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TTVARTSFGALRGEALDDVVVFRGVPYAASPTGERRWRPAQPVSTWTDVRDATAFGSIPPQDISPERLAK RGLTMSEDCLTLNVWTPAADDTRRPVLVFLHGGGQAQGHGSAPLLDGARLARRGGIVVVTMNFRLGVLGS LYAPDWHGADSTNLTVRDQQYALQWVRDEIGAFGGDPSAVTVAGQSSGAIAISVMLAGGCGLFDRAILQS GGLERVRSTEAAVAVAARLRALMRDDEPGVDEILAAQRGIDPGFVPPQGPFHPCIDGDVIAEHPLVVART RSMPAIPILAGTTRDEWRIFDAAFDDGVFTEQYVRDRAQALAGDRHDPDAVVDRYRADHGPLRDVASAMV TDYHFTAPTEQFVRAHAERGNAVLRYELQWPSPRAGFGACHDSCLALVFGNLDAAPALAGNDEAARHMSD VVQSLWVDFIRGGEPWVRYDGSGGSTMLLGRESGVTRDHRSEQLAIWEGRYPAYG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_4398 | - | - | 100% (476) | carboxylesterase, type B |
| M. gilvum PYR-GCK | Mflv_3419 | - | 4e-56 | 32.21% (503) | carboxylesterase, type B |
| M. gilvum PYR-GCK | Mflv_3125 | - | 4e-53 | 33.53% (510) | carboxylesterase, type B |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2071c | lipT | 7e-52 | 32.48% (505) | carboxylesterase LipT |
| M. tuberculosis H37Rv | Rv2045c | lipT | 7e-52 | 32.48% (505) | carboxylesterase LipT |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_1223 | - | 6e-52 | 32.39% (494) | carboxylesterase (LipT) |
| M. marinum M | MMAR_4363 | - | 9e-54 | 31.59% (516) | carboxylesterase |
| M. avium 104 | MAV_1226 | - | 5e-57 | 32.35% (507) | carboxylesterase superfamily protein |
| M. smegmatis MC2 155 | MSMEG_3667 | - | 3e-59 | 33.53% (504) | para-nitrobenzyl esterase |
| M. thermoresistible (build 8) | TH_3679 | - | 7e-58 | 32.93% (498) | PUTATIVE Carboxylesterase, type B |
| M. ulcerans Agy99 | MUL_2261 | lipT | 2e-51 | 34.38% (509) | carboxylesterase, LipT |
| M. vanbaalenii PYR-1 | Mvan_1303 | - | 2e-54 | 36.85% (464) | carboxylesterase, type B |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_3667|M.smegmatis_MC2_155 ---------------------------MANAARIADGPVAETGYGPVRG-
TH_3679|M.thermoresistible__bu ---------MPSTTPPDDRTPDDAPTRPAPAHSAVGSPVVDTVHGPVRG-
MMAR_4363|M.marinum_M -------------------------MTSDIRRMASDGYVVETAYGPVRGA
MAV_1226|M.avium_104 --------------------------------MAVDDLVVETGYGPVR--
Mb2071c|M.bovis_AF2122/97 ----------------------MALESATVGSMHERTVRARTATGIVEG-
Rv2045c|M.tuberculosis_H37Rv ----------------------MALESATVGSMHERTVRARTATGIVEG-
MUL_2261|M.ulcerans_Agy99 --------------------------------MHERTVRARTATGVVEG-
MAB_1223|M.abscessus_ATCC_1997 -----------------------------MRKGPSSAVRVHTTNGVVEG-
Mflv_4398|M.gilvum_PYR-GCK -----------------------------------MTTVARTSFGALRG-
Mvan_1303|M.vanbaalenii_PYR-1 MPIPRLGVLAVLMVLVAACGRGDAGDRGHEARSPVDPAVVQTAAGAVRG-
. * * :.
MSMEG_3667|M.smegmatis_MC2_155 ----TDDG---TAKAWLGIRYARAPIGELRWRAPEPPASWHDVFDATRVG
TH_3679|M.thermoresistible__bu ----RDDG---VVKVWRGIRYAAAPVGGLRWRAPEPPQPWREPMDAIRVG
MMAR_4363|M.marinum_M EDGIAAAGSGVRTKSWKGIRYGAPPVGELRFRAPQPPQPWTEIADATAFG
MAV_1226|M.avium_104 --GVPVDG----VKAWKGIRYAAPPIGDLRFRAPQPPERWTEVADATVFG
Mb2071c|M.bovis_AF2122/97 ---FTRDG----VHRWRSIPYARAPVGSLRFRAPQPAQPWPGVRHCHTFA
Rv2045c|M.tuberculosis_H37Rv ---FTRDG----VHRWRSIPYARAPVGSLRFRAPQPAQPWPGVRHCHTFA
MUL_2261|M.ulcerans_Agy99 ---FTRDG----VHRWRSIPYARAPIGLLRFRAPRPPQPWSGVRHCHGFT
MAB_1223|M.abscessus_ATCC_1997 ---FLDDD----VRRFRAIPYAEPPLGALRLRSPEPAQPWAGVLACDSWK
Mflv_4398|M.gilvum_PYR-GCK ---EALDD----VVVFRGVPYAASPTGERRWRPAQPVSTWTDVRDATAFG
Mvan_1303|M.vanbaalenii_PYR-1 ---TVEPD----HRLFAGIPYAAPPIGPLRWRDPEPAPRWDGVRDATAFG
. : .: *. .* * * * ..* * .
MSMEG_3667|M.smegmatis_MC2_155 AVCPQA-TDARIPIDLGGKQDEDSLVLNVWAPSGCRPGDRRPVMVWVHGG
TH_3679|M.thermoresistible__bu PACPQP-ADPRIPLDLGAAIGEDCLNLNVWASSDTEPGDRKPVLVWVHGG
MMAR_4363|M.marinum_M PVCPQP-VLANMPIDLGAPQDEDCLRLNIWAPANTAPGAAKPVMVWLHGG
MAV_1226|M.avium_104 PACPQP-VFPNMPLDLGAPQGEDCLRLNVWASADTQPGDAKPVMVWLHGG
Mb2071c|M.bovis_AF2122/97 NCAPQQRRYTVMGIGRYQTRSEDCLTLNVVTPEEPAT-QPLPVMVFIHGG
Rv2045c|M.tuberculosis_H37Rv NCAPQQRRYTVMGIGRYQTRSEDCLTLNVVTPEEPAT-QPLPVMVFIHGG
MUL_2261|M.ulcerans_Agy99 HCSPQQRRYTMLGLGKYQPMSEDCLTLNVVAPEAPTH-RPLPVMVFIHGG
MAB_1223|M.abscessus_ATCC_1997 SASPQKRVYVPLSLTNFQEVGEDCLTLNVTVPAANSS-DPLAVMFYIHGG
Mflv_4398|M.gilvum_PYR-GCK SIPPQD-ISPERLAKRGLTMSEDCLTLNVWTP-AADDTR-RPVLVFLHGG
Mvan_1303|M.vanbaalenii_PYR-1 SRCLQD-LAGDLELGR--QTDEDCLNLNVWTP-AAEPGRPRAVMVWIHGG
* .**.* **: .. .*:.::***
MSMEG_3667|M.smegmatis_MC2_155 AYVLGSASQPLCRGRVLASEGDVVVVTVNYRLGPFGFLDLSEYSSRAMRF
TH_3679|M.thermoresistible__bu AYVIGAASQPLYHGRELVRRGDVVLVTLNYRLGAFGFLELTALSSGRRRF
MMAR_4363|M.marinum_M AYMLGSASQALYDGRRLASSGEVIVVTVNYRLGALGFLDLSSLSHAGRSF
MAV_1226|M.avium_104 AYVLGSSSQTLYDGRRLVSHGDVVVVTVNYRLGALGFLDLSSLNSAGRSF
Mb2071c|M.bovis_AF2122/97 GYILGSSATPIYDGAALARRG-CVYVSVNYRLGALGCLDLSSLSTPQITL
Rv2045c|M.tuberculosis_H37Rv GYILGSSATPIYDGAALARRG-CVYVSVNYRLGALGCLDLSSLSTPQITL
MUL_2261|M.ulcerans_Agy99 GYILGSSATPIYDGAALARRG-CVYVSVNYRLGALGCLDLSSLSTPDIAI
MAB_1223|M.abscessus_ATCC_1997 AYVLGSSALALYDGADLARRG-CVFVSVNYRVGAYGAMDLSSLSDARHTI
Mflv_4398|M.gilvum_PYR-GCK GQAQGHGSAPLLDGARLARRGGIVVVTMNFRLGVLGSLYAPDWHG---AD
Mvan_1303|M.vanbaalenii_PYR-1 SFVAGSG--GIYDARRLAARGDIVVVTLNYRLGAPGFLAHPSLGPP--GE
. * . : . *. * : *::*:*:* * : .
MSMEG_3667|M.smegmatis_MC2_155 DTNLGLRDVIFALQWVRDNIAAFGGDPSRVTLFGESAGGGMITTLLASPA
TH_3679|M.thermoresistible__bu DTNVGLRDVLFALAWVRDNIAAFGGDPDRVTLFGESAGGGIVTTLLGSPA
MMAR_4363|M.marinum_M DSNVGLRDVLAALHWVRENIAAFGGDPANITLFGESAGAGLVTTLLVTPA
MAV_1226|M.avium_104 DSNVGLRDVLAALEWVRDNITAFGGDPRRVTLFGESAGAGIVTTLLASPA
Mb2071c|M.bovis_AF2122/97 DSNVYLRDLVLALRWVHDNIAEFGGDPGNVTIFGESAGAHITATLLAVPA
Rv2045c|M.tuberculosis_H37Rv DSNVYLRDLVLALRWVHDNIAEFGGDPGNVTIFGESAGAHITATLLAVPA
MUL_2261|M.ulcerans_Agy99 DGNLYLRDLVMALQWIQDNIAEFGGDPDNVTIFGESAGAHITATLLAVPA
MAB_1223|M.abscessus_ATCC_1997 DSNLYLRDLVLALQWVRENIAAFGGDPGSVTIFGESAGAHCVQMLLAVPA
Mflv_4398|M.gilvum_PYR-GCK STNLTVRDQQYALQWVRDEIGAFGGDPSAVTVAGQSSGAIAISVMLAG--
Mvan_1303|M.vanbaalenii_PYR-1 VGNYGLADQQAALRWVRDNIAAFGGDPGKVTVAGESAGAMSVCDHLVAPA
* : * ** *::::* ***** :*: *:*:*. *
MSMEG_3667|M.smegmatis_MC2_155 AEGLFSAAIAQSSPATSVYDAERSRRVARALLERLLIEPDDAA-RLAHVP
TH_3679|M.thermoresistible__bu AAGLFHRAIAQSSPATSCYGTERAIDVAEQFLGHLGLSPRDVD-RLPDVP
MMAR_4363|M.marinum_M ARGLFSRAIAQSSPATSVYDRERAQRVAVHLLDKLGVAASDVD-KLTQLP
MAV_1226|M.avium_104 AAGLFAAAIAQSSPATSVYDRDRAARVAEAFLGKLGITASESR-RLIDMP
Mb2071c|M.bovis_AF2122/97 AKGLFARAISESPAAGMVRSREVAAEFAARFANLIGARTQDAANALMQAS
Rv2045c|M.tuberculosis_H37Rv AKGLFARAISESPAAGMVRSREVAAEFAARFANLIGARTQDAANALMQAS
MUL_2261|M.ulcerans_Agy99 AKGLFARAISESPAAGMVRPREIAAEFATRFARLLGARKHDAASALMRAT
MAB_1223|M.abscessus_ATCC_1997 AAGLFHRAICQSTASGMIHTRDEAAANARRLVEYLGADARSPAEAVVNAR
Mflv_4398|M.gilvum_PYR-GCK GCGLFDRAILQSGGLERVR----STEAAVAVAARLRALMRDDEPGVDEIL
Mvan_1303|M.vanbaalenii_PYR-1 SQGLFDAAIIMSGPCQAQAPLPVAEQRSIEYAAALGCADKATAAECLRAL
. *** ** * : : :
MSMEG_3667|M.smegmatis_MC2_155 IPAILGASQQIFNEVPAQSPGTLAFAPIVDGDVVPDYPVQAARAGRTHRV
TH_3679|M.thermoresistible__bu VAAIVEVSKHVFDDVPARRPGTLAFAPIVDGDIVPDYPVALARAGRTLPV
MMAR_4363|M.marinum_M TAAIVAASTEVFNEVPVRNPGTLAFVPIVDGDVLTDYPVKVAQEGRSHPV
MAV_1226|M.avium_104 MAAILAASQQVFDEVPVRNPGTLAFVPIVDGDVLADYPVKVAQQGCSHPV
Mb2071c|M.bovis_AF2122/97 PAQLVEAQHHLIRQGMRKRLGAFPIGPVFGDDYLPMDPVEAMRSGRVHAV
Rv2045c|M.tuberculosis_H37Rv PAQLVEAQHHLIRQGMRKRLGAFPIGPVFGDDYLPMDPVEAMRSGRVHAV
MUL_2261|M.ulcerans_Agy99 AAQLVQTQHRLIDQGMQKRLGAFPIGPTFGDDCLPLDPVEAMRAGQSHKV
MAB_1223|M.abscessus_ATCC_1997 PRALVSATHRLLTAKTRESAFSLGVGPSIDGDVVPDDPIAMMEHGEAHRV
Mflv_4398|M.gilvum_PYR-GCK AAQRGIDPGFVPPQGP--------FHPCIDGDVIAEHPLVVARTRSMPAI
Mvan_1303|M.vanbaalenii_PYR-1 PGNKLRTPVWFYEIGDDR-----LSGPATGSAELPADPVTAFGAGRAARV
. * .. :. *: :
MSMEG_3667|M.smegmatis_MC2_155 PLIIGTNKHEASLFRWMKSPLMPITPEAIRAMFEGIASEQPGLALPTEEE
TH_3679|M.thermoresistible__bu PLVIGTNKDEASLFRWMKSPLLPITPDAIKKMFADIAAEQPGLRLPTETQ
MMAR_4363|M.marinum_M PLLIGTNKHEAALFRLMRSPLMPITPRAITSMFTQIAAEQPDLQLPTEEE
MAV_1226|M.avium_104 PLIIGTNQHEAALFRLMRSALMPITPHAITSMFNQIAAEQPDLQLPTEKQ
Mb2071c|M.bovis_AF2122/97 PLIVGTNAEEGRLFTRFLG----MLPTNEPMVEELLSGMKP----ADRER
Rv2045c|M.tuberculosis_H37Rv PLIVGTNAEEGRLFTRFLG----MLPTNEPMVEELLSGMKP----ADRER
MUL_2261|M.ulcerans_Agy99 PLIVGTNADEGRLFTRFLK----MLPTNKAMIDELLADTEP----ATRER
MAB_1223|M.abscessus_ATCC_1997 PLIIGYNAEEIRLFNRLLTRVMSLSRFDTRAVARALVQLRP----EHAQR
Mflv_4398|M.gilvum_PYR-GCK PILAGTTRDEWRIFDAAFDDG-VFTEQYVRDRAQALAGDR-HDPDAVVDR
Mvan_1303|M.vanbaalenii_PYR-1 PVLIGTTRDEWTLFVALQHLR-DGRDYTPEEYPRLLADTFGADARAVAGR
*:: * . .* :* : .
MSMEG_3667|M.smegmatis_MC2_155 IRAAYSGMRTKAIGMGVARDIGFRMPTLWFADGHSTSAPVYLYRFD--FA
TH_3679|M.thermoresistible__bu ISAAYRRQRGKRLGVGVASDIGFRMPSVWFAEGHTAVAPTYLYRFD--WS
MMAR_4363|M.marinum_M IGLAYSRLRRRARPLSIATDVGFRMPSVWLAEGHSRVAPVYLYRFD--YS
MAV_1226|M.avium_104 IGSAYSRFRRRARYLSIATDVGFRMPSVWLAEGHARVAPVYLYRFD--YS
Mb2071c|M.bovis_AF2122/97 ITAAYPNYPAPSACIQLGGDFAFSSAAWQIAEAHGANAPTYLYRYD--YA
Rv2045c|M.tuberculosis_H37Rv ITAAYPNYPAPSACIQLGGDFAFSSAAWQIAEAHGANAPTYLYRYD--YA
MUL_2261|M.ulcerans_Agy99 ITAAYPNYPESAACIQLGGDFAFNAAAWQIAEAQGVHAPTYLYRYD--YA
MAB_1223|M.abscessus_ATCC_1997 VIDCYQGYPARDVLVRLMGDAMFGSEAWRVAQAHSRHSSVYFYRYD--YA
Mflv_4398|M.gilvum_PYR-GCK YRADHGP-LRDVASAMVTDYHFTAPTEQFVRAHAERGNAVLRYELQ----
Mvan_1303|M.vanbaalenii_PYR-1 YPLSAFPDVALAYAATVTDGILACPAERWARQLS-RDASVYFYEFNDRNA
: .. *. :
MSMEG_3667|M.smegmatis_MC2_155 TPMLRLLRLGAAHATELPYVWGNLAAGPKDPTFKMGGLKQGRKVSQRIRR
TH_3679|M.thermoresistible__bu TPTLRLLRLGAAHATELPYVFGNLDT-PKDPTFTLGGRRTGRQVSQRIRT
MMAR_4363|M.marinum_M TPLLKLLLVRAAHATELPYVWGNLGG-PQDPTLRLGGAKTAKAVSKRMRT
MAV_1226|M.avium_104 TPLLRLLMVKAAHATELPYVWGTLGA-PKDPTLKLGGSKTAKAVSKRVRT
Mb2071c|M.bovis_AF2122/97 PRTLRWSGFGATHATELFAVFDIYRTRFGALLTAAADRRAALRVSNEVQR
Rv2045c|M.tuberculosis_H37Rv PRTLRWSGFGATHATELFAVFDIYRTRFGALLTAAADRRAALRVSNEVQR
MUL_2261|M.ulcerans_Agy99 PRTLRWSGFGATHATELFAVFDIYRTRFGALLTAAADRRHALRVSDEVIR
MAB_1223|M.abscessus_ATCC_1997 PRPLRRFGLGAAHATELFAVFGLFKR--WPALAGKKDRRHALALTEDIQS
Mflv_4398|M.gilvum_PYR-GCK -WPSPRAGFGACHDSCLALVFGNLDAAPALAGND----EAARHMSDVVQS
Mvan_1303|M.vanbaalenii_PYR-1 PAPDPLRTLPFPVGASHSLELRYLFDVGGAPPPD----PAQVRLGEQMVD
. : : . :
MSMEG_3667|M.smegmatis_MC2_155 RWVNFATTGEPTGALGEPVWRRYRREDRAALVIDKQDKTVTDLDQQLQAA
TH_3679|M.thermoresistible__bu RWINFAVHGRPDGPPGEPRWHAYDRAERPCLLIDRRDRVVRDVDEPIRLT
MMAR_4363|M.marinum_M RWINFATQDNPAGPAGEPDWPAYQDGDRACLVIDKSDRVARDIDAPIRAA
MAV_1226|M.avium_104 RWTNFAAHAKPAGPAGSPEWAPYQEQDRACLIIGKNDVLAHDVDAKARAA
Mb2071c|M.bovis_AF2122/97 RWRCFSQIGVPG-----DDWPAYTQDDRAVLVFDRRCRIEFDPHQHRRIA
Rv2045c|M.tuberculosis_H37Rv RWRCFSQIGVPG-----DDWPAYTQDDRAVLVFDRRCRIEFDPHQHRRIA
MUL_2261|M.ulcerans_Agy99 RWRSFSQTGTPG-----EDWPAYTHTRRAVMVIDRKSRVEIDPHRHRRLA
MAB_1223|M.abscessus_ATCC_1997 RWLAFSRTGVPG-----TGWPAYGEPERAVMVFDQERRIELDPHCAQREL
Mflv_4398|M.gilvum_PYR-GCK LWVDFIRGGEPW--------VRYDGSGGSTMLLGRESGVTRDHRSEQLAI
Mvan_1303|M.vanbaalenii_PYR-1 HWAAFVRAGDPG--------WPGVDAGVMSLQPDGSRMVETFGEVHQCSF
* * * : .
MSMEG_3667|M.smegmatis_MC2_155 WGDQVLNFR
TH_3679|M.thermoresistible__bu WGSEVLSFR
MMAR_4363|M.marinum_M WGREVVGFR
MAV_1226|M.avium_104 WGSEMVSFR
Mb2071c|M.bovis_AF2122/97 WDGFSLAN-
Rv2045c|M.tuberculosis_H37Rv WDGFSLAN-
MUL_2261|M.ulcerans_Agy99 WDGFSLAR-
MAB_1223|M.abscessus_ATCC_1997 WRDIGRVA-
Mflv_4398|M.gilvum_PYR-GCK WEGRYPAYG
Mvan_1303|M.vanbaalenii_PYR-1 WAGLQ----
*