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MAVDDLVVETGYGPVRGVPVDGVKAWKGIRYAAPPIGDLRFRAPQPPERWTEVADATVFGPACPQPVFPN MPLDLGAPQGEDCLRLNVWASADTQPGDAKPVMVWLHGGAYVLGSSSQTLYDGRRLVSHGDVVVVTVNYR LGALGFLDLSSLNSAGRSFDSNVGLRDVLAALEWVRDNITAFGGDPRRVTLFGESAGAGIVTTLLASPAA AGLFAAAIAQSSPATSVYDRDRAARVAEAFLGKLGITASESRRLIDMPMAAILAASQQVFDEVPVRNPGT LAFVPIVDGDVLADYPVKVAQQGCSHPVPLIIGTNQHEAALFRLMRSALMPITPHAITSMFNQIAAEQPD LQLPTEKQIGSAYSRFRRRARYLSIATDVGFRMPSVWLAEGHARVAPVYLYRFDYSTPLLRLLMVKAAHA TELPYVWGTLGAPKDPTLKLGGSKTAKAVSKRVRTRWTNFAAHAKPAGPAGSPEWAPYQEQDRACLIIGK NDVLAHDVDAKARAAWGSEMVSFR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_1226 | - | - | 100% (514) | carboxylesterase superfamily protein |
| M. avium 104 | MAV_2466 | - | 5e-82 | 39.29% (504) | LppT protein |
| M. avium 104 | MAV_0492 | - | 3e-57 | 33.53% (501) | para-nitrobenzyl esterase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1134 | - | 8e-89 | 76.53% (196) | hypothetical protein Mb1134 |
| M. gilvum PYR-GCK | Mflv_3419 | - | 0.0 | 62.20% (508) | carboxylesterase, type B |
| M. tuberculosis H37Rv | Rv1104 | - | 8e-89 | 76.53% (196) | hypothetical protein Rv1104 |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_3453c | - | 1e-83 | 40.16% (508) | carboxylesterase LipT |
| M. marinum M | MMAR_4363 | - | 0.0 | 76.67% (523) | carboxylesterase |
| M. smegmatis MC2 155 | MSMEG_3667 | - | 0.0 | 61.91% (512) | para-nitrobenzyl esterase |
| M. thermoresistible (build 8) | TH_3679 | - | 0.0 | 64.13% (513) | PUTATIVE Carboxylesterase, type B |
| M. ulcerans Agy99 | MUL_2261 | lipT | 1e-78 | 39.04% (502) | carboxylesterase, LipT |
| M. vanbaalenii PYR-1 | Mvan_3172 | - | 0.0 | 63.58% (508) | carboxylesterase, type B |
CLUSTAL 2.0.9 multiple sequence alignment
MAV_1226|M.avium_104 -----------------------MAVDDLVVETGYGPVR----GVPVDG-
MMAR_4363|M.marinum_M ----------------MTSDIRRMASDGYVVETAYGPVRGAEDGIAAAGS
Mb1134|M.bovis_AF2122/97 -----------------------MVVDSCVAESRYGPVRG-----ADDG-
Rv1104|M.tuberculosis_H37Rv -----------------------MVVDSCVAESRYGPVRG-----ADDG-
Mflv_3419|M.gilvum_PYR-GCK --------------MTAEATPRSSA---PVVDTSTGPVRG-----LDDG-
Mvan_3172|M.vanbaalenii_PYR-1 --------------MTADATTRSSAGGRPVVETTNGPVRG-----VDDG-
MSMEG_3667|M.smegmatis_MC2_155 ---------------MANAARIADG---PVAETGYGPVRG-----TDDG-
TH_3679|M.thermoresistible__bu MPSTTPPDDRTPDDAPTRPAPAHSAVGSPVVDTVHGPVRG-----RDDG-
MAB_3453c|M.abscessus_ATCC_199 -------------------MASGSKTPTVRVTTPNGIVEG----FVRGG-
MUL_2261|M.ulcerans_Agy99 -----------------------MHERTVRARTATGVVEG----FTRDG-
. : * *. *
MAV_1226|M.avium_104 ---VKAWKGIRYAAPPIGDLRFRAPQPPERWTEVADATVFGPACPQPVFP
MMAR_4363|M.marinum_M GVRTKSWKGIRYGAPPVGELRFRAPQPPQPWTEIADATAFGPVCPQPVLA
Mb1134|M.bovis_AF2122/97 --RVKVWKGIRYAAPPLGDLRFRTPEPPERWTEVADATTFGPACPQPAIP
Rv1104|M.tuberculosis_H37Rv --RVKVWKGIRYAAPPLGDLRFRTPEPPERWTEVADATTFGPACPQPAIP
Mflv_3419|M.gilvum_PYR-GCK --IIKSWKGVPYAAAPVGELRWRAPEPPPAWTEPRDATRVGPVCPQPTDP
Mvan_3172|M.vanbaalenii_PYR-1 --SVKSWKAVRYAAAPVGELRWRAPEPPQAWSEPVDAGRVGPVCPQPTDP
MSMEG_3667|M.smegmatis_MC2_155 --TAKAWLGIRYARAPIGELRWRAPEPPASWHDVFDATRVGAVCPQATDA
TH_3679|M.thermoresistible__bu --VVKVWRGIRYAAAPVGGLRWRAPEPPQPWREPMDAIRVGPACPQPADP
MAB_3453c|M.abscessus_ATCC_199 ---VRRFRSIPYARPPIGLLRLRAPQPALPWEGVRDCTEFGAAAPQRRRY
MUL_2261|M.ulcerans_Agy99 ---VHRWRSIPYARAPIGLLRFRAPRPPQPWSGVRHCHGFTHCSPQQRRY
: : .: *. .*:* ** *:*.*. * .. . .**
MAV_1226|M.avium_104 NMPLDLGAPQ--GEDCLRLNVWASADTQPGDAKPVMVWLHGGAYVLGSSS
MMAR_4363|M.marinum_M NMPIDLGAPQ--DEDCLRLNIWAPANTAPGAAKPVMVWLHGGAYMLGSAS
Mb1134|M.bovis_AF2122/97 NMPLDLGASQ--SEDCWSLNIWAPADTEPGDGKPVMVWLHGGAYILGSGS
Rv1104|M.tuberculosis_H37Rv NMPLDLGASQ--SEDCWSLNIWAPADTEPGDGKPVMVWLHGGAYILGSGS
Mflv_3419|M.gilvum_PYR-GCK KIPLDLGAPQ--GEDFLSLNVWAPSGTQPGDRKPVMVWVHGGAYVLGSAS
Mvan_3172|M.vanbaalenii_PYR-1 RIPIDLGAPQ--GEDFLTLNIWAPSGTQPGDAKPVMVWIHGGAYILGSAS
MSMEG_3667|M.smegmatis_MC2_155 RIPIDLGGKQ--DEDSLVLNVWAPSGCRPGDRRPVMVWVHGGAYVLGSAS
TH_3679|M.thermoresistible__bu RIPLDLGAAI--GEDCLNLNVWASSDTEPGDRKPVLVWVHGGAYVIGAAS
MAB_3453c|M.abscessus_ATCC_199 RV-LGPGRVQRASEDCLTVNVVTP-DRPSNEPLPVMFFIYGGGYLLGSSA
MUL_2261|M.ulcerans_Agy99 TM-LGLGKYQPMSEDCLTLNVVAP-EAPTHRPLPVMVFIHGGGYILGSSA
: :. * .** :*: :. . **:.:::**.*::*:.:
MAV_1226|M.avium_104 QTLYDGRRLVSHGDVVVVTVNYRLGALGFLDLSSLNSAGRSFDSNVGLRD
MMAR_4363|M.marinum_M QALYDGRRLASSGEVIVVTVNYRLGALGFLDLSSLSHAGRSFDSNVGLRD
Mb1134|M.bovis_AF2122/97 QPLYNGRRLAASGDVVVVTVNYRLGALGFLDLSSFNTSRRRFDSNIGLRD
Rv1104|M.tuberculosis_H37Rv QPLYNGRRLAASGDVVVVTVNYRLGALGFLDLSSFNTSRRRFDSNIGLRD
Mflv_3419|M.gilvum_PYR-GCK QPLYHGRAMAGAGDVIVVTVNYRLGALGFLELSTLD-DSGRFASNLGLRD
Mvan_3172|M.vanbaalenii_PYR-1 QPLYHGGTLASGGDAVVVTVNYRLGALGFLELSTLGADPERFATNLGLRD
MSMEG_3667|M.smegmatis_MC2_155 QPLCRGRVLASEGDVVVVTVNYRLGPFGFLDLSEYSSRAMRFDTNLGLRD
TH_3679|M.thermoresistible__bu QPLYHGRELVRRGDVVLVTLNYRLGAFGFLELTALSSGRRRFDTNVGLRD
MAB_3453c|M.abscessus_ATCC_199 TPLYDGAALARRG-CVYVSVNYRVGALGALDLSSLSDRDHTIDGNLFLRD
MUL_2261|M.ulcerans_Agy99 TPIYDGAALARRG-CVYVSVNYRLGALGCLDLSSLSTPDIAIDGNLYLRD
.: * :. * : *::***:*.:* *:*: . : *: ***
MAV_1226|M.avium_104 VLAALEWVRDNITAFGGDPRRVTLFGESAGAGIVTTLLASPAAAGLFAAA
MMAR_4363|M.marinum_M VLAALHWVRENIAAFGGDPANITLFGESAGAGLVTTLLVTPAARGLFSRA
Mb1134|M.bovis_AF2122/97 VLAVLRWVADNIAVFGGDPEKVTLFGESARE-------------------
Rv1104|M.tuberculosis_H37Rv VLAVLRWVADNIAVFGGDPEKVTLFGESARE-------------------
Mflv_3419|M.gilvum_PYR-GCK VLAALGWVRDNIAAFGGDPGRVTVFGESAGGGIVTSLLGSPAAAGLFHAA
Mvan_3172|M.vanbaalenii_PYR-1 VLAALEWVRDNIAAFGGDPGRVTVFGESAGGGIVASLLASPAAAGLFSAA
MSMEG_3667|M.smegmatis_MC2_155 VIFALQWVRDNIAAFGGDPSRVTLFGESAGGGMITTLLASPAAEGLFSAA
TH_3679|M.thermoresistible__bu VLFALAWVRDNIAAFGGDPDRVTLFGESAGGGIVTTLLGSPAAAGLFHRA
MAB_3453c|M.abscessus_ATCC_199 VVLALQWVHDNIGTFGGDPGNVTIFGESAGAHCVETLMATPAAAGLFHRA
MUL_2261|M.ulcerans_Agy99 LVMALQWIQDNIAEFGGDPDNVTIFGESAGAHITATLLAVPAAKGLFARA
:: .* *: :** ***** .:*:*****
MAV_1226|M.avium_104 IAQSSPATSVYDRDRAARVAEAFLGKLGI-TASESRRLIDMPMAAILAAS
MMAR_4363|M.marinum_M IAQSSPATSVYDRERAQRVAVHLLDKLGV-AASDVDKLTQLPTAAIVAAS
Mb1134|M.bovis_AF2122/97 --SSRPCS------------------------------------------
Rv1104|M.tuberculosis_H37Rv --SSRPCS------------------------------------------
Mflv_3419|M.gilvum_PYR-GCK IAQSSPATSMYDVGRARRVATRFLEVIGV-DRADMSALTTAPISALVEAS
Mvan_3172|M.vanbaalenii_PYR-1 IAQSAPVTSTYELGRAQRVAERFLDVLGA-RPDDLHRLSEAPIDVLVEAS
MSMEG_3667|M.smegmatis_MC2_155 IAQSSPATSVYDAERSRRVARALLERLLI-EPDDAARLAHVPIPAILGAS
TH_3679|M.thermoresistible__bu IAQSSPATSCYGTERAIDVAEQFLGHLGL-SPRDVDRLPDVPVAAIVEVS
MAB_3453c|M.abscessus_ATCC_199 ICQSTASGMAVPADSAAMYAQKFAQILGATTQSAAETVLRSSPAELGAAL
MUL_2261|M.ulcerans_Agy99 ISESPAAGMVRPREIAAEFATRFARLLGARKHDAASALMRATAAQLVQTQ
.* .
MAV_1226|M.avium_104 QQVFDEVPVRNPG-TLAFVPIVDGDVLADYPVKVAQQGCSHPVPLIIGTN
MMAR_4363|M.marinum_M TEVFNEVPVRNPG-TLAFVPIVDGDVLTDYPVKVAQEGRSHPVPLLIGTN
Mb1134|M.bovis_AF2122/97 -------PPRRP--------------------RVCSRRRSP---------
Rv1104|M.tuberculosis_H37Rv -------PPRRP--------------------RVCSRRRSP---------
Mflv_3419|M.gilvum_PYR-GCK RTVFNEVPVRTPG-TLAFAPTIDGDLLPDYPVNLARNGKTHPVPLLIGTN
Mvan_3172|M.vanbaalenii_PYR-1 RTVFDEVPVRTPG-TLAFAPTVDGDLLPDYPVNLARQGRTHPVPLIIGTN
MSMEG_3667|M.smegmatis_MC2_155 QQIFNEVPAQSPG-TLAFAPIVDGDVVPDYPVQAARAGRTHRVPLIIGTN
TH_3679|M.thermoresistible__bu KHVFDDVPARRPG-TLAFAPIVDGDIVPDYPVALARAGRTLPVPLVIGTN
MAB_3453c|M.abscessus_ATCC_199 NMLIADIVTNMPGGSFAIGPCIDGHYLPRHPIEAMEHGEAHRVPLIVGHN
MUL_2261|M.ulcerans_Agy99 HRLIDQGMQKRLG-AFPIGPTFGDDCLPLDPVEAMRAGQSHKVPLIVGTN
. :
MAV_1226|M.avium_104 QHEAALFRLMRSALMPITPHAITSMFNQIAAEQPDLQLPTEKQIGSAYSR
MMAR_4363|M.marinum_M KHEAALFRLMRSPLMPITPRAITSMFTQIAAEQPDLQLPTEEEIGLAYSR
Mb1134|M.bovis_AF2122/97 ---------------------------------------------RAHRR
Rv1104|M.tuberculosis_H37Rv ---------------------------------------------RAHRR
Mflv_3419|M.gilvum_PYR-GCK KNEAALFRYMKSPLMPVAPESVRAMFAEISAEQPTLQLPSEDHLRGIYRG
Mvan_3172|M.vanbaalenii_PYR-1 KNEAALFRYMKSPLMPIAPASIKAMFAEIAAEQPGLQLPSEDILKGTYRG
MSMEG_3667|M.smegmatis_MC2_155 KHEASLFRWMKSPLMPITPEAIRAMFEGIASEQPGLALPTEEEIRAAYSG
TH_3679|M.thermoresistible__bu KDEASLFRWMKSPLLPITPDAIKKMFADIAAEQPGLRLPTETQISAAYRR
MAB_3453c|M.abscessus_ATCC_199 ADEAKLFTRVLK-MMPLSESALEGMLARGGPG-------HRDRIVAAYPG
MUL_2261|M.ulcerans_Agy99 ADEGRLFTRFLK-MLPTNKAMIDELLADTEPA-------TRERITAAYPN
:
MAV_1226|M.avium_104 FRRRARYLSIATDVGFRMPSVWLAEGHARVAPVYLYRFDYSTPLLRLLMV
MMAR_4363|M.marinum_M LRRRARPLSIATDVGFRMPSVWLAEGHSRVAPVYLYRFDYSTPLLKLLLV
Mb1134|M.bovis_AF2122/97 HRSTTR--------------------------------------------
Rv1104|M.tuberculosis_H37Rv HRSTTR--------------------------------------------
Mflv_3419|M.gilvum_PYR-GCK -RGKNHALGLTSDLGFRMPSIWFADGHRAVAPVYLYRFDFATPLLRVARL
Mvan_3172|M.vanbaalenii_PYR-1 -RGKTKGLGLTSDLGFRMPSLWFADGHRAVAPVYLYRFDFHTPLLRLVRL
MSMEG_3667|M.smegmatis_MC2_155 MRTKAIGMGVARDIGFRMPTLWFADGHSTSAPVYLYRFDFATPMLRLLRL
TH_3679|M.thermoresistible__bu QRGKRLGVGVASDIGFRMPSVWFAEGHTAVAPTYLYRFDWSTPTLRLLRL
MAB_3453c|M.abscessus_ATCC_199 YPERSARVKLAGDMNFSTAAWQMAEAHHRYAPVYFYRYDYAPGALRIAGM
MUL_2261|M.ulcerans_Agy99 YPESAACIQLGGDFAFNAAAWQIAEAQGVHAPTYLYRYDYAPRTLRWSGF
MAV_1226|M.avium_104 KAAHATELPYVWGTLGA-PKDPTLKLGGSKTAKAVSKRVRTRWTNFAAHA
MMAR_4363|M.marinum_M RAAHATELPYVWGNLGG-PQDPTLRLGGAKTAKAVSKRMRTRWINFATQD
Mb1134|M.bovis_AF2122/97 --------------------------------------------------
Rv1104|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_3419|M.gilvum_PYR-GCK HAAHATELPFVWGNLGSGRKDPTFALGGRKSGTAVSQRMQSRWTNFAANG
Mvan_3172|M.vanbaalenii_PYR-1 HAAHATELPFVWGNLVAGRRDPTFALGGRKSGAAVSERMRARWVSFAAHG
MSMEG_3667|M.smegmatis_MC2_155 GAAHATELPYVWGNLAAGPKDPTFKMGGLKQGRKVSQRIRRRWVNFATTG
TH_3679|M.thermoresistible__bu GAAHATELPYVFGNLDT-PKDPTFTLGGRRTGRQVSQRIRTRWINFAVHG
MAB_3453c|M.abscessus_ATCC_199 GATHATELLAVFDSYRGAMGTVMAGALGRRDAVRVSNDVQRRWLAFARSG
MUL_2261|M.ulcerans_Agy99 GATHATELFAVFDIYRTRFGALLTAAADRRHALRVSDEVIRRWRSFSQTG
MAV_1226|M.avium_104 KPAGPAGSPEWAPYQEQDRACLIIGKNDVLAHDVDAKARAAWGSEMVSFR
MMAR_4363|M.marinum_M NPAGPAGEPDWPAYQDGDRACLVIDKSDRVARDIDAPIRAAWGREVVGFR
Mb1134|M.bovis_AF2122/97 --------------------------------------------------
Rv1104|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_3419|M.gilvum_PYR-GCK DPSAPG-APTWRPYDAS-RATLVIDKHDSVVDDLDAHVRRAWGDDVLSFL
Mvan_3172|M.vanbaalenii_PYR-1 APTGPAGEPVWRPYGADDRATLVIDKQDTVVDDLDADVRRAWGDDVLSFL
MSMEG_3667|M.smegmatis_MC2_155 EPTGALGEPVWRRYRREDRAALVIDKQDKTVTDLDQQLQAAWGDQVLNFR
TH_3679|M.thermoresistible__bu RPDGPPGEPRWHAYDRAERPCLLIDRRDRVVRDVDEPIRLTWGSEVLSFR
MAB_3453c|M.abscessus_ATCC_199 VP-----GDGWPTYGPPDRAVMVFDHATRVELDPEAARRAAWEGFSLTL-
MUL_2261|M.ulcerans_Agy99 TP-----GEDWPAYTHTRRAVMVIDRKSRVEIDPHRHRRLAWDGFSLAR-