|M.leprae_Br4923 LATLDHTRPTIGAQAVGIAQGALDAAIVYTKDRKQFGESISTFQSIQFML
: * * :. . . .. :: * :.*. **..: * * *
Mb2743c|M.bovis_AF2122/97 AELATEATVVRIMVDEFIKLHLAGKLTA-EQAAMAKWYATEKQVYLNDRC
Rv2724c|M.tuberculosis_H37Rv AELATEATVVRIMVDEFIKLHLAGKLTA-EQAAMAKWYATEKQVYLNDRC
MUL_3367|M.ulcerans_Agy99 AELATEATMVRIMVDESIELHLDGKLTA-EQAAMAKWYSTEKQVSLNDRC
Mvan_2439|M.vanbaalenii_PYR-1 AELSTEATVVRMMVDEFIKLHLQDKLTV-EQAAMAKWYSTEKQVHLIDRC
MSMEG_5197|M.smegmatis_MC2_155 AEMETELEVTENYIDRCLQGVVDGELTA-VEAAKAKWWATETAKKIVDNC
MMAR_3132|M.marinum_M AEAATETRIARVFLDYCIDLHLAGQLDV-QTVAMAKWWTTERAMKVLDDC
MAB_2081|M.abscessus_ATCC_1997 AEAATETRIARVFLDYCIDLHLAGQLDV-QTVAMAKWWTTERAMKVLDDC
Mflv_4601|M.gilvum_PYR-GCK AEVATDAHISRVFIDDCVARHLRGELDI-PTVAMAKWWTTERAMVALDDC
TH_3180|M.thermoresistible__bu AECATIARTCRAFFDQCVEAHLRGELDG-TDAAMAKYWLTDRQCEVVDRC
MAV_2703|M.avium_104 AECKTEALAIKTMVDYAVGQYLDGKNDP-ATASMAKLFAAEKSDQIVDKC
MLBr_00737|M.leprae_Br4923 ADMAMKVEAARLIVYAAAARAERGEPDLGFISAASKCFASDIAMEVTTDA
*: . . .: : :* : :: .
Mb2743c|M.bovis_AF2122/97 LQLHGGYGYMREYPVARAYLDSRVQTIYGGTTEIMKEIIGRGLGV
Rv2724c|M.tuberculosis_H37Rv LQLHGGYGYMREYPVARAYLDSRVQTIYGGTTEIMKEIIGRGLGV
MUL_3367|M.ulcerans_Agy99 LQLHGGYGYMREYPVARAYLDSRVQTIYGGTTEIMKEIIGRSLGI
Mvan_2439|M.vanbaalenii_PYR-1 LQLHGGYGYMREYDVARAYLDARVQTIYGGTTEIMKEIIGRSLGV
MSMEG_5197|M.smegmatis_MC2_155 VQLHGGYGYMMEYRVARAYVDGRIQTIFGGTTEIMKEIIGRDLGV
MMAR_3132|M.marinum_M LQLHGGYGYMTEYPISRLWVDQRVQKIYAGTNEVMKEIISRSL--
MAB_2081|M.abscessus_ATCC_1997 MQLHGGYGYMTEYPISRLWVDQRVQKIYAGTNEVMKEIISRSL--
Mflv_4601|M.gilvum_PYR-GCK LQLHGGYGYMTEYPIGRMWADARVQKIYGGTNEIMKEIIARSL--
TH_3180|M.thermoresistible__bu VQLHGGYGYMREYLIARMYEDARVQRIYAGANEVMKQIIARSL--
MAV_2703|M.avium_104 LQIFGGYGYMTEYPIANMYTASRVNRKYGRTSEIMKEIISRSL--
MLBr_00737|M.leprae_Br4923 VQLFGGAGYTSDFPVERFMRDAKITQIYEGTNQIQRVVMSRALLR
:*:.** ** :: : . :: : :.:: : ::.* *