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M. gilvum PYR-GCK Mflv_4158 (-)

annotation: TetR family transcriptional regulator
coordinates: 4413569 - 4414906
length: 445

MAADAAGQKPGRGRRAGRKRSGSAELAAVRDAAPADTTRRAEILKTANTVIAATGLRSSLQQIADAAGIL
AGSLYHHFDSKEAILVELIRLYHDDLDRIGDLALRKLDEPDPEPVSAQITALGCAIARCAVEHRAALQMS
FYEGPSADPELQALSARAPEKVQAAMLQALRAGRWSGEIRSDVDLPTLADRLCQSMLHVGLDVIRHKART
DDLATLKCRIALNGLASEAPSDASLDRSKAFAAAQSVISTWADDEDETDLKAAHLRAVARAEFGRRGYEM
TTIRDIASAAGLGTGTVYRIIGSKDELLMSIMLEFGRKVGGAWSDIVRTDSTTVEKLDALSWLNINALDQ
FPDEFRIQLAWLRQSPPDSANPAWSFTTRIRQMKSLLSEGIRAGEIHIDSPTADMLARCIIGEQWIPENI
LQEVGPRNALILARDTILRGVAVRT
Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. gilvum PYR-GCKMflv_4158--100% (445)TetR family transcriptional regulator
M. gilvum PYR-GCKMflv_1483-1e-1033.33% (153) TetR family transcriptional regulator
M. gilvum PYR-GCKMflv_0013-1e-1026.14% (352) TetR family transcriptional regulator

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb3587c-1e-0951.72% (58) TetR family transcriptional regulator
M. tuberculosis H37RvRv3557c-1e-0951.72% (58) TetR family transcriptional regulator
M. leprae Br4923MLBr_00316-4e-0629.35% (184) putative TetR/AcrR-family transcriptional regulator
M. abscessus ATCC 19977MAB_0599-5e-1333.72% (172) TetR family transcriptional regulator
M. marinum MMMAR_4325-1e-15665.88% (422) TetR family transcriptional regulator
M. avium 104MAV_1265-1e-16269.03% (423) transcriptional regulator, TetR family protein
M. smegmatis MC2 155MSMEG_6009-5e-1133.54% (164) transcriptional regulator, TetR family protein
M. thermoresistible (build 8)TH_3536-1e-15263.62% (426) PUTATIVE transcriptional regulator, TetR family
M. ulcerans Agy99MUL_0135-1e-12164.33% (342) TetR family transcriptional regulator
M. vanbaalenii PYR-1Mvan_5283-2e-1136.71% (158) TetR family transcriptional regulator

CLUSTAL 2.0.9 multiple sequence alignment


Mb3587c|M.bovis_AF2122/97           ------------MDR-VAGQVN---------------SRRGELLELAAAM
Rv3557c|M.tuberculosis_H37Rv        ------------MDR-VAGQVN---------------SRRGELLELAAAM
Mvan_5283|M.vanbaalenii_PYR-1       ------------MSSGQAPQAN---------------TRRDELLQLAATM
MSMEG_6009|M.smegmatis_MC2_155      ------------MAPDTPSQPA---------------SRRDELLQLAATM
MAB_0599|M.abscessus_ATCC_1997      ------------MDKVSEVRESD----ALRAGGSPQPSRRDELLSLAAEM
MMAR_4325|M.marinum_M               ------------MADHRDQAGTD-----------DSGTRRTEILQTAAAL
MUL_0135|M.ulcerans_Agy99           ------------MADHRDQAGTD-----------DSGTRRTEILQTAAAL
MAV_1265|M.avium_104                ----------MAKAESLRTGSTA-----------DSPTRRAEILATAASL
TH_3536|M.thermoresistible__bu      -----VVGRPQLTSEQRNVRKSAHTLASVAGRAYDDGTRRTEILQTAARL
Mflv_4158|M.gilvum_PYR-GCK          MAADAAGQKPGRGRRAGRKRSGSAELAAVRDAAPADTTRRAEILKTANTV
MLBr_00316|M.leprae_Br4923          ----MSVPRSGLSVQMAQPARPLR---------ADAARNRARILGVAYEA
                                                                          .* .:*  *   

Mb3587c|M.bovis_AF2122/97           FAERGLRATTVRDIADGAGILSGSLYHHFASKEEMVDELLRGFLDWLFAR
Rv3557c|M.tuberculosis_H37Rv        FAERGLRATTVRDIADGAGILSGSLYHHFASKEEMVDELLRGFLDWLFAR
Mvan_5283|M.vanbaalenii_PYR-1       FAERGLRATTVRDIADSAGILSGSLYHHFSSKEEMVDEVLRGFLDWLFDR
MSMEG_6009|M.smegmatis_MC2_155      FADRGLKATTVRDIADSAGILSGSLYHHFKSKEQMVEEVLRDFLDWLFGR
MAB_0599|M.abscessus_ATCC_1997      FAERGLRATTVRDIADAAGILSGSLYHHFDSKEAIVDELLRDFLEGLFAR
MMAR_4325|M.marinum_M               IASSGLR-TSLQEIADAAGILPGSLYHHFESKEAILIELIRRYQDDLHQI
MUL_0135|M.ulcerans_Agy99           IASSGLR-TSLQEIADAAGILPGSLYHHFESKEAILIELIRRYQDDLHQI
MAV_1265|M.avium_104                IASSGLR-TSLQEIADAAGILPGSLYHHFESKEAILVELIRRYQDDLERI
TH_3536|M.thermoresistible__bu      IASSGLR-TSLQEIADAAGILPGSLYHHFESKEAILVELLRRYHTDLDTI
Mflv_4158|M.gilvum_PYR-GCK          IAATGLR-SSLQQIADAAGILAGSLYHHFDSKEAILVELIRLYHDDLDRI
MLBr_00316|M.leprae_Br4923          FATEGLS-VPIDEIARRAGVGAGTVYRHFPTKEALCAAVIGDRMPHLVDD
                                    :*  **   .: :**  **: .*::*:** :** :   ::      *   

Mb3587c|M.bovis_AF2122/97           ----YRDIVDSTANPLERLQGLFMASFEAIEHHHAQVVIYQDEAQRLASQ
Rv3557c|M.tuberculosis_H37Rv        ----YRDIVDSTANPLERLQGLFMASFEAIEHHHAQVVIYQDEAQRLASQ
Mvan_5283|M.vanbaalenii_PYR-1       ----YQQIVATEPNPLERLKGLFMASFEAIETRHAEVVIYQDEAKRLSAQ
MSMEG_6009|M.smegmatis_MC2_155      ----YQQILDTATSPLEKLTGLFMASFEAIEHRHAQVVIYQDEAKRLSDL
MAB_0599|M.abscessus_ATCC_1997      ----YREIAAANLNPVDTLKGLFLASFDAIETKHAQVAIYQAEAPRLLSQ
MMAR_4325|M.marinum_M               GQSWQAKLDQPDSRTVAEKITQLGAAIANCAVAHRAALQMSFYEGPSADP
MUL_0135|M.ulcerans_Agy99           GQSWQAKLDQPDSRTVAEKITQLGAAIANCAVAHRAALQMSFYEGPSADP
MAV_1265|M.avium_104                GRTAQARLDEPDSRPVPEQIIELGSAIANCAVEHRAALQMSFYEGPGTDP
TH_3536|M.thermoresistible__bu      AAHAQERLDDPDPRSPSDRITDLGVAIARCAVTHRAALQMTFYEGPTSHP
Mflv_4158|M.gilvum_PYR-GCK          GDLALRKLDEPDPEPVSAQITALGCAIARCAVEHRAALQMSFYEGPSADP
MLBr_00316|M.leprae_Br4923          G-----YVLLKSAGPGEALFTYLRSLVLHWGATDRGLVDALAGAG---GI
                                           :      .       :   .      .                

Mb3587c|M.bovis_AF2122/97           PRFSYIEDRNKQQRKMWVDVLNQGIEEGYFRPDLDVDLVYRFIRDTTWVS
Rv3557c|M.tuberculosis_H37Rv        PRFSYIEDRNKQQRKMWVDVLNQGIEEGYFRPDLDVDLVYRFIRDTTWVS
Mvan_5283|M.vanbaalenii_PYR-1       GRFAYVEERNKEQRKMWVDVLTQGIDEGYFRPDVDVDLVYRFIRDTTWVS
MSMEG_6009|M.smegmatis_MC2_155      PQFDFVETRNKEQRKMWVDILQEGVADGSFRPDLDVDLVYRFIRDTTWVS
MAB_0599|M.abscessus_ATCC_1997      ERFAYLNELNTEQRQLWLEVLRDGIAQGYFRPDLDVAVVYRFIRDATWVS
MMAR_4325|M.marinum_M               ELMKLTSQRPLAIQEAMLQTLRAGRWSGCIRTEIDLPTLADRICQT-MLQ
MUL_0135|M.ulcerans_Agy99           ELMKLTSQRPLAIQEAMLQTLRAGRWSGYIRTEIDLPTFADRICQT-MLQ
MAV_1265|M.avium_104                ELTKLTRQRPVAIQEAMLQTLRAGRWSGYIKPDIDLPTLADRICQT-MLQ
TH_3536|M.thermoresistible__bu      EVTALAQQRPTGILEAMLQTLRAARWSGYLRADIDLPILADRIVQT-MLQ
Mflv_4158|M.gilvum_PYR-GCK          ELQALSARAPEKVQAAMLQALRAGRWSGEIRSDVDLPTLADRLCQS-MLH
MLBr_00316|M.leprae_Br4923          DILGVAPDAEDAFLTILSDLLYAAQYAGTARTDVGVREVKSILVGC----
                                                      : *  .   *  :.::.:  .   :       

Mb3587c|M.bovis_AF2122/97           VRWYRPGGPLTAQQVGQQYLAIVLGGITKEGV------------------
Rv3557c|M.tuberculosis_H37Rv        VRWYRPGGPLTAQQVGQQYLAIVLGGITKEGV------------------
Mvan_5283|M.vanbaalenii_PYR-1       VRWYQPGGPLTAQQVGRQYLSIVLGGITAEPTSKESTNG-----------
MSMEG_6009|M.smegmatis_MC2_155      VRWYKPGGPLSAEQVGQQYLAIVLGGITQSQGDKHA--------------
MAB_0599|M.abscessus_ATCC_1997      VRWFRPGGSRTAQEVAEQYLSIVLGGITVGSFSNSPEK------------
MMAR_4325|M.marinum_M               VGLDMMRRNASADQVSGLMCRTILQGLASHAPTDVDLDGSNALSAANDVI
MUL_0135|M.ulcerans_Agy99           VGLDMMRRNASADQVSGLMCRTILQALASHAPTDVDPDGSNALSAANDVI
MAV_1265|M.avium_104                VGLDVMRHTASADQVAELLCRIILQGLASRPPSDAALDRSKAFVAANEVI
TH_3536|M.thermoresistible__bu      VGLDVIRHNASPDKAATLLCRILLEGLATVLPTDEELDGSAAFRAADEVV
Mflv_4158|M.gilvum_PYR-GCK          VGLDVIRHKARTDDLATLKCRIALNGLASEAPSDASLDRSKAFAAAQSVI
MLBr_00316|M.leprae_Br4923          -----QAMEAYNSALAERVTDVVVDGLRAAR-------------------
                                                .  .       : .:                       

Mb3587c|M.bovis_AF2122/97           --------------------------------------------------
Rv3557c|M.tuberculosis_H37Rv        --------------------------------------------------
Mvan_5283|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_6009|M.smegmatis_MC2_155      --------------------------------------------------
MAB_0599|M.abscessus_ATCC_1997      --------------------------------------------------
MMAR_4325|M.marinum_M               ATWIDEKDADPSDKAAHVRAVARIEFGRKGYEVTTIRDIASASGLATGTV
MUL_0135|M.ulcerans_Agy99           ATWIDEKDTDPSDKAAHVRAVARMEFGRKGYEVTTVRDIASASGLGTGTV
MAV_1265|M.avium_104                ETWSDDSDADPGDKAALVRAVARAEFGRRGYEVTTIRDIAAAAGLGTGTV
TH_3536|M.thermoresistible__bu      QSWSLEAEAEADDKAAHVRAVARAEFGRRGYEGTTIRDIARAAGLGTGTV
Mflv_4158|M.gilvum_PYR-GCK          STWADD-EDETDLKAAHLRAVARAEFGRRGYEMTTIRDIASAAGLGTGTV
MLBr_00316|M.leprae_Br4923          --------------------------------------------------
                                                                                      

Mb3587c|M.bovis_AF2122/97           --------------------------------------------------
Rv3557c|M.tuberculosis_H37Rv        --------------------------------------------------
Mvan_5283|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_6009|M.smegmatis_MC2_155      --------------------------------------------------
MAB_0599|M.abscessus_ATCC_1997      --------------------------------------------------
MMAR_4325|M.marinum_M               YRVIGSKDKLLASIMRSFGQKVEAGWVAVLRSNATPIEKLDALSWVNINA
MUL_0135|M.ulcerans_Agy99           YRVIGSKDKLLASIMRSFGQKVEAGWVAVRRSNATPIEKLDALSWVNINA
MAV_1265|M.avium_104                YRVIGSKDELLDSIMRSFGKKVEAGWVSVLRSDATPTEKLDALSWVNVNA
TH_3536|M.thermoresistible__bu      YRLIGSKEELLASIMRSFGEKIAVGWTDVLRTDAPAIAKLDALSWVNTNA
Mflv_4158|M.gilvum_PYR-GCK          YRIIGSKDELLMSIMLEFGRKVGGAWSDIVRTDSTTVEKLDALSWLNINA
MLBr_00316|M.leprae_Br4923          --------------------------------------------------
                                                                                      

Mb3587c|M.bovis_AF2122/97           --------------------------------------------------
Rv3557c|M.tuberculosis_H37Rv        --------------------------------------------------
Mvan_5283|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_6009|M.smegmatis_MC2_155      --------------------------------------------------
MAB_0599|M.abscessus_ATCC_1997      --------------------------------------------------
MMAR_4325|M.marinum_M               LDQFSDEFRIQLAWMRQSPPDTPNPGWLYAARLRQMKSLLSEGLRSAEIQ
MUL_0135|M.ulcerans_Agy99           LDQFSDEFRIQLAWMRQ---------------------------------
MAV_1265|M.avium_104                LDQFSDEFRIQLAWMRLSPP-TANPGWSYATRLRQMKSLLSEGLRTGEIA
TH_3536|M.thermoresistible__bu      LDRFGDEFRIQLAWMRQSPPDTPNPGWLFAKRVRQVKSLLAAAIRSGEIS
Mflv_4158|M.gilvum_PYR-GCK          LDQFPDEFRIQLAWLRQSPPDSANPAWSFTTRIRQMKSLLSEGIRAGEIH
MLBr_00316|M.leprae_Br4923          --------------------------------------------------
                                                                                      

Mb3587c|M.bovis_AF2122/97           --------------------------------------------------
Rv3557c|M.tuberculosis_H37Rv        --------------------------------------------------
Mvan_5283|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_6009|M.smegmatis_MC2_155      --------------------------------------------------
MAB_0599|M.abscessus_ATCC_1997      --------------------------------------------------
MMAR_4325|M.marinum_M               IEPPSITMLARCVIGLQWIPENILHFVGTRAALIHARDTVLRGVAVRGQ-
MUL_0135|M.ulcerans_Agy99           --------------------------------------------------
MAV_1265|M.avium_104                IAAPSTAMLARCLIALQWIPENILAEIGKRPALLHVRDTVLRGVAVRGAA
TH_3536|M.thermoresistible__bu      IDSPSNELLARSVIGVGWVPENILRQIGTRAAQILVRDTVLRGAADRDVT
Mflv_4158|M.gilvum_PYR-GCK          IDSPTADMLARCIIGEQWIPENILQEVGPRNALILARDTILRGVAVRT--
MLBr_00316|M.leprae_Br4923          --------------------------------------------------
                                                                                      

Mb3587c|M.bovis_AF2122/97           ---
Rv3557c|M.tuberculosis_H37Rv        ---
Mvan_5283|M.vanbaalenii_PYR-1       ---
MSMEG_6009|M.smegmatis_MC2_155      ---
MAB_0599|M.abscessus_ATCC_1997      ---
MMAR_4325|M.marinum_M               ---
MUL_0135|M.ulcerans_Agy99           ---
MAV_1265|M.avium_104                VDN
TH_3536|M.thermoresistible__bu      R--
Mflv_4158|M.gilvum_PYR-GCK          ---
MLBr_00316|M.leprae_Br4923          ---