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MRVDTPVQDVEMDGPIDLRDPYPMFARHRAEGGVFRGSVMDWSKTPESLMPEKLYAAVSFDAVNRVFRDG KVFNSKIYDATIGLFIGPTILAMEGKPHWEHRNLVSAAFKTRSLARWEPEIVRPVVNGLIDEFIDRGSAD LVRDFTFEFPTRVISRLLGLPEDDLPWFRKRAVELISYTINHKRAFEASAALKDYFLAQIEKRRCAPTDD IIGDLVSAEIDGEHLTDEAIFSFLRLLLPAGLETTYRSSGNLLYLLLTHRDQFDAVDADHELIGQAIEEG LRYETPLTTVQRFTTEDTELEGVPIPAGAVIDVCIGSANRDEKRWERSEEFDIFRKRVPHLSFAAGEHTC MGLHLARMETRVAVETLLTRLSDIRLVTDDDPHIHGQPFRSPTALPVTFSPAAAK
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_4339 | - | - | 100% (405) | cytochrome P450 |
| M. gilvum PYR-GCK | Mflv_4150 | - | 2e-97 | 50.13% (385) | cytochrome P450 |
| M. gilvum PYR-GCK | Mflv_2431 | - | 3e-44 | 34.81% (362) | cytochrome P450 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0789c | cyp123 | 3e-42 | 29.74% (390) | cytochrome P450 123 |
| M. tuberculosis H37Rv | Rv3518c | cyp142 | 6e-45 | 34.67% (323) | cytochrome P450 monooxygenase 142 |
| M. leprae Br4923 | MLBr_02088 | - | 2e-34 | 29.14% (326) | putative cytochrome p450 |
| M. abscessus ATCC 19977 | MAB_1216c | - | 6e-46 | 31.99% (397) | cytochrome P450 |
| M. marinum M | MMAR_4008 | cyp187A5 | 1e-166 | 71.68% (399) | cytochrome P450 187A5 Cyp187A5 |
| M. avium 104 | MAV_1598 | - | 1e-177 | 78.12% (384) | cytochrome P450 superfamily protein |
| M. smegmatis MC2 155 | MSMEG_2240 | - | 0.0 | 80.30% (401) | cytochrome P450 |
| M. thermoresistible (build 8) | TH_2944 | - | 1e-175 | 78.12% (384) | PUTATIVE cytochrome P450 |
| M. ulcerans Agy99 | MUL_3872 | cyp187A5 | 1e-166 | 71.43% (399) | cytochrome P450 187A5 Cyp187A5 |
| M. vanbaalenii PYR-1 | Mvan_2007 | - | 0.0 | 86.60% (403) | cytochrome P450 |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_4339|M.gilvum_PYR-GCK ---------------------------MRVDTPVQD-VEM-DGPIDLRDP
Mvan_2007|M.vanbaalenii_PYR-1 -----------------------------METPVQD-LAK-DEPIDLRDP
MSMEG_2240|M.smegmatis_MC2_155 -----------------------------MDSRIRDDPAV-DTAALLRDP
TH_2944|M.thermoresistible__bu ------------------------------------MTAA-KPAGYLRDP
MMAR_4008|M.marinum_M -----------------------------MTSPVHSVAGTGDQAVNPRNP
MUL_3872|M.ulcerans_Agy99 -----------------------------MTSPVHSVAGTGDQAVNPRNP
MAV_1598|M.avium_104 -----------------------------MTTNVPTAAGG--ETVSLRDP
Mb0789c|M.bovis_AF2122/97 --------------------------MTVRVGDPE-LVLDPYDYDFHEDP
MAB_1216c|M.abscessus_ATCC_199 --------------------------MTVAETSAVPLVFDPYDYDFHEDP
MLBr_02088|M.leprae_Br4923 MRTCVPTRTCVYAFIEYLSHNRPMGTNPPSLVEAQMLLLRLIDPGTRADP
Rv3518c|M.tuberculosis_H37Rv ------------------------------MTEAPDVDLADGNFYASREA
:.
Mflv_4339|M.gilvum_PYR-GCK YPMFARHRAEGGVFRGSVMDWSKTPESLMPEKLYAAVSFDAVNRVFRDGK
Mvan_2007|M.vanbaalenii_PYR-1 YPMFARRRAEGGVFRGSVMDWSRTPDSLRPENLYAAVSFDAVNRVFRDGK
MSMEG_2240|M.smegmatis_MC2_155 YPIFARYRAQAGVFRGSVMDWSKTPKELMPEHQYAAMSFDAVNTVFRDGK
TH_2944|M.thermoresistible__bu YPFFAERRRGSGVFHGTVIDYSRTPESLRPTDGYAAMSFDAVNRVLRDGR
MMAR_4008|M.marinum_M YPFFAQQRRRGGVFPGTVMDYSKTPASLRPRREFSAMSFAAVNTVFRDSR
MUL_3872|M.ulcerans_Agy99 YPFFAQQRRRGGVFPGTVMDYSKTPESLRPRREFSAMSFAAVNTVFRDSR
MAV_1598|M.avium_104 YPFFARKRREAGVFAGTVMDYSKTPESLMPKQEYSAVSFDAVNTVFRDGR
Mb0789c|M.bovis_AF2122/97 YPYYRRLRDEAPLYRNEERNFWAVSRHHDVLQGFRDS--TALSNAYGVSL
MAB_1216c|M.abscessus_ATCC_199 YPYYRRLRDEAPLYRNDDLKFWALSRHHDVLQGFRNS--EALSNANGVSM
MLBr_02088|M.leprae_Br4923 FPVYRALIDYGPMQLPG-MPLTVFSSFSDCDEALRHP--LSASDRLKATL
Rv3518c|M.tuberculosis_H37Rv RAAYRWMRANQPVFRDR-NGLAAASTYQAVIDAERQP--ELFSNAGGIRP
. : : . .
Mflv_4339|M.gilvum_PYR-GCK VFNSKIYDATIGLFIGPTILAMEGKPHWEHRNLVSAAFKTRSLARWEPEI
Mvan_2007|M.vanbaalenii_PYR-1 VFNSHIYDSTIGLFIGPTILAMEGKTHWEHRNLVSAAFKTRSLARWEPEI
MSMEG_2240|M.smegmatis_MC2_155 TFNSKIYDSTIGLFIGPSILAMEGKTHRDHRNLVSAAFKSKSLARWEPEI
TH_2944|M.thermoresistible__bu VFSSALYDTTIGLFTGPTLLAMEGGTHRAHRNLISAAFKTKALARWEPSI
MMAR_4008|M.marinum_M AFTSKTYDKTIGLFMGPTILAMEGKQHRDHRNLVSAAFKSKALARWEPAV
MUL_3872|M.ulcerans_Agy99 AFTSKTYDKMIGLFMGPTILAMEGKQHRDHRNLVSAAFKSKALARWEPAV
MAV_1598|M.avium_104 VFSSKPYDKTIGLFMGPTILAMEGKKHRDHRNLVSAAFKSKALARWEPTI
Mb0789c|M.bovis_AF2122/97 DPSSRTS----EAYRVMSMLAMDDPAHLRMRTLVSKGFTPRRIRELE-PQ
MAB_1216c|M.abscessus_ATCC_199 DKASFGP----HAKLVMSFLAMDDPEHLRLRALVSKGFTPRRIRELE-GQ
MLBr_02088|M.leprae_Br4923 AQQAIAAGAEPRPFYASSFMFLDPPDHTRLRKLVSKAFAPKVVQALE-GD
Rv3518c|M.tuberculosis_H37Rv DQPALPM-----------MIDMDDPAHLLRRKLVNAGFTRKRVKDKE-AS
: :: :: * * *:. .* : : *
Mflv_4339|M.gilvum_PYR-GCK VRPVVNGLIDEFIDRGS---ADLVRDFTFEFPTRVISRLLGLPEDDLPWF
Mvan_2007|M.vanbaalenii_PYR-1 VRPVVNELIDEFIDDGR---ADLVRDFTFEFPTRVISRLLGLPEEDLPWF
MSMEG_2240|M.smegmatis_MC2_155 ARPICEALVDEFVDTGS---ADLVRDYTFEFPTRVISKLLGLPEEDLPWF
TH_2944|M.thermoresistible__bu VRPIVNALIDEFIDTGT---ADLVRDFTFEFPTRVISRMLGLPEEDLPTF
MMAR_4008|M.marinum_M IRPICNALIDDFIDAGR---AELVGDFTFEFPTRVIARLLGLPDEDLAMF
MUL_3872|M.ulcerans_Agy99 IRPICNALIDDFIDAGR---AELVGDFTFEFPTRVIARLLGLPDEDLAMF
MAV_1598|M.avium_104 VRPICNALIDDFIDAGT---ADLVRQFTFEFPTRVIARLLGLPDEDLPMF
Mb0789c|M.bovis_AF2122/97 VLELARIHLDSALQTES---FDFVAEFAGKLPMDVISELIGVPDTDRARI
MAB_1216c|M.abscessus_ATCC_199 VVALARTHLDRALANASDRSFDFIAEYAGKLPMDVISELMGVPESDRARI
MLBr_02088|M.leprae_Br4923 IAALVDSLLDKGAAAGQ---FDVIADLAFPLAVAVICRLLGVPYEDAPEF
Rv3518c|M.tuberculosis_H37Rv IAALCDTLIDAVCERGE---CDFVRDLAAPLPMAVIGDMLGVRPEQRDMF
: :* :.: : : :. ** ::*: : :
Mflv_4339|M.gilvum_PYR-GCK RKRAVELISYT-----------INHKRAFEASAALKDYFLAQIEKRRCAP
Mvan_2007|M.vanbaalenii_PYR-1 RKRAVELISYA-----------VNYKKAFEASAALKDYFLGQIDKRRSAP
MSMEG_2240|M.smegmatis_MC2_155 RRRAVELISYS-----------VKYKRAFEASAALKDYFLDQIERRRSRP
TH_2944|M.thermoresistible__bu RRWAVQLISYT-----------VDYQRAFEASAALKDYFLEQMESRRSKP
MMAR_4008|M.marinum_M HQRAVQLISYT-----------VNYQLAFEASAALKEYFLEQIDRRRSKP
MUL_3872|M.ulcerans_Agy99 HQRAVQLISYT-----------VNYQLAFEASAALKEYFLEQIDRRRSKP
MAV_1598|M.avium_104 HTRAVQLISYH-----------VDYERAFEASAALKDYFLEQIEQRKSKP
Mb0789c|M.bovis_AF2122/97 RALADAVLHREDGVADVP-------PPAMAASIELMRYYADLIAEFRRRP
MAB_1216c|M.abscessus_ATCC_199 RELADGVMHREDGLADVP-------PEAIQASFDLMTYYIEMVRERRRRP
MLBr_02088|M.leprae_Br4923 GRVSALLVQSVDPFITITGEPPEATEERLRAGVWLRDYLEQLVKCRRGTP
Rv3518c|M.tuberculosis_H37Rv LRWSDDLVTFLSSHVSQED-----FQITMDAFAAYNDFTRATIAARRADP
: :: : * : : : *
Mflv_4339|M.gilvum_PYR-GCK TDDIIGDLVSAEIDGEHLTDEAIFSFLRLLLPAGLETTYRSSGNLLYLLL
Mvan_2007|M.vanbaalenii_PYR-1 TEDIIGDLVSAEIDGERLTDEAIFSFLRLLLPAGLETTFRSSGNLLYLLL
MSMEG_2240|M.smegmatis_MC2_155 TEDIIGDLVTAEIDGEKLTDEAIYSFLRLLLPAGLETTYRSSGNLLYLLL
TH_2944|M.thermoresistible__bu TDDMIGDLVTAEIDGEKLSDEAIYSFLRLLLPAGLETTYRSSGNLIYLLL
MMAR_4008|M.marinum_M SEDIIGDLVTAEIDGEKLSEEAIYSFLRLLLPAGLETTYRSSGNLLYLLL
MUL_3872|M.ulcerans_Agy99 SEDIIGDLVTAEIDGEKLSEEAIYSFLRLLLPAGLETTYRSSGNLLYLLL
MAV_1598|M.avium_104 TEDIIGDLVTAEIDGEKLSDEAIYSFLRLLLPAGLETTYRSSGNLLYLLL
Mb0789c|M.bovis_AF2122/97 ANNLTSALLAAELDGDRLSDQEIMAFLFLMVIAGNETTTKLLANAVYWAA
MAB_1216c|M.abscessus_ATCC_199 TEDLTSALLQAEIDGDRLTDEEVLAFLFLMVIAGNETTTKLLANAVYWGH
MLBr_02088|M.leprae_Br4923 GEDLISRLIELDESGDQLTEEEIIATCGLLLVAGHETTVNLIANAVLAML
Rv3518c|M.tuberculosis_H37Rv TDDLVSVLVSSEVDGERLSDDELVMETLLILIGGDETTRHTLSGGTEQLL
::: . *: : .*::*::: : *:: .* *** . ..
Mflv_4339|M.gilvum_PYR-GCK THRDQFDAVDADHELIGQAIEEGLRYETPLTTVQRFTTEDTELEGVPIPA
Mvan_2007|M.vanbaalenii_PYR-1 THRDQFEAVNADHALIGAAIEEGLRYETPLTTVQRFANEDTEIDGVEIPA
MSMEG_2240|M.smegmatis_MC2_155 THPDQFAAVQNDHDLIGAAIEEGLRYETPLTTVQRSATKDTELEGVQIPA
TH_2944|M.thermoresistible__bu THPEQFAAVAADPGLIPQAIEEGLRHETPLTTVQRLTTEDTELCGAAIPA
MMAR_4008|M.marinum_M AHPDQFMAVRAHRELIPQAIEEGLRFETPLTTVQRFTTKDTEVQGVPIPA
MUL_3872|M.ulcerans_Agy99 AHPDQFMAVRAHRELIPQAIEEGLRFETPLTTVQRFTTKDTEVQGVPIPA
MAV_1598|M.avium_104 THPDQFAALQADRELLAPAIEEGLRFETPLTTVQRFTTEDTELHGVRIPA
Mb0789c|M.bovis_AF2122/97 HHPGQLARVFADHSRIPMWVEETLRYDTSSQILARTVAHDLTLYDTTIPE
MAB_1216c|M.abscessus_ATCC_199 RNPDQLATVHADHDRIPLWVEESLRYDTSSQILARTVAEDITVYDTKIPA
MLBr_02088|M.leprae_Br4923 RNPSQWKALSSNPQRAPLVVEETLRYDPAIHLIGRVAAKDMTIGQTTLTE
Rv3518c|M.tuberculosis_H37Rv RNRDQWDLLQRDPSLLPGAIEEMLRWTAPVKNMCRVLTADTEFHGTALCA
: * : . :** ** .. : * * . . :
Mflv_4339|M.gilvum_PYR-GCK GAVIDVCIGSANRDEKRWERSEEFDIFRKR-VPHLSFAAGEHTCMGLHLA
Mvan_2007|M.vanbaalenii_PYR-1 GSVIDVCIGSANRDESRWERAEQFDIFRTR-TPHISFAAGEHTCMGLHLA
MSMEG_2240|M.smegmatis_MC2_155 GAVIDVCIGSANRDENRWERPEEFDIFRKR-IPHITFAAGEHTCMGLHLA
TH_2944|M.thermoresistible__bu GAVVDTCIGSANRDETRWDRPEEFDIFRDR-VPHLSFAAGEHTCMGLHLA
MMAR_4008|M.marinum_M RSVIGVCMGSANRDEHRWQRPEVFDIFRER-IPHISFAAGEHTCLGLHLA
MUL_3872|M.ulcerans_Agy99 RSVIGVCMGSANRDEHRWQRPEVFDIFRER-IPHISFAAGEHTCLGLHLA
MAV_1598|M.avium_104 RSVIGVCIGSANRDERRWERSEEFDIFRKH-VPHISFAAGEHTCLGLHLA
Mb0789c|M.bovis_AF2122/97 GEVLLLLPGSANRDDRVFDDPDDYRIGREIGCKLVSFGSGAHFCLGAHLA
MAB_1216c|M.abscessus_ATCC_199 GDILLLLPGSANRDDRVFDDADQYRIGREIGAKLVSFGSGAHFCLGAHLA
MLBr_02088|M.leprae_Br4923 GDTMVLLLAAANRDPAVYSRPDEFDPDRPS-SRHLAFAVGSHFCLGAALA
Rv3518c|M.tuberculosis_H37Rv GEKMMLLFESANFDEAVFCEPEKFDVQRNP-NSHLAFGFGTHFCLGNQLA
: :** * : .: : * ::*. * * *:* **
Mflv_4339|M.gilvum_PYR-GCK RMETRVAVETLLTRLSDIRLVTDDDPHIHGQP--FRSPTALPVTFSPAAA
Mvan_2007|M.vanbaalenii_PYR-1 RMETRVAAETLLSRLSAIELLTDGDPHIHGQP--FRSPTALPVTFTPSRA
MSMEG_2240|M.smegmatis_MC2_155 RMETRVAMETLLNRVTDLRLIADDDPHIFGQP--FRSPTAIPVTFRPAG-
TH_2944|M.thermoresistible__bu RMETRVALETLLSRVHDLRLVTDGDPHIFGQP--FRSPTAIPVTFDPVR-
MMAR_4008|M.marinum_M RLETRVALECLLDRLTNIDLATADDPHIHGQP--FRSPTALPVTFEAVPT
MUL_3872|M.ulcerans_Agy99 RLETRVALECLLDRLTNIDLATADDPHIHGQP--FRSPKALPVTFEAVPT
MAV_1598|M.avium_104 RLETRVAMECLLNRLTNVTLLSDGDPHIHGQP--FRSPTALPVTFDAK--
Mb0789c|M.bovis_AF2122/97 RMEARVALGALLRRIRNYEVDDDNVVRVHSSN--VRGFAHLPISVQAR--
MAB_1216c|M.abscessus_ATCC_199 RMEAKVALTELFTRISGYEIDERNSVRVHSSN--VRGFAHLPMTVQLREG
MLBr_02088|M.leprae_Br4923 RLEATVTLSAISARFPQVQLAG-ELVYKPNVA--MRGMSALPVQV-----
Rv3518c|M.tuberculosis_H37Rv RLELSLMTERVLRRLPDLRLVADDSVLPLRPANFVSGLESMPVVFTPSPP
*:* : : *. : . . :*: .
Mflv_4339|M.gilvum_PYR-GCK K-
Mvan_2007|M.vanbaalenii_PYR-1 RP
MSMEG_2240|M.smegmatis_MC2_155 --
TH_2944|M.thermoresistible__bu --
MMAR_4008|M.marinum_M --
MUL_3872|M.ulcerans_Agy99 --
MAV_1598|M.avium_104 --
Mb0789c|M.bovis_AF2122/97 --
MAB_1216c|M.abscessus_ATCC_199 R-
MLBr_02088|M.leprae_Br4923 --
Rv3518c|M.tuberculosis_H37Rv LG