For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
SSYESIDFFTDPSLIPDPHPYFDYLRRQSPVLRLPQYGVVAVTGYEEATAVYKDTDSFSNCVALGGPFPP LPFTPNGDDVNAQIDAHREQFPMYEHMVTMDPPEHSRARSILSRLLTPSRLKQNEEFMWRLADRQLDEFL GAAECEFISEYAKPFATLVIADLLGVPEDDRKDFRVVLGADRMGRVGALDHESVGVNPLQWLDDKFSAYI EDRRRRPRNDVLTALATATYPDGSTPEIIDVVRWATFLFAAGQETTAKQLTAAMRVLGDRPDIQRQLREN RSLIPNFIEESLRMDSPVKSDSRLARKRTTVGGLDIAAGTVVMVLSGAANRDPRRFEDPHEFRLDRPNVR EHMAFARGVHSCPGGPLARVEGRVSLERILDRMLDIAINEDRHGPADDRRYTYEPTYILRGLTELHITFT PAG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_0314 | cyp150A6 | - | 100% (424) | cytochrome P450 150A6 Cyp150A6 |
| M. ulcerans Agy99 | MUL_3131 | cyp144A4 | 5e-45 | 31.97% (391) | cytochrome P450 144A4 Cyp144A4 |
| M. ulcerans Agy99 | MUL_0324 | cyp189A7 | 8e-42 | 30.81% (383) | cytochrome P450 189A7 Cyp189A7 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1806 | cyp144 | 1e-42 | 31.04% (393) | cytochrome p450 144 CYP144 |
| M. gilvum PYR-GCK | Mflv_2517 | - | 1e-179 | 69.32% (427) | cytochrome P450 |
| M. tuberculosis H37Rv | Rv1777 | cyp144 | 2e-42 | 31.04% (393) | cytochrome p450 144 CYP144 |
| M. leprae Br4923 | MLBr_02088 | - | 5e-35 | 30.48% (351) | putative cytochrome p450 |
| M. abscessus ATCC 19977 | MAB_1939 | - | 8e-41 | 29.23% (390) | cytochrome P450 |
| M. marinum M | MMAR_4694 | cyp150A6 | 0.0 | 97.88% (424) | cytochrome P450 150A6 Cyp150A6 |
| M. avium 104 | MAV_0964 | - | 0.0 | 81.13% (424) | cytochrome p450 |
| M. smegmatis MC2 155 | MSMEG_4780 | - | 0.0 | 70.95% (420) | cytochrome p450 |
| M. thermoresistible (build 8) | TH_4542 | - | 1e-179 | 68.63% (424) | PUTATIVE cytochrome P450 |
| M. vanbaalenii PYR-1 | Mvan_4141 | - | 1e-179 | 69.79% (427) | cytochrome P450 |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1806|M.bovis_AF2122/97 -MRRSPKGSPGAVLDLQRRVDQAVSADHAELMTIAKDANTFFGAESVQDP
Rv1777|M.tuberculosis_H37Rv -MRRSPKGSPGAVLDLQRRVDQAVSADHAELMTIAKDANTFFGAESVQDP
MAB_1939|M.abscessus_ATCC_1997 -----------------------------------MNTDELFDPQVLEDP
MUL_0314|M.ulcerans_Agy99 -------------------------------MSSYESIDFFTDPSLIPDP
MMAR_4694|M.marinum_M -------------------------------MSSYESIDFFTDPSLIPDP
MAV_0964|M.avium_104 -------------------------------MSNFDSIDFFTDPSLVPDP
Mflv_2517|M.gilvum_PYR-GCK -------------------------------MTDFDTIDYFTDPSLVPDP
Mvan_4141|M.vanbaalenii_PYR-1 -------------------------------MSDFDTIDYFTDPSLVPDP
MSMEG_4780|M.smegmatis_MC2_155 -------------------MTDSTATDPAATTPDFDTVDYFTDQSLVPDP
TH_4542|M.thermoresistible__bu ------------------------------MTTDFDSIDYFTDPSLVPDP
MLBr_02088|M.leprae_Br4923 MRTCVPTRTCVYAFIEYLSHNRPMGTNPPSLVEAQMLLLRLIDPGTRADP
: . **
Mb1806|M.bovis_AF2122/97 YPLYERMRAAGSVHRIANSDFYAVCGWDAVNEAIGRPEDFSSNLTAT---
Rv1777|M.tuberculosis_H37Rv YPLYERMRAAGSVHRIANSDFYAVCGWDAVNEAIGRPEDFSSNLTAT---
MAB_1939|M.abscessus_ATCC_1997 YPFYRRLRETAPVWPVGDSGFYFVSRWDLVVEATERAEDFSSNLTAA---
MUL_0314|M.ulcerans_Agy99 HPYFDYLRRQSPVLRLPQYGVVAVTGYEEATAVYKDTDSFSNCVALGGPF
MMAR_4694|M.marinum_M HPYFDYLRSQSPVLRLPQYGVVAVTGYEEATAVYKDTDSFSNCVALGGPF
MAV_0964|M.avium_104 HPYFDYLRSQNPVLRLPHYGVVAITGYEEATEVYKDPETFSNIVALGGPF
Mflv_2517|M.gilvum_PYR-GCK HPYFDHLRSKCPVVKEPHYGVLAVTGYEEAATVLKDSDTFSSCIAVAGPF
Mvan_4141|M.vanbaalenii_PYR-1 HPYFDHLRSKCPVVREPHYGVLAVTGYEEAATVLKDSDTFSSCIAVAGPF
MSMEG_4780|M.smegmatis_MC2_155 HPYFDHLRSKCPVVREPHYGVLAITSFEEATTVLKDTETFSSCIAVGGPF
TH_4542|M.thermoresistible__bu HPYFDHMRSKCPIAREPHHGVIAVTGWEEANDVYRDSENLSSCIAVMGPF
MLBr_02088|M.leprae_Br4923 FPVYRALIDYG-PMQLPGMPLTVFSSFSDCDEALRHPLSASDRLKAT---
.* : : . . :. . . *. :
Mb1806|M.bovis_AF2122/97 --MTYTAEGTAKPFEMDPLGGPT---HVLATADDPAHAVHRKLVLRHLAA
Rv1777|M.tuberculosis_H37Rv --MTYTAEGTAKPFEMDPLGGPT---HVLATADDPAHAVHRKLVLRHLAA
MAB_1939|M.abscessus_ATCC_1997 --LMKSAEGLAV-APMGPPADPT---HVLATGDDPLHHAHRRLVLPTLVA
MUL_0314|M.ulcerans_Agy99 PPLPFTPNGDDVNAQIDAHREQFPMYEHMVTMDPPEHSRARSILSRLLTP
MMAR_4694|M.marinum_M PPLPFAPNGDDVNAQIDAHREQFPMYEHMVTMDPPEHSRARSILSRLLTP
MAV_0964|M.avium_104 PPLPFTPEGDDISAQIDAHRSSFPMFEHMVTMDPPEHTKARSVLAKLLTP
Mflv_2517|M.gilvum_PYR-GCK PPLPFTPEGDDITDQITAHRPQMPMFEHMVTMDPPDHTNARSLLNRLLTP
Mvan_4141|M.vanbaalenii_PYR-1 PPLPFTPEGDDITGQIAAHRSQMPMFEHMVTMDPPDHTNARSLLNRLLTP
MSMEG_4780|M.smegmatis_MC2_155 PPLPFTPEGDDITGQIEQHRTQLPMFEHMVTMDPPEHTNARSLLNRLLTP
TH_4542|M.thermoresistible__bu TPLPFQPEGDDITEQIARHRTQIPMYEHMVTMDPPEHTNARSILARLLTP
MLBr_02088|M.leprae_Br4923 ----LAQQAIAAGAEPRPFYASS-----FMFLDPPDHTRLRKLVSKAFAP
:. : * * * * :: :..
Mb1806|M.bovis_AF2122/97 KRIRVMEQFTVQAADRLWVDGMQD---GCIEWMGAMANRLPMMVVAELIG
Rv1777|M.tuberculosis_H37Rv KRIRVMEQFTVQAADRLWVDGMQD---GCIEWMGAMANRLPMMVVAELIG
MAB_1939|M.abscessus_ATCC_1997 RRITALEPVMAQTGSCLWERGVNG---DGIDWMAAMGDALPMTMVARLIG
MUL_0314|M.ulcerans_Agy99 SRLKQNEEFMWRLADRQLDEFLGA---AECEFISEYAKPFATLVIADLLG
MMAR_4694|M.marinum_M SRLKQNEEFMWRLADRQLDEFLGA---GECEFISEYAKPFATLVIADLLG
MAV_0964|M.avium_104 SRLKQNEEFMWRLADRQLDEFLHN---GECEFIAEYSKPFATLVIADLLG
Mflv_2517|M.gilvum_PYR-GCK SRLKENEDFMWRLADEVLDDIIGAEPAGRCEFLTAYAKPFSLLVIADMLG
Mvan_4141|M.vanbaalenii_PYR-1 SRLKENEDFMWRLADEVLDDIISRDPVGRCEFLSAYAKPFSLLVIADMLG
MSMEG_4780|M.smegmatis_MC2_155 KRLKENEDFMWRLADECLDDFIDD---GSCEFLKQYAKPFSLLVIADLLG
TH_4542|M.thermoresistible__bu KRLKENEDFMWRLADRHIDEFIAD---GKCEFLAAYAKPFSLLVVADLLG
MLBr_02088|M.leprae_Br4923 KVVQALEGDIAALVDSLLDKGAAA---GQFDVIADLAFPLAVAVICRLLG
: * . : : . :. ::. ::*
Mb1806|M.bovis_AF2122/97 LPDPDIAQLV-----KWGYAATQLLEGLVENDQLVAAGVALMELSGYIFE
Rv1777|M.tuberculosis_H37Rv LPDPDIAQLV-----KWGYAATQLLEGLVENDQLVAAGVALMELSGYIFE
MAB_1939|M.abscessus_ATCC_1997 LPAGDVPQLV-----QWGYSSTEMLGGLNTPQRQAQVVTDTMHLVLYLRE
MUL_0314|M.ulcerans_Agy99 VPEDDRKDFR-----VVLGADRMG-RVGALDH-ESVGVNPLQWLDDKFSA
MMAR_4694|M.marinum_M VPEDDRKDFR-----VVLGADRMG-RVGALDH-ESVGVNPLQWLDDKFSA
MAV_0964|M.avium_104 VPEEDHTQFR-----TVLGADRPGARVGALDH-ETVGINPLEWLDDKFCN
Mflv_2517|M.gilvum_PYR-GCK VPEADHEEFR-----TVLGAPRPGANVGSLDHSDLVGANPLEWLDEKFIG
Mvan_4141|M.vanbaalenii_PYR-1 VPEADHEEFR-----TVLGAPRPGANVGSLDHSDLVGANPLEWLDEKFIG
MSMEG_4780|M.smegmatis_MC2_155 VPEEDHDEFR-----HVLGAPRPGAIVGSLDG-DQLAMNPLAWLDDKFVR
TH_4542|M.thermoresistible__bu VPEEDHDAFR-----EAFGAERPGTRIGSLDH-ETIATNPLEWADDKFTQ
MLBr_02088|M.leprae_Br4923 VPYEDAPEFGRVSALLVQSVDPFITITGEPPEATEERLRAGVWLRDYLEQ
:* * : :
Mb1806|M.bovis_AF2122/97 QFDRAAADPRDNLLGELATACAS--GELDTLTAQVMMVTLFAAGGESTAA
Rv1777|M.tuberculosis_H37Rv QFDRAAADPRDNLLGELATACAS--GELDTLTAQVMMVTLFAAGGESTAA
MAB_1939|M.abscessus_ATCC_1997 HLEEELAAPGDDLLGYLAQACNR--GDISLDIGVMILVQLVGAGGESTAG
MUL_0314|M.ulcerans_Agy99 YIEDRRRRPRNDVLTALATATYPDGSTPEIIDVVRWATFLFAAGQETTAK
MMAR_4694|M.marinum_M YIEDRRRQPRNDVLTALATATYPDGSTPEVIDVVRSATFLFAAGQETTAK
MAV_0964|M.avium_104 YIEERRREPRADVLTFLAEAKYPDGSTPPVIEVVRSATFLFAAGQETTAK
Mflv_2517|M.gilvum_PYR-GCK YLEDRRKEPRDDVLTALATAKYPDGSTPPVIEVVRSATFLFAAGQETTTK
Mvan_4141|M.vanbaalenii_PYR-1 YLEDRRKEPRDDVLTALATAKYPDGSTPPVIEVVRSATFLFAAGQETTTK
MSMEG_4780|M.smegmatis_MC2_155 YLEDRRKEPRDDVLTALATAKYPDGSTPEVIDVVRSATFLFAAGQETTTK
TH_4542|M.thermoresistible__bu YIEDRRREPRDDVLTAIATAKYPDGSTPEVIDVVRTATFLFAAGQETTAK
MLBr_02088|M.leprae_Br4923 LVKCRRGTPGEDLISRLIELDES-GDQLTEEEIIATCGLLLVAGHETTVN
.. * ::: : . *. ** *:*.
Mb1806|M.bovis_AF2122/97 LLGSAVWILATRPDIQQQVRANPELLGAFIEETLRYEPPFRGQYRHVRNA
Rv1777|M.tuberculosis_H37Rv LLGSAVWILATRPDIQQQVRANPELLGAFIEETLRYEPPFRGHYRHVRNA
MAB_1939|M.abscessus_ATCC_1997 LMGNAVRILGENPRLQQRIRENRALLPTFLEEALRLESPFRGHHRHVLTD
MUL_0314|M.ulcerans_Agy99 QLTAAMRVLGDRPDIQRQLRENRSLIPNFIEESLRMDSPVKSDSRLARKR
MMAR_4694|M.marinum_M LLTAAMRVLGDRPDIQRRLRENRSLIPNFIEESLRMDSPVKSDSRLARKR
MAV_0964|M.avium_104 LLSAALQVLGDRPDIQQQLREDRSLIPAFIEESLRMESPVKSDSRLARRA
Mflv_2517|M.gilvum_PYR-GCK LLSASMRVLGDHPEIQERLRRDRTRIPIFIEEALRMDAPVKSQFRLAKKN
Mvan_4141|M.vanbaalenii_PYR-1 LLSASLRVLGDHPDIQERLRRDRSRIPIFVEEALRMDAPVKSQFRLAKKN
MSMEG_4780|M.smegmatis_MC2_155 LLSASLRVLGDRPDIQQALREDRSRIPTFVEEALRMDAPVKSQFRLAKKT
TH_4542|M.thermoresistible__bu LLGAALQILGDRPDIQQTLREDRSRIPVFIEECLRMESPVKTVFRMVRKS
MLBr_02088|M.leprae_Br4923 LIANAVLAMLRNPSQWKALSSNPQRAPLVVEETLRYDPAIHLIGRVAAKD
: :: : .* . : : .:** ** :...: * .
Mb1806|M.bovis_AF2122/97 TTLDGTELPADSHLLLLWGAANRDPAQFEAPGEFRLDRAGGKGHISFGKG
Rv1777|M.tuberculosis_H37Rv TTLDGTELPADSHLLLLWGAANRDPAQFEAPGEFRLDRAGGKGHISFGKG
MAB_1939|M.abscessus_ATCC_1997 TTLGGVQLPAGSHLTLLWGAANRDPAIFEDPDVLRLDRPSPRGHITFGKG
MUL_0314|M.ulcerans_Agy99 TTVGGLDIAAGTVVMVLSGAANRDPRRFEDPHEFRLDRPNVREHMAFARG
MMAR_4694|M.marinum_M TTVGGLDIAAGTVVMVLPGAANRDPRRFEDPHEFRLDRPNVREHMAFARG
MAV_0964|M.avium_104 TTIGGVDIPAGTVVMILPGAANRDPRRFENPHEFDLRRKNVREHMAFARG
Mflv_2517|M.gilvum_PYR-GCK TKVGDMDVPAGTTMMVCPGAVNRDPSRFENPHDFDLDRKNVREHIAFGRG
Mvan_4141|M.vanbaalenii_PYR-1 TRVGDMDVPAGTTMMVCPGAVNRDPSRFEHPHEFDLDRKNVREHIAFGRG
MSMEG_4780|M.smegmatis_MC2_155 TQLGGVDVPAGTTLMVCPGAVNRDPVRFEDPHTFSLDRKNVREHIAFGRG
TH_4542|M.thermoresistible__bu TTVGDLDAPAGTTVMVAPGAANRDPRRFENPHEFDIDRKNVREHLAFSRG
MLBr_02088|M.leprae_Br4923 MTIGQTTLTEGDTMVLLLAAANRDPAVYSRPDEFDPDRPSSR-HLAFAVG
:. . . : : .*.**** :. * : * . : *::*. *
Mb1806|M.bovis_AF2122/97 AHFCVGAALARLEARIVLRLLLDRTSVIEAADVGG---------WLPSIL
Rv1777|M.tuberculosis_H37Rv AHFCVGAALARLEARIVLRLLLDRTSVIEAADVGG---------WLPSIL
MAB_1939|M.abscessus_ATCC_1997 LHFCVGAALARLEARTAINLLLDRTREFAIKPDGAH--------WVPSIM
MUL_0314|M.ulcerans_Agy99 VHSCPGGPLARVEGRVSLERILDRMLDIAINEDRHGPADDRRYTYEPTYI
MMAR_4694|M.marinum_M VHSCPGGPLARVEGRVSLERILDRMLDIAINEDRHGPADDRRYTYEPTYI
MAV_0964|M.avium_104 VHSCPGGPLARVEGRVSIERILDRMPHIEINETHHGPAGDRRYTYEPTYI
Mflv_2517|M.gilvum_PYR-GCK VHSCPGGPLARVEGRVSIERILDRMGDIAIDEELHGPPGDRRYNYEPTFI
Mvan_4141|M.vanbaalenii_PYR-1 VHSCPGGPLARVEGRVSIERILDRMGDIAIDEELHGPPGARRYNYEPTFI
MSMEG_4780|M.smegmatis_MC2_155 VHSCPGGPLARVEGRVSLERILDRMADIRIDEEHHGPADNRRYTYEPTYI
TH_4542|M.thermoresistible__bu IHSCPGAPLARVEGRVSIERLLDRLADIEIDADKHGGPGERNYTYEPTFI
MLBr_02088|M.leprae_Br4923 SHFCLGAALARLEATVTLSAISARFPQVQLAGELV---------YKPNVA
* * *..***:*. : : * . : *.
Mb1806|M.bovis_AF2122/97 VRRIERLELAVQ---------
Rv1777|M.tuberculosis_H37Rv VRRIERLELAVQ---------
MAB_1939|M.abscessus_ATCC_1997 VRRHQKLELEVSAA-------
MUL_0314|M.ulcerans_Agy99 LRGLTELHITFTPAG------
MMAR_4694|M.marinum_M LRGLTELHITFTPAG------
MAV_0964|M.avium_104 LRGLSELHLTFTTADAVAPVG
Mflv_2517|M.gilvum_PYR-GCK LRGLTDINITFTPIR------
Mvan_4141|M.vanbaalenii_PYR-1 LRGLTDLNITFTPVR------
MSMEG_4780|M.smegmatis_MC2_155 LRGLTDLHIKFEPVR------
TH_4542|M.thermoresistible__bu LRGLTELNITFKPIG------
MLBr_02088|M.leprae_Br4923 MRGMSALPVQV----------
:* : : .