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SNFDSIDFFTDPSLVPDPHPYFDYLRSQNPVLRLPHYGVVAITGYEEATEVYKDPETFSNIVALGGPFPP LPFTPEGDDISAQIDAHRSSFPMFEHMVTMDPPEHTKARSVLAKLLTPSRLKQNEEFMWRLADRQLDEFL HNGECEFIAEYSKPFATLVIADLLGVPEEDHTQFRTVLGADRPGARVGALDHETVGINPLEWLDDKFCNY IEERRREPRADVLTFLAEAKYPDGSTPPVIEVVRSATFLFAAGQETTAKLLSAALQVLGDRPDIQQQLRE DRSLIPAFIEESLRMESPVKSDSRLARRATTIGGVDIPAGTVVMILPGAANRDPRRFENPHEFDLRRKNV REHMAFARGVHSCPGGPLARVEGRVSIERILDRMPHIEINETHHGPAGDRRYTYEPTYILRGLSELHLTF TTADAVAPVG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_0964 | - | - | 100% (431) | cytochrome p450 |
| M. avium 104 | MAV_0849 | - | e-170 | 66.12% (425) | cytochrome p450 |
| M. avium 104 | MAV_0912 | - | e-136 | 56.50% (423) | cytochrome p450 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1806 | cyp144 | 2e-47 | 32.90% (389) | cytochrome p450 144 CYP144 |
| M. gilvum PYR-GCK | Mflv_2517 | - | 0.0 | 71.60% (426) | cytochrome P450 |
| M. tuberculosis H37Rv | Rv1777 | cyp144 | 3e-47 | 32.90% (389) | cytochrome p450 144 CYP144 |
| M. leprae Br4923 | MLBr_02088 | - | 2e-37 | 29.25% (424) | putative cytochrome p450 |
| M. abscessus ATCC 19977 | MAB_1406c | - | 7e-47 | 32.03% (384) | cytochrome P450 |
| M. marinum M | MMAR_4694 | cyp150A6 | 0.0 | 82.08% (424) | cytochrome P450 150A6 Cyp150A6 |
| M. smegmatis MC2 155 | MSMEG_4780 | - | 0.0 | 73.27% (419) | cytochrome p450 |
| M. thermoresistible (build 8) | TH_4542 | - | 0.0 | 71.90% (420) | PUTATIVE cytochrome P450 |
| M. ulcerans Agy99 | MUL_0314 | cyp150A6 | 0.0 | 81.13% (424) | cytochrome P450 150A6 Cyp150A6 |
| M. vanbaalenii PYR-1 | Mvan_4141 | - | 0.0 | 72.77% (426) | cytochrome P450 |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1806|M.bovis_AF2122/97 -MRRSPKGSPGAVLDLQRRVDQAVSADHAELMTIAKDANTFFGAESVQDP
Rv1777|M.tuberculosis_H37Rv -MRRSPKGSPGAVLDLQRRVDQAVSADHAELMTIAKDANTFFGAESVQDP
MMAR_4694|M.marinum_M -------------------------------MSSYESIDFFTDPSLIPDP
MUL_0314|M.ulcerans_Agy99 -------------------------------MSSYESIDFFTDPSLIPDP
MAV_0964|M.avium_104 -------------------------------MSNFDSIDFFTDPSLVPDP
Mflv_2517|M.gilvum_PYR-GCK -------------------------------MTDFDTIDYFTDPSLVPDP
Mvan_4141|M.vanbaalenii_PYR-1 -------------------------------MSDFDTIDYFTDPSLVPDP
MSMEG_4780|M.smegmatis_MC2_155 -------------------MTDSTATDPAATTPDFDTVDYFTDQSLVPDP
TH_4542|M.thermoresistible__bu ------------------------------MTTDFDSIDYFTDPSLVPDP
MAB_1406c|M.abscessus_ATCC_199 --------------------------MSVDVSHTVAPRYVPGTADNWTNP
MLBr_02088|M.leprae_Br4923 MRTCVPTRTCVYAFIEYLSHNRPMGTNPPSLVEAQMLLLRLIDPGTRADP
:*
Mb1806|M.bovis_AF2122/97 YPLYERMRAAGSVHRIA-----NSDFYAVCGWDAVNEAIGRPEDFSSNLT
Rv1777|M.tuberculosis_H37Rv YPLYERMRAAGSVHRIA-----NSDFYAVCGWDAVNEAIGRPEDFSSNLT
MMAR_4694|M.marinum_M HPYFDYLRSQSPVLRLP-----QYGVVAVTGYEEATAVYKDTDSFSNCVA
MUL_0314|M.ulcerans_Agy99 HPYFDYLRRQSPVLRLP-----QYGVVAVTGYEEATAVYKDTDSFSNCVA
MAV_0964|M.avium_104 HPYFDYLRSQNPVLRLP-----HYGVVAITGYEEATEVYKDPETFSNIVA
Mflv_2517|M.gilvum_PYR-GCK HPYFDHLRSKCPVVKEP-----HYGVLAVTGYEEAATVLKDSDTFSSCIA
Mvan_4141|M.vanbaalenii_PYR-1 HPYFDHLRSKCPVVREP-----HYGVLAVTGYEEAATVLKDSDTFSSCIA
MSMEG_4780|M.smegmatis_MC2_155 HPYFDHLRSKCPVVREP-----HYGVLAITSFEEATTVLKDTETFSSCIA
TH_4542|M.thermoresistible__bu HPYFDHMRSKCPIAREP-----HHGVIAVTGWEEANDVYRDSENLSSCIA
MAB_1406c|M.abscessus_ATCC_199 WPMYAALRDHDPVHHVVPEYTPDQDYYVLTRHADVYEAARDWETFSSARG
MLBr_02088|M.leprae_Br4923 FPVYRALIDYGPMQLPG------MPLTVFSSFSDCDEALRHPLSASDRLK
* : : .: .. . *.
Mb1806|M.bovis_AF2122/97 AT-----MTYTAEGTAKPFEMDPLGGPT---HVLATADDPAHAVHRKLVL
Rv1777|M.tuberculosis_H37Rv AT-----MTYTAEGTAKPFEMDPLGGPT---HVLATADDPAHAVHRKLVL
MMAR_4694|M.marinum_M LGGPFPPLPFAPNGDDVNAQIDAHREQFPMYEHMVTMDPPEHSRARSILS
MUL_0314|M.ulcerans_Agy99 LGGPFPPLPFTPNGDDVNAQIDAHREQFPMYEHMVTMDPPEHSRARSILS
MAV_0964|M.avium_104 LGGPFPPLPFTPEGDDISAQIDAHRSSFPMFEHMVTMDPPEHTKARSVLA
Mflv_2517|M.gilvum_PYR-GCK VAGPFPPLPFTPEGDDITDQITAHRPQMPMFEHMVTMDPPDHTNARSLLN
Mvan_4141|M.vanbaalenii_PYR-1 VAGPFPPLPFTPEGDDITGQIAAHRSQMPMFEHMVTMDPPDHTNARSLLN
MSMEG_4780|M.smegmatis_MC2_155 VGGPFPPLPFTPEGDDITGQIEQHRTQLPMFEHMVTMDPPEHTNARSLLN
TH_4542|M.thermoresistible__bu VMGPFTPLPFQPEGDDITEQIARHRTQIPMYEHMVTMDPPEHTNARSILA
MAB_1406c|M.abscessus_ATCC_199 LTVTYGDLEKTGMGDNP---------------PMVMQDPPTHTEFRKLVS
MLBr_02088|M.leprae_Br4923 ATLAQQAIAAGAEPRPFYAS------------SFMFLDPPDHTRLRKLVS
: : * * *: *.::
Mb1806|M.bovis_AF2122/97 RHLAAKRIRVMEQFTVQAADRLWVDGMQD---GCIEWMGAMANRLPMMVV
Rv1777|M.tuberculosis_H37Rv RHLAAKRIRVMEQFTVQAADRLWVDGMQD---GCIEWMGAMANRLPMMVV
MMAR_4694|M.marinum_M RLLTPSRLKQNEEFMWRLADRQLDEFLGA---GECEFISEYAKPFATLVI
MUL_0314|M.ulcerans_Agy99 RLLTPSRLKQNEEFMWRLADRQLDEFLGA---AECEFISEYAKPFATLVI
MAV_0964|M.avium_104 KLLTPSRLKQNEEFMWRLADRQLDEFLHN---GECEFIAEYSKPFATLVI
Mflv_2517|M.gilvum_PYR-GCK RLLTPSRLKENEDFMWRLADEVLDDIIGAEPAGRCEFLTAYAKPFSLLVI
Mvan_4141|M.vanbaalenii_PYR-1 RLLTPSRLKENEDFMWRLADEVLDDIISRDPVGRCEFLSAYAKPFSLLVI
MSMEG_4780|M.smegmatis_MC2_155 RLLTPKRLKENEDFMWRLADECLDDFIDD---GSCEFLKQYAKPFSLLVI
TH_4542|M.thermoresistible__bu RLLTPKRLKENEDFMWRLADRHIDEFIAD---GKCEFLAAYAKPFSLLVV
MAB_1406c|M.abscessus_ATCC_199 RGFTPRQVTAVEPKVREFVVQRLERLKER---GEGDIVVELFKPLPSMVV
MLBr_02088|M.leprae_Br4923 KAFAPKVVQALEGDIAALVDSLLDKGAAA---GQFDVIADLAFPLAVAVI
: ::. : * . . : : :. *:
Mb1806|M.bovis_AF2122/97 AELIGLPDPDIAQLVKWGYAATQLLEGLVENDQLVAAGVA-----LMELS
Rv1777|M.tuberculosis_H37Rv AELIGLPDPDIAQLVKWGYAATQLLEGLVENDQLVAAGVA-----LMELS
MMAR_4694|M.marinum_M ADLLGVPEDDRKDFRVVLGADRMG-RVGALDH-ESVGVNP-----LQWLD
MUL_0314|M.ulcerans_Agy99 ADLLGVPEDDRKDFRVVLGADRMG-RVGALDH-ESVGVNP-----LQWLD
MAV_0964|M.avium_104 ADLLGVPEEDHTQFRTVLGADRPGARVGALDH-ETVGINP-----LEWLD
Mflv_2517|M.gilvum_PYR-GCK ADMLGVPEADHEEFRTVLGAPRPGANVGSLDHSDLVGANP-----LEWLD
Mvan_4141|M.vanbaalenii_PYR-1 ADMLGVPEADHEEFRTVLGAPRPGANVGSLDHSDLVGANP-----LEWLD
MSMEG_4780|M.smegmatis_MC2_155 ADLLGVPEEDHDEFRHVLGAPRPGAIVGSLDG-DQLAMNP-----LAWLD
TH_4542|M.thermoresistible__bu ADLLGVPEEDHDAFREAFGAERPGTRIGSLDH-ETIATNP-----LEWAD
MAB_1406c|M.abscessus_ATCC_199 AHYLGVPEEDRTQFDAWTDGIVAAASGGAIDIEAMQGEVAQ---TIGELM
MLBr_02088|M.leprae_Br4923 CRLLGVPYEDAPEFGRVSALLVQSVDPFITITGEPPEATEERLRAGVWLR
. :*:* * :
Mb1806|M.bovis_AF2122/97 GYIFEQFDRAAADPRDNLLGELATA-CASG--ELDTLTAQVMMVTLFAAG
Rv1777|M.tuberculosis_H37Rv GYIFEQFDRAAADPRDNLLGELATA-CASG--ELDTLTAQVMMVTLFAAG
MMAR_4694|M.marinum_M DKFSAYIEDRRRQPRNDVLTALATA-TYPDGSTPEVIDVVRSATFLFAAG
MUL_0314|M.ulcerans_Agy99 DKFSAYIEDRRRRPRNDVLTALATA-TYPDGSTPEIIDVVRWATFLFAAG
MAV_0964|M.avium_104 DKFCNYIEERRREPRADVLTFLAEA-KYPDGSTPPVIEVVRSATFLFAAG
Mflv_2517|M.gilvum_PYR-GCK EKFIGYLEDRRKEPRDDVLTALATA-KYPDGSTPPVIEVVRSATFLFAAG
Mvan_4141|M.vanbaalenii_PYR-1 EKFIGYLEDRRKEPRDDVLTALATA-KYPDGSTPPVIEVVRSATFLFAAG
MSMEG_4780|M.smegmatis_MC2_155 DKFVRYLEDRRKEPRDDVLTALATA-KYPDGSTPEVIDVVRSATFLFAAG
TH_4542|M.thermoresistible__bu DKFTQYIEDRRREPRDDVLTAIATA-KYPDGSTPEVIDVVRTATFLFAAG
MAB_1406c|M.abscessus_ATCC_199 MYFTGLIERRRAEPEDDTVSHLVAAGVGADGDISGTLQILGFAFTMVTGG
MLBr_02088|M.leprae_Br4923 DYLEQLVKCRRGTPGEDLISRLIEL--DESGDQLTEEEIIATCGLLLVAG
: .. * : : : . :...*
Mb1806|M.bovis_AF2122/97 GESTAALLGSAVWILATRPDIQQQVRANPELLGAFIEETLRYEPPFRGQY
Rv1777|M.tuberculosis_H37Rv GESTAALLGSAVWILATRPDIQQQVRANPELLGAFIEETLRYEPPFRGHY
MMAR_4694|M.marinum_M QETTAKLLTAAMRVLGDRPDIQRRLRENRSLIPNFIEESLRMDSPVKSDS
MUL_0314|M.ulcerans_Agy99 QETTAKQLTAAMRVLGDRPDIQRQLRENRSLIPNFIEESLRMDSPVKSDS
MAV_0964|M.avium_104 QETTAKLLSAALQVLGDRPDIQQQLREDRSLIPAFIEESLRMESPVKSDS
Mflv_2517|M.gilvum_PYR-GCK QETTTKLLSASMRVLGDHPEIQERLRRDRTRIPIFIEEALRMDAPVKSQF
Mvan_4141|M.vanbaalenii_PYR-1 QETTTKLLSASLRVLGDHPDIQERLRRDRSRIPIFVEEALRMDAPVKSQF
MSMEG_4780|M.smegmatis_MC2_155 QETTTKLLSASLRVLGDRPDIQQALREDRSRIPTFVEEALRMDAPVKSQF
TH_4542|M.thermoresistible__bu QETTAKLLGAALQILGDRPDIQQTLREDRSRIPVFIEECLRMESPVKTVF
MAB_1406c|M.abscessus_ATCC_199 NDTTTGMLGGAIQLLHQNPAQRQKLIDDPSLIPGAVEEFLRLTSPVQGLA
MLBr_02088|M.leprae_Br4923 HETTVNLIANAVLAMLRNPSQWKALSSNPQRAPLVVEETLRYDPAIHLIG
::*. : :: : .* . : : :** ** ...:
Mb1806|M.bovis_AF2122/97 RHVRNATTLDGTELPADSHLLLLWGAANRDPAQFEAPGEFRLDRAGGKGH
Rv1777|M.tuberculosis_H37Rv RHVRNATTLDGTELPADSHLLLLWGAANRDPAQFEAPGEFRLDRAGGKGH
MMAR_4694|M.marinum_M RLARKRTTVGGLDIAAGTVVMVLPGAANRDPRRFEDPHEFRLDRPNVREH
MUL_0314|M.ulcerans_Agy99 RLARKRTTVGGLDIAAGTVVMVLSGAANRDPRRFEDPHEFRLDRPNVREH
MAV_0964|M.avium_104 RLARRATTIGGVDIPAGTVVMILPGAANRDPRRFENPHEFDLRRKNVREH
Mflv_2517|M.gilvum_PYR-GCK RLAKKNTKVGDMDVPAGTTMMVCPGAVNRDPSRFENPHDFDLDRKNVREH
Mvan_4141|M.vanbaalenii_PYR-1 RLAKKNTRVGDMDVPAGTTMMVCPGAVNRDPSRFEHPHEFDLDRKNVREH
MSMEG_4780|M.smegmatis_MC2_155 RLAKKTTQLGGVDVPAGTTLMVCPGAVNRDPVRFEDPHTFSLDRKNVREH
TH_4542|M.thermoresistible__bu RMVRKSTTVGDLDAPAGTTVMVAPGAANRDPRRFENPHEFDIDRKNVREH
MAB_1406c|M.abscessus_ATCC_199 RTATRDVIIGDTTIPAGRRALLLYGSANRDEREYGNDAAELDVLRKPRNI
MLBr_02088|M.leprae_Br4923 RVAAKDMTIGQTTLTEGDTMVLLLAAANRDPAVYSRPDEFDPDRPSSR-H
* . . :. . . :: .:.*** : :
Mb1806|M.bovis_AF2122/97 ISFGKGAHFCVGAALARLEARIVLRLLLDRTSVIEAADVGG---------
Rv1777|M.tuberculosis_H37Rv ISFGKGAHFCVGAALARLEARIVLRLLLDRTSVIEAADVGG---------
MMAR_4694|M.marinum_M MAFARGVHSCPGGPLARVEGRVSLERILDRMLDIAINEDRHGPADDRRYT
MUL_0314|M.ulcerans_Agy99 MAFARGVHSCPGGPLARVEGRVSLERILDRMLDIAINEDRHGPADDRRYT
MAV_0964|M.avium_104 MAFARGVHSCPGGPLARVEGRVSIERILDRMPHIEINETHHGPAGDRRYT
Mflv_2517|M.gilvum_PYR-GCK IAFGRGVHSCPGGPLARVEGRVSIERILDRMGDIAIDEELHGPPGDRRYN
Mvan_4141|M.vanbaalenii_PYR-1 IAFGRGVHSCPGGPLARVEGRVSIERILDRMGDIAIDEELHGPPGARRYN
MSMEG_4780|M.smegmatis_MC2_155 IAFGRGVHSCPGGPLARVEGRVSLERILDRMADIRIDEEHHGPADNRRYT
TH_4542|M.thermoresistible__bu LAFSRGIHSCPGAPLARVEGRVSIERLLDRLADIEIDADKHGGPGERNYT
MAB_1406c|M.abscessus_ATCC_199 LTFSHGNHHCLGAAAARMQSRIALEELLTRIPDFEVDLDGVT--------
MLBr_02088|M.leprae_Br4923 LAFAVGSHFCLGAALARLEATVTLSAISARFPQVQLAGELV---------
::*. * * * *.. **::. : : : * .
Mb1806|M.bovis_AF2122/97 WLPSILVRRIERLELAVQ---------
Rv1777|M.tuberculosis_H37Rv WLPSILVRRIERLELAVQ---------
MMAR_4694|M.marinum_M YEPTYILRGLTELHITFTPAG------
MUL_0314|M.ulcerans_Agy99 YEPTYILRGLTELHITFTPAG------
MAV_0964|M.avium_104 YEPTYILRGLSELHLTFTTADAVAPVG
Mflv_2517|M.gilvum_PYR-GCK YEPTFILRGLTDINITFTPIR------
Mvan_4141|M.vanbaalenii_PYR-1 YEPTFILRGLTDLNITFTPVR------
MSMEG_4780|M.smegmatis_MC2_155 YEPTYILRGLTDLHIKFEPVR------
TH_4542|M.thermoresistible__bu YEPTFILRGLTELNITFKPIG------
MAB_1406c|M.abscessus_ATCC_199 WADGSYVRRPLTVPIRVR---------
MLBr_02088|M.leprae_Br4923 YKPNVAMRGMSALPVQV----------
: :* : : .