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MRLEGRVAFITGAARGQGRAHAVRMAKEGADIIAVDIAGPLPPCVPYDHATADDLAETVELVKATGRRII ASAVDTRDGDALTAAVDSGVAELGRLDIIVANAGVTAPQAWDDISAEDFRDVIDVNVTGTWNTVMAGAHK IVDGGRGGSIILISSAAGIKLQPFMIHYTASKHAVTGMARAFAAELGKHSIRVNSVHPGPVVTDMGTGDM VTALGKAMETNPQLSNMMTPFLPTWAVEPEDIADAVCWLASDESKFVTASAISVDQGSTHY
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_4371 | - | - | 100% (271) | short-chain dehydrogenase/reductase SDR |
| M. gilvum PYR-GCK | Mflv_1589 | - | 3e-71 | 52.38% (273) | short-chain dehydrogenase/reductase SDR |
| M. gilvum PYR-GCK | Mflv_2430 | - | 1e-67 | 53.48% (273) | short-chain dehydrogenase/reductase SDR |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0706 | fabG | 2e-60 | 45.39% (271) | 3-ketoacyl-(acyl-carrier-protein) reductase |
| M. tuberculosis H37Rv | Rv0687 | fabG | 2e-60 | 45.39% (271) | 3-ketoacyl-(acyl-carrier-protein) reductase |
| M. leprae Br4923 | MLBr_01807 | fabG1 | 6e-23 | 31.18% (263) | 3-oxoacyl- |
| M. abscessus ATCC 19977 | MAB_3844c | - | 3e-63 | 45.19% (270) | putative short-chain dehydrogenase/reductase |
| M. marinum M | MMAR_4754 | - | 1e-65 | 50.00% (272) | short-chain type dehydrogenase/reductase |
| M. avium 104 | MAV_1570 | - | 1e-125 | 80.37% (270) | carveol dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_2204 | - | 1e-116 | 75.19% (270) | carveol dehydrogenase ((+)-trans-carveol dehydrogenase) |
| M. thermoresistible (build 8) | TH_3169 | - | 1e-111 | 72.96% (270) | PUTATIVE carveol dehydrogenase |
| M. ulcerans Agy99 | MUL_3392 | fabG | 4e-61 | 47.25% (273) | 3-ketoacyl-(acyl-carrier-protein) reductase |
| M. vanbaalenii PYR-1 | Mvan_1973 | - | 1e-146 | 93.33% (270) | short-chain dehydrogenase/reductase SDR |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0706|M.bovis_AF2122/97 -MSARGGSLHGRVAFVTGAARAQGRSHAVRLAREGADIVALDICAPVSGS
Rv0687|M.tuberculosis_H37Rv -MSARGGSLHGRVAFVTGAARAQGRSHAVRLAREGADIVALDICAPVSGS
MAB_3844c|M.abscessus_ATCC_199 -MADQP--LAGKVAFVTGAARGQGRQHAVRLAQAGADVVAIDACAPVSEY
Mflv_4371|M.gilvum_PYR-GCK ------MRLEGRVAFITGAARGQGRAHAVRMAKEGADIIAVDIAGPLPPC
Mvan_1973|M.vanbaalenii_PYR-1 -----MSRLEGRVAFITGAARGQGRAHAVRMATEGADIIAVDIAGPLPPC
MAV_1570|M.avium_104 ----MAGKLEGRVAFITGAARGQGRAHAVRMAAEGADIIAVDIAGKLPSC
MSMEG_2204|M.smegmatis_MC2_155 ----MAERLTGRVAFITGAARGQGRAHAVRMAKEGADIIAVDIAGPLPPS
TH_3169|M.thermoresistible__bu ----MTGRLAGRVAFITGAARGQGRAHAVRMAAEGADIIAVDIAGKLPDC
MMAR_4754|M.marinum_M MTEQLGGRVAGKVAFITGAARGQGRSHAVRLAQEGADIIAVDVCKPIVEN
MUL_3392|M.ulcerans_Agy99 MSRPLDGPLSGRVAFITGAARGQGRAHALRLARDGADVIAVDLCDQIAS-
MLBr_01807|M.leprae_Br4923 ---------MTDAAAKVSAAPGRGK-----PAFVSRSILVTGGNRGIGLA
.* ..** .:*: * . .::. . :
Mb0706|M.bovis_AF2122/97 VTYPPATSEDLGETVRAVEAEGRKVLAREVDIRDDAELRRLVADGVEQFG
Rv0687|M.tuberculosis_H37Rv VTYPPATSEDLGETVRAVEAEGRKVLAREVDIRDDAELRRLVADGVEQFG
MAB_3844c|M.abscessus_ATCC_199 AGYEAATPEDLKETVRLVEAAGRKIIAEQADVRNGAALQSVVEEAVAQFG
Mflv_4371|M.gilvum_PYR-GCK VPYDHATADDLAETVELVKATGRRIIASAVDTRDGDALTAAVDSGVAELG
Mvan_1973|M.vanbaalenii_PYR-1 VPYDHATPDDLAETVKLVEATGRRILASKVDTRDGEALRATVEKGVAELG
MAV_1570|M.avium_104 VPYDPASPEDLSETVRLVEAANRRIVAAVVDTRDFDGLRKVVDDGVAALG
MSMEG_2204|M.smegmatis_MC2_155 VPYDSATPEDLAETTRLVEATGRRILAARADTRDLEALRDVVGKGVAEFG
TH_3169|M.thermoresistible__bu VPYEPATPEDLDETVRLVTATGRRIHAAVADTRDLDGLREAVDAGVAALG
MMAR_4754|M.marinum_M TTIPASTPEDLAETADLVKGHNRRIFTAEADVRDYDALKAAVDAGVDELG
MUL_3392|M.ulcerans_Agy99 VPYPLGTAEELATTVKLVEDTGARIVASQADVRDREALAAALQAGIDELG
MLBr_01807|M.leprae_Br4923 VARRLVADGHRVAVTHRASVVPDWFFGVECDVTDNDAIGAAFKAVEEHQG
. : . .. . . * : : . *
Mb0706|M.bovis_AF2122/97 RLDIVVANAGVLGWGR-LWELTDEQWETVIGVNLTGTWRTLRATVPAMID
Rv0687|M.tuberculosis_H37Rv RLDIVVANAGVLGWGR-LWELTDEQWETVIGVNLTGTWRTLRATVPAMID
MAB_3844c|M.abscessus_ATCC_199 HIDILIANAGVLSWGR-LWEMSDQQWEDIIDTNLTGTWKTVKAVVPTMIE
Mflv_4371|M.gilvum_PYR-GCK RLDIIVANAGVTAPQA-WDDISAEDFRDVIDVNVTGTWNTVMAGAHKIVD
Mvan_1973|M.vanbaalenii_PYR-1 RLDVIVANAGITAPQA-WDDIGADDFRDVMDVNVTGTWNTVMAGAHKIID
MAV_1570|M.avium_104 RLDIIVANAGVAAPQA-WDDITPEDFRDVMDINVTGTWNTVMAGAPRIIE
MSMEG_2204|M.smegmatis_MC2_155 RLDVIVANAGITVPEP-WNETTPESFRDVMDINVTGTWNTVMAGAQHIID
TH_3169|M.thermoresistible__bu RLDVIVANAGICAPQT-WDAITPADFRDVMDINVTGTWNTVMAGARHIID
MMAR_4754|M.marinum_M RLDIIVANAGIGNGGATLDKTSEHDWQEMIDVNLSGVWKSVKAAVPHLIA
MUL_3392|M.ulcerans_Agy99 QVDIVVANAGIAPMQS-----GDDGWRDVIDVNLSGAYYTVEVAIPTMIE
MLBr_01807|M.leprae_Br4923 PVEVLVANAGITSDML-IMRMSEEQFQKVIDVNLTGVFRVAKLASRNMIK
:::::****: :. ::. *::*.: ::
Mb0706|M.bovis_AF2122/97 AGNGGSIVVVSSSAGLK----ATPGNGHYAASKHALVALTNTLAIELGEF
Rv0687|M.tuberculosis_H37Rv AGNGGSIVVVSSSAGLK----ATPGNGHYAASKHALVALTNTLAIELGEF
MAB_3844c|M.abscessus_ATCC_199 AGNGGSIVIVSSVSGLK----GTPGNGAYVASKFGLTGLTKSLTIELAEY
Mflv_4371|M.gilvum_PYR-GCK GGRGGSIILISSAAGIK----LQPFMIHYTASKHAVTGMARAFAAELGKH
Mvan_1973|M.vanbaalenii_PYR-1 GGRGGSIILISSAAGIK----LQPFMIHYTASKHAVTGMARAFAAELGKH
MAV_1570|M.avium_104 GGRGGSIILISSAAGMK----MQPFMIHYTASKHAVTGLARAFAAELGKH
MSMEG_2204|M.smegmatis_MC2_155 GGRGGSIILISSAAGIK----MQPFMVHYTASKHAVAGMARAFAAELGKH
TH_3169|M.thermoresistible__bu GRRGGSIILISSLAGMK----LQPFMVHYTTSKHAVAGMARAFAAELGRH
MMAR_4754|M.marinum_M GGNGGSIVLTSSVGGMK----AYPHCGNYVAAKHGVVGLMRSFAVELGQH
MUL_3392|M.ulcerans_Agy99 QGRGGSIVLISSAAGLVGISSADAGAIGYVASKHALVGLMRVYANLLAPH
MLBr_01807|M.leprae_Br4923 QRFG-RYIFMGSVVGLS----GVPGQANYAASKSGLIGMARSLARELGSR
* :. .* *: . *.::* .: .: . : *.
Mb0706|M.bovis_AF2122/97 GIRVNSIHPYSVDTPMIEPEAMIQT-FAKHPGY-----VHSFPPMPLQPK
Rv0687|M.tuberculosis_H37Rv GIRVNSIHPYSVDTPMIEPEAMIQT-FAKHPGY-----VHSFPPMPLQPK
MAB_3844c|M.abscessus_ATCC_199 GIRVNSIHPYGVTTPMITGDAMMKI-LAEHPNY-----LPSIAPMPLSPT
Mflv_4371|M.gilvum_PYR-GCK SIRVNSVHPGPVVTDMGTGDMVTALGKAMETNP-----QLSNMMTPFLPT
Mvan_1973|M.vanbaalenii_PYR-1 SIRVNSVHPGPVLTDMGTGDMVTALGKAMETNP-----QLSNMMTPFLPT
MAV_1570|M.avium_104 SIRVNSVHPGPVNTPMGSGDMVTAVGQAMETNP-----QLSHVLTPFLPD
MSMEG_2204|M.smegmatis_MC2_155 RIRVNSLHPGAVNTPMGTGDMLAALTRANDTNP-----GLMQMVTPFLPD
TH_3169|M.thermoresistible__bu RIRVNSLHPGAVATDMGGGEMVSALAATGESNP-----PLTQMITPFLPD
MMAR_4754|M.marinum_M MIRVNSVHPTHVRTPMLHNEGTFKMFRPDLENPGPDDMAPICQLFHTLPI
MUL_3392|M.ulcerans_Agy99 SIRVNSLHPSGVDPPMINNEFIRHWLADLVAET-----GSGPGAGNALPV
MLBr_01807|M.leprae_Br4923 SITANVVAPGFIDTEMTRAMDSKYQEAALQAIP---------------LG
* .* : * : . *
Mb0706|M.bovis_AF2122/97 GFMTPDEISDVVVWLAGDGSGALSGNQIPVDKGALKY-
Rv0687|M.tuberculosis_H37Rv GFMTPDEISDVVVWLAGDGSGALSGNQIPVDKGALKY-
MAB_3844c|M.abscessus_ATCC_199 KMLEPDEISDVVLWLASDASGTLAGAQVPVDKGHLTY-
Mflv_4371|M.gilvum_PYR-GCK WAVEPEDIADAVCWLASDESKFVTASAISVDQGSTHY-
Mvan_1973|M.vanbaalenii_PYR-1 WAVEPEDIADAVCWLASDESKFVTASAISVDQGSTHY-
MAV_1570|M.avium_104 WVAEPEDIADTVCWLASDESRKVTAAQIPVDQGSTQY-
MSMEG_2204|M.smegmatis_MC2_155 YIAEPEDIADAAVWLASDESRFVTASRVAVDLGSTQF-
TH_3169|M.thermoresistible__bu WIAQVDDIADAAVWLASDESRFVTAAKIPVDMGSSQF-
MMAR_4754|M.marinum_M PWVEAEDISNAVLFLASDESRYITGVTLPVDAGGCLK-
MUL_3392|M.ulcerans_Agy99 QILQADDIAGALAWLVSDEARYITGVALPVDAGCVNKR
MLBr_01807|M.leprae_Br4923 RIGAVEEIAGAVSFLASEDAGYISGAVIPVDGGLGMGH
::*:.. :*..: : ::. :.** *