For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
TDLATVDFFSDYAISQDPYAYWDFLREQSPVYREPHYGVVAVTGYKEVLAAFKDHDSFSAVNAIGGPFPP LPFTPEGDDITEQIEAHRHLFPIYEHMVVMDPPAHERARSLLNKLLTPRRLKENEDYMWRLVDSQIDQVI DKGRCEFLTEYAKPFATSAIIDLLGVPEEDRPEFLAALGAEQPDGARVGALDGEPVGLDPLQYLDDKFLG YLTERRREPRGDVLSGMATAVYPDGSTPDLIEVVKPATFLFAAGQETVTKLLSAAMKTLGEHPEYQPYLR EHPDRIPAFIEESLRMHSPTKIDFRLVRKTTTLGGMHLKAGTIVMLCLGAANRDPAKFDDPHEFRPDRKN VREHIAFGRGIHTCAGAPLARVEGQITVRRWLDRTSEIRLDEAVHGPAGDHRFSYDPTFLLRGLSELRIE YTAAS*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_1587 | - | - | 100% (426) | cytochrome P450 |
| M. gilvum PYR-GCK | Mflv_2517 | - | e-156 | 60.89% (427) | cytochrome P450 |
| M. gilvum PYR-GCK | Mflv_4149 | - | e-126 | 52.48% (423) | cytochrome P450 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0789c | cyp123 | 2e-43 | 30.99% (384) | cytochrome P450 123 |
| M. tuberculosis H37Rv | Rv0766c | cyp123 | 2e-43 | 30.99% (384) | cytochrome P450 123 |
| M. leprae Br4923 | MLBr_02088 | - | 9e-37 | 32.34% (337) | putative cytochrome p450 |
| M. abscessus ATCC 19977 | MAB_1216c | - | 1e-42 | 30.93% (388) | cytochrome P450 |
| M. marinum M | MMAR_4694 | cyp150A6 | 1e-158 | 61.41% (425) | cytochrome P450 150A6 Cyp150A6 |
| M. avium 104 | MAV_0849 | - | 0.0 | 73.18% (425) | cytochrome p450 |
| M. smegmatis MC2 155 | MSMEG_6030 | - | 0.0 | 80.42% (429) | cytochrome p450 |
| M. thermoresistible (build 8) | TH_4142 | - | 0.0 | 76.75% (400) | PUTATIVE cytochrome p450 |
| M. ulcerans Agy99 | MUL_0314 | cyp150A6 | 1e-157 | 61.18% (425) | cytochrome P450 150A6 Cyp150A6 |
| M. vanbaalenii PYR-1 | Mvan_5170 | - | 0.0 | 90.61% (426) | cytochrome P450 |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_1587|M.gilvum_PYR-GCK -------------------------------MTDLATVDFFSDYAISQDP
Mvan_5170|M.vanbaalenii_PYR-1 -------------------------------MTDLASADFFSDYALSQDP
MSMEG_6030|M.smegmatis_MC2_155 -------------------------------MTDLASVDYFSDPAVAQDP
TH_4142|M.thermoresistible__bu -------------------------------MTDLAAVDYFSDEAVSQNP
MAV_0849|M.avium_104 -------------------------------MTDLAQVDYFTDADVAQDP
MMAR_4694|M.marinum_M -------------------------------MSSYESIDFFTDPSLIPDP
MUL_0314|M.ulcerans_Agy99 -------------------------------MSSYESIDFFTDPSLIPDP
Mb0789c|M.bovis_AF2122/97 --------------------------MTVRVGDPE-LVLDPYDYDFHEDP
Rv0766c|M.tuberculosis_H37Rv --------------------------MTVRVGDPE-LVLDPYDYDFHEDP
MAB_1216c|M.abscessus_ATCC_199 --------------------------MTVAETSAVPLVFDPYDYDFHEDP
MLBr_02088|M.leprae_Br4923 MRTCVPTRTCVYAFIEYLSHNRPMGTNPPSLVEAQMLLLRLIDPGTRADP
* :*
Mflv_1587|M.gilvum_PYR-GCK YAYWDFLREQSPVYREPHYGVVAVTGYKEVLAAFKDHDSFSAVNAIGGPF
Mvan_5170|M.vanbaalenii_PYR-1 HPYWDHLREQNPVYREPHYGVVAVTGYQEVLAAFKDHDSFSAVNAIGGPF
MSMEG_6030|M.smegmatis_MC2_155 YEYYDFLRSRGPVTTEPHYGVVAVTGYQEVMAAFKDHDSFSAVNAIGGPF
TH_4142|M.thermoresistible__bu YEYYEYLRSQGPVFREPHHGVVAVTGYEEVLAAFKNHECFSAVNAIGGPF
MAV_0849|M.avium_104 YDYWDYLREQGPVFREPHYGVVAVTGYQEVQAAFKDVESFSAVNAIGGPF
MMAR_4694|M.marinum_M HPYFDYLRSQSPVLRLPQYGVVAVTGYEEATAVYKDTDSFSNCVALGGPF
MUL_0314|M.ulcerans_Agy99 HPYFDYLRRQSPVLRLPQYGVVAVTGYEEATAVYKDTDSFSNCVALGGPF
Mb0789c|M.bovis_AF2122/97 YPYYRRLRDEAPLYRNEERNFWAVSRHHDVLQGFRDSTALSNAYGVS---
Rv0766c|M.tuberculosis_H37Rv YPYYRRLRDEAPLYRNEERNFWAVSRHHDVLQGFRDSTALSNAYGVS---
MAB_1216c|M.abscessus_ATCC_199 YPYYRRLRDEAPLYRNDDLKFWALSRHHDVLQGFRNSEALSNANGVS---
MLBr_02088|M.leprae_Br4923 FPVYRALIDYGPMQLPG-MPLTVFSSFSDCDEALRHPLSASDRLKAT---
. : * *: . ..: . : :. . *
Mflv_1587|M.gilvum_PYR-GCK PPLPFTPEGDDITEQIEAHRHLFPIYEHMVVMDPPAHERARSLLNKLLTP
Mvan_5170|M.vanbaalenii_PYR-1 PPLPFTPEGDDITEQIEAHRHLFPIHEHLVVMDPPAHERARSLLNKLLTP
MSMEG_6030|M.smegmatis_MC2_155 PPLPFTPEGDDITEQIEAHRHLFPIHEHMVVMDPPAHERARSLLSKLLTP
TH_4142|M.thermoresistible__bu PPLPFEPEGDDISEQIEAHRHEFPIHEHMVVMDPPQHTRARSLLTKLLTP
MAV_0849|M.avium_104 PPLPFTPEGDDISELIEAHRHEFPIFEHMVVMDPPEHDKARSLLGRLLTP
MMAR_4694|M.marinum_M PPLPFAPNGDDVNAQIDAHREQFPMYEHMVTMDPPEHSRARSILSRLLTP
MUL_0314|M.ulcerans_Agy99 PPLPFTPNGDDVNAQIDAHREQFPMYEHMVTMDPPEHSRARSILSRLLTP
Mb0789c|M.bovis_AF2122/97 ---------LDPSSRTS----EAYRVMSMLAMDDPAHLRMRTLVSKGFTP
Rv0766c|M.tuberculosis_H37Rv ---------LDPSSRTS----EAYRVMSMLAMDDPAHLRMRTLVSKGFTP
MAB_1216c|M.abscessus_ATCC_199 ---------MDKASFGP----HAKLVMSFLAMDDPEHLRLRALVSKGFTP
MLBr_02088|M.leprae_Br4923 ---------LAQQAIAAGAEPRPFYASSFMFLDPPDHTRLRKLVSKAFAP
:: :* * * : * :: : ::*
Mflv_1587|M.gilvum_PYR-GCK RRLKENEDYMWRLVDSQIDQVID-----KGRCEFLTEYAKPFATSAIIDL
Mvan_5170|M.vanbaalenii_PYR-1 RRLKENEDYMWQLVDSQIDQVIG-----KGRCEFLSEYAKPFATSAIIDL
MSMEG_6030|M.smegmatis_MC2_155 RRLKENEDFMWQLVDRQLDAIIGNQA-DEGRCEFLSEYAKPFATSAIIDL
TH_4142|M.thermoresistible__bu RRLKENEDFMWQLADRQLDEFIA-----AGRCEFLSEYAKPFATMAIIDL
MAV_0849|M.avium_104 RRLQENKDYIWQLADRQFDEFIA-----NGHCEFLSEYAKPFATLAIADL
MMAR_4694|M.marinum_M SRLKQNEEFMWRLADRQLDEFLG-----AGECEFISEYAKPFATLVIADL
MUL_0314|M.ulcerans_Agy99 SRLKQNEEFMWRLADRQLDEFLG-----AAECEFISEYAKPFATLVIADL
Mb0789c|M.bovis_AF2122/97 RRIRELEPQVLELARIHLDSALQTES-----FDFVAEFAGKLPMDVISEL
Rv0766c|M.tuberculosis_H37Rv RRIRELEPQVLELARIHLDSALQTES-----FDFVAEFAGKLPMDVISEL
MAB_1216c|M.abscessus_ATCC_199 RRIRELEGQVVALARTHLDRALANASD--RSFDFIAEYAGKLPMDVISEL
MLBr_02088|M.leprae_Br4923 KVVQALEGDIAALVDSLLDKGAAAGQ-----FDVIADLAFPLAVAVICRL
:: : : *. :* :.::: * :. .* *
Mflv_1587|M.gilvum_PYR-GCK LGVPEEDRPEFLAALGAEQPDGARVGALDGE-----PVGLDPLQYLDDKF
Mvan_5170|M.vanbaalenii_PYR-1 LGVPEEDRPEFLAALGAEQPDGARVGALDGE-----PVGLDPLQYLDDKF
MSMEG_6030|M.smegmatis_MC2_155 LGVPEEDRAEFLEALGAAPREGARVGALDGE-----PVGLDPLQYLDCKF
TH_4142|M.thermoresistible__bu LGVPEEDRAEFRQALGADARPGSRVGALDGE-----PVGLNPLEYLDDKF
MAV_0849|M.avium_104 LGVPDEDRPQIRRNLGAGNAPGARVGALDHE-----PVGSNPLQYLDDLF
MMAR_4694|M.marinum_M LGVPEDDRKDFRVVLGADRMG--RVGALDHE-----SVGVNPLQWLDDKF
MUL_0314|M.ulcerans_Agy99 LGVPEDDRKDFRVVLGADRMG--RVGALDHE-----SVGVNPLQWLDDKF
Mb0789c|M.bovis_AF2122/97 IGVPDTDRARIRALADAVLHREDGVADVP-------PPAMAASIELMRYY
Rv0766c|M.tuberculosis_H37Rv IGVPDTDRARIRALADAVLHREDGVADVP-------PPAMAASIELMRYY
MAB_1216c|M.abscessus_ATCC_199 MGVPESDRARIRELADGVMHREDGLADVP-------PEAIQASFDLMTYY
MLBr_02088|M.leprae_Br4923 LGVPYEDAPEFGRVSALLVQSVDPFITITGEPPEATEERLRAGVWLRDYL
:*** * : . : . *
Mflv_1587|M.gilvum_PYR-GCK LGYLTERRREPRGDVLSGMATAVYPDGSTPDLIEVVKPATFLFAAGQETV
Mvan_5170|M.vanbaalenii_PYR-1 AGYLAERRREPRGDVLSGMATAVYPDGSTPELIEVVKPATFLFAAGQETV
MSMEG_6030|M.smegmatis_MC2_155 AGYLAERRREPRGDVLSGMATATYPDGSTPDLMEVVKPATFLFAAGQETV
TH_4142|M.thermoresistible__bu SEYIAERRREPRGDVLSGMAAATYPDGSTPELLEVVRPATFLFAAGQETV
MAV_0849|M.avium_104 SGYIADRRERPRDDVLTGLATATYPDGSTPPLLEVVRPATFLFAAGQETV
MMAR_4694|M.marinum_M SAYIEDRRRQPRNDVLTALATATYPDGSTPEVIDVVRSATFLFAAGQETT
MUL_0314|M.ulcerans_Agy99 SAYIEDRRRRPRNDVLTALATATYPDGSTPEIIDVVRWATFLFAAGQETT
Mb0789c|M.bovis_AF2122/97 ADLIAEFRRRPANNLTSALLAAEL-DGDRLSDQEIMAFLFLMVIAGNETT
Rv0766c|M.tuberculosis_H37Rv ADLIAEFRRRPANNLTSALLAAEL-DGDRLSDQEIMAFLFLMVIAGNETT
MAB_1216c|M.abscessus_ATCC_199 IEMVRERRRRPTEDLTSALLQAEI-DGDRLTDEEVLAFLFLMVIAGNETT
MLBr_02088|M.leprae_Br4923 EQLVKCRRGTPGEDLISRLIELDE-SGDQLTEEEIIATCGLLLVAGHETT
: * * :: : : .*. ::: ::. **:**.
Mflv_1587|M.gilvum_PYR-GCK TKLLSAAMKTLGEHPEYQPYLREHPDRIPAFIEESLRMHSPTKIDFRLVR
Mvan_5170|M.vanbaalenii_PYR-1 TKLLSAAVKTLAEQPEYQRILRAHPDRIPTFIEESLRMNAPTKVDFRLVR
MSMEG_6030|M.smegmatis_MC2_155 TKLLSSAVQTLAERPEFQERLRKEPDLIPVFIEEALRTQSPTKVDFRLAR
TH_4142|M.thermoresistible__bu TKLLSSAIKTLGERPEYQQMLRENRSLIPTFIEESLRMESPTKVDFRLAR
MAV_0849|M.avium_104 TKLLSAAVQVLGDQPELQAQLRADRGLIGPFIEEALRMQSPTKVDFRLAR
MMAR_4694|M.marinum_M AKLLTAAMRVLGDRPDIQRRLRENRSLIPNFIEESLRMDSPVKSDSRLAR
MUL_0314|M.ulcerans_Agy99 AKQLTAAMRVLGDRPDIQRQLRENRSLIPNFIEESLRMDSPVKSDSRLAR
Mb0789c|M.bovis_AF2122/97 TKLLANAVYWAAHHPGQLARVFADHSRIPMWVEETLRYDTSSQILARTVA
Rv0766c|M.tuberculosis_H37Rv TKLLANAVYWAAHHPGQLARVFADHSRIPMWVEETLRYDTSSQILARTVA
MAB_1216c|M.abscessus_ATCC_199 TKLLANAVYWGHRNPDQLATVHADHDRIPLWVEESLRYDTSSQILARTVA
MLBr_02088|M.leprae_Br4923 VNLIANAVLAMLRNPSQWKALSSNPQRAPLVVEETLRYDPAIHLIGRVAA
.: :: *: .* : . :**:** ... : * .
Mflv_1587|M.gilvum_PYR-GCK KTTTLGGMHLKAGTIVMLCLGAANRDPAKFDDPHEFRPDRKNVREHIAFG
Mvan_5170|M.vanbaalenii_PYR-1 KTTTLGGVHLKAGTIVMLCLGAANRDPRKFEDPHEFRPERKNVREHIAFG
MSMEG_6030|M.smegmatis_MC2_155 KTTTLGGVEIKAGTVLMLCLGAANRDPRKFEDPHEFRIDRPNVREHIAFG
TH_4142|M.thermoresistible__bu KTTELGGVRIAAGTVLMLCLGAANRDPRKFEQPHEFRPDRRNVREHIAFG
MAV_0849|M.avium_104 KTTTLGGVHIPAGTVIMLCLGAANRDPRKFENPNEFRIDRKNVREHIAFG
MMAR_4694|M.marinum_M KRTTVGGLDIAAGTVVMVLPGAANRDPRRFEDPHEFRLDRPNVREHMAFA
MUL_0314|M.ulcerans_Agy99 KRTTVGGLDIAAGTVVMVLSGAANRDPRRFEDPHEFRLDRPNVREHMAFA
Mb0789c|M.bovis_AF2122/97 HDLTLYDTTIPEGEVLLLLPGSANRDDRVFDDPDDYRIGREIGCKLVSFG
Rv0766c|M.tuberculosis_H37Rv HDLTLYDTTIPEGEVLLLLPGSANRDDRVFDDPDDYRIGREIGCKLVSFG
MAB_1216c|M.abscessus_ATCC_199 EDITVYDTKIPAGDILLLLPGSANRDDRVFDDADQYRIGREIGAKLVSFG
MLBr_02088|M.leprae_Br4923 KDMTIGQTTLTEGDTMVLLLAAANRDPAVYSRPDEFDPDRPS-SRHLAFA
. : : * ::: .:**** :. ..:: * . ::*.
Mflv_1587|M.gilvum_PYR-GCK RGIHTCAGAPLARVEGQITVRRWLD-------------------------
Mvan_5170|M.vanbaalenii_PYR-1 RGIHTCAGAPLARVEGQITVRRWLD-------------------------
MSMEG_6030|M.smegmatis_MC2_155 RGIHTCAGAPLARVEGQITVRRMLD-------------------------
TH_4142|M.thermoresistible__bu RGIHSCAGAPLARVEGRITVERVLXGADRPFSRRLRLHGRSRSGGLRRTG
MAV_0849|M.avium_104 RGIHTCAGAPLARVEGQITINRLLD-------------------------
MMAR_4694|M.marinum_M RGVHSCPGGPLARVEGRVSLERILD-------------------------
MUL_0314|M.ulcerans_Agy99 RGVHSCPGGPLARVEGRVSLERILD-------------------------
Mb0789c|M.bovis_AF2122/97 SGAHFCLGAHLARMEARVALGALLR-------------------------
Rv0766c|M.tuberculosis_H37Rv SGAHFCLGAHLARMEARVALGALLR-------------------------
MAB_1216c|M.abscessus_ATCC_199 SGAHFCLGAHLARMEAKVALTELFT-------------------------
MLBr_02088|M.leprae_Br4923 VGSHFCLGAALARLEATVTLSAISA-------------------------
* * * *. ***:*. :::
Mflv_1587|M.gilvum_PYR-GCK -----------------RTSEIRLDEA-----------------VHGPAG
Mvan_5170|M.vanbaalenii_PYR-1 -----------------RTDEIHLDES-----------------VHGPAG
MSMEG_6030|M.smegmatis_MC2_155 -----------------RLRDIRIDAT-----------------RHGPAD
TH_4142|M.thermoresistible__bu DRHRITGVTRHARGWSRREGDVQLGQAPQQKRRLVPVRAVTGGSVHGVVD
MAV_0849|M.avium_104 -----------------RTSELRINEA-----------------KHGPAS
MMAR_4694|M.marinum_M -----------------RMLDIAINED-----------------RHGPAD
MUL_0314|M.ulcerans_Agy99 -----------------RMLDIAINED-----------------RHGPAD
Mb0789c|M.bovis_AF2122/97 -----------------RIRNYEVDDD-----------------------
Rv0766c|M.tuberculosis_H37Rv -----------------RIRNYEVDDD-----------------------
MAB_1216c|M.abscessus_ATCC_199 -----------------RISGYEIDER-----------------------
MLBr_02088|M.leprae_Br4923 -----------------RFPQVQLAG------------------------
* :
Mflv_1587|M.gilvum_PYR-GCK -------DHRFSYDPTFLLRG------LSELRIEYTAAS--
Mvan_5170|M.vanbaalenii_PYR-1 -------QHHFAYDPTFLLRG------LSQLNIEFTAAT--
MSMEG_6030|M.smegmatis_MC2_155 -------SRTYAYEPTFLLRG------LTKLHIEYTPA---
TH_4142|M.thermoresistible__bu RQIAHPVQHPFHGDPPXGGGGGERPISTGPPRRPNRPATPT
MAV_0849|M.avium_104 -------SRQYRYESTFLLRG------LTELHIEFTQAG--
MMAR_4694|M.marinum_M -------DRRYTYEPTYILRG------LTELHITFTPAG--
MUL_0314|M.ulcerans_Agy99 -------DRRYTYEPTYILRG------LTELHITFTPAG--
Mb0789c|M.bovis_AF2122/97 ---------NVVRVHSSNVRG------FAHLPISVQAR---
Rv0766c|M.tuberculosis_H37Rv ---------NVVRVHSSNVRG------FAHLPISVQAR---
MAB_1216c|M.abscessus_ATCC_199 ---------NSVRVHSSNVRG------FAHLPMTVQLREGR
MLBr_02088|M.leprae_Br4923 ---------ELVYKPNVAMRG------MSALPVQV------
*