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TDFDTIDYFTDPSLVPDPHPYFDHLRSKCPVVKEPHYGVLAVTGYEEAATVLKDSDTFSSCIAVAGPFPP LPFTPEGDDITDQITAHRPQMPMFEHMVTMDPPDHTNARSLLNRLLTPSRLKENEDFMWRLADEVLDDII GAEPAGRCEFLTAYAKPFSLLVIADMLGVPEADHEEFRTVLGAPRPGANVGSLDHSDLVGANPLEWLDEK FIGYLEDRRKEPRDDVLTALATAKYPDGSTPPVIEVVRSATFLFAAGQETTTKLLSASMRVLGDHPEIQE RLRRDRTRIPIFIEEALRMDAPVKSQFRLAKKNTKVGDMDVPAGTTMMVCPGAVNRDPSRFENPHDFDLD RKNVREHIAFGRGVHSCPGGPLARVEGRVSIERILDRMGDIAIDEELHGPPGDRRYNYEPTFILRGLTDI NITFTPIR*
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. gilvum PYR-GCK | Mflv_2517 | - | - | 100% (429) | cytochrome P450 |
M. gilvum PYR-GCK | Mflv_1587 | - | e-156 | 60.89% (427) | cytochrome P450 |
M. gilvum PYR-GCK | Mflv_4149 | - | e-152 | 61.88% (425) | cytochrome P450 |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb1806 | cyp144 | 4e-40 | 29.82% (389) | cytochrome p450 144 CYP144 |
M. tuberculosis H37Rv | Rv1880c | cyp140 | 1e-39 | 30.17% (421) | cytochrome p450 140 CYP140 |
M. leprae Br4923 | MLBr_02088 | - | 8e-33 | 29.43% (333) | putative cytochrome p450 |
M. abscessus ATCC 19977 | MAB_1216c | - | 2e-38 | 26.32% (399) | cytochrome P450 |
M. marinum M | MMAR_4694 | cyp150A6 | 0.0 | 70.73% (427) | cytochrome P450 150A6 Cyp150A6 |
M. avium 104 | MAV_0964 | - | 0.0 | 71.60% (426) | cytochrome p450 |
M. smegmatis MC2 155 | MSMEG_4780 | - | 0.0 | 81.97% (427) | cytochrome p450 |
M. thermoresistible (build 8) | TH_4542 | - | 0.0 | 72.60% (427) | PUTATIVE cytochrome P450 |
M. ulcerans Agy99 | MUL_0314 | cyp150A6 | 1e-179 | 69.32% (427) | cytochrome P450 150A6 Cyp150A6 |
M. vanbaalenii PYR-1 | Mvan_4141 | - | 0.0 | 95.34% (429) | cytochrome P450 |
CLUSTAL 2.0.9 multiple sequence alignment Mflv_2517|M.gilvum_PYR-GCK -------------------------------MTDFDTIDYFTDPSLVPDP Mvan_4141|M.vanbaalenii_PYR-1 -------------------------------MSDFDTIDYFTDPSLVPDP MSMEG_4780|M.smegmatis_MC2_155 -------------------MTDSTATDPAATTPDFDTVDYFTDQSLVPDP TH_4542|M.thermoresistible__bu ------------------------------MTTDFDSIDYFTDPSLVPDP MMAR_4694|M.marinum_M -------------------------------MSSYESIDFFTDPSLIPDP MUL_0314|M.ulcerans_Agy99 -------------------------------MSSYESIDFFTDPSLIPDP MAV_0964|M.avium_104 -------------------------------MSNFDSIDFFTDPSLVPDP Rv1880c|M.tuberculosis_H37Rv ---------MKDKLHWLAMHGVIRGIAAIGIRRGDLQARLIADPAVATDP MLBr_02088|M.leprae_Br4923 MRTCVPTRTCVYAFIEYLSHNRPMGTNPPSLVEAQMLLLRLIDPGTRADP MAB_1216c|M.abscessus_ATCC_199 --------------------------MTVAETSAVPLVFDPYDYDFHEDP Mb1806|M.bovis_AF2122/97 -MRRSPKGSPGAVLDLQRRVDQAVSADHAELMTIAKDANTFFGAESVQDP . ** Mflv_2517|M.gilvum_PYR-GCK HPYFDHLRSKCPVVKEPHYGVLAVTGYEEAATVLKDSDTFSSCIAVAGPF Mvan_4141|M.vanbaalenii_PYR-1 HPYFDHLRSKCPVVREPHYGVLAVTGYEEAATVLKDSDTFSSCIAVAGPF MSMEG_4780|M.smegmatis_MC2_155 HPYFDHLRSKCPVVREPHYGVLAITSFEEATTVLKDTETFSSCIAVGGPF TH_4542|M.thermoresistible__bu HPYFDHMRSKCPIAREPHHGVIAVTGWEEANDVYRDSENLSSCIAVMGPF MMAR_4694|M.marinum_M HPYFDYLRSQSPVLRLPQYGVVAVTGYEEATAVYKDTDSFSNCVALGGPF MUL_0314|M.ulcerans_Agy99 HPYFDYLRRQSPVLRLPQYGVVAVTGYEEATAVYKDTDSFSNCVALGGPF MAV_0964|M.avium_104 HPYFDYLRSQNPVLRLPHYGVVAITGYEEATEVYKDPETFSNIVALGGPF Rv1880c|M.tuberculosis_H37Rv VPFYDEVRSHGALVRN-------RANYLTVDHRLAHDLLRSDDFRVV--S MLBr_02088|M.leprae_Br4923 FPVYRALIDYGPMQLPG-MPLTVFSSFSDCDEALRHPLSASDRLKAT--L MAB_1216c|M.abscessus_ATCC_199 YPYYRRLRDEAPLYRNDDLKFWALSRHHDVLQGFRNSEALSNANGVS--M Mb1806|M.bovis_AF2122/97 YPLYERMRAAGSVHRIANSDFYAVCGWDAVNEAIGRPEDFSSNLTATMTY * : : .: *. Mflv_2517|M.gilvum_PYR-GCK PPLPFTPEGDDITDQITAHRPQMPMFEHMVTMDPPDHTNARSLLNRLLTP Mvan_4141|M.vanbaalenii_PYR-1 PPLPFTPEGDDITGQIAAHRSQMPMFEHMVTMDPPDHTNARSLLNRLLTP MSMEG_4780|M.smegmatis_MC2_155 PPLPFTPEGDDITGQIEQHRTQLPMFEHMVTMDPPEHTNARSLLNRLLTP TH_4542|M.thermoresistible__bu TPLPFQPEGDDITEQIARHRTQIPMYEHMVTMDPPEHTNARSILARLLTP MMAR_4694|M.marinum_M PPLPFAPNGDDVNAQIDAHREQFPMYEHMVTMDPPEHSRARSILSRLLTP MUL_0314|M.ulcerans_Agy99 PPLPFTPNGDDVNAQIDAHREQFPMYEHMVTMDPPEHSRARSILSRLLTP MAV_0964|M.avium_104 PPLPFTPEGDDISAQIDAHRSSFPMFEHMVTMDPPEHTKARSVLAKLLTP Rv1880c|M.tuberculosis_H37Rv FGENLPPPLRWLERRTRGDQLHPLREPSLLAVEPPDHTRYRKTVSAVFTS MLBr_02088|M.leprae_Br4923 AQQAIAA----------GAEPRPFYASSFMFLDPPDHTRLRKLVSKAFAP MAB_1216c|M.abscessus_ATCC_199 DKASFGP--------------HAKLVMSFLAMDDPEHLRLRALVSKGFTP Mb1806|M.bovis_AF2122/97 TAEGTAKP--------FEMDPLGGPTHVLATADDPAHAVHRKLVLRHLAA : : * * * : ::. Mflv_2517|M.gilvum_PYR-GCK SRLKENEDFMWRLADEVLDDIIGAEPAGRCEFLTAYAKPFSLLVIADMLG Mvan_4141|M.vanbaalenii_PYR-1 SRLKENEDFMWRLADEVLDDIISRDPVGRCEFLSAYAKPFSLLVIADMLG MSMEG_4780|M.smegmatis_MC2_155 KRLKENEDFMWRLADECLDDFIDD---GSCEFLKQYAKPFSLLVIADLLG TH_4542|M.thermoresistible__bu KRLKENEDFMWRLADRHIDEFIAD---GKCEFLAAYAKPFSLLVVADLLG MMAR_4694|M.marinum_M SRLKQNEEFMWRLADRQLDEFLGA---GECEFISEYAKPFATLVIADLLG MUL_0314|M.ulcerans_Agy99 SRLKQNEEFMWRLADRQLDEFLGA---AECEFISEYAKPFATLVIADLLG MAV_0964|M.avium_104 SRLKQNEEFMWRLADRQLDEFLHN---GECEFIAEYSKPFATLVIADLLG Rv1880c|M.tuberculosis_H37Rv RAVSALRDLVEQTAINLLDRFAEQ--PGIVDVVGRYCSQLPIVVISEILG MLBr_02088|M.leprae_Br4923 KVVQALEGDIAALVDSLLDKGAA---AGQFDVIADLAFPLAVAVICRLLG MAB_1216c|M.abscessus_ATCC_199 RRIRELEGQVVALARTHLDRALANASDRSFDFIAEYAGKLPMDVISELMG Mb1806|M.bovis_AF2122/97 KRIRVMEQFTVQAADRLWVDGMQD---GCIEWMGAMANRLPMMVVAELIG : . . : : . :. *:. ::* Mflv_2517|M.gilvum_PYR-GCK VPEADHEEFRTVLGAPRPGANVGSLDHS-----DLVGANPLEWLDEKFIG Mvan_4141|M.vanbaalenii_PYR-1 VPEADHEEFRTVLGAPRPGANVGSLDHS-----DLVGANPLEWLDEKFIG MSMEG_4780|M.smegmatis_MC2_155 VPEEDHDEFRHVLGAPRPGAIVGSLDG------DQLAMNPLAWLDDKFVR TH_4542|M.thermoresistible__bu VPEEDHDAFREAFGAERPGTRIGSLDH------ETIATNPLEWADDKFTQ MMAR_4694|M.marinum_M VPEDDRKDFRVVLGADRMG-RVGALDH------ESVGVNPLQWLDDKFSA MUL_0314|M.ulcerans_Agy99 VPEDDRKDFRVVLGADRMG-RVGALDH------ESVGVNPLQWLDDKFSA MAV_0964|M.avium_104 VPEEDHTQFRTVLGADRPGARVGALDH------ETVGINPLEWLDDKFCN Rv1880c|M.tuberculosis_H37Rv VPEHDRPRVLEFGELAAPSLD--IGIPWRQYLRVQQGIRG---FDCWLEG MLBr_02088|M.leprae_Br4923 VPYEDAPEFGRVSALLVQSVDPFITITGEPPEATEERLRAGVWLRDYLEQ MAB_1216c|M.abscessus_ATCC_199 VPESDRARIRELADGVMHREDGLADVP-------PEAIQASFDLMTYYIE Mb1806|M.bovis_AF2122/97 LPDPDIAQLVKWGYAATQLLEGLVENDQ-----LVAAGVALMELSGYIFE :* * . Mflv_2517|M.gilvum_PYR-GCK YLEDRRKEPRDDVLTALATAKYPDG--STPPVIEVVRSATFLFAAGQETT Mvan_4141|M.vanbaalenii_PYR-1 YLEDRRKEPRDDVLTALATAKYPDG--STPPVIEVVRSATFLFAAGQETT MSMEG_4780|M.smegmatis_MC2_155 YLEDRRKEPRDDVLTALATAKYPDG--STPEVIDVVRSATFLFAAGQETT TH_4542|M.thermoresistible__bu YIEDRRREPRDDVLTAIATAKYPDG--STPEVIDVVRTATFLFAAGQETT MMAR_4694|M.marinum_M YIEDRRRQPRNDVLTALATATYPDG--STPEVIDVVRSATFLFAAGQETT MUL_0314|M.ulcerans_Agy99 YIEDRRRRPRNDVLTALATATYPDG--STPEIIDVVRWATFLFAAGQETT MAV_0964|M.avium_104 YIEERRREPRADVLTFLAEAKYPDG--STPPVIEVVRSATFLFAAGQETT Rv1880c|M.tuberculosis_H37Rv HLQQLRHAPGDDLMSQLIQIAESGDNETQLDETELRAIAGLVLVAGFETT MLBr_02088|M.leprae_Br4923 LVKCRRGTPGEDLISRLIELDESGD---QLTEEEIIATCGLLLVAGHETT MAB_1216c|M.abscessus_ATCC_199 MVRERRRRPTEDLTSALLQAEIDGD---RLTDEEVLAFLFLMVIAGNETT Mb1806|M.bovis_AF2122/97 QFDRAAADPRDNLLGELATACASGE----LDTLTAQVMMVTLFAAGGEST . * :: : . :. ** *:* Mflv_2517|M.gilvum_PYR-GCK TKLLSASMRVLGDHPEIQERLRRDRTRIPIFIEEALRMDAPVKSQFRLAK Mvan_4141|M.vanbaalenii_PYR-1 TKLLSASLRVLGDHPDIQERLRRDRSRIPIFVEEALRMDAPVKSQFRLAK MSMEG_4780|M.smegmatis_MC2_155 TKLLSASLRVLGDRPDIQQALREDRSRIPTFVEEALRMDAPVKSQFRLAK TH_4542|M.thermoresistible__bu AKLLGAALQILGDRPDIQQTLREDRSRIPVFIEECLRMESPVKTVFRMVR MMAR_4694|M.marinum_M AKLLTAAMRVLGDRPDIQRRLRENRSLIPNFIEESLRMDSPVKSDSRLAR MUL_0314|M.ulcerans_Agy99 AKQLTAAMRVLGDRPDIQRQLRENRSLIPNFIEESLRMDSPVKSDSRLAR MAV_0964|M.avium_104 AKLLSAALQVLGDRPDIQQQLREDRSLIPAFIEESLRMESPVKSDSRLAR Rv1880c|M.tuberculosis_H37Rv VNLLGNGIRMLLDTPEHLATLRQHPELWPNTVEEILRLDSPVQLTARVAC MLBr_02088|M.leprae_Br4923 VNLIANAVLAMLRNPSQWKALSSNPQRAPLVVEETLRYDPAIHLIGRVAA MAB_1216c|M.abscessus_ATCC_199 TKLLANAVYWGHRNPDQLATVHADHDRIPLWVEESLRYDTSSQILARTVA Mb1806|M.bovis_AF2122/97 AALLGSAVWILATRPDIQQQVRANPELLGAFIEETLRYEPPFRGQYRHVR . : .: *. : . :** ** :.. : * . Mflv_2517|M.gilvum_PYR-GCK KNTKVGDMDVPAGTTMMVCPGAVNRDPSRFENPHDFDLDRKNVREHIAFG Mvan_4141|M.vanbaalenii_PYR-1 KNTRVGDMDVPAGTTMMVCPGAVNRDPSRFEHPHEFDLDRKNVREHIAFG MSMEG_4780|M.smegmatis_MC2_155 KTTQLGGVDVPAGTTLMVCPGAVNRDPVRFEDPHTFSLDRKNVREHIAFG TH_4542|M.thermoresistible__bu KSTTVGDLDAPAGTTVMVAPGAANRDPRRFENPHEFDIDRKNVREHLAFS MMAR_4694|M.marinum_M KRTTVGGLDIAAGTVVMVLPGAANRDPRRFEDPHEFRLDRPNVREHMAFA MUL_0314|M.ulcerans_Agy99 KRTTVGGLDIAAGTVVMVLSGAANRDPRRFEDPHEFRLDRPNVREHMAFA MAV_0964|M.avium_104 RATTIGGVDIPAGTVVMILPGAANRDPRRFENPHEFDLRRKNVREHMAFA Rv1880c|M.tuberculosis_H37Rv RDVEVAGVRIKRGEVVVIYLAAANRDPAVFPDPHRFDIERPNAGRHLAFS MLBr_02088|M.leprae_Br4923 KDMTIGQTTLTEGDTMVLLLAAANRDPAVYSRPDEFDPDRPSS-RHLAFA MAB_1216c|M.abscessus_ATCC_199 EDITVYDTKIPAGDILLLLPGSANRDDRVFDDADQYRIGREIGAKLVSFG Mb1806|M.bovis_AF2122/97 NATTLDGTELPADSHLLLLWGAANRDPAQFEAPGEFRLDRAGGKGHISFG . : . ::: .:.*** : . : * ::*. Mflv_2517|M.gilvum_PYR-GCK RGVHSCPGGPLARVEGRVSIERILDRMGDIAIDEELHGPPGDRRYNYEPT Mvan_4141|M.vanbaalenii_PYR-1 RGVHSCPGGPLARVEGRVSIERILDRMGDIAIDEELHGPPGARRYNYEPT MSMEG_4780|M.smegmatis_MC2_155 RGVHSCPGGPLARVEGRVSLERILDRMADIRIDEEHHGPADNRRYTYEPT TH_4542|M.thermoresistible__bu RGIHSCPGAPLARVEGRVSIERLLDRLADIEIDADKHGGPGERNYTYEPT MMAR_4694|M.marinum_M RGVHSCPGGPLARVEGRVSLERILDRMLDIAINEDRHGPADDRRYTYEPT MUL_0314|M.ulcerans_Agy99 RGVHSCPGGPLARVEGRVSLERILDRMLDIAINEDRHGPADDRRYTYEPT MAV_0964|M.avium_104 RGVHSCPGGPLARVEGRVSIERILDRMPHIEINETHHGPAGDRRYTYEPT Rv1880c|M.tuberculosis_H37Rv TGRHFCLGAALARAEGEVGLRTFFDRFPDVRAAG---------AGSRRDT MLBr_02088|M.leprae_Br4923 VGSHFCLGAALARLEATVTLSAISARFPQVQLAG---------ELVYKPN MAB_1216c|M.abscessus_ATCC_199 SGAHFCLGAHLARMEAKVALTELFTRISGYEIDER--------NSVRVHS Mb1806|M.bovis_AF2122/97 KGAHFCVGAALARLEARIVLRLLLDRTSVIEAADVG---------GWLPS * * * *. *** *. : : : * . Mflv_2517|M.gilvum_PYR-GCK FILRGLTDINITFTPIR------ Mvan_4141|M.vanbaalenii_PYR-1 FILRGLTDLNITFTPVR------ MSMEG_4780|M.smegmatis_MC2_155 YILRGLTDLHIKFEPVR------ TH_4542|M.thermoresistible__bu FILRGLTELNITFKPIG------ MMAR_4694|M.marinum_M YILRGLTELHITFTPAG------ MUL_0314|M.ulcerans_Agy99 YILRGLTELHITFTPAG------ MAV_0964|M.avium_104 YILRGLSELHLTFTTADAVAPVG Rv1880c|M.tuberculosis_H37Rv RVLRGWSTLPVTLGPARSMVSP- MLBr_02088|M.leprae_Br4923 VAMRGMSALPVQV---------- MAB_1216c|M.abscessus_ATCC_199 SNVRGFAHLPMTVQLREGR---- Mb1806|M.bovis_AF2122/97 ILVRRIERLELAVQ--------- :* : : .