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AKAESLRTGSTADSPTRRAEILATAASLIASSGLRTSLQEIADAAGILPGSLYHHFESKEAILVELIRRY QDDLERIGRTAQARLDEPDSRPVPEQIIELGSAIANCAVEHRAALQMSFYEGPGTDPELTKLTRQRPVAI QEAMLQTLRAGRWSGYIKPDIDLPTLADRICQTMLQVGLDVMRHTASADQVAELLCRIILQGLASRPPSD AALDRSKAFVAANEVIETWSDDSDADPGDKAALVRAVARAEFGRRGYEVTTIRDIAAAAGLGTGTVYRVI GSKDELLDSIMRSFGKKVEAGWVSVLRSDATPTEKLDALSWVNVNALDQFSDEFRIQLAWMRLSPPTANP GWSYATRLRQMKSLLSEGLRTGEIAIAAPSTAMLARCLIALQWIPENILAEIGKRPALLHVRDTVLRGVA VRGAAVDN*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_1265 | - | - | 100% (429) | transcriptional regulator, TetR family protein |
| M. avium 104 | MAV_0603 | - | 3e-14 | 33.50% (203) | transcriptional regulator, TetR family protein |
| M. avium 104 | MAV_4046 | - | 1e-06 | 48.15% (54) | transcriptional regulator, TetR family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3587c | - | 3e-13 | 32.31% (195) | TetR family transcriptional regulator |
| M. gilvum PYR-GCK | Mflv_4158 | - | 1e-162 | 69.03% (423) | TetR family transcriptional regulator |
| M. tuberculosis H37Rv | Rv3557c | - | 3e-13 | 32.31% (195) | TetR family transcriptional regulator |
| M. leprae Br4923 | MLBr_00316 | - | 2e-06 | 41.07% (56) | putative TetR/AcrR-family transcriptional regulator |
| M. abscessus ATCC 19977 | MAB_0599 | - | 3e-18 | 33.64% (214) | TetR family transcriptional regulator |
| M. marinum M | MMAR_4325 | - | 0.0 | 79.47% (414) | TetR family transcriptional regulator |
| M. smegmatis MC2 155 | MSMEG_6009 | - | 7e-13 | 34.20% (193) | transcriptional regulator, TetR family protein |
| M. thermoresistible (build 8) | TH_3536 | - | 1e-159 | 69.16% (415) | PUTATIVE transcriptional regulator, TetR family |
| M. ulcerans Agy99 | MUL_0135 | - | 1e-149 | 79.52% (332) | TetR family transcriptional regulator |
| M. vanbaalenii PYR-1 | Mvan_5283 | - | 8e-14 | 32.24% (214) | TetR family transcriptional regulator |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_4325|M.marinum_M -------------MADHRDQAGTD-----------DSGTRRTEILQTAAA
MUL_0135|M.ulcerans_Agy99 -------------MADHRDQAGTD-----------DSGTRRTEILQTAAA
MAV_1265|M.avium_104 -----------MAKAESLRTGSTA-----------DSPTRRAEILATAAS
TH_3536|M.thermoresistible__bu ------VVGRPQLTSEQRNVRKSAHTLASVAGRAYDDGTRRTEILQTAAR
Mflv_4158|M.gilvum_PYR-GCK MAADAAGQKPGRGRRAGRKRSGSAELAAVR-DAAPADTTRRAEILKTANT
Mb3587c|M.bovis_AF2122/97 -------------MDR-VAGQVN---------------SRRGELLELAAA
Rv3557c|M.tuberculosis_H37Rv -------------MDR-VAGQVN---------------SRRGELLELAAA
Mvan_5283|M.vanbaalenii_PYR-1 -------------MSSGQAPQAN---------------TRRDELLQLAAT
MSMEG_6009|M.smegmatis_MC2_155 -------------MAPDTPSQPA---------------SRRDELLQLAAT
MAB_0599|M.abscessus_ATCC_1997 -------------MDKVSEVRESDALRAGG----SPQPSRRDELLSLAAE
MLBr_00316|M.leprae_Br4923 ------MSVPRSGLSVQMAQPARPLR--------ADAARNRARILGVAYE
.* .:* *
MMAR_4325|M.marinum_M LIASSGLR-TSLQEIADAAGILPGSLYHHFESKEAILIELIRRYQDDLHQ
MUL_0135|M.ulcerans_Agy99 LIASSGLR-TSLQEIADAAGILPGSLYHHFESKEAILIELIRRYQDDLHQ
MAV_1265|M.avium_104 LIASSGLR-TSLQEIADAAGILPGSLYHHFESKEAILVELIRRYQDDLER
TH_3536|M.thermoresistible__bu LIASSGLR-TSLQEIADAAGILPGSLYHHFESKEAILVELLRRYHTDLDT
Mflv_4158|M.gilvum_PYR-GCK VIAATGLR-SSLQQIADAAGILAGSLYHHFDSKEAILVELIRLYHDDLDR
Mb3587c|M.bovis_AF2122/97 MFAERGLRATTVRDIADGAGILSGSLYHHFASKEEMVDELLRGFLDWLFA
Rv3557c|M.tuberculosis_H37Rv MFAERGLRATTVRDIADGAGILSGSLYHHFASKEEMVDELLRGFLDWLFA
Mvan_5283|M.vanbaalenii_PYR-1 MFAERGLRATTVRDIADSAGILSGSLYHHFSSKEEMVDEVLRGFLDWLFD
MSMEG_6009|M.smegmatis_MC2_155 MFADRGLKATTVRDIADSAGILSGSLYHHFKSKEQMVEEVLRDFLDWLFG
MAB_0599|M.abscessus_ATCC_1997 MFAERGLRATTVRDIADAAGILSGSLYHHFDSKEAIVDELLRDFLEGLFA
MLBr_00316|M.leprae_Br4923 AFATEGLS-VPIDEIARRAGVGAGTVYRHFPTKEALCAAVIGDRMPHLVD
:* ** .: :** **: .*::*:** :** : :: *
MMAR_4325|M.marinum_M IGQSWQAKLDQPDSRTVAEKITQLGAAIANCAVAHRAALQMSFYEGP-SA
MUL_0135|M.ulcerans_Agy99 IGQSWQAKLDQPDSRTVAEKITQLGAAIANCAVAHRAALQMSFYEGP-SA
MAV_1265|M.avium_104 IGRTAQARLDEPDSRPVPEQIIELGSAIANCAVEHRAALQMSFYEGP-GT
TH_3536|M.thermoresistible__bu IAAHAQERLDDPDPRSPSDRITDLGVAIARCAVTHRAALQMTFYEGP-TS
Mflv_4158|M.gilvum_PYR-GCK IGDLALRKLDEPDPEPVSAQITALGCAIARCAVEHRAALQMSFYEGP-SA
Mb3587c|M.bovis_AF2122/97 RYRDIVDSTANP-----LERLQGLFMASFEAIEHHHAQVVIYQDEAQRLA
Rv3557c|M.tuberculosis_H37Rv RYRDIVDSTANP-----LERLQGLFMASFEAIEHHHAQVVIYQDEAQRLA
Mvan_5283|M.vanbaalenii_PYR-1 RYQQIVATEPNP-----LERLKGLFMASFEAIETRHAEVVIYQDEAKRLS
MSMEG_6009|M.smegmatis_MC2_155 RYQQILDTATSP-----LEKLTGLFMASFEAIEHRHAQVVIYQDEAKRLS
MAB_0599|M.abscessus_ATCC_1997 RYREIAAANLNP-----VDTLKGLFLASFDAIETKHAQVAIYQAEAPRLL
MLBr_00316|M.leprae_Br4923 DGYVLLKSAGPG-----EALFTYLRSLVLHWGATDRGLVDALAGAGG---
: * :. : .
MMAR_4325|M.marinum_M DPELMKLTSQRPLAIQEAMLQTLRAGRWSGCIRTEIDLPTLADRICQT-M
MUL_0135|M.ulcerans_Agy99 DPELMKLTSQRPLAIQEAMLQTLRAGRWSGYIRTEIDLPTFADRICQT-M
MAV_1265|M.avium_104 DPELTKLTRQRPVAIQEAMLQTLRAGRWSGYIKPDIDLPTLADRICQT-M
TH_3536|M.thermoresistible__bu HPEVTALAQQRPTGILEAMLQTLRAARWSGYLRADIDLPILADRIVQT-M
Mflv_4158|M.gilvum_PYR-GCK DPELQALSARAPEKVQAAMLQALRAGRWSGEIRSDVDLPTLADRLCQS-M
Mb3587c|M.bovis_AF2122/97 SQPRFSYIEDRNKQQRKMWVDVLNQGIEEGYFRPDLDVDLVYRFIRDTTW
Rv3557c|M.tuberculosis_H37Rv SQPRFSYIEDRNKQQRKMWVDVLNQGIEEGYFRPDLDVDLVYRFIRDTTW
Mvan_5283|M.vanbaalenii_PYR-1 AQGRFAYVEERNKEQRKMWVDVLTQGIDEGYFRPDVDVDLVYRFIRDTTW
MSMEG_6009|M.smegmatis_MC2_155 DLPQFDFVETRNKEQRKMWVDILQEGVADGSFRPDLDVDLVYRFIRDTTW
MAB_0599|M.abscessus_ATCC_1997 SQERFAYLNELNTEQRQLWLEVLRDGIAQGYFRPDLDVAVVYRFIRDATW
MLBr_00316|M.leprae_Br4923 -IDILGVAPDAEDAFLTILSDLLYAAQYAGTARTDVGVREVKSILVGC--
: * . * :.::.: . :
MMAR_4325|M.marinum_M LQVGLDMMRRNASADQVSGLMCRTILQGLASHAPTDVDLDGSNALSAAND
MUL_0135|M.ulcerans_Agy99 LQVGLDMMRRNASADQVSGLMCRTILQALASHAPTDVDPDGSNALSAAND
MAV_1265|M.avium_104 LQVGLDVMRHTASADQVAELLCRIILQGLASRPPSDAALDRSKAFVAANE
TH_3536|M.thermoresistible__bu LQVGLDVIRHNASPDKAATLLCRILLEGLATVLPTDEELDGSAAFRAADE
Mflv_4158|M.gilvum_PYR-GCK LHVGLDVIRHKARTDDLATLKCRIALNGLASEAPSDASLDRSKAFAAAQS
Mb3587c|M.bovis_AF2122/97 VSVRWYRPGGPLTAQQVGQQYLAIVLGGITKEGV----------------
Rv3557c|M.tuberculosis_H37Rv VSVRWYRPGGPLTAQQVGQQYLAIVLGGITKEGV----------------
Mvan_5283|M.vanbaalenii_PYR-1 VSVRWYQPGGPLTAQQVGRQYLSIVLGGITAEPTSKESTNG---------
MSMEG_6009|M.smegmatis_MC2_155 VSVRWYKPGGPLSAEQVGQQYLAIVLGGITQSQGDKHA------------
MAB_0599|M.abscessus_ATCC_1997 VSVRWFRPGGSRTAQEVAEQYLSIVLGGITVGSFSNSPEK----------
MLBr_00316|M.leprae_Br4923 -------QAMEAYNSALAERVTDVVVDGLRAAR-----------------
. . : .:
MMAR_4325|M.marinum_M VIATWIDEKDADPSDKAAHVRAVARIEFGRKGYEVTTIRDIASASGLATG
MUL_0135|M.ulcerans_Agy99 VIATWIDEKDTDPSDKAAHVRAVARMEFGRKGYEVTTVRDIASASGLGTG
MAV_1265|M.avium_104 VIETWSDDSDADPGDKAALVRAVARAEFGRRGYEVTTIRDIAAAAGLGTG
TH_3536|M.thermoresistible__bu VVQSWSLEAEAEADDKAAHVRAVARAEFGRRGYEGTTIRDIARAAGLGTG
Mflv_4158|M.gilvum_PYR-GCK VISTWADD-EDETDLKAAHLRAVARAEFGRRGYEMTTIRDIASAAGLGTG
Mb3587c|M.bovis_AF2122/97 --------------------------------------------------
Rv3557c|M.tuberculosis_H37Rv --------------------------------------------------
Mvan_5283|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_6009|M.smegmatis_MC2_155 --------------------------------------------------
MAB_0599|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_00316|M.leprae_Br4923 --------------------------------------------------
MMAR_4325|M.marinum_M TVYRVIGSKDKLLASIMRSFGQKVEAGWVAVLRSNATPIEKLDALSWVNI
MUL_0135|M.ulcerans_Agy99 TVYRVIGSKDKLLASIMRSFGQKVEAGWVAVRRSNATPIEKLDALSWVNI
MAV_1265|M.avium_104 TVYRVIGSKDELLDSIMRSFGKKVEAGWVSVLRSDATPTEKLDALSWVNV
TH_3536|M.thermoresistible__bu TVYRLIGSKEELLASIMRSFGEKIAVGWTDVLRTDAPAIAKLDALSWVNT
Mflv_4158|M.gilvum_PYR-GCK TVYRIIGSKDELLMSIMLEFGRKVGGAWSDIVRTDSTTVEKLDALSWLNI
Mb3587c|M.bovis_AF2122/97 --------------------------------------------------
Rv3557c|M.tuberculosis_H37Rv --------------------------------------------------
Mvan_5283|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_6009|M.smegmatis_MC2_155 --------------------------------------------------
MAB_0599|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_00316|M.leprae_Br4923 --------------------------------------------------
MMAR_4325|M.marinum_M NALDQFSDEFRIQLAWMRQSPPDTPNPGWLYAARLRQMKSLLSEGLRSAE
MUL_0135|M.ulcerans_Agy99 NALDQFSDEFRIQLAWMRQ-------------------------------
MAV_1265|M.avium_104 NALDQFSDEFRIQLAWMRLSPP-TANPGWSYATRLRQMKSLLSEGLRTGE
TH_3536|M.thermoresistible__bu NALDRFGDEFRIQLAWMRQSPPDTPNPGWLFAKRVRQVKSLLAAAIRSGE
Mflv_4158|M.gilvum_PYR-GCK NALDQFPDEFRIQLAWLRQSPPDSANPAWSFTTRIRQMKSLLSEGIRAGE
Mb3587c|M.bovis_AF2122/97 --------------------------------------------------
Rv3557c|M.tuberculosis_H37Rv --------------------------------------------------
Mvan_5283|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_6009|M.smegmatis_MC2_155 --------------------------------------------------
MAB_0599|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_00316|M.leprae_Br4923 --------------------------------------------------
MMAR_4325|M.marinum_M IQIEPPSITMLARCVIGLQWIPENILHFVGTRAALIHARDTVLRGVAVRG
MUL_0135|M.ulcerans_Agy99 --------------------------------------------------
MAV_1265|M.avium_104 IAIAAPSTAMLARCLIALQWIPENILAEIGKRPALLHVRDTVLRGVAVRG
TH_3536|M.thermoresistible__bu ISIDSPSNELLARSVIGVGWVPENILRQIGTRAAQILVRDTVLRGAADRD
Mflv_4158|M.gilvum_PYR-GCK IHIDSPTADMLARCIIGEQWIPENILQEVGPRNALILARDTILRGVAVRT
Mb3587c|M.bovis_AF2122/97 --------------------------------------------------
Rv3557c|M.tuberculosis_H37Rv --------------------------------------------------
Mvan_5283|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_6009|M.smegmatis_MC2_155 --------------------------------------------------
MAB_0599|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_00316|M.leprae_Br4923 --------------------------------------------------
MMAR_4325|M.marinum_M Q----
MUL_0135|M.ulcerans_Agy99 -----
MAV_1265|M.avium_104 AAVDN
TH_3536|M.thermoresistible__bu VTR--
Mflv_4158|M.gilvum_PYR-GCK -----
Mb3587c|M.bovis_AF2122/97 -----
Rv3557c|M.tuberculosis_H37Rv -----
Mvan_5283|M.vanbaalenii_PYR-1 -----
MSMEG_6009|M.smegmatis_MC2_155 -----
MAB_0599|M.abscessus_ATCC_1997 -----
MLBr_00316|M.leprae_Br4923 -----