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VPIPRLGVLAVLMVLVAACGRGDAGDRGHEARSPVDPAVVQTAAGAVRGTVEPDHRLFAGIPYAAPPIGP LRWRDPEPAPRWDGVRDATAFGSRCLQDLAGDLELGRQTDEDCLNLNVWTPAAEPGRPRAVMVWIHGGSF VAGSGGIYDARRLAARGDIVVVTLNYRLGAPGFLAHPSLGPPGEVGNYGLADQQAALRWVRDNIAAFGGD PGKVTVAGESAGAMSVCDHLVAPASQGLFDAAIIMSGPCQAQAPLPVAEQRSIEYAAALGCADKATAAEC LRALPGNKLRTPVWFYEIGDDRLSGPATGSAELPADPVTAFGAGRAARVPVLIGTTRDEWTLFVALQHLR DGRDYTPEEYPRLLADTFGADARAVAGRYPLSAFPDVALAYAATVTDGILACPAERWARQLSRDASVYFY EFNDRNAPAPDPLRTLPFPVGASHSLELRYLFDVGGAPPPDPAQVRLGEQMVDHWAAFVRAGDPGWPGVD AGVMSLQPDGSRMVETFGEVHQCSFWAGLQ
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_1303 | - | - | 100% (520) | carboxylesterase, type B |
| M. vanbaalenii PYR-1 | Mvan_3408 | - | 6e-54 | 35.01% (477) | carboxylesterase, type B |
| M. vanbaalenii PYR-1 | Mvan_3172 | - | 6e-53 | 41.49% (323) | carboxylesterase, type B |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2071c | lipT | 1e-54 | 35.39% (469) | carboxylesterase LipT |
| M. gilvum PYR-GCK | Mflv_5051 | - | 0.0 | 75.15% (511) | carboxylesterase, type B |
| M. tuberculosis H37Rv | Rv2045c | lipT | 1e-54 | 35.39% (469) | carboxylesterase LipT |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_3803c | - | 1e-112 | 46.63% (519) | carboxylesterase |
| M. marinum M | MMAR_4363 | - | 5e-62 | 36.91% (512) | carboxylesterase |
| M. avium 104 | MAV_1226 | - | 4e-60 | 37.65% (486) | carboxylesterase superfamily protein |
| M. smegmatis MC2 155 | MSMEG_1432 | - | 0.0 | 61.33% (525) | acetylcholinesterase |
| M. thermoresistible (build 8) | TH_3456 | - | 1e-170 | 58.67% (513) | PUTATIVE Carboxylesterase, type B |
| M. ulcerans Agy99 | MUL_2261 | lipT | 3e-57 | 36.38% (470) | carboxylesterase, LipT |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_1303|M.vanbaalenii_PYR-1 MPIPRLGVLAVLMVLVAACGRGDAGDRGHEARSPVDPAVVQTAAGAVRG-
Mflv_5051|M.gilvum_PYR-GCK --------MLVALVVAVACGSQAS------PQPAPDPAVVQTSTGPVRG-
MSMEG_1432|M.smegmatis_MC2_155 MRRAR-QVSALLFGLVIVLNAAVVGCRAAEAPVATDPVVVHTASGTVRG-
TH_3456|M.thermoresistible__bu --------------------------------------VVQTDAGAVRG-
MAB_3803c|M.abscessus_ATCC_199 -------MTRLLVAVLVVLAAAVS----CSPTKAADPTVVTTRAGAVRG-
Mb2071c|M.bovis_AF2122/97 ----------------------MALESATVGSMHERTVRARTATGIVEG-
Rv2045c|M.tuberculosis_H37Rv ----------------------MALESATVGSMHERTVRARTATGIVEG-
MUL_2261|M.ulcerans_Agy99 --------------------------------MHERTVRARTATGVVEG-
MMAR_4363|M.marinum_M -------------------------MTSDIRRMASDGYVVETAYGPVRGA
MAV_1226|M.avium_104 --------------------------------MAVDDLVVETGYGPVR--
. * * *.
Mvan_1303|M.vanbaalenii_PYR-1 ---TVEPD----HRLFAGIPYAAPPIGPLRWRDPEPAPRWDGVRDATAFG
Mflv_5051|M.gilvum_PYR-GCK ---TVADD----HRLFAGIPYAAPPVGALRWQGPRPAPKWDGVRDATAYG
MSMEG_1432|M.smegmatis_MC2_155 ---LVAEG----HRLFAGIPYAAPPVGSLRFAAPEPAASWPGERDATRPG
TH_3456|M.thermoresistible__bu ---TVTDR----YRFFGGIPYAAAPVGDLRWRAPEPPRSWPQVRDATIPG
MAB_3803c|M.abscessus_ATCC_199 ---HIDDQ----VRVFAAIPYAAPPVGPRRFAEPGPVTPWPDTRDATGPG
Mb2071c|M.bovis_AF2122/97 ---FTRDG----VHRWRSIPYARAPVGSLRFRAPQPAQPWPGVRHCHTFA
Rv2045c|M.tuberculosis_H37Rv ---FTRDG----VHRWRSIPYARAPVGSLRFRAPQPAQPWPGVRHCHTFA
MUL_2261|M.ulcerans_Agy99 ---FTRDG----VHRWRSIPYARAPIGLLRFRAPRPPQPWSGVRHCHGFT
MMAR_4363|M.marinum_M EDGIAAAGSGVRTKSWKGIRYGAPPVGELRFRAPQPPQPWTEIADATAFG
MAV_1226|M.avium_104 --GVPVDG----VKAWKGIRYAAPPIGDLRFRAPQPPERWTEVADATVFG
: : .* *. .*:* *: * * * ..
Mvan_1303|M.vanbaalenii_PYR-1 SRCLQDLAGDLELG---RQTDEDCLNLNVWTPAAEPGRP--RAVMVWIHG
Mflv_5051|M.gilvum_PYR-GCK PRCMQDLDGDLELG---RQTDEDCLNLNVWTPPVAGDRPEPKPVMVWIHG
MSMEG_1432|M.smegmatis_MC2_155 PRCVQDPDADLEHG---DNSGEDCLTLNVWTPPVGKDLR---PVMVWIHG
TH_3456|M.thermoresistible__bu PRCIQNPAGDPEGG---RNSDEDCLTLNVWTPPPDGVLR---PVLVWIHG
MAB_3803c|M.abscessus_ATCC_199 VECPQP---GQESN---LPQTEDCLLLTVTMPRHTQGKV---PVLVWIHG
Mb2071c|M.bovis_AF2122/97 NCAPQQRRYTVMGIGRYQTRSEDCLTLNVVTPE-EPAT-QPLPVMVFIHG
Rv2045c|M.tuberculosis_H37Rv NCAPQQRRYTVMGIGRYQTRSEDCLTLNVVTPE-EPAT-QPLPVMVFIHG
MUL_2261|M.ulcerans_Agy99 HCSPQQRRYTMLGLGKYQPMSEDCLTLNVVAPE-APTH-RPLPVMVFIHG
MMAR_4363|M.marinum_M PVCPQP-VLANMPIDLGAPQDEDCLRLNIWAPA-NTAPGAAKPVMVWLHG
MAV_1226|M.avium_104 PACPQP-VFPNMPLDLGAPQGEDCLRLNVWASA-DTQPGDAKPVMVWLHG
. * **** *.: . .*:*::**
Mvan_1303|M.vanbaalenii_PYR-1 GSFVAGSGG--IYDARRLAARGDIVVVTLNYRLGAPGFLAHPSLGPPGEV
Mflv_5051|M.gilvum_PYR-GCK GSFVAGSSG--VYDSRRLVARGDIIVVTVNYRLGALGFLAHPALGPPGAV
MSMEG_1432|M.smegmatis_MC2_155 GGFVNGSSD--VYDASRLASRGDIVVVTVNYRLGTLGFLAHPALEAPGEV
TH_3456|M.thermoresistible__bu GGFVNGGGA--MFNSEWFVERGDIVVVTINYRLGTLGFLAHPELGPPGAV
MAB_3803c|M.abscessus_ATCC_199 GAFIAGNGV--DYNARKLAAQGGIAVVTFNYRLGTLGFLAAPGLS--GGI
Mb2071c|M.bovis_AF2122/97 GGYILGSSATPIYDGAALARRG-CVYVSVNYRLGALGCLDLSSLSTPQIT
Rv2045c|M.tuberculosis_H37Rv GGYILGSSATPIYDGAALARRG-CVYVSVNYRLGALGCLDLSSLSTPQIT
MUL_2261|M.ulcerans_Agy99 GGYILGSSATPIYDGAALARRG-CVYVSVNYRLGALGCLDLSSLSTPDIA
MMAR_4363|M.marinum_M GAYMLGSASQALYDGRRLASSGEVIVVTVNYRLGALGFLDLSSLSHAGRS
MAV_1226|M.avium_104 GAYVLGSSSQTLYDGRRLVSHGDVVVVTVNYRLGALGFLDLSSLNSAGRS
*.:: *.. ::. :. * *:.*****: * * . *
Mvan_1303|M.vanbaalenii_PYR-1 GN--YGLADQQAALRWVRDNIAAFGGDPGKVTVAGESAGAMSVCDHLVAP
Mflv_5051|M.gilvum_PYR-GCK GN--YGLADQQAALRWVRDNIANFGGDPARVTVAGESAGAMSVCDHLVAP
MSMEG_1432|M.smegmatis_MC2_155 GN--YGIADQQAALRWVRDNIAAFGGDPQRVTLAGESAGGTSVCDHLVAP
TH_3456|M.thermoresistible__bu GN--YGFLDQQAALRWVRANIAGFGGDPDRVTIAGESAGGMAVCDHLAAP
MAB_3803c|M.abscessus_ATCC_199 GN--YGLLDQEAALRWVRDNIAEFGGDPARVTIAGQSAGGVSVCDLMVSP
Mb2071c|M.bovis_AF2122/97 LDSNVYLRDLVLALRWVHDNIAEFGGDPGNVTIFGESAGAHITATLLAVP
Rv2045c|M.tuberculosis_H37Rv LDSNVYLRDLVLALRWVHDNIAEFGGDPGNVTIFGESAGAHITATLLAVP
MUL_2261|M.ulcerans_Agy99 IDGNLYLRDLVMALQWIQDNIAEFGGDPDNVTIFGESAGAHITATLLAVP
MMAR_4363|M.marinum_M FDSNVGLRDVLAALHWVRENIAAFGGDPANITLFGESAGAGLVTTLLVTP
MAV_1226|M.avium_104 FDSNVGLRDVLAALEWVRDNITAFGGDPRRVTLFGESAGAGIVTTLLASP
: : * **.*:: **: ***** .:*: *:***. . :. *
Mvan_1303|M.vanbaalenii_PYR-1 ASQGLFDAAIIMSGPCQAQAPLPVAEQRSIEYAAALGCADKATAAECLRA
Mflv_5051|M.gilvum_PYR-GCK GSDGLFDAAIVMSGLCQSQADLPTAEKRSLDYAAQAGCGG-PVPAECLRG
MSMEG_1432|M.smegmatis_MC2_155 GSAGLFDAVVLMSAPCQVQADLPTAEQRSVAYAAEAGCPDPASAGDCLRA
TH_3456|M.thermoresistible__bu GSAGLFHAAIIMSAPCQGQVDVDTAEQVSLRYAAEVGCGDPGAAAACLRG
MAB_3803c|M.abscessus_ATCC_199 QASGLFRSAIMESAPCQAQAPVSSAVRDSTAYAAEVGCPAGPDMARCLRA
Mb2071c|M.bovis_AF2122/97 AAKGLFARAISESPAAGMVRSREVAAEFAARFANLIGARTQDAANALMQA
Rv2045c|M.tuberculosis_H37Rv AAKGLFARAISESPAAGMVRSREVAAEFAARFANLIGARTQDAANALMQA
MUL_2261|M.ulcerans_Agy99 AAKGLFARAISESPAAGMVRPREIAAEFATRFARLLGARKHDAASALMRA
MMAR_4363|M.marinum_M AARGLFSRAIAQSSPATSVYDRERAQRVAVHLLDKLGVAASDVD-KLTQL
MAV_1226|M.avium_104 AAAGLFAAAIAQSSPATSVYDRDRAARVAEAFLGKLGITASESR-RLIDM
: *** .: * . * . : *
Mvan_1303|M.vanbaalenii_PYR-1 LPGNKLRTPVWFYEIGDD-----RLSGPATGSAELPADPVTAFGAGRAAR
Mflv_5051|M.gilvum_PYR-GCK LDANALRTPVWYYDIGDD-----RLSGPVTGSAVLPTAPPVAFGDGKAAR
MSMEG_1432|M.smegmatis_MC2_155 LPVDRLRKPVWYFNIGSD-----QMTTPVTGTAMLPRAPLRSLG--EAPD
TH_3456|M.thermoresistible__bu LPPEAVAAPVSYFEFGTE-----KLSGPVTGTEALPVDPVDAIAEGRVAR
MAB_3803c|M.abscessus_ATCC_199 LSVDALRDSPQFTGIG-------LPVSPVIGTPELPAAPLDAFTSGLAAS
Mb2071c|M.bovis_AF2122/97 SPAQLVEAQHHLIRQGMRKRLGAFPIGPVFGDDYLPMDPVEAMRSGRVHA
Rv2045c|M.tuberculosis_H37Rv SPAQLVEAQHHLIRQGMRKRLGAFPIGPVFGDDYLPMDPVEAMRSGRVHA
MUL_2261|M.ulcerans_Agy99 TAAQLVQTQHRLIDQGMQKRLGAFPIGPTFGDDCLPLDPVEAMRAGQSHK
MMAR_4363|M.marinum_M PTAAIVAASTEVFNEVPVRNPGTLAFVPIVDGDVLTDYPVKVAQEGRSHP
MAV_1226|M.avium_104 PMAAILAASQQVFDEVPVRNPGTLAFVPIVDGDVLADYPVKVAQQGCSHP
: * . *. *
Mvan_1303|M.vanbaalenii_PYR-1 -VPVLIGTTRDEWTLFVALQHLRDGRD-YTPEEYPRLLADTFGADARAVA
Mflv_5051|M.gilvum_PYR-GCK -VPVLMGTTRDEWTLFVALQHLRDGKD-YAPQEYPRLLADTFGADAPAVE
MSMEG_1432|M.smegmatis_MC2_155 -VPVLIGTTRDEFTLFVALRYLRQDQR-FTPEEYPELLRQTFGADADAVG
TH_3456|M.thermoresistible__bu -VPVLIGTNRDEFTLFAGLRYLREGER-FAAEDHPRLLAEIFGDDAAAVA
MAB_3803c|M.abscessus_ATCC_199 PVPVLIGSNANEATVFEAKQYQHRPVP-RTAEEYQSVLESKYGTRATELG
Mb2071c|M.bovis_AF2122/97 -VPLIVGTNAEEGRLFTRFLG-MLPTN----EPMVEELLS---GMKPADR
Rv2045c|M.tuberculosis_H37Rv -VPLIVGTNAEEGRLFTRFLG-MLPTN----EPMVEELLS---GMKPADR
MUL_2261|M.ulcerans_Agy99 -VPLIVGTNADEGRLFTRFLK-MLPTN----KAMIDELLA---DTEPATR
MMAR_4363|M.marinum_M -VPLLIGTNKHEAALFRLMRSPLMPITPRAITSMFTQIAAEQPDLQLPTE
MAV_1226|M.avium_104 -VPLIIGTNQHEAALFRLMRSALMPITPHAITSMFNQIAAEQPDLQLPTE
**:::*:. .* :* :
Mvan_1303|M.vanbaalenii_PYR-1 GRYPLSAFPDVAL-AYAATVTDGILACPAERWARQLSRDASVYFYEFNDR
Mflv_5051|M.gilvum_PYR-GCK AHYPLTAFSSVAL-AYAATVTDGVFACAGRRWAGDLAETAPVYFYEFNDR
MSMEG_1432|M.smegmatis_MC2_155 AHYPLERYGGAAQ-AYSAAVTDSAFSCVAEQMADELPG--TVYAYEFADR
TH_3456|M.thermoresistible__bu ARYPLEDYPSPAL-AYSAAVTDSLFACLSERLADQLARHQPVYSYEFADR
MAB_3803c|M.abscessus_ATCC_199 RRYPLADFDGNVLGALAAIDTDNSYACPTFAMAEALARRAPVYAYEFADP
Mb2071c|M.bovis_AF2122/97 ERITAAYPNYPAPSACIQLGGDFAFSSAAWQIAEAHGANAPTYLYRYDYA
Rv2045c|M.tuberculosis_H37Rv ERITAAYPNYPAPSACIQLGGDFAFSSAAWQIAEAHGANAPTYLYRYDYA
MUL_2261|M.ulcerans_Agy99 ERITAAYPNYPESAACIQLGGDFAFNAAAWQIAEAQGVHAPTYLYRYDYA
MMAR_4363|M.marinum_M EEIGLAYSRLRRRARPLSIATDVGFRMPSVWLAEGHSRVAPVYLYRFDYS
MAV_1226|M.avium_104 KQIGSAYSRFRRRARYLSIATDVGFRMPSVWLAEGHARVAPVYLYRFDYS
. * * ..* *.:
Mvan_1303|M.vanbaalenii_PYR-1 NAPAPDPLRTLPFPVGASHSLELRYLFDVGGAPPPDPAQV--------RL
Mflv_5051|M.gilvum_PYR-GCK DAPAPDPLRTVPFPVGASHSLELRYLFDTGGAPPPSPAQV--------RL
MSMEG_1432|M.smegmatis_MC2_155 DAPAPEVMRTLPFPVGASHSLELRYLFDVGGAPPLNPRQQ--------AL
TH_3456|M.thermoresistible__bu DAPAPEPLRTLPFPVGAGHSLELRYLFDVGGAPALTAAQR--------AL
MAB_3803c|M.abscessus_ATCC_199 VAPVEQQYRDAPLPLGASHGSELGYLFDLS--RTMNPESA--------AL
Mb2071c|M.bovis_AF2122/97 PRTLRWSG------FGATHATELFAVFDIYRTRFGALLTAAADRRAALRV
Rv2045c|M.tuberculosis_H37Rv PRTLRWSG------FGATHATELFAVFDIYRTRFGALLTAAADRRAALRV
MUL_2261|M.ulcerans_Agy99 PRTLRWSG------FGATHATELFAVFDIYRTRFGALLTAAADRRHALRV
MMAR_4363|M.marinum_M TPLLKLLL------VRAAHATELPYVWGNLGGPQDPTLRLGGAK-TAKAV
MAV_1226|M.avium_104 TPLLRLLM------VKAAHATELPYVWGTLGAPKDPTLKLGGSK-TAKAV
. * *. ** ::. :
Mvan_1303|M.vanbaalenii_PYR-1 GEQMVDHWAAFVRAGD-------PGWPGVDAG------------------
Mflv_5051|M.gilvum_PYR-GCK GEQMIDYWASFVKTGD-------PGFPGIDSG------------------
MSMEG_1432|M.smegmatis_MC2_155 ADQMIGYWSQFVRTGDPA-AEDQPEWPAYSASESS---------------
TH_3456|M.thermoresistible__bu SEQMIDYWSAFVATGVPA-TDGHPDWPAHRAAADSGAGPDESPTDRDPGD
MAB_3803c|M.abscessus_ATCC_199 STQMTRYWAQFVKTGNPN-VEGQPEWPAYISGG-----------------
Mb2071c|M.bovis_AF2122/97 SNEVQRRWRCFSQIGVPG-----DDWPAYTQDD-----------------
Rv2045c|M.tuberculosis_H37Rv SNEVQRRWRCFSQIGVPG-----DDWPAYTQDD-----------------
MUL_2261|M.ulcerans_Agy99 SDEVIRRWRSFSQTGTPG-----EDWPAYTHTR-----------------
MMAR_4363|M.marinum_M SKRMRTRWINFATQDNPAGPAGEPDWPAYQDGD-----------------
MAV_1226|M.avium_104 SKRVRTRWTNFAAHAKPAGPAGSPEWAPYQEQD-----------------
. .: * * :.
Mvan_1303|M.vanbaalenii_PYR-1 --------VMSLQPDGSRMVETFGEVHQCSFWAGLQ----
Mflv_5051|M.gilvum_PYR-GCK --------VMSLQPDGSRMIEDFDRVHQCVFWDGLG----
MSMEG_1432|M.smegmatis_MC2_155 -----GRQWMSLRPDGSRMASDFGEEHQCPFWVGLKEK--
TH_3456|M.thermoresistible__bu GGPGAGPARMSLRPGGSTVVDDFATEHRCVFWAELAG---
MAB_3803c|M.abscessus_ATCC_199 -------AFQRLAPPAPRSEGGFASRHQCGYWR-------
Mb2071c|M.bovis_AF2122/97 --------RAVLVFDRRCRIEFDPHQHRRIAWDGFSLAN-
Rv2045c|M.tuberculosis_H37Rv --------RAVLVFDRRCRIEFDPHQHRRIAWDGFSLAN-
MUL_2261|M.ulcerans_Agy99 --------RAVMVIDRKSRVEIDPHRHRRLAWDGFSLAR-
MMAR_4363|M.marinum_M --------RACLVIDKSDRVARDIDAPIRAAWGREVVGFR
MAV_1226|M.avium_104 --------RACLIIGKNDVLAHDVDAKARAAWGSEMVSFR
: *