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ETPVQDLAKDEPIDLRDPYPMFARRRAEGGVFRGSVMDWSRTPDSLRPENLYAAVSFDAVNRVFRDGKVF NSHIYDSTIGLFIGPTILAMEGKTHWEHRNLVSAAFKTRSLARWEPEIVRPVVNELIDEFIDDGRADLVR DFTFEFPTRVISRLLGLPEEDLPWFRKRAVELISYAVNYKKAFEASAALKDYFLGQIDKRRSAPTEDIIG DLVSAEIDGERLTDEAIFSFLRLLLPAGLETTFRSSGNLLYLLLTHRDQFEAVNADHALIGAAIEEGLRY ETPLTTVQRFANEDTEIDGVEIPAGSVIDVCIGSANRDESRWERAEQFDIFRTRTPHISFAAGEHTCMGL HLARMETRVAAETLLSRLSAIELLTDGDPHIHGQPFRSPTALPVTFTPSRARP*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_2007 | - | - | 100% (404) | cytochrome P450 |
| M. vanbaalenii PYR-1 | Mvan_0317 | - | 5e-49 | 34.68% (395) | cytochrome P450 |
| M. vanbaalenii PYR-1 | Mvan_5481 | - | 2e-42 | 37.59% (290) | cytochrome P450 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0789c | cyp123 | 7e-42 | 30.63% (395) | cytochrome P450 123 |
| M. gilvum PYR-GCK | Mflv_4339 | - | 0.0 | 86.60% (403) | cytochrome P450 |
| M. tuberculosis H37Rv | Rv0766c | cyp123 | 7e-42 | 30.63% (395) | cytochrome P450 123 |
| M. leprae Br4923 | MLBr_02088 | - | 3e-36 | 29.14% (326) | putative cytochrome p450 |
| M. abscessus ATCC 19977 | MAB_1216c | - | 2e-47 | 33.68% (389) | cytochrome P450 |
| M. marinum M | MMAR_4008 | cyp187A5 | 1e-164 | 71.79% (397) | cytochrome P450 187A5 Cyp187A5 |
| M. avium 104 | MAV_1598 | - | 1e-174 | 75.44% (395) | cytochrome P450 superfamily protein |
| M. smegmatis MC2 155 | MSMEG_2240 | - | 0.0 | 79.70% (394) | cytochrome P450 |
| M. thermoresistible (build 8) | TH_2944 | - | 1e-173 | 76.17% (386) | PUTATIVE cytochrome P450 |
| M. ulcerans Agy99 | MUL_3872 | cyp187A5 | 1e-163 | 71.28% (397) | cytochrome P450 187A5 Cyp187A5 |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_2007|M.vanbaalenii_PYR-1 -----------------------------METPVQD-LAK-DEPIDLRDP
Mflv_4339|M.gilvum_PYR-GCK ---------------------------MRVDTPVQD-VEM-DGPIDLRDP
MSMEG_2240|M.smegmatis_MC2_155 -----------------------------MDSRIRDDPAV-DTAALLRDP
TH_2944|M.thermoresistible__bu ------------------------------------MTAA-KPAGYLRDP
MMAR_4008|M.marinum_M -----------------------------MTSPVHSVAGTGDQAVNPRNP
MUL_3872|M.ulcerans_Agy99 -----------------------------MTSPVHSVAGTGDQAVNPRNP
MAV_1598|M.avium_104 -----------------------------MTTNVPTAAGG--ETVSLRDP
Mb0789c|M.bovis_AF2122/97 --------------------------MTVRVGDPE-LVLDPYDYDFHEDP
Rv0766c|M.tuberculosis_H37Rv --------------------------MTVRVGDPE-LVLDPYDYDFHEDP
MAB_1216c|M.abscessus_ATCC_199 --------------------------MTVAETSAVPLVFDPYDYDFHEDP
MLBr_02088|M.leprae_Br4923 MRTCVPTRTCVYAFIEYLSHNRPMGTNPPSLVEAQMLLLRLIDPGTRADP
:*
Mvan_2007|M.vanbaalenii_PYR-1 YPMFARRRAEGGVFRGSVMDWSRTPDSLRPENLYAAVSFDAVNRVFRDGK
Mflv_4339|M.gilvum_PYR-GCK YPMFARHRAEGGVFRGSVMDWSKTPESLMPEKLYAAVSFDAVNRVFRDGK
MSMEG_2240|M.smegmatis_MC2_155 YPIFARYRAQAGVFRGSVMDWSKTPKELMPEHQYAAMSFDAVNTVFRDGK
TH_2944|M.thermoresistible__bu YPFFAERRRGSGVFHGTVIDYSRTPESLRPTDGYAAMSFDAVNRVLRDGR
MMAR_4008|M.marinum_M YPFFAQQRRRGGVFPGTVMDYSKTPASLRPRREFSAMSFAAVNTVFRDSR
MUL_3872|M.ulcerans_Agy99 YPFFAQQRRRGGVFPGTVMDYSKTPESLRPRREFSAMSFAAVNTVFRDSR
MAV_1598|M.avium_104 YPFFARKRREAGVFAGTVMDYSKTPESLMPKQEYSAVSFDAVNTVFRDGR
Mb0789c|M.bovis_AF2122/97 YPYYRRLRDEAPLYRNEERNFWAVSRHHDVLQGFRDS--TALSNAYGVSL
Rv0766c|M.tuberculosis_H37Rv YPYYRRLRDEAPLYRNEERNFWAVSRHHDVLQGFRDS--TALSNAYGVSL
MAB_1216c|M.abscessus_ATCC_199 YPYYRRLRDEAPLYRNDDLKFWALSRHHDVLQGFRNS--EALSNANGVSM
MLBr_02088|M.leprae_Br4923 FPVYRALIDYGPMQLPG-MPLTVFSSFSDCDEALRHP--LSASDRLKATL
:* : . : . : .
Mvan_2007|M.vanbaalenii_PYR-1 VFNSHIYDSTIGLFIGPTILAMEGKTHWEHRNLVSAAFKTRSLARWEPEI
Mflv_4339|M.gilvum_PYR-GCK VFNSKIYDATIGLFIGPTILAMEGKPHWEHRNLVSAAFKTRSLARWEPEI
MSMEG_2240|M.smegmatis_MC2_155 TFNSKIYDSTIGLFIGPSILAMEGKTHRDHRNLVSAAFKSKSLARWEPEI
TH_2944|M.thermoresistible__bu VFSSALYDTTIGLFTGPTLLAMEGGTHRAHRNLISAAFKTKALARWEPSI
MMAR_4008|M.marinum_M AFTSKTYDKTIGLFMGPTILAMEGKQHRDHRNLVSAAFKSKALARWEPAV
MUL_3872|M.ulcerans_Agy99 AFTSKTYDKMIGLFMGPTILAMEGKQHRDHRNLVSAAFKSKALARWEPAV
MAV_1598|M.avium_104 VFSSKPYDKTIGLFMGPTILAMEGKKHRDHRNLVSAAFKSKALARWEPTI
Mb0789c|M.bovis_AF2122/97 DPSSRTS----EAYRVMSMLAMDDPAHLRMRTLVSKGFTPRRIRELEPQV
Rv0766c|M.tuberculosis_H37Rv DPSSRTS----EAYRVMSMLAMDDPAHLRMRTLVSKGFTPRRIRELEPQV
MAB_1216c|M.abscessus_ATCC_199 DKASFGP----HAKLVMSFLAMDDPEHLRLRALVSKGFTPRRIRELEGQV
MLBr_02088|M.leprae_Br4923 AQQAIAAGAEPRPFYASSFMFLDPPDHTRLRKLVSKAFAPKVVQALEGDI
: ::: :: * * *:* .* .: : * :
Mvan_2007|M.vanbaalenii_PYR-1 VRPVVNELIDEFIDDG--RADLVRDFTFEFPTRVISRLLGLPEEDLPWFR
Mflv_4339|M.gilvum_PYR-GCK VRPVVNGLIDEFIDRG--SADLVRDFTFEFPTRVISRLLGLPEDDLPWFR
MSMEG_2240|M.smegmatis_MC2_155 ARPICEALVDEFVDTG--SADLVRDYTFEFPTRVISKLLGLPEEDLPWFR
TH_2944|M.thermoresistible__bu VRPIVNALIDEFIDTG--TADLVRDFTFEFPTRVISRMLGLPEEDLPTFR
MMAR_4008|M.marinum_M IRPICNALIDDFIDAG--RAELVGDFTFEFPTRVIARLLGLPDEDLAMFH
MUL_3872|M.ulcerans_Agy99 IRPICNALIDDFIDAG--RAELVGDFTFEFPTRVIARLLGLPDEDLAMFH
MAV_1598|M.avium_104 VRPICNALIDDFIDAG--TADLVRQFTFEFPTRVIARLLGLPDEDLPMFH
Mb0789c|M.bovis_AF2122/97 LELARIHLDSALQTES---FDFVAEFAGKLPMDVISELIGVPDTDRARIR
Rv0766c|M.tuberculosis_H37Rv LELARIHLDSALQTES---FDFVAEFAGKLPMDVISELIGVPDTDRARIR
MAB_1216c|M.abscessus_ATCC_199 VALARTHLDRALANASDRSFDFIAEYAGKLPMDVISELMGVPESDRARIR
MLBr_02088|M.leprae_Br4923 AALVDSLLDKGAAAGQ---FDVIADLAFPLAVAVICRLLGVPYEDAPEFG
* :.: : : :. **..::*:* * . :
Mvan_2007|M.vanbaalenii_PYR-1 KRAVELIS-----YAVN------YKKAFEASAALKDYFLGQIDKRRSAPT
Mflv_4339|M.gilvum_PYR-GCK KRAVELIS-----YTIN------HKRAFEASAALKDYFLAQIEKRRCAPT
MSMEG_2240|M.smegmatis_MC2_155 RRAVELIS-----YSVK------YKRAFEASAALKDYFLDQIERRRSRPT
TH_2944|M.thermoresistible__bu RWAVQLIS-----YTVD------YQRAFEASAALKDYFLEQMESRRSKPT
MMAR_4008|M.marinum_M QRAVQLIS-----YTVN------YQLAFEASAALKEYFLEQIDRRRSKPS
MUL_3872|M.ulcerans_Agy99 QRAVQLIS-----YTVN------YQLAFEASAALKEYFLEQIDRRRSKPS
MAV_1598|M.avium_104 TRAVQLIS-----YHVD------YERAFEASAALKDYFLEQIEQRKSKPT
Mb0789c|M.bovis_AF2122/97 ALADAVLHREDGVADVP-------PPAMAASIELMRYYADLIAEFRRRPA
Rv0766c|M.tuberculosis_H37Rv ALADAVLHREDGVADVP-------PPAMAASIELMRYYADLIAEFRRRPA
MAB_1216c|M.abscessus_ATCC_199 ELADGVMHREDGLADVP-------PEAIQASFDLMTYYIEMVRERRRRPT
MLBr_02088|M.leprae_Br4923 RVSALLVQSVDPFITITGEPPEATEERLRAGVWLRDYLEQLVKCRRGTPG
: :: : : *. * * : : *
Mvan_2007|M.vanbaalenii_PYR-1 EDIIGDLVSAEIDGERLTDEAIFSFLRLLLPAGLETTFRSSGNLLYLLLT
Mflv_4339|M.gilvum_PYR-GCK DDIIGDLVSAEIDGEHLTDEAIFSFLRLLLPAGLETTYRSSGNLLYLLLT
MSMEG_2240|M.smegmatis_MC2_155 EDIIGDLVTAEIDGEKLTDEAIYSFLRLLLPAGLETTYRSSGNLLYLLLT
TH_2944|M.thermoresistible__bu DDMIGDLVTAEIDGEKLSDEAIYSFLRLLLPAGLETTYRSSGNLIYLLLT
MMAR_4008|M.marinum_M EDIIGDLVTAEIDGEKLSEEAIYSFLRLLLPAGLETTYRSSGNLLYLLLA
MUL_3872|M.ulcerans_Agy99 EDIIGDLVTAEIDGEKLSEEAIYSFLRLLLPAGLETTYRSSGNLLYLLLA
MAV_1598|M.avium_104 EDIIGDLVTAEIDGEKLSDEAIYSFLRLLLPAGLETTYRSSGNLLYLLLT
Mb0789c|M.bovis_AF2122/97 NNLTSALLAAELDGDRLSDQEIMAFLFLMVIAGNETTTKLLANAVYWAAH
Rv0766c|M.tuberculosis_H37Rv NNLTSALLAAELDGDRLSDQEIMAFLFLMVIAGNETTTKLLANAVYWAAH
MAB_1216c|M.abscessus_ATCC_199 EDLTSALLQAEIDGDRLTDEEVLAFLFLMVIAGNETTTKLLANAVYWGHR
MLBr_02088|M.leprae_Br4923 EDLISRLIELDESGDQLTEEEIIATCGLLLVAGHETTVNLIANAVLAMLR
::: . *: : .*::*::: : : *:: ** *** . .* :
Mvan_2007|M.vanbaalenii_PYR-1 HRDQFEAVNADHALIGAAIEEGLRYETPLTTVQRFANEDTEIDGVEIPAG
Mflv_4339|M.gilvum_PYR-GCK HRDQFDAVDADHELIGQAIEEGLRYETPLTTVQRFTTEDTELEGVPIPAG
MSMEG_2240|M.smegmatis_MC2_155 HPDQFAAVQNDHDLIGAAIEEGLRYETPLTTVQRSATKDTELEGVQIPAG
TH_2944|M.thermoresistible__bu HPEQFAAVAADPGLIPQAIEEGLRHETPLTTVQRLTTEDTELCGAAIPAG
MMAR_4008|M.marinum_M HPDQFMAVRAHRELIPQAIEEGLRFETPLTTVQRFTTKDTEVQGVPIPAR
MUL_3872|M.ulcerans_Agy99 HPDQFMAVRAHRELIPQAIEEGLRFETPLTTVQRFTTKDTEVQGVPIPAR
MAV_1598|M.avium_104 HPDQFAALQADRELLAPAIEEGLRFETPLTTVQRFTTEDTELHGVRIPAR
Mb0789c|M.bovis_AF2122/97 HPGQLARVFADHSRIPMWVEETLRYDTSSQILARTVAHDLTLYDTTIPEG
Rv0766c|M.tuberculosis_H37Rv HPGQLARVFADHSRIPMWVEETLRYDTSSQILARTVAHDLTLYDTTIPEG
MAB_1216c|M.abscessus_ATCC_199 NPDQLATVHADHDRIPLWVEESLRYDTSSQILARTVAEDITVYDTKIPAG
MLBr_02088|M.leprae_Br4923 NPSQWKALSSNPQRAPLVVEETLRYDPAIHLIGRVAAKDMTIGQTTLTEG
: * : . :** **.:.. : * . .* : . :.
Mvan_2007|M.vanbaalenii_PYR-1 SVIDVCIGSANRDESRWERAEQFDIFRTR-TPHISFAAGEHTCMGLHLAR
Mflv_4339|M.gilvum_PYR-GCK AVIDVCIGSANRDEKRWERSEEFDIFRKR-VPHLSFAAGEHTCMGLHLAR
MSMEG_2240|M.smegmatis_MC2_155 AVIDVCIGSANRDENRWERPEEFDIFRKR-IPHITFAAGEHTCMGLHLAR
TH_2944|M.thermoresistible__bu AVVDTCIGSANRDETRWDRPEEFDIFRDR-VPHLSFAAGEHTCMGLHLAR
MMAR_4008|M.marinum_M SVIGVCMGSANRDEHRWQRPEVFDIFRER-IPHISFAAGEHTCLGLHLAR
MUL_3872|M.ulcerans_Agy99 SVIGVCMGSANRDEHRWQRPEVFDIFRER-IPHISFAAGEHTCLGLHLAR
MAV_1598|M.avium_104 SVIGVCIGSANRDERRWERSEEFDIFRKH-VPHISFAAGEHTCLGLHLAR
Mb0789c|M.bovis_AF2122/97 EVLLLLPGSANRDDRVFDDPDDYRIGREIGCKLVSFGSGAHFCLGAHLAR
Rv0766c|M.tuberculosis_H37Rv EVLLLLPGSANRDDRVFDDPDDYRIGREIGCKLVSFGSGAHFCLGAHLAR
MAB_1216c|M.abscessus_ATCC_199 DILLLLPGSANRDDRVFDDADQYRIGREIGAKLVSFGSGAHFCLGAHLAR
MLBr_02088|M.leprae_Br4923 DTMVLLLAAANRDPAVYSRPDEFDPDRPS-SRHLAFAVGSHFCLGAALAR
: .:**** :. .: : * ::*. * * *:* ***
Mvan_2007|M.vanbaalenii_PYR-1 METRVAAETLLSRLSAIELLTDGDPHIHGQPFRSPTALPVTFTPSRARP
Mflv_4339|M.gilvum_PYR-GCK METRVAVETLLTRLSDIRLVTDDDPHIHGQPFRSPTALPVTFSPAAAK-
MSMEG_2240|M.smegmatis_MC2_155 METRVAMETLLNRVTDLRLIADDDPHIFGQPFRSPTAIPVTFRPAG---
TH_2944|M.thermoresistible__bu METRVALETLLSRVHDLRLVTDGDPHIFGQPFRSPTAIPVTFDPVR---
MMAR_4008|M.marinum_M LETRVALECLLDRLTNIDLATADDPHIHGQPFRSPTALPVTFEAVPT--
MUL_3872|M.ulcerans_Agy99 LETRVALECLLDRLTNIDLATADDPHIHGQPFRSPKALPVTFEAVPT--
MAV_1598|M.avium_104 LETRVAMECLLNRLTNVTLLSDGDPHIHGQPFRSPTALPVTFDAK----
Mb0789c|M.bovis_AF2122/97 MEARVALGALLRRIRNYEVDDDNVVRVHSSNVRGFAHLPISVQAR----
Rv0766c|M.tuberculosis_H37Rv MEARVALGALLRRIRNYEVDDDNVVRVHSSNVRGFAHLPISVQAR----
MAB_1216c|M.abscessus_ATCC_199 MEAKVALTELFTRISGYEIDERNSVRVHSSNVRGFAHLPMTVQLREGR-
MLBr_02088|M.leprae_Br4923 LEATVTLSAISARFPQVQLAG-ELVYKPNVAMRGMSALPVQV-------
:*: *: : *. : . .*. :*: .