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MKLATRLAILCGTALVAIVAANTLYTIQTNSVGALYEQRQQAREAQITALDVGRDVQALLATYSQMLFQD DPAERAQLSGELDEWDRMIDEDLRAAARDTADSNTRNQYQQALTTWESFQRSYRSDLQSVRTAEDAATAM SEVDGDVALLENQLNQIDEETSRRVAEVNRAAGDSIRTSRAFLWTFASLIVVALGALMFITSRNIHRTVT SSARQNERARRAKEIQAELMTDVQSVDDIAAACGIILSGSAKAVGAKHAALYLQQPDDPGRYALTASYAF HRRKGLPNSYGLGDGLVGQCALEGVRIEVTDVGDDYVEITSGLGKSRPMSLLLVPVKFESEVVGVIELAA LRLFSEEDTDLLDSIALGAGVALSAIESAQKTRELLRVSQAQTEELQTQEEELRAANEQLTQREDMLSAQ NAELEETTEELRTQKEELRASSERLEAQAHSLEEKNEELQHLSASLEAKAEELAVSSRYKSEFLANMSHE LRTPLNSILILAGLLTESDEPLNAKQHEFAETIQQSGKDLLNLIDEVLDLAKVESGSLYVDNEPITIAEL VTFLERTFRPIAGDKGIEFLVSVDDSAPGQITSDYTRVKQIAKNLVANAIKFTDTGSVSVKFSGCVDTDG SPGDGYLSMAVVDTGIGIDEKDHHLIFESFQQAGRGSAKQYGGTGLGLAISRELARHLGGDIALRSALGE GSTFTCYLPVESPTEPDAPAPPRPAPARPVAPPSDDTDTDTADRFGPVDTSDVAWPQGDKPVLLIVEDDP TFARMLSGLAAEAGFDSVITASGRMALALAKQHQPAAITLDIGLPDMAGWVVLDVLKHDLATRHIPVNVV SGTEDDGRGMRMGAIRTVNKPAEISDLRSMFSSIADFLKPGPRHVLVAEDDANQRQVVKHMIESDDIAIT CVGTGAQVLDELSGGTSYDCLVLDLGLPDIDGIDLIERIKDQLKEKRLPVIVHTGRELTAVETERLENLA AAIVLKNARSPERLLDETALFLHRVADDMPNSARQILANPRRVDESLEGNTVLLVDDDVRNVFSLGSALK RYGITVLPARNGQAGLDALGEHPEVGLVLMDIMMPVMDGYEAMRRIRAEPRWRHLPIVALTAKAMKGDRQ KCLEAGASDYVTKPVDMDQLTSVLRVWLAGAPRGQRKPPET
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_1000 | - | - | 100% (1161) | multi-sensor hybrid histidine kinase |
| M. gilvum PYR-GCK | Mflv_4423 | - | 2e-31 | 28.47% (418) | multi-sensor signal transduction histidine kinase |
| M. gilvum PYR-GCK | Mflv_0083 | - | 2e-26 | 32.20% (236) | histidine kinase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3273c | mtrB | 1e-22 | 27.96% (279) | two component sensory transduction histidine kinase MTRB |
| M. tuberculosis H37Rv | Rv3245c | mtrB | 1e-22 | 27.96% (279) | two component sensory transduction histidine kinase MTRB |
| M. leprae Br4923 | MLBr_00774 | mtrB | 1e-22 | 26.52% (279) | putative two-component system sensor kinase |
| M. abscessus ATCC 19977 | MAB_4048c | - | 1e-25 | 30.92% (262) | sensor-like histidine kinase senX3 |
| M. marinum M | MMAR_0815 | senX3 | 3e-26 | 27.48% (404) | two-component sensor histidine kinase SenX3 |
| M. avium 104 | MAV_4661 | - | 1e-22 | 27.44% (317) | hisitidine protein kinase SenX3 |
| M. smegmatis MC2 155 | MSMEG_0936 | senX3 | 2e-23 | 30.34% (234) | sensor histidine kinase SenX3 |
| M. thermoresistible (build 8) | TH_2898 | - | 8e-24 | 29.87% (231) | PUTATIVE sensor histidine kinase SenX3 |
| M. ulcerans Agy99 | MUL_4559 | senX3 | 3e-26 | 27.48% (404) | two component sensor histidine kinase SenX3 |
| M. vanbaalenii PYR-1 | Mvan_1931 | - | 9e-34 | 27.62% (420) | multi-sensor signal transduction histidine kinase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3273c|M.bovis_AF2122/97 --------------------------------------------------
Rv3245c|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_00774|M.leprae_Br4923 --------------------------------------------------
MSMEG_0936|M.smegmatis_MC2_155 --------------------------------------------------
TH_2898|M.thermoresistible__bu --------------------------------------------------
MMAR_0815|M.marinum_M --------------------------------------------------
MUL_4559|M.ulcerans_Agy99 --------------------------------------------------
MAV_4661|M.avium_104 --------------------------------------------------
MAB_4048c|M.abscessus_ATCC_199 --------------------------------------------------
Mflv_1000|M.gilvum_PYR-GCK MKLATRLAILCGTALVAIVAANTLYTIQTNSVGALYEQRQQAREAQITAL
Mvan_1931|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb3273c|M.bovis_AF2122/97 --------------------------------------------------
Rv3245c|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_00774|M.leprae_Br4923 --------------------------------------------------
MSMEG_0936|M.smegmatis_MC2_155 --------------------------------------------------
TH_2898|M.thermoresistible__bu --------------------------------------------------
MMAR_0815|M.marinum_M --------------------------------------------------
MUL_4559|M.ulcerans_Agy99 --------------------------------------------------
MAV_4661|M.avium_104 --------------------------------------------------
MAB_4048c|M.abscessus_ATCC_199 --------------------------------------------------
Mflv_1000|M.gilvum_PYR-GCK DVGRDVQALLATYSQMLFQDDPAERAQLSGELDEWDRMIDEDLRAAARDT
Mvan_1931|M.vanbaalenii_PYR-1 -----------------MTGDGRGESFSPAGIFADGGEVGRDHARVDWAA
Mb3273c|M.bovis_AF2122/97 ---------------------------------------MIFGSRRRIRG
Rv3245c|M.tuberculosis_H37Rv ---------------------------------------MIFGSRRRIRG
MLBr_00774|M.leprae_Br4923 ---------------------------------------MIFSSRRRIRG
MSMEG_0936|M.smegmatis_MC2_155 --------------------------------------------------
TH_2898|M.thermoresistible__bu --------------------------------------------------
MMAR_0815|M.marinum_M --------------------------------------------------
MUL_4559|M.ulcerans_Agy99 --------------------------------------------------
MAV_4661|M.avium_104 --------------------------------------------------
MAB_4048c|M.abscessus_ATCC_199 --------------------------------------------------
Mflv_1000|M.gilvum_PYR-GCK ADSNTRNQYQQALTTWESFQRSYRSDLQSVRTAEDAATAMSEVDGDVALL
Mvan_1931|M.vanbaalenii_PYR-1 TPLGPPSRWPQSLLTAASILLSSRFPMWMAWG-----PELTFFCNDAYRR
Mb3273c|M.bovis_AF2122/97 RRGRSGPMTRGLSALSRAVAVAWRRSLQLRVVALTLGLSLAVILALGFVL
Rv3245c|M.tuberculosis_H37Rv RRGRSGPMTRGLSALSRAVAVAWRRSLQLRVVALTLGLSLAVILALGFVL
MLBr_00774|M.leprae_Br4923 RWGRSGPMMRGMGALTRVVGVVWRRSLQLRVVALTFGLSLAVILALGFVL
MSMEG_0936|M.smegmatis_MC2_155 --------------------------------------MSLLTLIAGVAV
TH_2898|M.thermoresistible__bu --------------------------------------------------
MMAR_0815|M.marinum_M --------------------------MTVFSALLLAGVLSALALAAGVAV
MUL_4559|M.ulcerans_Agy99 ----------------------------MFSALLLAGVLSALALAAGVAV
MAV_4661|M.avium_104 ----------------------------MFSALLLAGVLSVLALAAGVAV
MAB_4048c|M.abscessus_ATCC_199 ---------------------------MTAASALLVATAALAALAVGAAL
Mflv_1000|M.gilvum_PYR-GCK ENQLNQIDEETSRRVAEVNRAAGDSIRTSRAFLWTFASLIVVALGALMFI
Mvan_1931|M.vanbaalenii_PYR-1 DTLGRKYPWALGRPASEVWAEIWDDIGPRIERVLSTGQATWDTALLLFLE
Mb3273c|M.bovis_AF2122/97 TSQVTNRVLDIKVRAAIDQIERARTTVSGIVNGEETRSLDSSLQLARNTL
Rv3245c|M.tuberculosis_H37Rv TSQVTNRVLDIKVRAAIDQIERARTTVSGIVNGEETRSLDSSLQLARNTL
MLBr_00774|M.leprae_Br4923 TSQLTSRVLDVKVRVAIEQIERARTTVTGIVNGEETRSLDSSLQLARNTL
MSMEG_0936|M.smegmatis_MC2_155 GVTVVPRIVARRQRRAAYAAG-----------------------MTVSQM
TH_2898|M.thermoresistible__bu --------------------------------------------------
MMAR_0815|M.marinum_M GARLSQRLVRRRQQASTEWTG-----------------------ITVAQM
MUL_4559|M.ulcerans_Agy99 GARLSQRLVRRRQQASTEWTG-----------------------ITVAQM
MAV_4661|M.avium_104 GTRLSPRAAQRRQRISTEWTG-----------------------ITVAQM
MAB_4048c|M.abscessus_ATCC_199 GVWYSRRASTHRNASEVAQTG-----------------------LTVSQM
Mflv_1000|M.gilvum_PYR-GCK TSRNIHRTVTSSARQNERARRAKEIQAELMTDVQSVDDIAAACGIILSGS
Mvan_1931|M.vanbaalenii_PYR-1 RSGYPEETYHTFSYSPLRDDDGRVVGMLCVVSEDTVRVIGERRMATLRDL
Mb3273c|M.bovis_AF2122/97 TSKTDPASGAGLAGAFDAVLMVPGDGPRAASTAGPVD-------------
Rv3245c|M.tuberculosis_H37Rv TSKTDPASGAGLAGAFDAVLMVPGDGPRAASTAGPVD-------------
MLBr_00774|M.leprae_Br4923 TSKTDPTSGAGLVGAFDAVLIVPGDGPRTATTAGPVD-------------
MSMEG_0936|M.smegmatis_MC2_155 LQHITSLSPMGVA-------------------------------------
TH_2898|M.thermoresistible__bu ---------VGII-------------------------------------
MMAR_0815|M.marinum_M LQRIVALMPMGVA-------------------------------------
MUL_4559|M.ulcerans_Agy99 LQRIVALMPMGVA-------------------------------------
MAV_4661|M.avium_104 LERIVALMPLGAA-------------------------------------
MAB_4048c|M.abscessus_ATCC_199 LERIVAISPTGIV-------------------------------------
Mflv_1000|M.gilvum_PYR-GCK AKAVGAKHAALYLQQPDDPGRYALTASYAFHRRKGLPNSYGLGDGLVGQC
Mvan_1931|M.vanbaalenii_PYR-1 GSDLSLVRSEVDILRFADEQLGHNLRDLPFTLTYLFD-------------
Mb3273c|M.bovis_AF2122/97 -------QVPNALRGFVKAGQ-----AAYQYATVQTEGFSGPALIIGTPT
Rv3245c|M.tuberculosis_H37Rv -------QVPNALRGFVKAGQ-----AAYQYATVQTEGFSGPALIIGTPT
MLBr_00774|M.leprae_Br4923 -------QVPNSLRGFIKAGQ-----AAYQYATVHTEGFSGPALIIGTPT
MSMEG_0936|M.smegmatis_MC2_155 --------VVDTFNDVVYSND-----RAVELNVVRDRILDDRAWQAAQRV
TH_2898|M.thermoresistible__bu --------VVDTFRDVVYSNE-----QARQLNLVRDGLIDDKTWEAVQQT
MMAR_0815|M.marinum_M --------VVDSHRDVVYLND-----RAKELGLVRDRQLDDQAWEAAQQA
MUL_4559|M.ulcerans_Agy99 --------VVDSHRDVVYLND-----RAKELGLVRDRQLDDQAWEAAQQA
MAV_4661|M.avium_104 --------VVDAHRDVVYLND-----RAKELGLVRDRQLDDQAWEAAQQA
MAB_4048c|M.abscessus_ATCC_199 --------VVDKHQDVVLVNA-----RARELGLVRDRQLDGQAWNAAQRT
Mflv_1000|M.gilvum_PYR-GCK ALEGVRIEVTDVGDDYVEITSGLGKSRPMSLLLVPVKFESEVVGVIELAA
Mvan_1931|M.vanbaalenii_PYR-1 ---------GDGSARLAGTSG-----IAPEHPAVPTRLSADGGGIWPVAE
: . . *
Mb3273c|M.bovis_AF2122/97 LSRVANLELYLIFPLASEQATITLVRGTMATGGLVLLVLLAGIALLVSRQ
Rv3245c|M.tuberculosis_H37Rv LSRVANLELYLIFPLASEQATITLVRGTMATGGLVLLVLLAGIALLVSRQ
MLBr_00774|M.leprae_Br4923 SSQVTNLELYLIFPLKNEQATVTLVRGTMATGGMVLLVLLSGIALLVSRQ
MSMEG_0936|M.smegmatis_MC2_155 FETGQDVEVDLSPLKVAN---------PGRSG-----ISVRGKVRLLT--
TH_2898|M.thermoresistible__bu LITGADGDVDLSEVRTPSWG------WPGRSANRSTPRSIRGHVRLLT--
MMAR_0815|M.marinum_M LR-GSDVEFDLSPGKRPG----------GRSG-----LSVHGQARLLS--
MUL_4559|M.ulcerans_Agy99 LR-GSDVEFDLSPGKRPG----------GRSG-----LSVHGQARLLS--
MAV_4661|M.avium_104 LT-GVDVEFDLRPAKRSG----------GRSG-----LSVHGQARLLS--
MAB_4048c|M.abscessus_ATCC_199 LATGEAVEVDLTTKPRAP----------GRAG-----FSLRGHVRRLS--
Mflv_1000|M.gilvum_PYR-GCK LRLFSEEDTDLLDSIALGAGVALSAIESAQKTRELLRVSQAQTEELQTQE
Mvan_1931|M.vanbaalenii_PYR-1 PARSESVLVDLDGDSYPSLPTGDWREPPAQALVVPLLHQGGSPSGFLVVG
*
Mb3273c|M.bovis_AF2122/97 VVVPVRSASRIAERFAEGHLSERMPVRGEDDMARLAVSFNDMAESLSRQI
Rv3245c|M.tuberculosis_H37Rv VVVPVRSASRIAERFAEGHLSERMPVRGEDDMARLAVSFNDMAESLSRQI
MLBr_00774|M.leprae_Br4923 VVVPVRSASRIAERFAEGHLSERMPVRGEDDMARLAVSFNDMAESLSRQI
MSMEG_0936|M.smegmatis_MC2_155 -----------------------------DDDRRFAVVYIDDQSEHAR--
TH_2898|M.thermoresistible__bu -----------------------------DEDRRFAVVYINDESEHAR--
MMAR_0815|M.marinum_M -----------------------------EEDRRFTVVFAYDQSDYAR--
MUL_4559|M.ulcerans_Agy99 -----------------------------EEDRRFTVVFAYDQSDYAR--
MAV_4661|M.avium_104 -----------------------------EEDRRFAVVFAHDQSDYAR--
MAB_4048c|M.abscessus_ATCC_199 -----------------------------DADTRWVVIYVDDDSEHVR--
Mflv_1000|M.gilvum_PYR-GCK EELRAAN----EQLTQREDMLSAQNAELEETTEELRTQKEELRASSERLE
Mvan_1931|M.vanbaalenii_PYR-1 -----------LNRYRLLDDGYRGFLTLVAGHIAAGIGLARSYRAQQRRA
*
Mb3273c|M.bovis_AF2122/97 AQLEEFGNLQR------------------------RFTSDVSHELRTPLT
Rv3245c|M.tuberculosis_H37Rv AQLEEFGNLQR------------------------RFTSDVSHELRTPLT
MLBr_00774|M.leprae_Br4923 TQLEEFGNLQR------------------------RFTSDVSHELRTPLT
MSMEG_0936|M.smegmatis_MC2_155 -----MEATRR------------------------DFVANVSHELKTPVG
TH_2898|M.thermoresistible__bu -----MEATRR------------------------DFVANVSHELKTPVG
MMAR_0815|M.marinum_M -----MEATRR------------------------DFVANVSHELKTPVG
MUL_4559|M.ulcerans_Agy99 -----MEATRR------------------------DFVANVSHELKTPVG
MAV_4661|M.avium_104 -----MEATRR------------------------DFVANVSHELKTPVG
MAB_4048c|M.abscessus_ATCC_199 -----MEATRR------------------------DFVANVSHELKTPVG
Mflv_1000|M.gilvum_PYR-GCK AQAHSLEEKNEELQHLSASLEAKAEELAVSSRYKSEFLANMSHELRTPLN
Mvan_1931|M.vanbaalenii_PYR-1 EELAELDRVKT------------------------TFFSNISHEFRTPLT
: . * :::***::**:
Mb3273c|M.bovis_AF2122/97 TVRMAADLIYDHSADLDPTLRRSTELMVSELDRFETLLNDLLEISRHDAG
Rv3245c|M.tuberculosis_H37Rv TVRMAADLIYDHSADLDPTLRRSTELMVSELDRFETLLNDLLEISRHDAG
MLBr_00774|M.leprae_Br4923 TVRMAADLIYDHSSDLDPTLRRSTELMVSELDRFETLLNDLLEISRHDAG
MSMEG_0936|M.smegmatis_MC2_155 AMSVLAEALLASADDPD-TVRRFAEKMVAESHRLADMIGELIELSRLQGA
TH_2898|M.thermoresistible__bu ALKVLAEALLASADDEE-TVRRFADRMVAESTRLADMIGELIDLSRLQGG
MMAR_0815|M.marinum_M AMALLAEALLASADDSD-TVRRFAEKVLIEANRLGDMVAELIELSRLQGA
MUL_4559|M.ulcerans_Agy99 AMALLAEALLASADDSD-TVRRFAEKVLIEANRLGDMVAELIELSRLQGA
MAV_4661|M.avium_104 AMALLAEALLASADDSE-TVRRFAEKVLVEANRLGDMVAELIELSRLQGA
MAB_4048c|M.abscessus_ATCC_199 AMGVLAEALLESSDDPE-TVRHFGEQVLAESRRLGNMVTELIALSRLQGA
Mflv_1000|M.gilvum_PYR-GCK SILILAGLLTESDEPLNAKQHEFAETIQQSGKDLLNLIDEVLDLAKVESG
Mvan_1931|M.vanbaalenii_PYR-1 LILDPVSELR-RAESIDEPVRRELDVVWRNGLRLTKLVNTLLDFSRIEAG
: . : : :. : : . : :: :: ::: :..
Mb3273c|M.bovis_AF2122/97 VAELSVEAVDLRTTVNNALGNVGHLAEEAGIELLVDLP-AEQVIAEVDAR
Rv3245c|M.tuberculosis_H37Rv VAELSVEAVDLRTTVNNALGNVGHLAEEAGIELLVDLP-AEQVIAEVDAR
MLBr_00774|M.leprae_Br4923 VAELSVEAVDLRVMVNNALGNVGHLAEEAGIELLVDMP-VDEVIAEVDAR
MSMEG_0936|M.smegmatis_MC2_155 ERLPDLDAVDVDSIVSEAVSRHKVAADNSQISITTDAP-TGYRVLG-DEG
TH_2898|M.thermoresistible__bu EPLPDLTAVDVDTVVAEALSRHKVAADNADITIITDPP-SGYRVRG-DLG
MMAR_0815|M.marinum_M ERLHNVTDVDVDTIVSEAISRHKVAADNAEIEVRTDSS-SGLHVLG-DQT
MUL_4559|M.ulcerans_Agy99 ERLHNVTDVDVDTIVSEAISRHKVAADNAEIEVRTDSS-SGLHVLG-DQT
MAV_4661|M.avium_104 ERLTNVTEVDVDSVVNEAISRHKVAADNANIEVRTDAP-SGLRVLG-DET
MAB_4048c|M.abscessus_ATCC_199 EKLPDLEVVDVDFVVSEALSRSKVAAENADIAVTTDAP-SGFEVRG-DPT
Mflv_1000|M.gilvum_PYR-GCK SLYVDNEPITIAELVTFLERTFRPIAGDKGIEFLVSVDDSAPGQITSDYT
Mvan_1931|M.vanbaalenii_PYR-1 RTQARYQPVDLGALTAELASMFRSAVERAGLTFDIDCD-PLDEVVYVDRD
: : . . : . . *
Mb3273c|M.bovis_AF2122/97 RVERILRNLIANAIDHAEH--------KPVRIRMAADEDTVAVTVRDYGV
Rv3245c|M.tuberculosis_H37Rv RVERILRNLIANAIDHAEH--------KPVRIRMAADEDTVAVTVRDYGV
MLBr_00774|M.leprae_Br4923 RVERILRNLIANAIDHSEH--------KPVRIRMAADEDTVAVTVRDYGI
MSMEG_0936|M.smegmatis_MC2_155 LLVTAIANLVSNAIAYSPNG-------TDVSISRRKRGGNIEIAVTDRGI
TH_2898|M.thermoresistible__bu LLVTAVANLVSNAIAYSPNG-------STVSISRQRRGGFVEISVTDRGI
MMAR_0815|M.marinum_M LLVTALANLVSNAIAYSSPG-------SPVSISRRKRGDNVEIAVTDRGI
MUL_4559|M.ulcerans_Agy99 LLVTALANLVSNAIAYSSPG-------SPVSISRRKRGDNVEIAVTDRGI
MAV_4661|M.avium_104 LLVTALANLVSNAIAYSPPG-------SPVSISRRRRGDNIEIAVTDRGI
MAB_4048c|M.abscessus_ATCC_199 LLITAISNLVANAIAYSPQG-------SPVSISRRRRGDKVEIAVTDRGI
Mflv_1000|M.gilvum_PYR-GCK RVKQIAKNLVANAIKFTDTGSVSVKFSGCVDTDGSPGDGYLSMAVVDTGI
Mvan_1931|M.vanbaalenii_PYR-1 MWEKVIFNLLSNALKFTFEG--------AVSVRVRRDGHQAVVVVADTGT
**::**: .: * : * * *
Mb3273c|M.bovis_AF2122/97 GLRPGEEKLVFSRFWRSDPSRVRRSGGTGLGLAISVEDARLHQGRLEAWG
Rv3245c|M.tuberculosis_H37Rv GLRPGEEKLVFSRFWRSDPSRVRRSGGTGLGLAISVEDARLHQGRLEAWG
MLBr_00774|M.leprae_Br4923 GLRPGEEKLVFSRFWRSDPSRVRRSGGTGLGLAISIEDARLHQGRLEAWG
MSMEG_0936|M.smegmatis_MC2_155 GIAKDDQERVFERFFRVDKARSRATGGTGLGLAIVKHVAANHNGSIRLWS
TH_2898|M.thermoresistible__bu GIAPEDQERVFERFFRVDKARSRATGGTGLGLAIVKHVAANHNGTIRLWS
MMAR_0815|M.marinum_M GIALEDQERVFERFFRGDKARSRATGGSGLGLAIVKHVAANHNGSIGVWS
MUL_4559|M.ulcerans_Agy99 GIALEDQERVFERFFRGDKARSRATGGSGLGLAIVKHVAANHNGSIGVWS
MAV_4661|M.avium_104 GIALEDQERVFERFFRGDKARSRATGGSGLGLAIVKHVAANHNGTIGVWS
MAB_4048c|M.abscessus_ATCC_199 GIAKEHQERVFERFFRVDKARSRDTGGTGLGLAIVKHVAANHNGVIKLWS
Mflv_1000|M.gilvum_PYR-GCK GIDEKDHHLIFESFQQAGRGSAKQYGGTGLGLAISRELARHLGGDIALRS
Mvan_1931|M.vanbaalenii_PYR-1 GVPADEMPRLFERFHRIENAKARSNEGSGIGLALVKELIGLHGGTIVADS
*: . :*. * : . : *:*:***: . * : .
Mb3273c|M.bovis_AF2122/97 EPGEGACFRLTLPLVRGHKVTTSPLPMKPIPQPVLQPVAQPNPQPMPPEY
Rv3245c|M.tuberculosis_H37Rv EPGEGACFRLTLPMVRGHKVTTSPLPMKPIPQPVLQPVAQPNPQPMPPEY
MLBr_00774|M.leprae_Br4923 EPGQGACFRLTLPLVRGHKVTTSPLPMKPILQPSPQ--ASTAGQQHG---
MSMEG_0936|M.smegmatis_MC2_155 QPGTGSTFTLSIPEYPDPESHS---------DEREDQRER----------
TH_2898|M.thermoresistible__bu QPGTGSTFTLSIPAYPDSDVAS---------DEREDQKQS----------
MMAR_0815|M.marinum_M KPGTGSTFTLSIPASSAPDDSD-QPDQPRARDARPNRSQREEELSR----
MUL_4559|M.ulcerans_Agy99 KPGTGSTFTLSIPTSSAPDDSD-QPDQPRGRDARPNRSQREEELSR----
MAV_4661|M.avium_104 KPGTGSTFTLSIPAAVASHRGDGESEQPQGREVRPNRSQREEELSR----
MAB_4048c|M.abscessus_ATCC_199 QPGTGSTFTLSLPVYEDDVDDD-DAEDTQADSPTGDTTPRKDATNHPPRP
Mflv_1000|M.gilvum_PYR-GCK ALGEGSTFTCYLPVESPTEPDAPAPPRPAPARPVAPPSDDTDTDTADRFG
Mvan_1931|M.vanbaalenii_PYR-1 AEGQGTAFTIRMPFGAAHLPDDALAPVGDGREAAGGADAYVEEALRWIPA
* *: * :*
Mb3273c|M.bovis_AF2122/97 KERQRPREHAEWSG------------------------------------
Rv3245c|M.tuberculosis_H37Rv KERQRPREHAEWSG------------------------------------
MLBr_00774|M.leprae_Br4923 TQRQRLREHAERSR------------------------------------
MSMEG_0936|M.smegmatis_MC2_155 --------------------------------------------------
TH_2898|M.thermoresistible__bu --------------------------------------------------
MMAR_0815|M.marinum_M --------------------------------------------------
MUL_4559|M.ulcerans_Agy99 --------------------------------------------------
MAV_4661|M.avium_104 --------------------------------------------------
MAB_4048c|M.abscessus_ATCC_199 HGLPASGSSKADGLLTSTS------PADGLRIGSSPADGLRIGSSPADGL
Mflv_1000|M.gilvum_PYR-GCK PVDTSDVAWPQGDKPVLLI------VEDDPTFARMLSGLAAEAGFDSVIT
Mvan_1931|M.vanbaalenii_PYR-1 DTEADDESAHAPTGSVTAASARVLVADDNADMREYLTRLLRSDGYRVDAV
Mb3273c|M.bovis_AF2122/97 --------------------------------------------------
Rv3245c|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_00774|M.leprae_Br4923 --------------------------------------------------
MSMEG_0936|M.smegmatis_MC2_155 --------------------------------------------------
TH_2898|M.thermoresistible__bu --------------------------------------------------
MMAR_0815|M.marinum_M --------------------------------------------------
MUL_4559|M.ulcerans_Agy99 --------------------------------------------------
MAV_4661|M.avium_104 --------------------------------------------------
MAB_4048c|M.abscessus_ATCC_199 RIGSSPADGLRIGSSQVPPSRLREEHKATTREEHVRR-------------
Mflv_1000|M.gilvum_PYR-GCK ASGRMALALAKQHQPAAITLDIGLPDMAGWVVLDVLKHDLATRHIPVNVV
Mvan_1931|M.vanbaalenii_PYR-1 ADGLEALEAIRAGAPDIVVSDVMMPRLDGLGLVAELRADRRTAATPVLLL
Mb3273c|M.bovis_AF2122/97 --------------------------------------------------
Rv3245c|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_00774|M.leprae_Br4923 --------------------------------------------------
MSMEG_0936|M.smegmatis_MC2_155 --------------------------------------------------
TH_2898|M.thermoresistible__bu --------------------------------------------------
MMAR_0815|M.marinum_M --------------------------------------------------
MUL_4559|M.ulcerans_Agy99 --------------------------------------------------
MAV_4661|M.avium_104 --------------------------------------------------
MAB_4048c|M.abscessus_ATCC_199 --------------------------------------------------
Mflv_1000|M.gilvum_PYR-GCK SG---TEDDGRGMRMGAIRTVNKPAEISDLRSMFSSIADFLKPGPRHVLV
Mvan_1931|M.vanbaalenii_PYR-1 SARAGQQESISGLRAGADDYLVKPFAAAELLARVRTNVELARLRHHHAQW
Mb3273c|M.bovis_AF2122/97 --------------------------------------------------
Rv3245c|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_00774|M.leprae_Br4923 --------------------------------------------------
MSMEG_0936|M.smegmatis_MC2_155 --------------------------------------------------
TH_2898|M.thermoresistible__bu --------------------------------------------------
MMAR_0815|M.marinum_M --------------------------------------------------
MUL_4559|M.ulcerans_Agy99 --------------------------------------------------
MAV_4661|M.avium_104 --------------------------------------------------
MAB_4048c|M.abscessus_ATCC_199 --------------------------------------------------
Mflv_1000|M.gilvum_PYR-GCK AEDDANQRQVVKHMIESDDIAITCVGTGAQVLDELSGGTSYDCLVLDLGL
Mvan_1931|M.vanbaalenii_PYR-1 RTALVDSLQEAFFVCDADGAVIEINPAFTEILGYDRAGLPYRPMHPWWPS
Mb3273c|M.bovis_AF2122/97 --------------------------------------------------
Rv3245c|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_00774|M.leprae_Br4923 --------------------------------------------------
MSMEG_0936|M.smegmatis_MC2_155 --------------------------------------------------
TH_2898|M.thermoresistible__bu --------------------------------------------------
MMAR_0815|M.marinum_M --------------------------------------------------
MUL_4559|M.ulcerans_Agy99 --------------------------------------------------
MAV_4661|M.avium_104 --------------------------------------------------
MAB_4048c|M.abscessus_ATCC_199 --------------------------------------------------
Mflv_1000|M.gilvum_PYR-GCK PDIDGIDLIERIKDQLKEKRLPVIVHTGRELTAVETERLENLAAAIVLKN
Mvan_1931|M.vanbaalenii_PYR-1 ADNDPDAHRQVAEAFDSLLGNRRGTITAVPVTHRDGHRLWVTATFAHAED
Mb3273c|M.bovis_AF2122/97 --------------------------------------------------
Rv3245c|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_00774|M.leprae_Br4923 --------------------------------------------------
MSMEG_0936|M.smegmatis_MC2_155 --------------------------------------------------
TH_2898|M.thermoresistible__bu --------------------------------------------------
MMAR_0815|M.marinum_M --------------------------------------------------
MUL_4559|M.ulcerans_Agy99 --------------------------------------------------
MAV_4661|M.avium_104 --------------------------------------------------
MAB_4048c|M.abscessus_ATCC_199 --------------------------------------------------
Mflv_1000|M.gilvum_PYR-GCK ARSPERLLDETALFLHRVADDMPNSARQILANPRRVDESLEGNTVLLVDD
Mvan_1931|M.vanbaalenii_PYR-1 PETGGDVVVGTVRDVSAEHFVVQRETALASLNESLAQADTLGDAVRAATA
Mb3273c|M.bovis_AF2122/97 --------------------------------------------------
Rv3245c|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_00774|M.leprae_Br4923 --------------------------------------------------
MSMEG_0936|M.smegmatis_MC2_155 --------------------------------------------------
TH_2898|M.thermoresistible__bu --------------------------------------------------
MMAR_0815|M.marinum_M --------------------------------------------------
MUL_4559|M.ulcerans_Agy99 --------------------------------------------------
MAV_4661|M.avium_104 --------------------------------------------------
MAB_4048c|M.abscessus_ATCC_199 --------------------------------------------------
Mflv_1000|M.gilvum_PYR-GCK DVRNVFSLG-----------------------------------SALKRY
Mvan_1931|M.vanbaalenii_PYR-1 EFAAVWRARRVLAVTWPDGYPVDTETPVDPHLVCAGEPARWSDLPAHTRE
Mb3273c|M.bovis_AF2122/97 --------------------------------------------------
Rv3245c|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_00774|M.leprae_Br4923 --------------------------------------------------
MSMEG_0936|M.smegmatis_MC2_155 --------------------------------------------------
TH_2898|M.thermoresistible__bu --------------------------------------------------
MMAR_0815|M.marinum_M --------------------------------------------------
MUL_4559|M.ulcerans_Agy99 --------------------------------------------------
MAV_4661|M.avium_104 --------------------------------------------------
MAB_4048c|M.abscessus_ATCC_199 --------------------------------------------------
Mflv_1000|M.gilvum_PYR-GCK GITVLPARNGQAGLDALGEHPEVGLVLMDIMMPVMDGYEAMRRIRAEPRW
Mvan_1931|M.vanbaalenii_PYR-1 RITALRDDDLLDPDTSTAGAAGVALQHPQGVLVIYVELFERRRFTAEDHT
Mb3273c|M.bovis_AF2122/97 --------------------------------------------------
Rv3245c|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_00774|M.leprae_Br4923 --------------------------------------------------
MSMEG_0936|M.smegmatis_MC2_155 --------------------------------------------------
TH_2898|M.thermoresistible__bu --------------------------------------------------
MMAR_0815|M.marinum_M --------------------------------------------------
MUL_4559|M.ulcerans_Agy99 --------------------------------------------------
MAV_4661|M.avium_104 --------------------------------------------------
MAB_4048c|M.abscessus_ATCC_199 --------------------------------------------------
Mflv_1000|M.gilvum_PYR-GCK RHLPIVALTAKAMKGDRQKCLEAGASDYVTKPVDMDQLTSVLRVWLAGAP
Mvan_1931|M.vanbaalenii_PYR-1 LLTVLAGRLGQGLQRVQQIDQQRETALALQHAILGPALSGGFAVRYQPAT
Mb3273c|M.bovis_AF2122/97 --------------------------------------------------
Rv3245c|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_00774|M.leprae_Br4923 --------------------------------------------------
MSMEG_0936|M.smegmatis_MC2_155 --------------------------------------------------
TH_2898|M.thermoresistible__bu --------------------------------------------------
MMAR_0815|M.marinum_M --------------------------------------------------
MUL_4559|M.ulcerans_Agy99 --------------------------------------------------
MAV_4661|M.avium_104 --------------------------------------------------
MAB_4048c|M.abscessus_ATCC_199 --------------------------------------------------
Mflv_1000|M.gilvum_PYR-GCK RGQRKPPET-----------------------------------------
Mvan_1931|M.vanbaalenii_PYR-1 RPLQVGGDWYDVVDLDDGRIALIVGDCVGHGLAAAAIMGQLRSACRALLL
Mb3273c|M.bovis_AF2122/97 --------------------------------------------------
Rv3245c|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_00774|M.leprae_Br4923 --------------------------------------------------
MSMEG_0936|M.smegmatis_MC2_155 --------------------------------------------------
TH_2898|M.thermoresistible__bu --------------------------------------------------
MMAR_0815|M.marinum_M --------------------------------------------------
MUL_4559|M.ulcerans_Agy99 --------------------------------------------------
MAV_4661|M.avium_104 --------------------------------------------------
MAB_4048c|M.abscessus_ATCC_199 --------------------------------------------------
Mflv_1000|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_1931|M.vanbaalenii_PYR-1 EHPSPAAALSGLDRFAARLPGARCTTAFCAVLDPETGEVVYSCAGHPPPI
Mb3273c|M.bovis_AF2122/97 --------------------------------------------------
Rv3245c|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_00774|M.leprae_Br4923 --------------------------------------------------
MSMEG_0936|M.smegmatis_MC2_155 --------------------------------------------------
TH_2898|M.thermoresistible__bu --------------------------------------------------
MMAR_0815|M.marinum_M --------------------------------------------------
MUL_4559|M.ulcerans_Agy99 --------------------------------------------------
MAV_4661|M.avium_104 --------------------------------------------------
MAB_4048c|M.abscessus_ATCC_199 --------------------------------------------------
Mflv_1000|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_1931|M.vanbaalenii_PYR-1 LIGADRSTRLLEEARATPLGLKNPPHRTEARETMAPRATLLLYTDGLVER
Mb3273c|M.bovis_AF2122/97 --------------------------------------------------
Rv3245c|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_00774|M.leprae_Br4923 --------------------------------------------------
MSMEG_0936|M.smegmatis_MC2_155 --------------------------------------------------
TH_2898|M.thermoresistible__bu --------------------------------------------------
MMAR_0815|M.marinum_M --------------------------------------------------
MUL_4559|M.ulcerans_Agy99 --------------------------------------------------
MAV_4661|M.avium_104 --------------------------------------------------
MAB_4048c|M.abscessus_ATCC_199 --------------------------------------------------
Mflv_1000|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_1931|M.vanbaalenii_PYR-1 RRESIDDGIARAAGVVEDNRATALDELANAVMAGLAPADGYHDDVALLLY
Mb3273c|M.bovis_AF2122/97 --------------------------------------------------
Rv3245c|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_00774|M.leprae_Br4923 --------------------------------------------------
MSMEG_0936|M.smegmatis_MC2_155 --------------------------------------------------
TH_2898|M.thermoresistible__bu --------------------------------------------------
MMAR_0815|M.marinum_M --------------------------------------------------
MUL_4559|M.ulcerans_Agy99 --------------------------------------------------
MAV_4661|M.avium_104 --------------------------------------------------
MAB_4048c|M.abscessus_ATCC_199 --------------------------------------------------
Mflv_1000|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_1931|M.vanbaalenii_PYR-1 RQPAPLDLEFAADVAELAVGREALRGWLDRAGVGAEQSLDVLIATGEALA
Mb3273c|M.bovis_AF2122/97 --------------------------------------------------
Rv3245c|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_00774|M.leprae_Br4923 --------------------------------------------------
MSMEG_0936|M.smegmatis_MC2_155 --------------------------------------------------
TH_2898|M.thermoresistible__bu --------------------------------------------------
MMAR_0815|M.marinum_M --------------------------------------------------
MUL_4559|M.ulcerans_Agy99 --------------------------------------------------
MAV_4661|M.avium_104 --------------------------------------------------
MAB_4048c|M.abscessus_ATCC_199 --------------------------------------------------
Mflv_1000|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_1931|M.vanbaalenii_PYR-1 NAIEHGHREQPRGPVRLRAIALPDRVHVTVVDSGTWKPPATVPALHRGRG
Mb3273c|M.bovis_AF2122/97 -----------------------------
Rv3245c|M.tuberculosis_H37Rv -----------------------------
MLBr_00774|M.leprae_Br4923 -----------------------------
MSMEG_0936|M.smegmatis_MC2_155 -----------------------------
TH_2898|M.thermoresistible__bu -----------------------------
MMAR_0815|M.marinum_M -----------------------------
MUL_4559|M.ulcerans_Agy99 -----------------------------
MAV_4661|M.avium_104 -----------------------------
MAB_4048c|M.abscessus_ATCC_199 -----------------------------
Mflv_1000|M.gilvum_PYR-GCK -----------------------------
Mvan_1931|M.vanbaalenii_PYR-1 IALMRALMHDVTIDSQTTGTTVHMNARIV