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MEQLFDDLEDFGAFDDAVSGDVRDPYTELARLRREEPIQRLDTSGMPHEESKPVFIVYRHEDAQQMLRDN ETFSSAAVIAAFGPVLGERVMLGMDEPVHGRLRSLVSKAFSQKALARWEDELVGRVGNSLIDRFAGNGKA DLVKEFTFDYPSRIIAGLLGLPEQDYPQFQRWSISLLSWILNPQRGLAASAALCDYFAPILAARRTEPKD DLISGLAQAEIDGEKLEDEEIYSFLRLLLPAGVETTYRALGSLLLALLSDPEQLDAIRGDRSLLPQAIEE GVRWEPPLLTITRVATRDTELGGVPIPAGSTVMPMLGAANRQEDRYPDPDRFDIFRAPKSHLGWGHGVHV CLGMHLARLEMRTAVNLLLDRLPNLRLDPDADDPHIRGQVFRSPTSVPVLFDPQ
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_1274 | - | - | 100% (404) | cytochrome P450 superfamily protein |
| M. avium 104 | MAV_1598 | - | 6e-93 | 48.07% (389) | cytochrome P450 superfamily protein |
| M. avium 104 | MAV_1615 | - | 2e-87 | 45.08% (386) | cytochrome P450 superfamily protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0801 | cyp126 | 9e-51 | 36.78% (397) | cytochrome P450 126 |
| M. gilvum PYR-GCK | Mflv_4150 | - | 0.0 | 85.32% (402) | cytochrome P450 |
| M. tuberculosis H37Rv | Rv3518c | cyp142 | 2e-52 | 35.36% (379) | cytochrome P450 monooxygenase 142 |
| M. leprae Br4923 | MLBr_02088 | - | 3e-44 | 35.81% (296) | putative cytochrome p450 |
| M. abscessus ATCC 19977 | MAB_3825 | - | 4e-52 | 32.18% (404) | cytochrome P450 |
| M. marinum M | MMAR_4008 | cyp187A5 | 1e-92 | 47.34% (395) | cytochrome P450 187A5 Cyp187A5 |
| M. smegmatis MC2 155 | MSMEG_2240 | - | 5e-95 | 47.15% (386) | cytochrome P450 |
| M. thermoresistible (build 8) | TH_2944 | - | 1e-100 | 49.23% (390) | PUTATIVE cytochrome P450 |
| M. ulcerans Agy99 | MUL_3872 | cyp187A5 | 4e-92 | 47.09% (395) | cytochrome P450 187A5 Cyp187A5 |
| M. vanbaalenii PYR-1 | Mvan_2007 | - | 1e-92 | 45.74% (387) | cytochrome P450 |
CLUSTAL 2.0.9 multiple sequence alignment
MAV_1274|M.avium_104 ------------MEQLFDDLEDFGAFDDAVSGDVRDPYTELARLRREEPI
Mflv_4150|M.gilvum_PYR-GCK ------------MSQLFEDLEDFGSFDDAVSGDVRDPYPELARLRREEPI
MMAR_4008|M.marinum_M ------------MTSPVHSVAG--TGDQAVN--PRNPYPFFAQQRRRGGV
MUL_3872|M.ulcerans_Agy99 ------------MTSPVHSVAG--TGDQAVN--PRNPYPFFAQQRRRGGV
MSMEG_2240|M.smegmatis_MC2_155 ------------MDSRIRDDP---AVDTAAL--LRDPYPIFARYRAQAGV
Mvan_2007|M.vanbaalenii_PYR-1 ------------METPVQD-L---AKDEPID--LRDPYPMFARRRAEGGV
TH_2944|M.thermoresistible__bu ------------MT----------AAKPAGY--LRDPYPFFAERRRGSGV
Mb0801|M.bovis_AF2122/97 ------------MTTAAGLSG--IDLTDLDNFADGFPHHLFAIHRREAPV
Rv3518c|M.tuberculosis_H37Rv -----------------MTEAPDVDLADGNFYASREARAAYRWMRANQPV
MAB_3825|M.abscessus_ATCC_1997 ----------MATALSEIEEAGRVLADPAAYADELRLHAAMTLLRREQPV
MLBr_02088|M.leprae_Br4923 MRTCVPTRTCVYAFIEYLSHNRPMGTNPPSLVEAQMLLLRLIDPGTRADP
MAV_1274|M.avium_104 QR---LDTSGMPHEE-SKPVFIVYRHEDAQQMLRDNETFSSAA-----VI
Mflv_4150|M.gilvum_PYR-GCK QR---IDMSAMPGEE-GKPVFIVYRYEDAQQMLRDNVTFSSSG-----VI
MMAR_4008|M.marinum_M FPGTVMDYSKTPASLRPRREFSAMSFAAVNTVFRDSRAFTSKT-----YD
MUL_3872|M.ulcerans_Agy99 FPGTVMDYSKTPESLRPRREFSAMSFAAVNTVFRDSRAFTSKT-----YD
MSMEG_2240|M.smegmatis_MC2_155 FRGSVMDWSKTPKELMPEHQYAAMSFDAVNTVFRDGKTFNSKI-----YD
Mvan_2007|M.vanbaalenii_PYR-1 FRGSVMDWSRTPDSLRPENLYAAVSFDAVNRVFRDGKVFNSHI-----YD
TH_2944|M.thermoresistible__bu FHGTVIDYSRTPESLRPTDGYAAMSFDAVNRVLRDGRVFSSAL-----YD
Mb0801|M.bovis_AF2122/97 YWHRPTEHTPD-----GEGFWSVATYAETLEVLRDPVTYSSVT----GGQ
Rv3518c|M.tuberculosis_H37Rv FRD-------------RNGLAAASTYQAVIDAERQPELFSNAGGIRP-DQ
MAB_3825|M.abscessus_ATCC_1997 TKVITDDYRPFWAVTKHDDIMAVERDNALWINEPRPLLMNLEQEAELDKQ
MLBr_02088|M.leprae_Br4923 FPVYRALIDYGPMQLPGMPLTVFSSFSDCDEALRHPLSASDRLKATLAQQ
.
MAV_1274|M.avium_104 AAFG------PVLGERVMLGMDEPVHGRLRSLVSKAFSQKALARWEDELV
Mflv_4150|M.gilvum_PYR-GCK AAFG------PVLGERVMLGMDEPVHGRLRSLVSKAFSQKGLARWQDELV
MMAR_4008|M.marinum_M KTIG------LFMGP-TILAMEGKQHRDHRNLVSAAFKSKALARWEPAVI
MUL_3872|M.ulcerans_Agy99 KMIG------LFMGP-TILAMEGKQHRDHRNLVSAAFKSKALARWEPAVI
MSMEG_2240|M.smegmatis_MC2_155 STIG------LFIGP-SILAMEGKTHRDHRNLVSAAFKSKSLARWEPEIA
Mvan_2007|M.vanbaalenii_PYR-1 STIG------LFIGP-TILAMEGKTHWEHRNLVSAAFKTRSLARWEPEIV
TH_2944|M.thermoresistible__bu TTIG------LFTGP-TLLAMEGGTHRAHRNLISAAFKTKALARWEPSIV
Mb0801|M.bovis_AF2122/97 RRFGGTVLQDLPVAGQVLNMMDDPRHTRIRRLVSSGLTPRMIRRVEDDLR
Rv3518c|M.tuberculosis_H37Rv P------------ALPMMIDMDDPAHLLRRKLVNAGFTRKRVKDKEASIA
MAB_3825|M.abscessus_ATCC_1997 AAMG--------IELKTLVHIDDPKHRVLRAIGADWFRPKAMRDMKLRTD
MLBr_02088|M.leprae_Br4923 AIAAG--AEPRPFYASSFMFLDPPDHTRLRKLVSKAFAPKVVQALEGDIA
: :: * * : : : : :
MAV_1274|M.avium_104 GRVGNSLIDRFAGNGKADLVKEFTFDYPSRIIAGLLGLPEQDYPQFQRWS
Mflv_4150|M.gilvum_PYR-GCK GRVGNELIDRFQADGKADLVKQFTFDYPSRIIAGLLGLPEQDYPQFQRWS
MMAR_4008|M.marinum_M RPICNALIDDFIDAGRAELVGDFTFEFPTRVIARLLGLPDEDLAMFHQRA
MUL_3872|M.ulcerans_Agy99 RPICNALIDDFIDAGRAELVGDFTFEFPTRVIARLLGLPDEDLAMFHQRA
MSMEG_2240|M.smegmatis_MC2_155 RPICEALVDEFVDTGSADLVRDYTFEFPTRVISKLLGLPEEDLPWFRRRA
Mvan_2007|M.vanbaalenii_PYR-1 RPVVNELIDEFIDDGRADLVRDFTFEFPTRVISRLLGLPEEDLPWFRKRA
TH_2944|M.thermoresistible__bu RPIVNALIDEFIDTGTADLVRDFTFEFPTRVISRMLGLPEEDLPTFRRWA
Mb0801|M.bovis_AF2122/97 RRAR-GLLDGVEPGAPFDFVVEIAAELPMQMICILLGVPETDRHWLFEAV
Rv3518c|M.tuberculosis_H37Rv -ALCDTLIDAVCERGECDFVRDLAAPLPMAVIGDMLGVRPEQRDMFLRWS
MAB_3825|M.abscessus_ATCC_1997 ELANRYVNKLLEAGGSCDFAQDIAVHFPLYVIMSLLGIPESDFDRMLKLT
MLBr_02088|M.leprae_Br4923 -ALVDSLLDKGAAAGQFDVIADLAFPLAVAVICRLLGVPYEDAPEFGRVS
: . . :. : : . :* :**: : : .
MAV_1274|M.avium_104 ISLLSWI-----LNPQRGL------AASAALCDYFAPILAARRTEPKDDL
Mflv_4150|M.gilvum_PYR-GCK ISLLSWI-----LNPERGL------AAAAALCEYFAPILEARRTDPQDDL
MMAR_4008|M.marinum_M VQLISYT-----VNYQLAF------EASAALKEYFLEQIDRRRSKPSEDI
MUL_3872|M.ulcerans_Agy99 VQLISYT-----VNYQLAF------EASAALKEYFLEQIDRRRSKPSEDI
MSMEG_2240|M.smegmatis_MC2_155 VELISYS-----VKYKRAF------EASAALKDYFLDQIERRRSRPTEDI
Mvan_2007|M.vanbaalenii_PYR-1 VELISYA-----VNYKKAF------EASAALKDYFLGQIDKRRSAPTEDI
TH_2944|M.thermoresistible__bu VQLISYT-----VDYQRAF------EASAALKDYFLEQMESRRSKPTDDM
Mb0801|M.bovis_AF2122/97 EPGFDFR-----GSRRATMPRLNVEDAGSRLYTYALELIAGKRAEPADDM
Rv3518c|M.tuberculosis_H37Rv DDLVTFL-----SSHVSQEDFQITMDAFAAYNDFTRATIAARRADPTDDL
MAB_3825|M.abscessus_ATCC_1997 QELFGGDD----SEFQRGTTPEEQLMALLDFFGYFSGLTASRRQHPTDDL
MLBr_02088|M.leprae_Br4923 ALLVQSVDPFITITGEPPEATEERLRAGVWLRDYLEQLVKCRRGTPGEDL
. * : :* * :*:
MAV_1274|M.avium_104 ISGLAQAEID---GEKLEDEEIYSFLRLLLPAGVETTYRALGSLLLALLS
Mflv_4150|M.gilvum_PYR-GCK ISLLAEAEID---GEKLTDEEIFSFLRLLLPAGVETTYRSLGNLLFALLS
MMAR_4008|M.marinum_M IGDLVTAEID---GEKLSEEAIYSFLRLLLPAGLETTYRSSGNLLYLLLA
MUL_3872|M.ulcerans_Agy99 IGDLVTAEID---GEKLSEEAIYSFLRLLLPAGLETTYRSSGNLLYLLLA
MSMEG_2240|M.smegmatis_MC2_155 IGDLVTAEID---GEKLTDEAIYSFLRLLLPAGLETTYRSSGNLLYLLLT
Mvan_2007|M.vanbaalenii_PYR-1 IGDLVSAEID---GERLTDEAIFSFLRLLLPAGLETTFRSSGNLLYLLLT
TH_2944|M.thermoresistible__bu IGDLVTAEID---GEKLSDEAIYSFLRLLLPAGLETTYRSSGNLIYLLLT
Mb0801|M.bovis_AF2122/97 LSVVANATIDDPDAPALSDAELYLFFHLLFSAGAETTRNSIAGGLLALAE
Rv3518c|M.tuberculosis_H37Rv VSVLVSSEVD---GERLSDDELVMETLLILIGGDETTRHTLSGGTEQLLR
MAB_3825|M.abscessus_ATCC_1997 ASTIANARVD---GELLSDVDTASYYTIIATAGHDTTSATIAGGLEALLE
MLBr_02088|M.leprae_Br4923 ISRLIELDES---GDQLTEEEIIATCGLLLVAGHETTVNLIANAVLAMLR
. : . . * : :: .* :** .. :
MAV_1274|M.avium_104 DPEQLDAIRGDRSLLPQAIEEGVRWEPPLLTITRVATRDTELGGVPIPAG
Mflv_4150|M.gilvum_PYR-GCK DTAQLDAVRADRSLLPQAIEEGVRWNPPLLTITRTTTCDTELGGVPIPAG
MMAR_4008|M.marinum_M HPDQFMAVRAHRELIPQAIEEGLRFETPLTTVQRFTTKDTEVQGVPIPAR
MUL_3872|M.ulcerans_Agy99 HPDQFMAVRAHRELIPQAIEEGLRFETPLTTVQRFTTKDTEVQGVPIPAR
MSMEG_2240|M.smegmatis_MC2_155 HPDQFAAVQNDHDLIGAAIEEGLRYETPLTTVQRSATKDTELEGVQIPAG
Mvan_2007|M.vanbaalenii_PYR-1 HRDQFEAVNADHALIGAAIEEGLRYETPLTTVQRFANEDTEIDGVEIPAG
TH_2944|M.thermoresistible__bu HPEQFAAVAADPGLIPQAIEEGLRHETPLTTVQRLTTEDTELCGAAIPAG
Mb0801|M.bovis_AF2122/97 NPDQLQTLRSDFELLPTAIEEIVRWTSPSPSKRRTASRAVSLGGQPIEAG
Rv3518c|M.tuberculosis_H37Rv NRDQWDLLQRDPSLLPGAIEEMLRWTAPVKNMCRVLTADTEFHGTALCAG
MAB_3825|M.abscessus_ATCC_1997 HPDQLARLRENPGLMPLAVDEMIRWVTPVKEFMRTATADTEIRGVPITEG
MLBr_02088|M.leprae_Br4923 NPSQWKALSSNPQRAPLVVEETLRYDPAIHLIGRVAAKDMTIGQTTLTEG
. * : . .::* :* .. * . :
MAV_1274|M.avium_104 STVMPMLGAANRQEDRYPDPDRFDIFRAPKSHLGWGHGVHVCLGMHLARL
Mflv_4150|M.gilvum_PYR-GCK CSVLPMLGSTNRQEDRWEDPDEFNLFRAQKANLGWGYGVHVCLGMHLARL
MMAR_4008|M.marinum_M SVIGVCMGSANRDEHRWQRPEVFDIFRERIPHISFAAGEHTCLGLHLARL
MUL_3872|M.ulcerans_Agy99 SVIGVCMGSANRDEHRWQRPEVFDIFRERIPHISFAAGEHTCLGLHLARL
MSMEG_2240|M.smegmatis_MC2_155 AVIDVCIGSANRDENRWERPEEFDIFRKRIPHITFAAGEHTCMGLHLARM
Mvan_2007|M.vanbaalenii_PYR-1 SVIDVCIGSANRDESRWERAEQFDIFRTRTPHISFAAGEHTCMGLHLARM
TH_2944|M.thermoresistible__bu AVVDTCIGSANRDETRWDRPEEFDIFRDRVPHLSFAAGEHTCMGLHLARM
Mb0801|M.bovis_AF2122/97 QKVVVWEGSANRDPSVFDRADEFDITRKPNPHLGFGQGVHYCLGANLARL
Rv3518c|M.tuberculosis_H37Rv EKMMLLFESANFDEAVFCEPEKFDVQRNPNSHLAFGFGTHFCLGNQLARL
MAB_3825|M.abscessus_ATCC_1997 ESVLLSYPSGNRDEDIFTDPFTFDIARDPNKHLAFGFGVHFCLGAALARM
MLBr_02088|M.leprae_Br4923 DTMVLLLAAANRDPAVYSRPDEFDPDRPSSRHLAFAVGSHFCLGAALARL
: : * : : . *: * :: :. * * *:* ***:
MAV_1274|M.avium_104 EMRTAVNLLLDRLPNLRLDPDADDPHIRGQVFRS-PTSVPVLFDPQ----
Mflv_4150|M.gilvum_PYR-GCK EMRTAVNLLLDRLPGLRLDPDGDDPHIRGQVFRS-PTSLPVLFDAVGSDA
MMAR_4008|M.marinum_M ETRVALECLLDRLTNIDLATA-DDPHIHGQPFRS-PTALPVTFEAVPT--
MUL_3872|M.ulcerans_Agy99 ETRVALECLLDRLTNIDLATA-DDPHIHGQPFRS-PKALPVTFEAVPT--
MSMEG_2240|M.smegmatis_MC2_155 ETRVAMETLLNRVTDLRLIAD-DDPHIFGQPFRS-PTAIPVTFRPAG---
Mvan_2007|M.vanbaalenii_PYR-1 ETRVAAETLLSRLSAIELLTD-GDPHIHGQPFRS-PTALPVTFTPSRARP
TH_2944|M.thermoresistible__bu ETRVALETLLSRVHDLRLVTD-GDPHIFGQPFRS-PTAIPVTFDPVR---
Mb0801|M.bovis_AF2122/97 ELRVLFEELLSRFGSVRVVEP--AEWTRSNRHTG-IRHLVVELRGG----
Rv3518c|M.tuberculosis_H37Rv ELSLMTERVLRRLPDLRLVADDSVLPLRPANFVSGLESMPVVFTPSPPLG
MAB_3825|M.abscessus_ATCC_1997 EVNSFFSALLPRLESIEVDGN---IERTSTIFVGGIKHLPIRYTLR----
MLBr_02088|M.leprae_Br4923 EATVTLSAISARFPQVQLAGE--LVYKPNVAMRG-MSALPVQV-------
* . : *. : : . : :