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MAADAAGQKPGRGRRAGRKRSGSAELAAVRDAAPADTTRRAEILKTANTVIAATGLRSSLQQIADAAGIL AGSLYHHFDSKEAILVELIRLYHDDLDRIGDLALRKLDEPDPEPVSAQITALGCAIARCAVEHRAALQMS FYEGPSADPELQALSARAPEKVQAAMLQALRAGRWSGEIRSDVDLPTLADRLCQSMLHVGLDVIRHKART DDLATLKCRIALNGLASEAPSDASLDRSKAFAAAQSVISTWADDEDETDLKAAHLRAVARAEFGRRGYEM TTIRDIASAAGLGTGTVYRIIGSKDELLMSIMLEFGRKVGGAWSDIVRTDSTTVEKLDALSWLNINALDQ FPDEFRIQLAWLRQSPPDSANPAWSFTTRIRQMKSLLSEGIRAGEIHIDSPTADMLARCIIGEQWIPENI LQEVGPRNALILARDTILRGVAVRT
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. gilvum PYR-GCK | Mflv_4158 | - | - | 100% (445) | TetR family transcriptional regulator |
M. gilvum PYR-GCK | Mflv_1483 | - | 1e-10 | 33.33% (153) | TetR family transcriptional regulator |
M. gilvum PYR-GCK | Mflv_0013 | - | 1e-10 | 26.14% (352) | TetR family transcriptional regulator |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb3587c | - | 1e-09 | 51.72% (58) | TetR family transcriptional regulator |
M. tuberculosis H37Rv | Rv3557c | - | 1e-09 | 51.72% (58) | TetR family transcriptional regulator |
M. leprae Br4923 | MLBr_00316 | - | 4e-06 | 29.35% (184) | putative TetR/AcrR-family transcriptional regulator |
M. abscessus ATCC 19977 | MAB_0599 | - | 5e-13 | 33.72% (172) | TetR family transcriptional regulator |
M. marinum M | MMAR_4325 | - | 1e-156 | 65.88% (422) | TetR family transcriptional regulator |
M. avium 104 | MAV_1265 | - | 1e-162 | 69.03% (423) | transcriptional regulator, TetR family protein |
M. smegmatis MC2 155 | MSMEG_6009 | - | 5e-11 | 33.54% (164) | transcriptional regulator, TetR family protein |
M. thermoresistible (build 8) | TH_3536 | - | 1e-152 | 63.62% (426) | PUTATIVE transcriptional regulator, TetR family |
M. ulcerans Agy99 | MUL_0135 | - | 1e-121 | 64.33% (342) | TetR family transcriptional regulator |
M. vanbaalenii PYR-1 | Mvan_5283 | - | 2e-11 | 36.71% (158) | TetR family transcriptional regulator |
CLUSTAL 2.0.9 multiple sequence alignment Mb3587c|M.bovis_AF2122/97 ------------MDR-VAGQVN---------------SRRGELLELAAAM Rv3557c|M.tuberculosis_H37Rv ------------MDR-VAGQVN---------------SRRGELLELAAAM Mvan_5283|M.vanbaalenii_PYR-1 ------------MSSGQAPQAN---------------TRRDELLQLAATM MSMEG_6009|M.smegmatis_MC2_155 ------------MAPDTPSQPA---------------SRRDELLQLAATM MAB_0599|M.abscessus_ATCC_1997 ------------MDKVSEVRESD----ALRAGGSPQPSRRDELLSLAAEM MMAR_4325|M.marinum_M ------------MADHRDQAGTD-----------DSGTRRTEILQTAAAL MUL_0135|M.ulcerans_Agy99 ------------MADHRDQAGTD-----------DSGTRRTEILQTAAAL MAV_1265|M.avium_104 ----------MAKAESLRTGSTA-----------DSPTRRAEILATAASL TH_3536|M.thermoresistible__bu -----VVGRPQLTSEQRNVRKSAHTLASVAGRAYDDGTRRTEILQTAARL Mflv_4158|M.gilvum_PYR-GCK MAADAAGQKPGRGRRAGRKRSGSAELAAVRDAAPADTTRRAEILKTANTV MLBr_00316|M.leprae_Br4923 ----MSVPRSGLSVQMAQPARPLR---------ADAARNRARILGVAYEA .* .:* * Mb3587c|M.bovis_AF2122/97 FAERGLRATTVRDIADGAGILSGSLYHHFASKEEMVDELLRGFLDWLFAR Rv3557c|M.tuberculosis_H37Rv FAERGLRATTVRDIADGAGILSGSLYHHFASKEEMVDELLRGFLDWLFAR Mvan_5283|M.vanbaalenii_PYR-1 FAERGLRATTVRDIADSAGILSGSLYHHFSSKEEMVDEVLRGFLDWLFDR MSMEG_6009|M.smegmatis_MC2_155 FADRGLKATTVRDIADSAGILSGSLYHHFKSKEQMVEEVLRDFLDWLFGR MAB_0599|M.abscessus_ATCC_1997 FAERGLRATTVRDIADAAGILSGSLYHHFDSKEAIVDELLRDFLEGLFAR MMAR_4325|M.marinum_M IASSGLR-TSLQEIADAAGILPGSLYHHFESKEAILIELIRRYQDDLHQI MUL_0135|M.ulcerans_Agy99 IASSGLR-TSLQEIADAAGILPGSLYHHFESKEAILIELIRRYQDDLHQI MAV_1265|M.avium_104 IASSGLR-TSLQEIADAAGILPGSLYHHFESKEAILVELIRRYQDDLERI TH_3536|M.thermoresistible__bu IASSGLR-TSLQEIADAAGILPGSLYHHFESKEAILVELLRRYHTDLDTI Mflv_4158|M.gilvum_PYR-GCK IAATGLR-SSLQQIADAAGILAGSLYHHFDSKEAILVELIRLYHDDLDRI MLBr_00316|M.leprae_Br4923 FATEGLS-VPIDEIARRAGVGAGTVYRHFPTKEALCAAVIGDRMPHLVDD :* ** .: :** **: .*::*:** :** : :: * Mb3587c|M.bovis_AF2122/97 ----YRDIVDSTANPLERLQGLFMASFEAIEHHHAQVVIYQDEAQRLASQ Rv3557c|M.tuberculosis_H37Rv ----YRDIVDSTANPLERLQGLFMASFEAIEHHHAQVVIYQDEAQRLASQ Mvan_5283|M.vanbaalenii_PYR-1 ----YQQIVATEPNPLERLKGLFMASFEAIETRHAEVVIYQDEAKRLSAQ MSMEG_6009|M.smegmatis_MC2_155 ----YQQILDTATSPLEKLTGLFMASFEAIEHRHAQVVIYQDEAKRLSDL MAB_0599|M.abscessus_ATCC_1997 ----YREIAAANLNPVDTLKGLFLASFDAIETKHAQVAIYQAEAPRLLSQ MMAR_4325|M.marinum_M GQSWQAKLDQPDSRTVAEKITQLGAAIANCAVAHRAALQMSFYEGPSADP MUL_0135|M.ulcerans_Agy99 GQSWQAKLDQPDSRTVAEKITQLGAAIANCAVAHRAALQMSFYEGPSADP MAV_1265|M.avium_104 GRTAQARLDEPDSRPVPEQIIELGSAIANCAVEHRAALQMSFYEGPGTDP TH_3536|M.thermoresistible__bu AAHAQERLDDPDPRSPSDRITDLGVAIARCAVTHRAALQMTFYEGPTSHP Mflv_4158|M.gilvum_PYR-GCK GDLALRKLDEPDPEPVSAQITALGCAIARCAVEHRAALQMSFYEGPSADP MLBr_00316|M.leprae_Br4923 G-----YVLLKSAGPGEALFTYLRSLVLHWGATDRGLVDALAGAG---GI : . : . . Mb3587c|M.bovis_AF2122/97 PRFSYIEDRNKQQRKMWVDVLNQGIEEGYFRPDLDVDLVYRFIRDTTWVS Rv3557c|M.tuberculosis_H37Rv PRFSYIEDRNKQQRKMWVDVLNQGIEEGYFRPDLDVDLVYRFIRDTTWVS Mvan_5283|M.vanbaalenii_PYR-1 GRFAYVEERNKEQRKMWVDVLTQGIDEGYFRPDVDVDLVYRFIRDTTWVS MSMEG_6009|M.smegmatis_MC2_155 PQFDFVETRNKEQRKMWVDILQEGVADGSFRPDLDVDLVYRFIRDTTWVS MAB_0599|M.abscessus_ATCC_1997 ERFAYLNELNTEQRQLWLEVLRDGIAQGYFRPDLDVAVVYRFIRDATWVS MMAR_4325|M.marinum_M ELMKLTSQRPLAIQEAMLQTLRAGRWSGCIRTEIDLPTLADRICQT-MLQ MUL_0135|M.ulcerans_Agy99 ELMKLTSQRPLAIQEAMLQTLRAGRWSGYIRTEIDLPTFADRICQT-MLQ MAV_1265|M.avium_104 ELTKLTRQRPVAIQEAMLQTLRAGRWSGYIKPDIDLPTLADRICQT-MLQ TH_3536|M.thermoresistible__bu EVTALAQQRPTGILEAMLQTLRAARWSGYLRADIDLPILADRIVQT-MLQ Mflv_4158|M.gilvum_PYR-GCK ELQALSARAPEKVQAAMLQALRAGRWSGEIRSDVDLPTLADRLCQS-MLH MLBr_00316|M.leprae_Br4923 DILGVAPDAEDAFLTILSDLLYAAQYAGTARTDVGVREVKSILVGC---- : * . * :.::.: . : Mb3587c|M.bovis_AF2122/97 VRWYRPGGPLTAQQVGQQYLAIVLGGITKEGV------------------ Rv3557c|M.tuberculosis_H37Rv VRWYRPGGPLTAQQVGQQYLAIVLGGITKEGV------------------ Mvan_5283|M.vanbaalenii_PYR-1 VRWYQPGGPLTAQQVGRQYLSIVLGGITAEPTSKESTNG----------- MSMEG_6009|M.smegmatis_MC2_155 VRWYKPGGPLSAEQVGQQYLAIVLGGITQSQGDKHA-------------- MAB_0599|M.abscessus_ATCC_1997 VRWFRPGGSRTAQEVAEQYLSIVLGGITVGSFSNSPEK------------ MMAR_4325|M.marinum_M VGLDMMRRNASADQVSGLMCRTILQGLASHAPTDVDLDGSNALSAANDVI MUL_0135|M.ulcerans_Agy99 VGLDMMRRNASADQVSGLMCRTILQALASHAPTDVDPDGSNALSAANDVI MAV_1265|M.avium_104 VGLDVMRHTASADQVAELLCRIILQGLASRPPSDAALDRSKAFVAANEVI TH_3536|M.thermoresistible__bu VGLDVIRHNASPDKAATLLCRILLEGLATVLPTDEELDGSAAFRAADEVV Mflv_4158|M.gilvum_PYR-GCK VGLDVIRHKARTDDLATLKCRIALNGLASEAPSDASLDRSKAFAAAQSVI MLBr_00316|M.leprae_Br4923 -----QAMEAYNSALAERVTDVVVDGLRAAR------------------- . . : .: Mb3587c|M.bovis_AF2122/97 -------------------------------------------------- Rv3557c|M.tuberculosis_H37Rv -------------------------------------------------- Mvan_5283|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_6009|M.smegmatis_MC2_155 -------------------------------------------------- MAB_0599|M.abscessus_ATCC_1997 -------------------------------------------------- MMAR_4325|M.marinum_M ATWIDEKDADPSDKAAHVRAVARIEFGRKGYEVTTIRDIASASGLATGTV MUL_0135|M.ulcerans_Agy99 ATWIDEKDTDPSDKAAHVRAVARMEFGRKGYEVTTVRDIASASGLGTGTV MAV_1265|M.avium_104 ETWSDDSDADPGDKAALVRAVARAEFGRRGYEVTTIRDIAAAAGLGTGTV TH_3536|M.thermoresistible__bu QSWSLEAEAEADDKAAHVRAVARAEFGRRGYEGTTIRDIARAAGLGTGTV Mflv_4158|M.gilvum_PYR-GCK STWADD-EDETDLKAAHLRAVARAEFGRRGYEMTTIRDIASAAGLGTGTV MLBr_00316|M.leprae_Br4923 -------------------------------------------------- Mb3587c|M.bovis_AF2122/97 -------------------------------------------------- Rv3557c|M.tuberculosis_H37Rv -------------------------------------------------- Mvan_5283|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_6009|M.smegmatis_MC2_155 -------------------------------------------------- MAB_0599|M.abscessus_ATCC_1997 -------------------------------------------------- MMAR_4325|M.marinum_M YRVIGSKDKLLASIMRSFGQKVEAGWVAVLRSNATPIEKLDALSWVNINA MUL_0135|M.ulcerans_Agy99 YRVIGSKDKLLASIMRSFGQKVEAGWVAVRRSNATPIEKLDALSWVNINA MAV_1265|M.avium_104 YRVIGSKDELLDSIMRSFGKKVEAGWVSVLRSDATPTEKLDALSWVNVNA TH_3536|M.thermoresistible__bu YRLIGSKEELLASIMRSFGEKIAVGWTDVLRTDAPAIAKLDALSWVNTNA Mflv_4158|M.gilvum_PYR-GCK YRIIGSKDELLMSIMLEFGRKVGGAWSDIVRTDSTTVEKLDALSWLNINA MLBr_00316|M.leprae_Br4923 -------------------------------------------------- Mb3587c|M.bovis_AF2122/97 -------------------------------------------------- Rv3557c|M.tuberculosis_H37Rv -------------------------------------------------- Mvan_5283|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_6009|M.smegmatis_MC2_155 -------------------------------------------------- MAB_0599|M.abscessus_ATCC_1997 -------------------------------------------------- MMAR_4325|M.marinum_M LDQFSDEFRIQLAWMRQSPPDTPNPGWLYAARLRQMKSLLSEGLRSAEIQ MUL_0135|M.ulcerans_Agy99 LDQFSDEFRIQLAWMRQ--------------------------------- MAV_1265|M.avium_104 LDQFSDEFRIQLAWMRLSPP-TANPGWSYATRLRQMKSLLSEGLRTGEIA TH_3536|M.thermoresistible__bu LDRFGDEFRIQLAWMRQSPPDTPNPGWLFAKRVRQVKSLLAAAIRSGEIS Mflv_4158|M.gilvum_PYR-GCK LDQFPDEFRIQLAWLRQSPPDSANPAWSFTTRIRQMKSLLSEGIRAGEIH MLBr_00316|M.leprae_Br4923 -------------------------------------------------- Mb3587c|M.bovis_AF2122/97 -------------------------------------------------- Rv3557c|M.tuberculosis_H37Rv -------------------------------------------------- Mvan_5283|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_6009|M.smegmatis_MC2_155 -------------------------------------------------- MAB_0599|M.abscessus_ATCC_1997 -------------------------------------------------- MMAR_4325|M.marinum_M IEPPSITMLARCVIGLQWIPENILHFVGTRAALIHARDTVLRGVAVRGQ- MUL_0135|M.ulcerans_Agy99 -------------------------------------------------- MAV_1265|M.avium_104 IAAPSTAMLARCLIALQWIPENILAEIGKRPALLHVRDTVLRGVAVRGAA TH_3536|M.thermoresistible__bu IDSPSNELLARSVIGVGWVPENILRQIGTRAAQILVRDTVLRGAADRDVT Mflv_4158|M.gilvum_PYR-GCK IDSPTADMLARCIIGEQWIPENILQEVGPRNALILARDTILRGVAVRT-- MLBr_00316|M.leprae_Br4923 -------------------------------------------------- Mb3587c|M.bovis_AF2122/97 --- Rv3557c|M.tuberculosis_H37Rv --- Mvan_5283|M.vanbaalenii_PYR-1 --- MSMEG_6009|M.smegmatis_MC2_155 --- MAB_0599|M.abscessus_ATCC_1997 --- MMAR_4325|M.marinum_M --- MUL_0135|M.ulcerans_Agy99 --- MAV_1265|M.avium_104 VDN TH_3536|M.thermoresistible__bu R-- Mflv_4158|M.gilvum_PYR-GCK --- MLBr_00316|M.leprae_Br4923 ---