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MRKGPSSAVRVHTTNGVVEGFLDDDVRRFRAIPYAEPPLGALRLRSPEPAQPWAGVLACDSWKSASPQKR VYVPLSLTNFQEVGEDCLTLNVTVPAANSSDPLAVMFYIHGGAYVLGSSALALYDGADLARRGCVFVSVN YRVGAYGAMDLSSLSDARHTIDSNLYLRDLVLALQWVRENIAAFGGDPGSVTIFGESAGAHCVQMLLAVP AAAGLFHRAICQSTASGMIHTRDEAAANARRLVEYLGADARSPAEAVVNARPRALVSATHRLLTAKTRES AFSLGVGPSIDGDVVPDDPIAMMEHGEAHRVPLIIGYNAEEIRLFNRLLTRVMSLSRFDTRAVARALVQL RPEHAQRVIDCYQGYPARDVLVRLMGDAMFGSEAWRVAQAHSRHSSVYFYRYDYAPRPLRRFGLGAAHAT ELFAVFGLFKRWPALAGKKDRRHALALTEDIQSRWLAFSRTGVPGTGWPAYGEPERAVMVFDQERRIELD PHCAQRELWRDIGRVA
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_1223 | - | - | 100% (506) | carboxylesterase (LipT) |
| M. abscessus ATCC 19977 | MAB_3452c | - | e-164 | 56.85% (496) | carboxylesterase LipT |
| M. abscessus ATCC 19977 | MAB_3453c | - | e-159 | 56.68% (494) | carboxylesterase LipT |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2071c | lipT | 1e-141 | 51.12% (493) | carboxylesterase LipT |
| M. gilvum PYR-GCK | Mflv_3125 | - | 1e-140 | 51.11% (497) | carboxylesterase, type B |
| M. tuberculosis H37Rv | Rv2045c | lipT | 1e-141 | 51.12% (493) | carboxylesterase LipT |
| M. leprae Br4923 | - | - | - | - | - |
| M. marinum M | MMAR_3020 | lipT | 1e-138 | 50.30% (493) | carboxylesterase, LipT |
| M. avium 104 | MAV_2466 | - | 1e-141 | 51.51% (497) | LppT protein |
| M. smegmatis MC2 155 | MSMEG_3848 | - | 1e-143 | 52.94% (493) | para-nitrobenzyl esterase |
| M. thermoresistible (build 8) | TH_0737 | lipT | 1e-144 | 53.43% (496) | Probable carboxylesterase LipT |
| M. ulcerans Agy99 | MUL_2261 | lipT | 1e-138 | 50.30% (493) | carboxylesterase, LipT |
| M. vanbaalenii PYR-1 | Mvan_3408 | - | 1e-140 | 50.91% (497) | carboxylesterase, type B |
CLUSTAL 2.0.9 multiple sequence alignment
TH_0737|M.thermoresistible__bu -------------VMHEHRVRVQISTGTIEGFTRDGVHRWRAIPYAKPPV
Mvan_3408|M.vanbaalenii_PYR-1 --------------MHEHTVRVRTASGTVEGFTRDGVHRWRSIPYARPPV
MSMEG_3848|M.smegmatis_MC2_155 --------------MHERTVRAEISTGIIEGFTRDGVHRWRSIPYARAPI
Mb2071c|M.bovis_AF2122/97 ----MALESATVGSMHERTVRARTATGIVEGFTRDGVHRWRSIPYARAPV
Rv2045c|M.tuberculosis_H37Rv ----MALESATVGSMHERTVRARTATGIVEGFTRDGVHRWRSIPYARAPV
MMAR_3020|M.marinum_M --------------MHERTVRARTATGIVEGFTRDGVHRWRSIPYARAPI
MUL_2261|M.ulcerans_Agy99 --------------MHERTVRARTATGVVEGFTRDGVHRWRSIPYARAPI
MAV_2466|M.avium_104 --------------MHDRTVRARTATGIVEGFTRDGVHRWRSIPYARPPV
Mflv_3125|M.gilvum_PYR-GCK MVRQAGREFDTVGRMHEHTVRVKIASGTVEGFTRDGVHRWRSIPYARPPV
MAB_1223|M.abscessus_ATCC_1997 -----------MRKGPSSAVRVHTTNGVVEGFLDDDVRRFRAIPYAEPPL
. **.. :.* :*** *.*:*:*:****..*:
TH_0737|M.thermoresistible__bu GPLRLRAPEPADPWPGVRHCHGFGNCAPQERKYTLIGLG----KYQPMGE
Mvan_3408|M.vanbaalenii_PYR-1 GRLRYRAPEPVQPWSGVRHCHGFLSCAPQHRRYTLIGVR----KYQPTSE
MSMEG_3848|M.smegmatis_MC2_155 GPLRLRAPQPAEPWPGVRYCHGFGFCAPQQRRYTLLGVG----KYQPTSE
Mb2071c|M.bovis_AF2122/97 GSLRFRAPQPAQPWPGVRHCHTFANCAPQQRRYTVMGIG----RYQTRSE
Rv2045c|M.tuberculosis_H37Rv GSLRFRAPQPAQPWPGVRHCHTFANCAPQQRRYTVMGIG----RYQTRSE
MMAR_3020|M.marinum_M GPLRFRAPRPPQPWSGVRHCHGFTHCSPQQRRYTMLGLG----KYQPMSE
MUL_2261|M.ulcerans_Agy99 GLLRFRAPRPPQPWSGVRHCHGFTHCSPQQRRYTMLGLG----KYQPMSE
MAV_2466|M.avium_104 GDLRFRAPQPAQPWSGVRHCHGFANCAPQQRRYTLLGLSGLGGRYQPMSE
Mflv_3125|M.gilvum_PYR-GCK GPLRYRAPRPVQPWPGVRYCHGFGACAPQQRMYTLLAPG----RYQPMSE
MAB_1223|M.abscessus_ATCC_1997 GALRLRSPEPAQPWAGVLACDSWKSASPQKRVYVPLSLT----NFQEVGE
* ** *:*.* :**.** *. : .:**.* *. :. .:* .*
TH_0737|M.thermoresistible__bu DCLTLNVVAPEHPPDS----PMPVLVFIHGGGYLLGSSATPIYDGAALAR
Mvan_3408|M.vanbaalenii_PYR-1 DCLTLNVVAPEGAASAGE--PLPVMFFIHGGGYILGSSATPLYDGAALAR
MSMEG_3848|M.smegmatis_MC2_155 DCLTLNVVAPEKPHDG----PLPVMFFVHGGGYVLGSSATPIYDGAALAR
Mb2071c|M.bovis_AF2122/97 DCLTLNVVTPEEPATQ----PLPVMVFIHGGGYILGSSATPIYDGAALAR
Rv2045c|M.tuberculosis_H37Rv DCLTLNVVTPEEPATQ----PLPVMVFIHGGGYILGSSATPIYDGAALAR
MMAR_3020|M.marinum_M DCLTLNVVAPEAPSHR----PLPVMVFIHGGGYILGSSATPIYDGAALAR
MUL_2261|M.ulcerans_Agy99 DCLTLNVVAPEAPTHR----PLPVMVFIHGGGYILGSSATPIYDGAALAR
MAV_2466|M.avium_104 DCLTLNVVTPEAPAEG----PLPVMVFIHGGGYFLGSSATPLYDGAALAR
Mflv_3125|M.gilvum_PYR-GCK DCLTLNVVAPADAEARAADGPLPVMVFIHGGGYLLGSSATPVYDGASLAR
MAB_1223|M.abscessus_ATCC_1997 DCLTLNVTVPAANSSD----PLAVMFYIHGGAYVLGSSALALYDGADLAR
*******..* *:.*:.::***.*.***** .:**** ***
TH_0737|M.thermoresistible__bu RGCVYVSVNYRLGALGCMDLSSLSTRRHPIDSNLFLRDLVLALQWVRDNI
Mvan_3408|M.vanbaalenii_PYR-1 RGCVYVSVNYRLGPLGCMDLSSLSTPENPIDDNLFLRDLVMALRWVRDNV
MSMEG_3848|M.smegmatis_MC2_155 RGCVYVSVNYRLGVLGAMELSSLSTPEHPIDDNLFLRDLVLALQWVRDNI
Mb2071c|M.bovis_AF2122/97 RGCVYVSVNYRLGALGCLDLSSLSTPQITLDSNVYLRDLVLALRWVHDNI
Rv2045c|M.tuberculosis_H37Rv RGCVYVSVNYRLGALGCLDLSSLSTPQITLDSNVYLRDLVLALRWVHDNI
MMAR_3020|M.marinum_M RGCVYVSVNYRLGALGCLDLSSLSTPDIAIDGNLYLRDLVMALQWIQDNI
MUL_2261|M.ulcerans_Agy99 RGCVYVSVNYRLGALGCLDLSSLSTPDIAIDGNLYLRDLVMALQWIQDNI
MAV_2466|M.avium_104 RGCVYVSVNYRLGALGCVDFSSLSTPEIPLESNLYLRDLVLALQWVRDNI
Mflv_3125|M.gilvum_PYR-GCK KGCVYISVNYRLGALGCLELSSLSTPEAPIDDNLFLRDLVMALRWVRDNV
MAB_1223|M.abscessus_ATCC_1997 RGCVFVSVNYRVGAYGAMDLSSLSDARHTIDSNLYLRDLVLALQWVRENI
:***::*****:* *.:::**** .::.*::*****:**:*:::*:
TH_0737|M.thermoresistible__bu SVFGGDPGNVTIFGESAGAHAVATLMAVPAAKGLFSQAISQSPASGMVRS
Mvan_3408|M.vanbaalenii_PYR-1 AAFGGDPDKVTIFGESAGAHAVATLLATPQAKGLFAQAISESPASGMVRS
MSMEG_3848|M.smegmatis_MC2_155 AVFGGDPDNVTIFGESAGAHAVATLLAVPAARGLFARVISESPASGMVSS
Mb2071c|M.bovis_AF2122/97 AEFGGDPGNVTIFGESAGAHITATLLAVPAAKGLFARAISESPAAGMVRS
Rv2045c|M.tuberculosis_H37Rv AEFGGDPGNVTIFGESAGAHITATLLAVPAAKGLFARAISESPAAGMVRS
MMAR_3020|M.marinum_M AEFGGDPDNVTIFGESAGAHITATLLAVPAAKGLFARAISESPAAGMVRP
MUL_2261|M.ulcerans_Agy99 AEFGGDPDNVTIFGESAGAHITATLLAVPAAKGLFARAISESPAAGMVRP
MAV_2466|M.avium_104 AEFGGDPDNVTIFGESAGACITATLLAVPAAKGLFAQAISESPASGLVRS
Mflv_3125|M.gilvum_PYR-GCK AAFGGDPGNVTIFGESAGAHAVSTLVATPEAEGLFAQAIAQSPASGMISD
MAB_1223|M.abscessus_ATCC_1997 AAFGGDPGSVTIFGESAGAHCVQMLLAVPAAAGLFHRAICQSTASGMIHT
: *****..********** . *:*.* * *** :.*.:*.*:*::
TH_0737|M.thermoresistible__bu ADVAAEFARRFADLLG-AGRDPAAALMAASPADLVRALDELISRGMTDMP
Mvan_3408|M.vanbaalenii_PYR-1 TEMAAKFASRFADLVANDGGDAAAALMSASPHALIAALDDLVANGFKDMP
MSMEG_3848|M.smegmatis_MC2_155 ADTAARLAGQYAGIIGHGGRDAAEALKTLSPAQLGRALEELINRGMTDMP
Mb2071c|M.bovis_AF2122/97 REVAAEFAARFANLIGARTQDAANALMQASPAQLVEAQHHLIRQGMRKRL
Rv2045c|M.tuberculosis_H37Rv REVAAEFAARFANLIGARTQDAANALMQASPAQLVEAQHHLIRQGMRKRL
MMAR_3020|M.marinum_M REIAAEFATRFARLLGARKHDAASALMRATAAQLVQTQHRLIDQGMQKRL
MUL_2261|M.ulcerans_Agy99 REIAAEFATRFARLLGARKHDAASALMRATAAQLVQTQHRLIDQGMQKRL
MAV_2466|M.avium_104 QEVAAEFANRFANLLGVRRQDAANALMQASAAQLVKTQHRLIDEGMQDRL
Mflv_3125|M.gilvum_PYR-GCK ADIAADYAQRFARQLGADGKDGARALLAARPADLVDALERLIVEGQRDLV
MAB_1223|M.abscessus_ATCC_1997 RDEAAANARRLVEYLGADARSPAEAVVNARPRALVSATHRLLTAKTRESA
: ** * : . :. . * *: . * : . *: .
TH_0737|M.thermoresistible__bu GAFAVGPSYGDDCLPRHPVEAMRDGRAHDVPLIVGTNAEEGRLFRRFLP-
Mvan_3408|M.vanbaalenii_PYR-1 GAFPVGPTYGTEYLPKDPVEAMRDGTAHRVPLIVGTNAEEGRLFTRFLP-
MSMEG_3848|M.smegmatis_MC2_155 GAFPVGPTYGTEFLPTDPVEAMAAGSAHRVPLIVGNNAEEGRLFTRFLP-
Mb2071c|M.bovis_AF2122/97 GAFPIGPVFGDDYLPMDPVEAMRSGRVHAVPLIVGTNAEEGRLFTRFLG-
Rv2045c|M.tuberculosis_H37Rv GAFPIGPVFGDDYLPMDPVEAMRSGRVHAVPLIVGTNAEEGRLFTRFLG-
MMAR_3020|M.marinum_M GAFPIGPTFGDDCLPLDPVEAMRAGQSHKVPLIVGTNADEGRLFTRFLK-
MUL_2261|M.ulcerans_Agy99 GAFPIGPTFGDDCLPLDPVEAMRAGQSHKVPLIVGTNADEGRLFTRFLK-
MAV_2466|M.avium_104 GAFPIGPVVGDDILPTDPVEAMRRGEAHRVPLIVGTNAEEGRLFTRFLA-
Mflv_3125|M.gilvum_PYR-GCK GAFAIGPTYGTEYLPEDPVEAMRSGRAHPVPLIVGTNADEGRLFTRFLK-
MAB_1223|M.abscessus_ATCC_1997 FSLGVGPSIDGDVVPDDPIAMMEHGEAHRVPLIIGYNAEEIRLFNRLLTR
:: :** . : :* .*: * * * ****:* **:* *** *:*
TH_0737|M.thermoresistible__bu ---LLPISEPMIEALFGDTDAEVRDRIIAAYPGYPDADACIRLGGDFAFG
Mvan_3408|M.vanbaalenii_PYR-1 ---LLPTTEQTIEIMLGDTDAEVRNRIMSAYPDYPKPDACVQIGGDFTFS
MSMEG_3848|M.smegmatis_MC2_155 ---LLPTNEPMIEKLFADADPEHRERILSAYPGYPDRDVCVRLGGDFAFG
Mb2071c|M.bovis_AF2122/97 ---MLPTNEPMVEELLSGMKPADRERITAAYPNYPAPSACIQLGGDFAFS
Rv2045c|M.tuberculosis_H37Rv ---MLPTNEPMVEELLSGMKPADRERITAAYPNYPAPSACIQLGGDFAFS
MMAR_3020|M.marinum_M ---MLPTNKAMIDELLADTEPATRERITAAYPNYPESAACIQLGGDFAFN
MUL_2261|M.ulcerans_Agy99 ---MLPTNKAMIDELLADTEPATRERITAAYPNYPESAACIQLGGDFAFN
MAV_2466|M.avium_104 ---MLPTNESMVEELLADAEPAVRERITAAYPDYPDRSACIQLGGDFAFG
Mflv_3125|M.gilvum_PYR-GCK ---LLPTNEQAIEQLLSAVEPEARQRVLAAYPKYPAVDACVAFGGDFIFG
MAB_1223|M.abscessus_ATCC_1997 VMSLSRFDTRAVARALVQLRPEHAQRVIDCYQGYPARDVLVRLMGDAMFG
: : : . :*: .* ** . : : ** *.
TH_0737|M.thermoresistible__bu TAAWEISEAHSRHAPTYVYRYDYAPRMLHWSGIGATHATELLAVFGTYRT
Mvan_3408|M.vanbaalenii_PYR-1 TAAWQIGEAHSRHAPTFVYRYDYAPRPLHWSGMGATHATELLAVFDIYRT
MSMEG_3848|M.smegmatis_MC2_155 SATWQVAEAHSRHAPTYVYRYDYAPRALRWSGLGATHAMELLAVFDTYRT
Mb2071c|M.bovis_AF2122/97 SAAWQIAEAHGANAPTYLYRYDYAPRTLRWSGFGATHATELFAVFDIYRT
Rv2045c|M.tuberculosis_H37Rv SAAWQIAEAHGANAPTYLYRYDYAPRTLRWSGFGATHATELFAVFDIYRT
MMAR_3020|M.marinum_M AAAWQIAEAQGAHAPTYLYRYDYAPRTLRWSGFGATHATELFAVFDIYRT
MUL_2261|M.ulcerans_Agy99 AAAWQIAEAQGVHAPTYLYRYDYAPRTLRWSGFGATHATELFAVFDIYRT
MAV_2466|M.avium_104 SAAWQIAEAHCAHAPTYLYRYDYAPRTLRWSGFGATHATELLAVFDVYRT
Mflv_3125|M.gilvum_PYR-GCK SAVWQIAHAHSAFAPTYVYRYDYATAALRLSGMGATHATELLAVFDVYRS
MAB_1223|M.abscessus_ATCC_1997 SEAWRVAQAHSRHSSVYFYRYDYAPRPLRRFGLGAAHATELFAVFGLFKR
: .*.:..*: :..:.******. *: *:**:** **:***. ::
TH_0737|M.thermoresistible__bu RPGRLLTLAGDWVSAQRVSSDLQRRWLAFGRTGVPGDDWPAYTAEHRPVR
Mvan_3408|M.vanbaalenii_PYR-1 MPGALLTLAGDWRSARRVSKDVQRRWSSFSRTGVPGADWPRYSAEDRPVM
MSMEG_3848|M.smegmatis_MC2_155 RYGSMLTAMADRRSARRVSRDIQTRWRDFSRAGVPGDGWPAYRHDERAVY
Mb2071c|M.bovis_AF2122/97 RFGALLTAAADRRAALRVSNEVQRRWRCFSQIGVPGDDWPAYTQDDRAVL
Rv2045c|M.tuberculosis_H37Rv RFGALLTAAADRRAALRVSNEVQRRWRCFSQIGVPGDDWPAYTQDDRAVL
MMAR_3020|M.marinum_M RFGALLTAAADRRHALRVSDEVIRRWRSFSQTGTPGEDWPAYTHTRRAVM
MUL_2261|M.ulcerans_Agy99 RFGALLTAAADRRHALRVSDEVIRRWRSFSQTGTPGEDWPAYTHTRRAVM
MAV_2466|M.avium_104 RFGALLTAAADRRAALRVSNQVQRRWRAFSRTGVPGEDWPRYTAADRAVL
Mflv_3125|M.gilvum_PYR-GCK RFGKLLAAGLDSRSAKKVTDDVQKRWLGFAERAVPGGDWPQYTRDERAVL
MAB_1223|M.abscessus_ATCC_1997 WP--ALAGKKDRRHALALTEDIQSRWLAFSRTGVPGTGWPAYGEPERAVM
*: * * :: :: ** *.. ..** .** * *.*
TH_0737|M.thermoresistible__bu VFDRNPRVEYDPDAHRRQAWQGFTLTRPDRN
Mvan_3408|M.vanbaalenii_PYR-1 VFDRHPRLEYDPHAHRRQAWEGFSLA-----
MSMEG_3848|M.smegmatis_MC2_155 VFDTRPRVEYDPDADRRLAWEGFSLAQR---
Mb2071c|M.bovis_AF2122/97 VFDRRCRIEFDPHQHRRIAWDGFSLAN----
Rv2045c|M.tuberculosis_H37Rv VFDRRCRIEFDPHQHRRIAWDGFSLAN----
MMAR_3020|M.marinum_M VIDRKSRVEIDPHQHRRLAWDGFSLAR----
MUL_2261|M.ulcerans_Agy99 VIDRKSRVEIDPHRHRRLAWDGFSLAR----
MAV_2466|M.avium_104 VFDRKSRVEFDPHPHRRMAWDGFSLAR----
Mflv_3125|M.gilvum_PYR-GCK VLDRRRRVEFDPHSERRQAWEGFFLATR---
MAB_1223|M.abscessus_ATCC_1997 VFDQERRIELDPHCAQRELWRDIGRVA----
*:* . *:* **. :* * .: .