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TDHPDADGIDFETVDYFTDAALVPDPYPYFDHLRSKCPVTQATPFNVLAVTGYTEALSVYKNPAFSSCNS VAGPFSGMPFGPGESDDVTDLIEQHRAAVPMAEHITSQDPPLHTRTRGLLSRLITPKRLKENEDFMWRLA DRQLDTFIGRGSAEFLTDYAKPFSLLVIADLLGVPAEDHEQFKAVFAGETVGELGKEAPTTHNPLQWLND KFHAYIEDRRREPRDDVLTELAQAKHEDGSTPDIEDVMNLSTFLFAAGTETTTKLVSSAVRFIADNPGYE AMLRRDRSKIPAFLEETLRLESPVKSHFRMAATSTTIGDVDVPAGTTVMVLPGACNRDARKFADPNSFRP DRQNVREQIAFIRGAHSCPGAPLARAEGRISLERILDRMQDITISEDHHGPAGDRRYAYEPTFIMRGLSE LHITFTEKEH*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_4149 | - | - | 100% (431) | cytochrome P450 |
| M. gilvum PYR-GCK | Mflv_2517 | - | e-152 | 61.88% (425) | cytochrome P450 |
| M. gilvum PYR-GCK | Mflv_1587 | - | e-126 | 52.48% (423) | cytochrome P450 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0789c | cyp123 | 1e-42 | 31.03% (377) | cytochrome P450 123 |
| M. tuberculosis H37Rv | Rv0766c | cyp123 | 1e-42 | 31.03% (377) | cytochrome P450 123 |
| M. leprae Br4923 | MLBr_02088 | - | 4e-38 | 32.10% (324) | putative cytochrome p450 |
| M. abscessus ATCC 19977 | MAB_1216c | - | 2e-43 | 31.93% (379) | cytochrome P450 |
| M. marinum M | MMAR_4694 | cyp150A6 | 1e-149 | 59.67% (419) | cytochrome P450 150A6 Cyp150A6 |
| M. avium 104 | MAV_0964 | - | 1e-147 | 59.48% (422) | cytochrome p450 |
| M. smegmatis MC2 155 | MSMEG_4780 | - | 1e-154 | 62.76% (427) | cytochrome p450 |
| M. thermoresistible (build 8) | TH_2718 | - | 0.0 | 80.82% (417) | PUTATIVE cytochrome P450 |
| M. ulcerans Agy99 | MUL_0314 | cyp150A6 | 1e-146 | 58.95% (419) | cytochrome P450 150A6 Cyp150A6 |
| M. vanbaalenii PYR-1 | Mvan_4141 | - | 1e-150 | 61.65% (425) | cytochrome P450 |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_4149|M.gilvum_PYR-GCK -----------------------MTDHPDADGIDFETVDYFTDAALVPDP
TH_2718|M.thermoresistible__bu -------------------------------VTDFDTVDFFTDESLVGDP
MSMEG_4780|M.smegmatis_MC2_155 -------------------MTDSTATDPAATTPDFDTVDYFTDQSLVPDP
Mvan_4141|M.vanbaalenii_PYR-1 -------------------------------MSDFDTIDYFTDPSLVPDP
MMAR_4694|M.marinum_M -------------------------------MSSYESIDFFTDPSLIPDP
MUL_0314|M.ulcerans_Agy99 -------------------------------MSSYESIDFFTDPSLIPDP
MAV_0964|M.avium_104 -------------------------------MSNFDSIDFFTDPSLVPDP
Mb0789c|M.bovis_AF2122/97 --------------------------MTVRVGDPE-LVLDPYDYDFHEDP
Rv0766c|M.tuberculosis_H37Rv --------------------------MTVRVGDPE-LVLDPYDYDFHEDP
MAB_1216c|M.abscessus_ATCC_199 --------------------------MTVAETSAVPLVFDPYDYDFHEDP
MLBr_02088|M.leprae_Br4923 MRTCVPTRTCVYAFIEYLSHNRPMGTNPPSLVEAQMLLLRLIDPGTRADP
: * **
Mflv_4149|M.gilvum_PYR-GCK YPYFDHLRSKCPVTQATPFNVLAVTGYTEALSVYKNP-AFSSCNSVAGPF
TH_2718|M.thermoresistible__bu YSYFEHLRSKCPVVEATPHKVLAVTGYEEALEVYRNP-AFSSCVSVAGPF
MSMEG_4780|M.smegmatis_MC2_155 HPYFDHLRSKCPVVREPHYGVLAITSFEEATTVLKDTETFSSCIAVGGPF
Mvan_4141|M.vanbaalenii_PYR-1 HPYFDHLRSKCPVVREPHYGVLAVTGYEEAATVLKDSDTFSSCIAVAGPF
MMAR_4694|M.marinum_M HPYFDYLRSQSPVLRLPQYGVVAVTGYEEATAVYKDTDSFSNCVALGGPF
MUL_0314|M.ulcerans_Agy99 HPYFDYLRRQSPVLRLPQYGVVAVTGYEEATAVYKDTDSFSNCVALGGPF
MAV_0964|M.avium_104 HPYFDYLRSQNPVLRLPHYGVVAITGYEEATEVYKDPETFSNIVALGGPF
Mb0789c|M.bovis_AF2122/97 YPYYRRLRDEAPLYRNEERNFWAVSRHHDVLQGFRDSTALSNAYGVSLDP
Rv0766c|M.tuberculosis_H37Rv YPYYRRLRDEAPLYRNEERNFWAVSRHHDVLQGFRDSTALSNAYGVSLDP
MAB_1216c|M.abscessus_ATCC_199 YPYYRRLRDEAPLYRNDDLKFWALSRHHDVLQGFRNSEALSNANGVSMDK
MLBr_02088|M.leprae_Br4923 FPVYRALIDYGPMQLPG-MPLTVFSSFSDCDEALRHPLSASDRLKATLAQ
.. : * *: . ..: . : :.. : *.
Mflv_4149|M.gilvum_PYR-GCK SGMPFGPGESDDVTDLIEQHRAAVPMAEHITSQDPPLHTRTRGLLSRLIT
TH_2718|M.thermoresistible__bu SGMPFGPDGRDDVSDLIEQYRDGVPMAEHITSQDPPLHTRTRGLLNKLIT
MSMEG_4780|M.smegmatis_MC2_155 PPLPFTPEG-DDITGQIEQHRTQLPMFEHMVTMDPPEHTNARSLLNRLLT
Mvan_4141|M.vanbaalenii_PYR-1 PPLPFTPEG-DDITGQIAAHRSQMPMFEHMVTMDPPDHTNARSLLNRLLT
MMAR_4694|M.marinum_M PPLPFAPNG-DDVNAQIDAHREQFPMYEHMVTMDPPEHSRARSILSRLLT
MUL_0314|M.ulcerans_Agy99 PPLPFTPNG-DDVNAQIDAHREQFPMYEHMVTMDPPEHSRARSILSRLLT
MAV_0964|M.avium_104 PPLPFTPEG-DDISAQIDAHRSSFPMFEHMVTMDPPEHTKARSVLAKLLT
Mb0789c|M.bovis_AF2122/97 SSRTS-----------------EAYRVMSMLAMDDPAHLRMRTLVSKGFT
Rv0766c|M.tuberculosis_H37Rv SSRTS-----------------EAYRVMSMLAMDDPAHLRMRTLVSKGFT
MAB_1216c|M.abscessus_ATCC_199 ASFGP-----------------HAKLVMSFLAMDDPEHLRLRALVSKGFT
MLBr_02088|M.leprae_Br4923 QAIAAGAEP-------------RPFYASSFMFLDPPDHTRLRKLVSKAFA
: * * * . * :: : ::
Mflv_4149|M.gilvum_PYR-GCK PKRLKENEDFMWRLADRQLDTFIGR---GSAEFLTDYAKPFSLLVIADLL
TH_2718|M.thermoresistible__bu PKRLKENEEFMWRLADQQLDRFLDR---GSAEFLEDYAKPFSLLVIADLL
MSMEG_4780|M.smegmatis_MC2_155 PKRLKENEDFMWRLADECLDDFIDD---GSCEFLKQYAKPFSLLVIADLL
Mvan_4141|M.vanbaalenii_PYR-1 PSRLKENEDFMWRLADEVLDDIISRDPVGRCEFLSAYAKPFSLLVIADML
MMAR_4694|M.marinum_M PSRLKQNEEFMWRLADRQLDEFLGA---GECEFISEYAKPFATLVIADLL
MUL_0314|M.ulcerans_Agy99 PSRLKQNEEFMWRLADRQLDEFLGA---AECEFISEYAKPFATLVIADLL
MAV_0964|M.avium_104 PSRLKQNEEFMWRLADRQLDEFLHN---GECEFIAEYSKPFATLVIADLL
Mb0789c|M.bovis_AF2122/97 PRRIRELEPQVLELARIHLDSALQTES---FDFVAEFAGKLPMDVISELI
Rv0766c|M.tuberculosis_H37Rv PRRIRELEPQVLELARIHLDSALQTES---FDFVAEFAGKLPMDVISELI
MAB_1216c|M.abscessus_ATCC_199 PRRIRELEGQVVALARTHLDRALANASDRSFDFIAEYAGKLPMDVISELM
MLBr_02088|M.leprae_Br4923 PKVVQALEGDIAALVDSLLDKGAAAGQ---FDVIADLAFPLAVAVICRLL
* :: * : *. ** :.: : :. **. ::
Mflv_4149|M.gilvum_PYR-GCK GVPAEDHEQFKAVFAG----ETVGELGKE-----APTTHNPLQWLNDKFH
TH_2718|M.thermoresistible__bu GVPAADHEEFKAAFAL----ETVGELGKD-----APTSHNPLEWLNDKFR
MSMEG_4780|M.smegmatis_MC2_155 GVPEEDHDEFRHVLGAPRPGAIVGSLDG------DQLAMNPLAWLDDKFV
Mvan_4141|M.vanbaalenii_PYR-1 GVPEADHEEFRTVLGAPRPGANVGSLDHS-----DLVGANPLEWLDEKFI
MMAR_4694|M.marinum_M GVPEDDRKDFRVVLGADRMG-RVGALDH------ESVGVNPLQWLDDKFS
MUL_0314|M.ulcerans_Agy99 GVPEDDRKDFRVVLGADRMG-RVGALDH------ESVGVNPLQWLDDKFS
MAV_0964|M.avium_104 GVPEEDHTQFRTVLGADRPGARVGALDH------ETVGINPLEWLDDKFC
Mb0789c|M.bovis_AF2122/97 GVPDTDRARIRALADAVLHREDGVADVP-------PPAMAASIELMRYYA
Rv0766c|M.tuberculosis_H37Rv GVPDTDRARIRALADAVLHREDGVADVP-------PPAMAASIELMRYYA
MAB_1216c|M.abscessus_ATCC_199 GVPESDRARIRELADGVMHREDGLADVP-------PEAIQASFDLMTYYI
MLBr_02088|M.leprae_Br4923 GVPYEDAPEFGRVSALLVQSVDPFITITGEPPEATEERLRAGVWLRDYLE
*** * : . *
Mflv_4149|M.gilvum_PYR-GCK AYIEDRRREPRDDVLTELAQAKHEDGSTPDIEDVMNLSTFLFAAGTETTT
TH_2718|M.thermoresistible__bu AYIEDRRRAPRADVLTELAHARYEDGSTPDIDDVMNVSTFLFAAGTETTT
MSMEG_4780|M.smegmatis_MC2_155 RYLEDRRKEPRDDVLTALATAKYPDGSTPEVIDVVRSATFLFAAGQETTT
Mvan_4141|M.vanbaalenii_PYR-1 GYLEDRRKEPRDDVLTALATAKYPDGSTPPVIEVVRSATFLFAAGQETTT
MMAR_4694|M.marinum_M AYIEDRRRQPRNDVLTALATATYPDGSTPEVIDVVRSATFLFAAGQETTA
MUL_0314|M.ulcerans_Agy99 AYIEDRRRRPRNDVLTALATATYPDGSTPEIIDVVRWATFLFAAGQETTA
MAV_0964|M.avium_104 NYIEERRREPRADVLTFLAEAKYPDGSTPPVIEVVRSATFLFAAGQETTA
Mb0789c|M.bovis_AF2122/97 DLIAEFRRRPANNLTSALLAAEL-DGDRLSDQEIMAFLFLMVIAGNETTT
Rv0766c|M.tuberculosis_H37Rv DLIAEFRRRPANNLTSALLAAEL-DGDRLSDQEIMAFLFLMVIAGNETTT
MAB_1216c|M.abscessus_ATCC_199 EMVRERRRRPTEDLTSALLQAEI-DGDRLTDEEVLAFLFLMVIAGNETTT
MLBr_02088|M.leprae_Br4923 QLVKCRRGTPGEDLISRLIELDE-SGDQLTEEEIIATCGLLLVAGHETTV
: * * :: : * .*. ::: ::. ** ***.
Mflv_4149|M.gilvum_PYR-GCK KLVSSAVRFIADNPGYEAMLRRDRSKIPAFLEETLRLESPVKSHFRMAAT
TH_2718|M.thermoresistible__bu KLVSFAVRSIAEDQRLQQELRADRSRIPAFLEETLRMESPVKAHFRMART
MSMEG_4780|M.smegmatis_MC2_155 KLLSASLRVLGDRPDIQQALREDRSRIPTFVEEALRMDAPVKSQFRLAKK
Mvan_4141|M.vanbaalenii_PYR-1 KLLSASLRVLGDHPDIQERLRRDRSRIPIFVEEALRMDAPVKSQFRLAKK
MMAR_4694|M.marinum_M KLLTAAMRVLGDRPDIQRRLRENRSLIPNFIEESLRMDSPVKSDSRLARK
MUL_0314|M.ulcerans_Agy99 KQLTAAMRVLGDRPDIQRQLRENRSLIPNFIEESLRMDSPVKSDSRLARK
MAV_0964|M.avium_104 KLLSAALQVLGDRPDIQQQLREDRSLIPAFIEESLRMESPVKSDSRLARR
Mb0789c|M.bovis_AF2122/97 KLLANAVYWAAHHPGQLARVFADHSRIPMWVEETLRYDTSSQILARTVAH
Rv0766c|M.tuberculosis_H37Rv KLLANAVYWAAHHPGQLARVFADHSRIPMWVEETLRYDTSSQILARTVAH
MAB_1216c|M.abscessus_ATCC_199 KLLANAVYWGHRNPDQLATVHADHDRIPLWVEESLRYDTSSQILARTVAE
MLBr_02088|M.leprae_Br4923 NLIANAVLAMLRNPSQWKALSSNPQRAPLVVEETLRYDPAIHLIGRVAAK
: :: :: : : . * :**:** :.. : * .
Mflv_4149|M.gilvum_PYR-GCK STTIGDVDVPAGTTVMVLPGACNRDARKFADPNSFRPDRQNVREQIAFIR
TH_2718|M.thermoresistible__bu TTTIGDVKVPAGTTIMLLPGACNRDPRKFIDPDSFRPDRPNVREQIAFIR
MSMEG_4780|M.smegmatis_MC2_155 TTQLGGVDVPAGTTLMVCPGAVNRDPVRFEDPHTFSLDRKNVREHIAFGR
Mvan_4141|M.vanbaalenii_PYR-1 NTRVGDMDVPAGTTMMVCPGAVNRDPSRFEHPHEFDLDRKNVREHIAFGR
MMAR_4694|M.marinum_M RTTVGGLDIAAGTVVMVLPGAANRDPRRFEDPHEFRLDRPNVREHMAFAR
MUL_0314|M.ulcerans_Agy99 RTTVGGLDIAAGTVVMVLSGAANRDPRRFEDPHEFRLDRPNVREHMAFAR
MAV_0964|M.avium_104 ATTIGGVDIPAGTVVMILPGAANRDPRRFENPHEFDLRRKNVREHMAFAR
Mb0789c|M.bovis_AF2122/97 DLTLYDTTIPEGEVLLLLPGSANRDDRVFDDPDDYRIGREIGCKLVSFGS
Rv0766c|M.tuberculosis_H37Rv DLTLYDTTIPEGEVLLLLPGSANRDDRVFDDPDDYRIGREIGCKLVSFGS
MAB_1216c|M.abscessus_ATCC_199 DITVYDTKIPAGDILLLLPGSANRDDRVFDDADQYRIGREIGAKLVSFGS
MLBr_02088|M.leprae_Br4923 DMTIGQTTLTEGDTMVLLLAAANRDPAVYSRPDEFDPDRPS-SRHLAFAV
: :. * ::: .: *** : .. : * . ::*
Mflv_4149|M.gilvum_PYR-GCK GAHSCPGAPLARAEGRISLERILDRMQDITISEDHHGPAGDRRYAYEPTF
TH_2718|M.thermoresistible__bu GPHSCPGAPLARAEGRISLNRILDRMTDIRISQAHHGPAEHRRYTYEPTF
MSMEG_4780|M.smegmatis_MC2_155 GVHSCPGGPLARVEGRVSLERILDRMADIRIDEEHHGPADNRRYTYEPTY
Mvan_4141|M.vanbaalenii_PYR-1 GVHSCPGGPLARVEGRVSIERILDRMGDIAIDEELHGPPGARRYNYEPTF
MMAR_4694|M.marinum_M GVHSCPGGPLARVEGRVSLERILDRMLDIAINEDRHGPADDRRYTYEPTY
MUL_0314|M.ulcerans_Agy99 GVHSCPGGPLARVEGRVSLERILDRMLDIAINEDRHGPADDRRYTYEPTY
MAV_0964|M.avium_104 GVHSCPGGPLARVEGRVSIERILDRMPHIEINETHHGPAGDRRYTYEPTY
Mb0789c|M.bovis_AF2122/97 GAHFCLGAHLARMEARVALGALLRRIRNYEVDDD--------NVVRVHSS
Rv0766c|M.tuberculosis_H37Rv GAHFCLGAHLARMEARVALGALLRRIRNYEVDDD--------NVVRVHSS
MAB_1216c|M.abscessus_ATCC_199 GAHFCLGAHLARMEAKVALTELFTRISGYEIDER--------NSVRVHSS
MLBr_02088|M.leprae_Br4923 GSHFCLGAALARLEATVTLSAISARFPQVQLAG---------ELVYKPNV
* * * *. *** *. ::: : *: : . .
Mflv_4149|M.gilvum_PYR-GCK IMRGLSELHITFTEKEH-----
TH_2718|M.thermoresistible__bu IMRGLNELHIEFSPGS------
MSMEG_4780|M.smegmatis_MC2_155 ILRGLTDLHIKFEPVR------
Mvan_4141|M.vanbaalenii_PYR-1 ILRGLTDLNITFTPVR------
MMAR_4694|M.marinum_M ILRGLTELHITFTPAG------
MUL_0314|M.ulcerans_Agy99 ILRGLTELHITFTPAG------
MAV_0964|M.avium_104 ILRGLSELHLTFTTADAVAPVG
Mb0789c|M.bovis_AF2122/97 NVRGFAHLPISVQAR-------
Rv0766c|M.tuberculosis_H37Rv NVRGFAHLPISVQAR-------
MAB_1216c|M.abscessus_ATCC_199 NVRGFAHLPMTVQLREGR----
MLBr_02088|M.leprae_Br4923 AMRGMSALPVQV----------
:**: * : .