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VRRDLFTEDHEAFRELARDFVEKEVVPHYPDWEKGGRMPRPVFEQMGSLGILGVAIPEEYGGGGQPDYRY NVVLQEEAARALVTLSTVRTQLEVILPYFLHYANAEQRERWFPGLASGTLLTAIAMTEPGTGSDLAGMRT TAVRDGSGPDADYIVNGAKTFITGGMQADLVIVVARTSTDPDNRRKGLTLLVVEDGMEGFTRGRELEKMG CKVQDTAELSFVDVRVPAANVLGEVDEAFGYLGHNLAQERLTVAVGSVAQARSAIAAAIDYTRNRKAFGT PVASFQNTKFELAACSTEVEAAQAMLDRAVSLHVEGELSGADAARTKLFCTEMQQRVVDRCLQLFGGYGY MMEYPIARLYTDARVARIYAGTSEVMKVMIAKSLGL
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_2446 | - | - | 100% (386) | acyl-CoA dehydrogenase domain-containing protein |
| M. gilvum PYR-GCK | Mflv_4558 | - | e-108 | 51.41% (389) | acyl-CoA dehydrogenase domain-containing protein |
| M. gilvum PYR-GCK | Mflv_2118 | - | e-103 | 46.37% (386) | acyl-CoA dehydrogenase domain-containing protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2743c | fadE20 | 1e-103 | 48.57% (385) | acyl-CoA dehydrogenase FADE20 |
| M. tuberculosis H37Rv | Rv2724c | fadE20 | 1e-104 | 48.83% (385) | acyl-CoA dehydrogenase FADE20 |
| M. leprae Br4923 | MLBr_00737 | fadE25 | 4e-54 | 32.81% (384) | putative acyl-CoA dehydrogenase |
| M. abscessus ATCC 19977 | MAB_3040c | - | 1e-105 | 50.65% (383) | acyl-CoA dehydrogenase |
| M. marinum M | MMAR_1989 | fadE20 | 1e-106 | 48.83% (385) | acyl-CoA dehydrogenase FadE20 |
| M. avium 104 | MAV_3616 | - | 1e-109 | 50.13% (385) | long-chain specific acyl-CoA dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_4832 | - | 0.0 | 88.08% (386) | acyl-CoA dehydrogenase |
| M. thermoresistible (build 8) | TH_3610 | - | 0.0 | 86.01% (386) | PUTATIVE acyl-CoA dehydrogenase domain protein |
| M. ulcerans Agy99 | MUL_3367 | fadE20 | 1e-104 | 48.57% (385) | acyl-CoA dehydrogenase FadE20 |
| M. vanbaalenii PYR-1 | Mvan_4205 | - | 0.0 | 95.60% (386) | acyl-CoA dehydrogenase domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_2446|M.gilvum_PYR-GCK ---------MRRDLFTEDHEAFRELARDFVEKEVVPHYPDWEKGGRMPRP
Mvan_4205|M.vanbaalenii_PYR-1 ---------MRRDLFTEDHEAFRELARDFVDKEVVPHYPQWEKGGRMPRE
MSMEG_4832|M.smegmatis_MC2_155 ---------MQRNLFTEDHEAFRTLARDFIEKEVVSAYPEWEKAGRMPRD
TH_3610|M.thermoresistible__bu ---------VRREVFTDDHEAFRELARDFIEKEVVPNYPDWEKAGRMPRE
Mb2743c|M.bovis_AF2122/97 ---MGSATKYQRTLFEPEHELFRESYRAFLDRHVAAYHDEWEKTKIVDRG
Rv2724c|M.tuberculosis_H37Rv ---MGSATKYQRTLFEPEHELFRESYRAFLDRHVAPYHDEWEKTKIVDRG
MMAR_1989|M.marinum_M ---MGSAIKYQRTLFEPEHDLFRESYRGFLERHVAPYHDEWEKAKIVDRG
MUL_3367|M.ulcerans_Agy99 ---MGSAIKYQRTLFEPEHDLFRESYRGFLERHVALYHDEWEKAKIVDRG
MAV_3616|M.avium_104 ---MSSAIKYQRTLFESEHELFRESYRAFLDRHVAPYHDEWEKAKIVDRG
MAB_3040c|M.abscessus_ATCC_199 ---MAGAVKFKRTIFEPEHELFRESFKTFLDRHAEPYKEEWEKNKIVDRA
MLBr_00737|M.leprae_Br4923 MVGWSGNPLFDLFKLPEEHNELRATIRALAEKEIAPHAADVDQRARFPEE
: :*: :* : : ::. : :: . .
Mflv_2446|M.gilvum_PYR-GCK VFEQMGSLGILGVAIPEEYGGGGQPDYRYNVVLQEEAARALVTLSTVRTQ
Mvan_4205|M.vanbaalenii_PYR-1 VFERMGGLGILGVAIPEEYGGGGQPDYRYNVVLQEEAARALVTLSTVRTQ
MSMEG_4832|M.smegmatis_MC2_155 VFKQMGELGMLGMAIPEEYGGAGIPDYRYNVVLQEEAARALVTLSTVRTQ
TH_3610|M.thermoresistible__bu AFELMGSLGMLGMAIPEQYGGAGIVDYRYNVVLQEEAARALVTLSTVRTQ
Mb2743c|M.bovis_AF2122/97 VWLEAGKQGFLGMAVPEEYGGGGNADFRYNTVITEETCAGRYSGIGFGLH
Rv2724c|M.tuberculosis_H37Rv VWLEAGKQGFLGMAVPEEYGGGGNADFRYNTVITEETCAGRYSGIGFGLH
MMAR_1989|M.marinum_M VWLEAGKQGFLGMAVPEEYGGGGNPDFRYNTIITEETSAGRYSGIGFGLH
MUL_3367|M.ulcerans_Agy99 VWLEAGKQGFLGMAVPEEYGGGGNPDFRYNTIITEETSAGRYSGIGFGLH
MAV_3616|M.avium_104 VWLEAGKQGFLGMAVPEEYGGGGNPDFRYNTIITEETTRGRYSGIGFGLH
MAB_3040c|M.abscessus_ATCC_199 LWVEAGKQGFLGTDMPEEFGGGGLIDFRYNTIITEEVTKGRHTGVGFSLH
MLBr_00737|M.leprae_Br4923 ALAALNASGFNAIHVPEEYGGQG-ADSVAACIVIEEVARVDASASLIPAV
. *: . :**::** * * :: **. : .
Mflv_2446|M.gilvum_PYR-GCK LEVILPYFLHYANAEQRERWFPGLASGTLLTAIAMTEPGTGSDLAGMRTT
Mvan_4205|M.vanbaalenii_PYR-1 LEVILPYFLHYANDEQRDRWFPGLASGTVLTAIAMTEPGTGSDLAGMRTT
MSMEG_4832|M.smegmatis_MC2_155 LEVILPYFLHYADTEQRQRWFPGLAAGTLLTAIAMTEPGTGSDLAGVRTT
TH_3610|M.thermoresistible__bu LDVILPYFLHYADEEQRARWFPGLAAGKLLTAIAMTEPGTGSDLAGVRTT
Mb2743c|M.bovis_AF2122/97 NDIVAPYLLALATEEQKRRWFPNFCTGELTTAIAMTEPGTGSDLQGITTR
Rv2724c|M.tuberculosis_H37Rv NDIVAPYLLALATEEQKRRWFPNFCTGELITAIAMTEPGTGSDLQGITTR
MMAR_1989|M.marinum_M NDIVAPYLLALATEEQKQRWLPKFCTGEFITAIAMTEPGTGSDLQGIKTR
MUL_3367|M.ulcerans_Agy99 NEIVAPYLLALATEEQKQRRLPKFCTGEFITAIAMTEPGTGSDLQGIKTR
MAV_3616|M.avium_104 NDIVAPYLLALATEEQKQRWLPKFCTGELITAIAMTEPGTGSDLQGIKTR
MAB_3040c|M.abscessus_ATCC_199 NDVAGPYFRDLANDEQKARWFPGFCSGELISAIAMTEPGTGSDLQGIKTR
MLBr_00737|M.leprae_Br4923 NKLGTMGLILRGSEELKKQVLPSLAAEGAMASYALSEREAGSDAASMRTR
.: : . * : : :* :.: :: *::* :*** .: *
Mflv_2446|M.gilvum_PYR-GCK AVRDGSGPDADYIVNGAKTFITGGMQADLVIVVARTSTDPDNRRKGLTLL
Mvan_4205|M.vanbaalenii_PYR-1 AVRDGD----DYIVNGAKTFITGGMQADLVIVVARTSTDPDNRRKGLTLL
MSMEG_4832|M.smegmatis_MC2_155 AVRDGD----HYVVNGAKTFITGGIQADLVVVVARTSTDPDNRRKGLTLL
TH_3610|M.thermoresistible__bu AVRDGD----DYILNGAKTFITGGIQADLVIVVARTSTDPDNRRRGLTLL
Mb2743c|M.bovis_AF2122/97 AVKHGD----HYVLNGSKTFITNGINSDLVIVVAQT--DPEKGAQGFSLL
Rv2724c|M.tuberculosis_H37Rv AVKHGD----HYVLNGSKTFITNGINSDLVIVVAQT--DPEKGAQGFSLL
MMAR_1989|M.marinum_M AVKQGD----HYLLNGSKTFITNGINADLVIVVAQT--DPEKGAQGFSLL
MUL_3367|M.ulcerans_Agy99 AVKQGD----HYLLNGSKTFITNGINADLVIVVAQT--DPEKGAQGFSLL
MAV_3616|M.avium_104 AVKQGD----HYVLNGSKTFITNGINSDLVIVVAQT--DPDKGAQGFSLL
MAB_3040c|M.abscessus_ATCC_199 AVKDGD----HYILNGAKTFITNGINADLVIVVAQT--DPEKGALGFSLI
MLBr_00737|M.leprae_Br4923 AKADGD----DWILNGFKCWITNGGKSTWYTVMAVT--DPDKGANGISAF
* .*. .:::** * :**.* :: *:* * **:: *:: :
Mflv_2446|M.gilvum_PYR-GCK VVEDGMEGFTRGRELEKMGCKVQDTAELSFVDVRVPAANVLGEVDEAFGY
Mvan_4205|M.vanbaalenii_PYR-1 VVEDGMDGFTRGRELEKMGCKVQDTAELSFVDVRVPAANVLGEVDEAFGY
MSMEG_4832|M.smegmatis_MC2_155 VVEDGMAGFSRGRELEKMGCKVQDTAELSFTDVRVPVANVLGEEGEAFSY
TH_3610|M.thermoresistible__bu VVEDGMPGFTRGRELEKMGCKVQDTAELSFTDVRVPVANRLGEEGEAFSY
Mb2743c|M.bovis_AF2122/97 VVERGMAGFERGRQLDKIGLDAQDTAELSFTDVAVPAENLLGQEGMGFIY
Rv2724c|M.tuberculosis_H37Rv VVERGMAGFERGRQLDKIGLDAQDTAELSFTDVAVPAENLLGQEGMGFIY
MMAR_1989|M.marinum_M VVERGMEGFERGRHLDKIGLDAQDTAELSFSDVQVPVENLLGQEGMGFIY
MUL_3367|M.ulcerans_Agy99 VVERGMEGFERGRHLDKIGLDAQDTAELSFSDVQVPVENLLGQEGMGFIY
MAV_3616|M.avium_104 VVERGMEGFERGRHLDKIGLDAQDTAELSFTDVHVPAENLLGQEGMGFIY
MAB_3040c|M.abscessus_ATCC_199 VVERGMEGFERGRKLDKVGLDAQDTAELSFTDVRVPAANLLGEEGQGFIY
MLBr_00737|M.leprae_Br4923 IVHKDDEGFSIGPKEKKLGIKGSPTTELYFDKCRIPGDRIIGEPGTGFKT
:*. . ** * . .*:* . . *:** * . :* . :*: . .*
Mflv_2446|M.gilvum_PYR-GCK LGHNLAQERLTVAVGSVAQARSAIAAAIDYTRNRKAFGTPVASFQNTKFE
Mvan_4205|M.vanbaalenii_PYR-1 LGHNLAQERLTVAVGSVAQARSAIAAAIEYTQSRKAFGTPVASFQNTKFE
MSMEG_4832|M.smegmatis_MC2_155 LGHNLAQERLTVAVGSVAQARSAIDAAIDYTKTRKAFGTPVASFQNTKFE
TH_3610|M.thermoresistible__bu LGHNLAQERMTVAVGSVAQARSAIDTTIEYVKSRKAFGTPVASFQNTKFE
Mb2743c|M.bovis_AF2122/97 LMQNLPQERISIAIMAAAGMESVLEQTLQYAKERKAFGRSIGSFQNSRFL
Rv2724c|M.tuberculosis_H37Rv LMQNLPQERISIAIMAAAGMESVLEQTLQYAKERKAFGRSIGSFQNSRFL
MMAR_1989|M.marinum_M LMQNLPQERISIAIMAAAGMESVLDQTLQYTKERKAFGRSIGNFQNSRFV
MUL_3367|M.ulcerans_Agy99 LMQNLPQERISIAIMAAAGMESVLDQTLQYTKERKAFGRSIGNFQNSRFV
MAV_3616|M.avium_104 LMQNLPQERISIAVMAAAAMEQVLEQTLEYTKERKAFGKSIGSFQNSRFV
MAB_3040c|M.abscessus_ATCC_199 LMKNLPQERMSIAVMAAAAMESVLEETIAYTTERKAFGKPIKSFQNSRFL
MLBr_00737|M.leprae_Br4923 ALATLDHTRPTIGAQAVGIAQGALDAAIVYTKDRKQFGESISTFQSIQFM
.* : * ::. :.. . .: :: *. ** ** .: .**. :*
Mflv_2446|M.gilvum_PYR-GCK LAACSTEVEAAQAMLDRAVSLHVEGE-LSGADAARTKLFCTEMQQRVVDR
Mvan_4205|M.vanbaalenii_PYR-1 LAACSTEVEAAQAMLDRAVSLHVEGE-LSGADAARTKLFCTEMQQRVVDR
MSMEG_4832|M.smegmatis_MC2_155 LAACSAEVEAAQAMLDRAVALHVDGE-LSGADAARVKLFCTEMQARVVDR
TH_3610|M.thermoresistible__bu LAACSAEVEAAQAMLDRAVLDLVDGQ-LSGADAARVKLFCTEMQARVVDR
Mb2743c|M.bovis_AF2122/97 LAELATEATVVRIMVDEFIKLHLAGK-LTAEQAAMAKWYATEKQVYLNDR
Rv2724c|M.tuberculosis_H37Rv LAELATEATVVRIMVDEFIKLHLAGK-LTAEQAAMAKWYATEKQVYLNDR
MMAR_1989|M.marinum_M LAELATEATMVRIMVDEFIELHLDGK-LTAEQAAMAKWYSTEKQVSLNDR
MUL_3367|M.ulcerans_Agy99 LAELATEATMVRIMVDESIELHLDGK-LTAEQAAMAKWYSTEKQVSLNDR
MAV_3616|M.avium_104 LAELATEATVVRMMVDEFVRLHLDHK-LTAEQAAMAKWYSTEKQVHLIDR
MAB_3040c|M.abscessus_ATCC_199 LAELATDATVIRVMVDEFISLLNKEE-LSVEQAAMAKWYSTEKQVHLIDR
MLBr_00737|M.leprae_Br4923 LADMAMKVEAARLIVYAAAARAERGEPDLGFISAASKCFASDIAMEVTTD
** : .. : :: : :* * :.:: :
Mflv_2446|M.gilvum_PYR-GCK CLQLFGGYGYMMEYPIARLYTDARVARIYAGTSEVMKVMIAKSLGL
Mvan_4205|M.vanbaalenii_PYR-1 CLQLFGGYGYMMEYPIARLYTDARVARIYAGTSEVMKVMIAKSLGL
MSMEG_4832|M.smegmatis_MC2_155 CLQLFGGYGYMMEYPIARLYTDARVARIYAGTSEVMKVIIAKSLGL
TH_3610|M.thermoresistible__bu CLQLFGGYGYMMEYPIARLYTDARVARIYAGTSEVMKVIIAKSLGL
Mb2743c|M.bovis_AF2122/97 CLQLHGGYGYMREYPVARAYLDSRVQTIYGGTTEIMKEIIGRGLGV
Rv2724c|M.tuberculosis_H37Rv CLQLHGGYGYMREYPVARAYLDSRVQTIYGGTTEIMKEIIGRGLGV
MMAR_1989|M.marinum_M CLQLHGGYGYMREYPVARAYLDSRVQTIYGGTTEIMKEIIGRSLGI
MUL_3367|M.ulcerans_Agy99 CLQLHGGYGYMREYPVARAYLDSRVQTIYGGTTEIMKEIIGRSLGI
MAV_3616|M.avium_104 CLQLHGGYGYMREYPVARAYLDARVQTIYGGTTEIMKEIIGRSLGV
MAB_3040c|M.abscessus_ATCC_199 CLQLHGGYGFMREYPVARAYMDSRIQTIYGGTTEIMKEIIGRSL--
MLBr_00737|M.leprae_Br4923 AVQLFGGAGYTSDFPVERFMRDAKITQIYEGTNQIQRVVMSRALLR
.:**.** *: ::*: * *::: ** **.:: : ::.:.*