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SQLFEDLEDFGSFDDAVSGDVRDPYPELARLRREEPIQRIDMSAMPGEEGKPVFIVYRYEDAQQMLRDNV TFSSSGVIAAFGPVLGERVMLGMDEPVHGRLRSLVSKAFSQKGLARWQDELVGRVGNELIDRFQADGKAD LVKQFTFDYPSRIIAGLLGLPEQDYPQFQRWSISLLSWILNPERGLAAAAALCEYFAPILEARRTDPQDD LISLLAEAEIDGEKLTDEEIFSFLRLLLPAGVETTYRSLGNLLFALLSDTAQLDAVRADRSLLPQAIEEG VRWNPPLLTITRTTTCDTELGGVPIPAGCSVLPMLGSTNRQEDRWEDPDEFNLFRAQKANLGWGYGVHVC LGMHLARLEMRTAVNLLLDRLPGLRLDPDGDDPHIRGQVFRSPTSLPVLFDAVGSDA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_4150 | - | - | 100% (408) | cytochrome P450 |
| M. gilvum PYR-GCK | Mflv_4339 | - | 2e-97 | 50.13% (385) | cytochrome P450 |
| M. gilvum PYR-GCK | Mflv_1508 | - | 4e-46 | 31.88% (389) | cytochrome P450 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0801 | cyp126 | 6e-47 | 35.28% (394) | cytochrome P450 126 |
| M. tuberculosis H37Rv | Rv0778 | cyp126 | 6e-47 | 35.28% (394) | cytochrome P450 126 |
| M. leprae Br4923 | MLBr_02088 | - | 7e-40 | 30.35% (402) | putative cytochrome p450 |
| M. abscessus ATCC 19977 | MAB_3825 | - | 2e-46 | 31.44% (388) | cytochrome P450 |
| M. marinum M | MMAR_4008 | cyp187A5 | 1e-90 | 46.60% (397) | cytochrome P450 187A5 Cyp187A5 |
| M. avium 104 | MAV_1274 | - | 0.0 | 85.32% (402) | cytochrome P450 superfamily protein |
| M. smegmatis MC2 155 | MSMEG_2240 | - | 2e-92 | 46.65% (388) | cytochrome P450 |
| M. thermoresistible (build 8) | TH_2944 | - | 6e-97 | 48.59% (391) | PUTATIVE cytochrome P450 |
| M. ulcerans Agy99 | MUL_3872 | cyp187A5 | 7e-90 | 46.73% (398) | cytochrome P450 187A5 Cyp187A5 |
| M. vanbaalenii PYR-1 | Mvan_2007 | - | 6e-94 | 46.75% (385) | cytochrome P450 |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0801|M.bovis_AF2122/97 ----------MTTAAGLSG----IDLTDLDNFADGFPHHLFAIH--RREA
Rv0778|M.tuberculosis_H37Rv ----------MTTAAGLSG----IDLTDLDNFADGFPHHLFAIH--RREA
Mflv_4150|M.gilvum_PYR-GCK ----------MSQLFEDLEDF--GSFDDAVSGDVRDPYPELARL--RREE
MAV_1274|M.avium_104 ----------MEQLFDDLEDF--GAFDDAVSGDVRDPYTELARL--RREE
MSMEG_2240|M.smegmatis_MC2_155 ----------MDSRIRDDP-----AVDTAAL--LRDPYPIFARY--RAQA
Mvan_2007|M.vanbaalenii_PYR-1 ----------METPVQD-L-----AKDEPID--LRDPYPMFARR--RAEG
TH_2944|M.thermoresistible__bu ----------MT------------AAKPAGY--LRDPYPFFAER--RRGS
MMAR_4008|M.marinum_M ----------MTSPVHSVAG----TGDQAVN--PRNPYPFFAQQ--RRRG
MUL_3872|M.ulcerans_Agy99 ----------MTSPVHSVAG----TGDQAVN--PRNPYPFFAQQ--RRRG
MAB_3825|M.abscessus_ATCC_1997 ----------MATALSEIEEAGRVLADPAAYADELRLHAAMTLL--RREQ
MLBr_02088|M.leprae_Br4923 MRTCVPTRTCVYAFIEYLSHNRPMGTNPPSLVEAQMLLLRLIDPGTRADP
: : *
Mb0801|M.bovis_AF2122/97 PVYWHRPTEHTPD-----GEGFWSVAT----YAETLEVLRDPVTYSSVTG
Rv0778|M.tuberculosis_H37Rv PVYWHRPTEHTPD-----GEGFWSVAT----YAETLEVLRDPVTYSSVTG
Mflv_4150|M.gilvum_PYR-GCK PIQR---IDMSAMPGEE-GKPVFIVYR----YEDAQQMLRDNVTFSSSG-
MAV_1274|M.avium_104 PIQR---LDTSGMPHEE-SKPVFIVYR----HEDAQQMLRDNETFSSAA-
MSMEG_2240|M.smegmatis_MC2_155 GVFRGSVMDWSKTPKELMPEHQYAAMS----FDAVNTVFRDGKTFNSKI-
Mvan_2007|M.vanbaalenii_PYR-1 GVFRGSVMDWSRTPDSLRPENLYAAVS----FDAVNRVFRDGKVFNSHI-
TH_2944|M.thermoresistible__bu GVFHGTVIDYSRTPESLRPTDGYAAMS----FDAVNRVLRDGRVFSSAL-
MMAR_4008|M.marinum_M GVFPGTVMDYSKTPASLRPRREFSAMS----FAAVNTVFRDSRAFTSKT-
MUL_3872|M.ulcerans_Agy99 GVFPGTVMDYSKTPESLRPRREFSAMS----FAAVNTVFRDSRAFTSKT-
MAB_3825|M.abscessus_ATCC_1997 PVTKVITDDYRPFWAVTKHDDIMAVERDNALWINEPRPLLMNLEQEAELD
MLBr_02088|M.leprae_Br4923 FPVYRALIDYGPMQLPGMPLTVFSSFS--DCDEALRHPLSASDRLKATLA
: : :
Mb0801|M.bovis_AF2122/97 GQRRFGGTVLQDLPVAGQVLNMMDDPRHTRIRRLVSSGLTPRMIRRVEDD
Rv0778|M.tuberculosis_H37Rv GQRRFGGTVLQDLPVAGQVLNMMDDPRHTRIRRLVSSGLTPRMIRRVEDD
Mflv_4150|M.gilvum_PYR-GCK VIAAFG------PVLGERVMLGMDEPVHGRLRSLVSKAFSQKGLARWQDE
MAV_1274|M.avium_104 VIAAFG------PVLGERVMLGMDEPVHGRLRSLVSKAFSQKALARWEDE
MSMEG_2240|M.smegmatis_MC2_155 YDSTIG------LFIGP-SILAMEGKTHRDHRNLVSAAFKSKSLARWEPE
Mvan_2007|M.vanbaalenii_PYR-1 YDSTIG------LFIGP-TILAMEGKTHWEHRNLVSAAFKTRSLARWEPE
TH_2944|M.thermoresistible__bu YDTTIG------LFTGP-TLLAMEGGTHRAHRNLISAAFKTKALARWEPS
MMAR_4008|M.marinum_M YDKTIG------LFMGP-TILAMEGKQHRDHRNLVSAAFKSKALARWEPA
MUL_3872|M.ulcerans_Agy99 YDKMIG------LFMGP-TILAMEGKQHRDHRNLVSAAFKSKALARWEPA
MAB_3825|M.abscessus_ATCC_1997 KQAAMG--------IELKTLVHIDDPKHRVLRAIGADWFRPKAMRDMKLR
MLBr_02088|M.leprae_Br4923 QQAIAAG--AEPRPFYASSFMFLDPPDHTRLRKLVSKAFAPKVVQALEGD
. : :: * * : : : : : :
Mb0801|M.bovis_AF2122/97 LRRRAR-GLLDGVEPGAPFDFVVEIAAELPMQMICILLGVPETDRHWLFE
Rv0778|M.tuberculosis_H37Rv LRRRAR-GLLDGVEPGAPFDFVVEIAAELPMQMICILLGVPETDRHWLFE
Mflv_4150|M.gilvum_PYR-GCK LVGRVGNELIDRFQADGKADLVKQFTFDYPSRIIAGLLGLPEQDYPQFQR
MAV_1274|M.avium_104 LVGRVGNSLIDRFAGNGKADLVKEFTFDYPSRIIAGLLGLPEQDYPQFQR
MSMEG_2240|M.smegmatis_MC2_155 IARPICEALVDEFVDTGSADLVRDYTFEFPTRVISKLLGLPEEDLPWFRR
Mvan_2007|M.vanbaalenii_PYR-1 IVRPVVNELIDEFIDDGRADLVRDFTFEFPTRVISRLLGLPEEDLPWFRK
TH_2944|M.thermoresistible__bu IVRPIVNALIDEFIDTGTADLVRDFTFEFPTRVISRMLGLPEEDLPTFRR
MMAR_4008|M.marinum_M VIRPICNALIDDFIDAGRAELVGDFTFEFPTRVIARLLGLPDEDLAMFHQ
MUL_3872|M.ulcerans_Agy99 VIRPICNALIDDFIDAGRAELVGDFTFEFPTRVIARLLGLPDEDLAMFHQ
MAB_3825|M.abscessus_ATCC_1997 TDELANRYVNKLLEAGGSCDFAQDIAVHFPLYVIMSLLGIPESDFDRMLK
MLBr_02088|M.leprae_Br4923 IAALVD-SLLDKGAAAGQFDVIADLAFPLAVAVICRLLGVPYEDAPEFGR
: . . :. : : . :* :**:* * : .
Mb0801|M.bovis_AF2122/97 AVEPGFDFR-----GSRRATMPRLNVEDAGSRLYTYALELIAGKRAEPAD
Rv0778|M.tuberculosis_H37Rv AVEPGFDFR-----GSRRATMPRLNVEDAGSRLYTYALELIAGKRAEPAD
Mflv_4150|M.gilvum_PYR-GCK WSISLLSWI-----LNPERGL------AAAAALCEYFAPILEARRTDPQD
MAV_1274|M.avium_104 WSISLLSWI-----LNPQRGL------AASAALCDYFAPILAARRTEPKD
MSMEG_2240|M.smegmatis_MC2_155 RAVELISYS-----VKYKRAF------EASAALKDYFLDQIERRRSRPTE
Mvan_2007|M.vanbaalenii_PYR-1 RAVELISYA-----VNYKKAF------EASAALKDYFLGQIDKRRSAPTE
TH_2944|M.thermoresistible__bu WAVQLISYT-----VDYQRAF------EASAALKDYFLEQMESRRSKPTD
MMAR_4008|M.marinum_M RAVQLISYT-----VNYQLAF------EASAALKEYFLEQIDRRRSKPSE
MUL_3872|M.ulcerans_Agy99 RAVQLISYT-----VNYQLAF------EASAALKEYFLEQIDRRRSKPSE
MAB_3825|M.abscessus_ATCC_1997 LTQELFGGDD----SEFQRGTTPEEQLMALLDFFGYFSGLTASRRQHPTD
MLBr_02088|M.leprae_Br4923 VSALLVQSVDPFITITGEPPEATEERLRAGVWLRDYLEQLVKCRRGTPGE
. . * : * :* * :
Mb0801|M.bovis_AF2122/97 DMLSVVANATIDDPDAPALSDAELYLFFHLLFSAGAETTRNSIAGGLLAL
Rv0778|M.tuberculosis_H37Rv DMLSVVANATIDDPDAPALSDAELYLFFHLLFSAGAETTRNSIAGGLLAL
Mflv_4150|M.gilvum_PYR-GCK DLISLLAEAEID---GEKLTDEEIFSFLRLLLPAGVETTYRSLGNLLFAL
MAV_1274|M.avium_104 DLISGLAQAEID---GEKLEDEEIYSFLRLLLPAGVETTYRALGSLLLAL
MSMEG_2240|M.smegmatis_MC2_155 DIIGDLVTAEID---GEKLTDEAIYSFLRLLLPAGLETTYRSSGNLLYLL
Mvan_2007|M.vanbaalenii_PYR-1 DIIGDLVSAEID---GERLTDEAIFSFLRLLLPAGLETTFRSSGNLLYLL
TH_2944|M.thermoresistible__bu DMIGDLVTAEID---GEKLSDEAIYSFLRLLLPAGLETTYRSSGNLIYLL
MMAR_4008|M.marinum_M DIIGDLVTAEID---GEKLSEEAIYSFLRLLLPAGLETTYRSSGNLLYLL
MUL_3872|M.ulcerans_Agy99 DIIGDLVTAEID---GEKLSEEAIYSFLRLLLPAGLETTYRSSGNLLYLL
MAB_3825|M.abscessus_ATCC_1997 DLASTIANARVD---GELLSDVDTASYYTIIATAGHDTTSATIAGGLEAL
MLBr_02088|M.leprae_Br4923 DLISRLIELDES---GDQLTEEEIIATCGLLLVAGHETTVNLIANAVLAM
*: . : . . * : :: ** :** .. : :
Mb0801|M.bovis_AF2122/97 AENPDQLQTLRSDFELLPTAIEEIVRWTSPSPSKRRTASRAVSLGGQPIE
Rv0778|M.tuberculosis_H37Rv AENPDQLQTLRSDFELLPTAIEEIVRWTSPSPSKRRTASRAVSLGGQPIE
Mflv_4150|M.gilvum_PYR-GCK LSDTAQLDAVRADRSLLPQAIEEGVRWNPPLLTITRTTTCDTELGGVPIP
MAV_1274|M.avium_104 LSDPEQLDAIRGDRSLLPQAIEEGVRWEPPLLTITRVATRDTELGGVPIP
MSMEG_2240|M.smegmatis_MC2_155 LTHPDQFAAVQNDHDLIGAAIEEGLRYETPLTTVQRSATKDTELEGVQIP
Mvan_2007|M.vanbaalenii_PYR-1 LTHRDQFEAVNADHALIGAAIEEGLRYETPLTTVQRFANEDTEIDGVEIP
TH_2944|M.thermoresistible__bu LTHPEQFAAVAADPGLIPQAIEEGLRHETPLTTVQRLTTEDTELCGAAIP
MMAR_4008|M.marinum_M LAHPDQFMAVRAHRELIPQAIEEGLRFETPLTTVQRFTTKDTEVQGVPIP
MUL_3872|M.ulcerans_Agy99 LAHPDQFMAVRAHRELIPQAIEEGLRFETPLTTVQRFTTKDTEVQGVPIP
MAB_3825|M.abscessus_ATCC_1997 LEHPDQLARLRENPGLMPLAVDEMIRWVTPVKEFMRTATADTEIRGVPIT
MLBr_02088|M.leprae_Br4923 LRNPSQWKALSSNPQRAPLVVEETLRYDPAIHLIGRVAAKDMTIGQTTLT
. * : . .::* :* .. * : : :
Mb0801|M.bovis_AF2122/97 AGQKVVVWEGSANRDPSVFDRADEFDITRKPNPHLGFGQGVHYCLGANLA
Rv0778|M.tuberculosis_H37Rv AGQKVVVWEGSANRDPSVFDRADEFDITRKPNPHLGFGQGVHYCLGANLA
Mflv_4150|M.gilvum_PYR-GCK AGCSVLPMLGSTNRQEDRWEDPDEFNLFRAQKANLGWGYGVHVCLGMHLA
MAV_1274|M.avium_104 AGSTVMPMLGAANRQEDRYPDPDRFDIFRAPKSHLGWGHGVHVCLGMHLA
MSMEG_2240|M.smegmatis_MC2_155 AGAVIDVCIGSANRDENRWERPEEFDIFRKRIPHITFAAGEHTCMGLHLA
Mvan_2007|M.vanbaalenii_PYR-1 AGSVIDVCIGSANRDESRWERAEQFDIFRTRTPHISFAAGEHTCMGLHLA
TH_2944|M.thermoresistible__bu AGAVVDTCIGSANRDETRWDRPEEFDIFRDRVPHLSFAAGEHTCMGLHLA
MMAR_4008|M.marinum_M ARSVIGVCMGSANRDEHRWQRPEVFDIFRERIPHISFAAGEHTCLGLHLA
MUL_3872|M.ulcerans_Agy99 ARSVIGVCMGSANRDEHRWQRPEVFDIFRERIPHISFAAGEHTCLGLHLA
MAB_3825|M.abscessus_ATCC_1997 EGESVLLSYPSGNRDEDIFTDPFTFDIARDPNKHLAFGFGVHFCLGAALA
MLBr_02088|M.leprae_Br4923 EGDTMVLLLAAANRDPAVYSRPDEFDPDRPSSRHLAFAVGSHFCLGAALA
: : **: : . *: * :: :. * * *:* **
Mb0801|M.bovis_AF2122/97 RLELRVLFEELLSRFGSVRVVEP--AEWTRSNRHTGIRHLVVELRGG---
Rv0778|M.tuberculosis_H37Rv RLELRVLFEELLSRFGSVRVVEP--AEWTRSNRHTGIRHLVVELRGG---
Mflv_4150|M.gilvum_PYR-GCK RLEMRTAVNLLLDRLPGLRLDPDGDDPHIRGQVFRSPTSLPVLFDAVGSD
MAV_1274|M.avium_104 RLEMRTAVNLLLDRLPNLRLDPDADDPHIRGQVFRSPTSVPVLFDPQ---
MSMEG_2240|M.smegmatis_MC2_155 RMETRVAMETLLNRVTDLRLIAD-DDPHIFGQPFRSPTAIPVTFRPAG--
Mvan_2007|M.vanbaalenii_PYR-1 RMETRVAAETLLSRLSAIELLTD-GDPHIHGQPFRSPTALPVTFTPSRAR
TH_2944|M.thermoresistible__bu RMETRVALETLLSRVHDLRLVTD-GDPHIFGQPFRSPTAIPVTFDPVR--
MMAR_4008|M.marinum_M RLETRVALECLLDRLTNIDLATA-DDPHIHGQPFRSPTALPVTFEAVPT-
MUL_3872|M.ulcerans_Agy99 RLETRVALECLLDRLTNIDLATA-DDPHIHGQPFRSPKALPVTFEAVPT-
MAB_3825|M.abscessus_ATCC_1997 RMEVNSFFSALLPRLESIEVDGN--IERTSTIFVGGIKHLPIRYTLR---
MLBr_02088|M.leprae_Br4923 RLEATVTLSAISARFPQVQLAGE--LVYKPNVAMRGMSALPVQV------
*:* . : *. : : . : :
Mb0801|M.bovis_AF2122/97 -
Rv0778|M.tuberculosis_H37Rv -
Mflv_4150|M.gilvum_PYR-GCK A
MAV_1274|M.avium_104 -
MSMEG_2240|M.smegmatis_MC2_155 -
Mvan_2007|M.vanbaalenii_PYR-1 P
TH_2944|M.thermoresistible__bu -
MMAR_4008|M.marinum_M -
MUL_3872|M.ulcerans_Agy99 -
MAB_3825|M.abscessus_ATCC_1997 -
MLBr_02088|M.leprae_Br4923 -