For questions or suggestions e-mail us at: ioerger@cs.tamu.edu

M. gilvum PYR-GCK Mflv_2517 (-)

annotation: cytochrome P450
coordinates: 2617579 - 2618868
length: 429

TDFDTIDYFTDPSLVPDPHPYFDHLRSKCPVVKEPHYGVLAVTGYEEAATVLKDSDTFSSCIAVAGPFPP
LPFTPEGDDITDQITAHRPQMPMFEHMVTMDPPDHTNARSLLNRLLTPSRLKENEDFMWRLADEVLDDII
GAEPAGRCEFLTAYAKPFSLLVIADMLGVPEADHEEFRTVLGAPRPGANVGSLDHSDLVGANPLEWLDEK
FIGYLEDRRKEPRDDVLTALATAKYPDGSTPPVIEVVRSATFLFAAGQETTTKLLSASMRVLGDHPEIQE
RLRRDRTRIPIFIEEALRMDAPVKSQFRLAKKNTKVGDMDVPAGTTMMVCPGAVNRDPSRFENPHDFDLD
RKNVREHIAFGRGVHSCPGGPLARVEGRVSIERILDRMGDIAIDEELHGPPGDRRYNYEPTFILRGLTDI
NITFTPIR*
Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. gilvum PYR-GCKMflv_2517--100% (429)cytochrome P450
M. gilvum PYR-GCKMflv_1587-e-15660.89% (427) cytochrome P450
M. gilvum PYR-GCKMflv_4149-e-15261.88% (425) cytochrome P450

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb1806cyp1444e-4029.82% (389) cytochrome p450 144 CYP144
M. tuberculosis H37RvRv1880ccyp1401e-3930.17% (421) cytochrome p450 140 CYP140
M. leprae Br4923MLBr_02088-8e-3329.43% (333) putative cytochrome p450
M. abscessus ATCC 19977MAB_1216c-2e-3826.32% (399) cytochrome P450
M. marinum MMMAR_4694cyp150A60.070.73% (427) cytochrome P450 150A6 Cyp150A6
M. avium 104MAV_0964-0.071.60% (426) cytochrome p450
M. smegmatis MC2 155MSMEG_4780-0.081.97% (427) cytochrome p450
M. thermoresistible (build 8)TH_4542-0.072.60% (427) PUTATIVE cytochrome P450
M. ulcerans Agy99MUL_0314cyp150A61e-17969.32% (427) cytochrome P450 150A6 Cyp150A6
M. vanbaalenii PYR-1Mvan_4141-0.095.34% (429) cytochrome P450

CLUSTAL 2.0.9 multiple sequence alignment


Mflv_2517|M.gilvum_PYR-GCK          -------------------------------MTDFDTIDYFTDPSLVPDP
Mvan_4141|M.vanbaalenii_PYR-1       -------------------------------MSDFDTIDYFTDPSLVPDP
MSMEG_4780|M.smegmatis_MC2_155      -------------------MTDSTATDPAATTPDFDTVDYFTDQSLVPDP
TH_4542|M.thermoresistible__bu      ------------------------------MTTDFDSIDYFTDPSLVPDP
MMAR_4694|M.marinum_M               -------------------------------MSSYESIDFFTDPSLIPDP
MUL_0314|M.ulcerans_Agy99           -------------------------------MSSYESIDFFTDPSLIPDP
MAV_0964|M.avium_104                -------------------------------MSNFDSIDFFTDPSLVPDP
Rv1880c|M.tuberculosis_H37Rv        ---------MKDKLHWLAMHGVIRGIAAIGIRRGDLQARLIADPAVATDP
MLBr_02088|M.leprae_Br4923          MRTCVPTRTCVYAFIEYLSHNRPMGTNPPSLVEAQMLLLRLIDPGTRADP
MAB_1216c|M.abscessus_ATCC_199      --------------------------MTVAETSAVPLVFDPYDYDFHEDP
Mb1806|M.bovis_AF2122/97            -MRRSPKGSPGAVLDLQRRVDQAVSADHAELMTIAKDANTFFGAESVQDP
                                                                              .     **

Mflv_2517|M.gilvum_PYR-GCK          HPYFDHLRSKCPVVKEPHYGVLAVTGYEEAATVLKDSDTFSSCIAVAGPF
Mvan_4141|M.vanbaalenii_PYR-1       HPYFDHLRSKCPVVREPHYGVLAVTGYEEAATVLKDSDTFSSCIAVAGPF
MSMEG_4780|M.smegmatis_MC2_155      HPYFDHLRSKCPVVREPHYGVLAITSFEEATTVLKDTETFSSCIAVGGPF
TH_4542|M.thermoresistible__bu      HPYFDHMRSKCPIAREPHHGVIAVTGWEEANDVYRDSENLSSCIAVMGPF
MMAR_4694|M.marinum_M               HPYFDYLRSQSPVLRLPQYGVVAVTGYEEATAVYKDTDSFSNCVALGGPF
MUL_0314|M.ulcerans_Agy99           HPYFDYLRRQSPVLRLPQYGVVAVTGYEEATAVYKDTDSFSNCVALGGPF
MAV_0964|M.avium_104                HPYFDYLRSQNPVLRLPHYGVVAITGYEEATEVYKDPETFSNIVALGGPF
Rv1880c|M.tuberculosis_H37Rv        VPFYDEVRSHGALVRN-------RANYLTVDHRLAHDLLRSDDFRVV--S
MLBr_02088|M.leprae_Br4923          FPVYRALIDYGPMQLPG-MPLTVFSSFSDCDEALRHPLSASDRLKAT--L
MAB_1216c|M.abscessus_ATCC_199      YPYYRRLRDEAPLYRNDDLKFWALSRHHDVLQGFRNSEALSNANGVS--M
Mb1806|M.bovis_AF2122/97            YPLYERMRAAGSVHRIANSDFYAVCGWDAVNEAIGRPEDFSSNLTATMTY
                                     * :  :    .:                           *.        

Mflv_2517|M.gilvum_PYR-GCK          PPLPFTPEGDDITDQITAHRPQMPMFEHMVTMDPPDHTNARSLLNRLLTP
Mvan_4141|M.vanbaalenii_PYR-1       PPLPFTPEGDDITGQIAAHRSQMPMFEHMVTMDPPDHTNARSLLNRLLTP
MSMEG_4780|M.smegmatis_MC2_155      PPLPFTPEGDDITGQIEQHRTQLPMFEHMVTMDPPEHTNARSLLNRLLTP
TH_4542|M.thermoresistible__bu      TPLPFQPEGDDITEQIARHRTQIPMYEHMVTMDPPEHTNARSILARLLTP
MMAR_4694|M.marinum_M               PPLPFAPNGDDVNAQIDAHREQFPMYEHMVTMDPPEHSRARSILSRLLTP
MUL_0314|M.ulcerans_Agy99           PPLPFTPNGDDVNAQIDAHREQFPMYEHMVTMDPPEHSRARSILSRLLTP
MAV_0964|M.avium_104                PPLPFTPEGDDISAQIDAHRSSFPMFEHMVTMDPPEHTKARSVLAKLLTP
Rv1880c|M.tuberculosis_H37Rv        FGENLPPPLRWLERRTRGDQLHPLREPSLLAVEPPDHTRYRKTVSAVFTS
MLBr_02088|M.leprae_Br4923          AQQAIAA----------GAEPRPFYASSFMFLDPPDHTRLRKLVSKAFAP
MAB_1216c|M.abscessus_ATCC_199      DKASFGP--------------HAKLVMSFLAMDDPEHLRLRALVSKGFTP
Mb1806|M.bovis_AF2122/97            TAEGTAKP--------FEMDPLGGPTHVLATADDPAHAVHRKLVLRHLAA
                                                                :   : * *   *  :   ::.

Mflv_2517|M.gilvum_PYR-GCK          SRLKENEDFMWRLADEVLDDIIGAEPAGRCEFLTAYAKPFSLLVIADMLG
Mvan_4141|M.vanbaalenii_PYR-1       SRLKENEDFMWRLADEVLDDIISRDPVGRCEFLSAYAKPFSLLVIADMLG
MSMEG_4780|M.smegmatis_MC2_155      KRLKENEDFMWRLADECLDDFIDD---GSCEFLKQYAKPFSLLVIADLLG
TH_4542|M.thermoresistible__bu      KRLKENEDFMWRLADRHIDEFIAD---GKCEFLAAYAKPFSLLVVADLLG
MMAR_4694|M.marinum_M               SRLKQNEEFMWRLADRQLDEFLGA---GECEFISEYAKPFATLVIADLLG
MUL_0314|M.ulcerans_Agy99           SRLKQNEEFMWRLADRQLDEFLGA---AECEFISEYAKPFATLVIADLLG
MAV_0964|M.avium_104                SRLKQNEEFMWRLADRQLDEFLHN---GECEFIAEYSKPFATLVIADLLG
Rv1880c|M.tuberculosis_H37Rv        RAVSALRDLVEQTAINLLDRFAEQ--PGIVDVVGRYCSQLPIVVISEILG
MLBr_02088|M.leprae_Br4923          KVVQALEGDIAALVDSLLDKGAA---AGQFDVIADLAFPLAVAVICRLLG
MAB_1216c|M.abscessus_ATCC_199      RRIRELEGQVVALARTHLDRALANASDRSFDFIAEYAGKLPMDVISELMG
Mb1806|M.bovis_AF2122/97            KRIRVMEQFTVQAADRLWVDGMQD---GCIEWMGAMANRLPMMVVAELIG
                                      :   .      .                : :   .  :.  *:. ::*

Mflv_2517|M.gilvum_PYR-GCK          VPEADHEEFRTVLGAPRPGANVGSLDHS-----DLVGANPLEWLDEKFIG
Mvan_4141|M.vanbaalenii_PYR-1       VPEADHEEFRTVLGAPRPGANVGSLDHS-----DLVGANPLEWLDEKFIG
MSMEG_4780|M.smegmatis_MC2_155      VPEEDHDEFRHVLGAPRPGAIVGSLDG------DQLAMNPLAWLDDKFVR
TH_4542|M.thermoresistible__bu      VPEEDHDAFREAFGAERPGTRIGSLDH------ETIATNPLEWADDKFTQ
MMAR_4694|M.marinum_M               VPEDDRKDFRVVLGADRMG-RVGALDH------ESVGVNPLQWLDDKFSA
MUL_0314|M.ulcerans_Agy99           VPEDDRKDFRVVLGADRMG-RVGALDH------ESVGVNPLQWLDDKFSA
MAV_0964|M.avium_104                VPEEDHTQFRTVLGADRPGARVGALDH------ETVGINPLEWLDDKFCN
Rv1880c|M.tuberculosis_H37Rv        VPEHDRPRVLEFGELAAPSLD--IGIPWRQYLRVQQGIRG---FDCWLEG
MLBr_02088|M.leprae_Br4923          VPYEDAPEFGRVSALLVQSVDPFITITGEPPEATEERLRAGVWLRDYLEQ
MAB_1216c|M.abscessus_ATCC_199      VPESDRARIRELADGVMHREDGLADVP-------PEAIQASFDLMTYYIE
Mb1806|M.bovis_AF2122/97            LPDPDIAQLVKWGYAATQLLEGLVENDQ-----LVAAGVALMELSGYIFE
                                    :*  *   .                                         

Mflv_2517|M.gilvum_PYR-GCK          YLEDRRKEPRDDVLTALATAKYPDG--STPPVIEVVRSATFLFAAGQETT
Mvan_4141|M.vanbaalenii_PYR-1       YLEDRRKEPRDDVLTALATAKYPDG--STPPVIEVVRSATFLFAAGQETT
MSMEG_4780|M.smegmatis_MC2_155      YLEDRRKEPRDDVLTALATAKYPDG--STPEVIDVVRSATFLFAAGQETT
TH_4542|M.thermoresistible__bu      YIEDRRREPRDDVLTAIATAKYPDG--STPEVIDVVRTATFLFAAGQETT
MMAR_4694|M.marinum_M               YIEDRRRQPRNDVLTALATATYPDG--STPEVIDVVRSATFLFAAGQETT
MUL_0314|M.ulcerans_Agy99           YIEDRRRRPRNDVLTALATATYPDG--STPEIIDVVRWATFLFAAGQETT
MAV_0964|M.avium_104                YIEERRREPRADVLTFLAEAKYPDG--STPPVIEVVRSATFLFAAGQETT
Rv1880c|M.tuberculosis_H37Rv        HLQQLRHAPGDDLMSQLIQIAESGDNETQLDETELRAIAGLVLVAGFETT
MLBr_02088|M.leprae_Br4923          LVKCRRGTPGEDLISRLIELDESGD---QLTEEEIIATCGLLLVAGHETT
MAB_1216c|M.abscessus_ATCC_199      MVRERRRRPTEDLTSALLQAEIDGD---RLTDEEVLAFLFLMVIAGNETT
Mb1806|M.bovis_AF2122/97            QFDRAAADPRDNLLGELATACASGE----LDTLTAQVMMVTLFAAGGEST
                                     .      *  ::   :      .                 :. ** *:*

Mflv_2517|M.gilvum_PYR-GCK          TKLLSASMRVLGDHPEIQERLRRDRTRIPIFIEEALRMDAPVKSQFRLAK
Mvan_4141|M.vanbaalenii_PYR-1       TKLLSASLRVLGDHPDIQERLRRDRSRIPIFVEEALRMDAPVKSQFRLAK
MSMEG_4780|M.smegmatis_MC2_155      TKLLSASLRVLGDRPDIQQALREDRSRIPTFVEEALRMDAPVKSQFRLAK
TH_4542|M.thermoresistible__bu      AKLLGAALQILGDRPDIQQTLREDRSRIPVFIEECLRMESPVKTVFRMVR
MMAR_4694|M.marinum_M               AKLLTAAMRVLGDRPDIQRRLRENRSLIPNFIEESLRMDSPVKSDSRLAR
MUL_0314|M.ulcerans_Agy99           AKQLTAAMRVLGDRPDIQRQLRENRSLIPNFIEESLRMDSPVKSDSRLAR
MAV_0964|M.avium_104                AKLLSAALQVLGDRPDIQQQLREDRSLIPAFIEESLRMESPVKSDSRLAR
Rv1880c|M.tuberculosis_H37Rv        VNLLGNGIRMLLDTPEHLATLRQHPELWPNTVEEILRLDSPVQLTARVAC
MLBr_02088|M.leprae_Br4923          VNLIANAVLAMLRNPSQWKALSSNPQRAPLVVEETLRYDPAIHLIGRVAA
MAB_1216c|M.abscessus_ATCC_199      TKLLANAVYWGHRNPDQLATVHADHDRIPLWVEESLRYDTSSQILARTVA
Mb1806|M.bovis_AF2122/97            AALLGSAVWILATRPDIQQQVRANPELLGAFIEETLRYEPPFRGQYRHVR
                                    .  :  .:      *.    :  .       :** ** :.. :   * . 

Mflv_2517|M.gilvum_PYR-GCK          KNTKVGDMDVPAGTTMMVCPGAVNRDPSRFENPHDFDLDRKNVREHIAFG
Mvan_4141|M.vanbaalenii_PYR-1       KNTRVGDMDVPAGTTMMVCPGAVNRDPSRFEHPHEFDLDRKNVREHIAFG
MSMEG_4780|M.smegmatis_MC2_155      KTTQLGGVDVPAGTTLMVCPGAVNRDPVRFEDPHTFSLDRKNVREHIAFG
TH_4542|M.thermoresistible__bu      KSTTVGDLDAPAGTTVMVAPGAANRDPRRFENPHEFDIDRKNVREHLAFS
MMAR_4694|M.marinum_M               KRTTVGGLDIAAGTVVMVLPGAANRDPRRFEDPHEFRLDRPNVREHMAFA
MUL_0314|M.ulcerans_Agy99           KRTTVGGLDIAAGTVVMVLSGAANRDPRRFEDPHEFRLDRPNVREHMAFA
MAV_0964|M.avium_104                RATTIGGVDIPAGTVVMILPGAANRDPRRFENPHEFDLRRKNVREHMAFA
Rv1880c|M.tuberculosis_H37Rv        RDVEVAGVRIKRGEVVVIYLAAANRDPAVFPDPHRFDIERPNAGRHLAFS
MLBr_02088|M.leprae_Br4923          KDMTIGQTTLTEGDTMVLLLAAANRDPAVYSRPDEFDPDRPSS-RHLAFA
MAB_1216c|M.abscessus_ATCC_199      EDITVYDTKIPAGDILLLLPGSANRDDRVFDDADQYRIGREIGAKLVSFG
Mb1806|M.bovis_AF2122/97            NATTLDGTELPADSHLLLLWGAANRDPAQFEAPGEFRLDRAGGKGHISFG
                                    .   :       .  :::  .:.***   :  .  :   *      ::*.

Mflv_2517|M.gilvum_PYR-GCK          RGVHSCPGGPLARVEGRVSIERILDRMGDIAIDEELHGPPGDRRYNYEPT
Mvan_4141|M.vanbaalenii_PYR-1       RGVHSCPGGPLARVEGRVSIERILDRMGDIAIDEELHGPPGARRYNYEPT
MSMEG_4780|M.smegmatis_MC2_155      RGVHSCPGGPLARVEGRVSLERILDRMADIRIDEEHHGPADNRRYTYEPT
TH_4542|M.thermoresistible__bu      RGIHSCPGAPLARVEGRVSIERLLDRLADIEIDADKHGGPGERNYTYEPT
MMAR_4694|M.marinum_M               RGVHSCPGGPLARVEGRVSLERILDRMLDIAINEDRHGPADDRRYTYEPT
MUL_0314|M.ulcerans_Agy99           RGVHSCPGGPLARVEGRVSLERILDRMLDIAINEDRHGPADDRRYTYEPT
MAV_0964|M.avium_104                RGVHSCPGGPLARVEGRVSIERILDRMPHIEINETHHGPAGDRRYTYEPT
Rv1880c|M.tuberculosis_H37Rv        TGRHFCLGAALARAEGEVGLRTFFDRFPDVRAAG---------AGSRRDT
MLBr_02088|M.leprae_Br4923          VGSHFCLGAALARLEATVTLSAISARFPQVQLAG---------ELVYKPN
MAB_1216c|M.abscessus_ATCC_199      SGAHFCLGAHLARMEAKVALTELFTRISGYEIDER--------NSVRVHS
Mb1806|M.bovis_AF2122/97            KGAHFCVGAALARLEARIVLRLLLDRTSVIEAADVG---------GWLPS
                                     * * * *. *** *. : :  :  *                       .

Mflv_2517|M.gilvum_PYR-GCK          FILRGLTDINITFTPIR------
Mvan_4141|M.vanbaalenii_PYR-1       FILRGLTDLNITFTPVR------
MSMEG_4780|M.smegmatis_MC2_155      YILRGLTDLHIKFEPVR------
TH_4542|M.thermoresistible__bu      FILRGLTELNITFKPIG------
MMAR_4694|M.marinum_M               YILRGLTELHITFTPAG------
MUL_0314|M.ulcerans_Agy99           YILRGLTELHITFTPAG------
MAV_0964|M.avium_104                YILRGLSELHLTFTTADAVAPVG
Rv1880c|M.tuberculosis_H37Rv        RVLRGWSTLPVTLGPARSMVSP-
MLBr_02088|M.leprae_Br4923          VAMRGMSALPVQV----------
MAB_1216c|M.abscessus_ATCC_199      SNVRGFAHLPMTVQLREGR----
Mb1806|M.bovis_AF2122/97            ILVRRIERLELAVQ---------
                                      :*    : : .