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MRDVLVVDDDFMVAEIHRRFVDRVDGFRAVGVARTGAEAMASADALRPDLILLDVYLPDMTGLEVLKRLR ADGNLVGVIMITAARELDTVRGALDGGAADYLIKPFEFDQLRAKLVAFAARADALAADGGADQSMIDALF GGSAPTATAALPKGLGAETGRLVMDAVRNAGEVSAAQCAELVGISRVSARRYLEHFLSTGALELRLQYGT GRPERRYRIP
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_4212 | - | - | 100% (220) | transcriptional regulatory protein CitT |
| M. smegmatis MC2 155 | MSMEG_5306 | - | 2e-29 | 37.05% (224) | two-component system response regulator |
| M. smegmatis MC2 155 | MSMEG_5488 | - | 7e-17 | 37.88% (132) | DNA-binding response regulator |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3791c | - | 6e-17 | 36.72% (128) | putative two component transcriptional regulatory protein |
| M. gilvum PYR-GCK | Mflv_3002 | - | 7e-95 | 79.00% (219) | response regulator receiver/unknown domain-containing protein |
| M. tuberculosis H37Rv | Rv3765c | - | 6e-17 | 36.72% (128) | two component transcriptional regulatory protein |
| M. leprae Br4923 | MLBr_00773 | mtrA | 1e-16 | 41.67% (120) | putative two-component response regulator |
| M. abscessus ATCC 19977 | MAB_3591c | - | 2e-16 | 40.83% (120) | DNA-binding response regulator MtrA |
| M. marinum M | MMAR_5317 | tcrX | 7e-20 | 35.91% (181) | two-component transcriptional regulatory protein TcrX |
| M. avium 104 | MAV_0304 | - | 1e-18 | 33.52% (182) | DNA-binding response regulator |
| M. thermoresistible (build 8) | TH_1732 | phoP | 7e-16 | 37.59% (133) | DNA-binding response regulator PhoP |
| M. ulcerans Agy99 | MUL_4391 | tcrX | 1e-19 | 35.36% (181) | two component transcriptional regulatory protein TcrX |
| M. vanbaalenii PYR-1 | Mvan_3504 | - | 8e-96 | 80.82% (219) | response regulator receiver/unknown domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3791c|M.bovis_AF2122/97 ------------MRRADGQPVTVLVVDDEPVLAEMVS-MALRYEGWNIT-
Rv3765c|M.tuberculosis_H37Rv ------------MRRADGQPVTVLVVDDEPVLAEMVS-MALRYEGWNIT-
MAV_0304|M.avium_104 MSQPRASAERVVMCRADGNPINVLVVDDEAVLAEMVS-MALRYEGWNIA-
MMAR_5317|M.marinum_M -----------MMCRADGQPVSVLVVDDEPVLAEMVS-MALRYEGWNIA-
MUL_4391|M.ulcerans_Agy99 ------------MCRADGQPVSVLVVDDEPVLADMVS-MALRYEGWNIA-
TH_1732|M.thermoresistible__bu ------------------VAVRILVVDDDRAVRESLR-RSLSFNGYSVE-
MLBr_00773|M.leprae_Br4923 ---------------MDIMRQRILVVDDDASLAEMLT-IVLRGEGFDTA-
MAB_3591c|M.abscessus_ATCC_199 ------------------MRQRILVVDDDASLAEMLT-IVLRGEGFETA-
Mflv_3002|M.gilvum_PYR-GCK -------------------MRDVLVVDDDFMVAEIHRRFVDRIDGFRVVG
Mvan_3504|M.vanbaalenii_PYR-1 -------------------MRDVLVVDDDFMVADIHRRFVDRVDGFRAVG
MSMEG_4212|M.smegmatis_MC2_155 -------------------MRDVLVVDDDFMVAEIHRRFVDRVDGFRAVG
:*****: : : :*:
Mb3791c|M.bovis_AF2122/97 TAGDGSSAIAAARRQRPDVVVLDVMLPDMSGLDVLHKLRSENPGLPVLLL
Rv3765c|M.tuberculosis_H37Rv TAGDGSSAIAAARRQRPDVVVLDVMLPDMSGLDVLHKLRSENPGLPVLLL
MAV_0304|M.avium_104 TASDGASAIAAARNQRPDVVVLDVMLPDMSGLDVLHKLREENPQLPVLLL
MMAR_5317|M.marinum_M TASDGASAIASARAERPDVVVLDVMLPDMSGLEVLHRLRKENPALPVLLL
MUL_4391|M.ulcerans_Agy99 TASDGASAIASARAERPDVVVLDVMLPDMSGLEVLHRLRKENPRLPVLLL
TH_1732|M.thermoresistible__bu LAEDGVEALDLIANDRPDAVVLDVMMPRLDGLEVCRQLRSTGDDLPILVL
MLBr_00773|M.leprae_Br4923 VIGDGTQALTAVRELRPDLVLLDLMLPGMNGIDVCRVLRADS-GVPIVML
MAB_3591c|M.abscessus_ATCC_199 VVSDGTQALTAVRELRPDLVLLDLMLPGMNGIDVCRVLRSDS-GVPIVML
Mflv_3002|M.gilvum_PYR-GCK VARTGAEALEATRQLRPQLILLDVYLPDMTGLEVLQQLRSGGDRVDVIVI
Mvan_3504|M.vanbaalenii_PYR-1 VARTGEEALTATKELRPQLILLDVYLPDMTGLDVLQRLRAEGDRVDVIMI
MSMEG_4212|M.smegmatis_MC2_155 VARTGAEAMASADALRPDLILLDVYLPDMTGLEVLKRLRADGNLVGVIMI
* .*: **: ::**: :* : *::* : ** . : ::::
Mb3791c|M.bovis_AF2122/97 TAKDAVEDRIAGLTAGGDDYVTKPFSIEEVVLRLRALLRRTGVTTVDSGA
Rv3765c|M.tuberculosis_H37Rv TAKDAVEDRIAGLTAGGDDYVTKPFSIEEVVLRLRALLRRTGVTTVDSGA
MAV_0304|M.avium_104 TAKDAVEDRIAGLTAGGDDYVTKPFSIEEVVLRLRALLRRTGVTTVDSGA
MMAR_5317|M.marinum_M TAKDAVEDRIAGLTAGGDDYVTKPFSIEEVVLRLRALLRRTGVTTVDSGA
MUL_4391|M.ulcerans_Agy99 TAKDAVEDRIAGLTAGGDDYVTKPFSIEEIVLRLRALLRRTGVTTVDSGA
TH_1732|M.thermoresistible__bu TARDSVSERVAGLDAGADDYLPKPFALEELLARLRALLRRTTPDDAADSQ
MLBr_00773|M.leprae_Br4923 TAKTDTVDVVLGLESGADDYIMKPFKPKELVARVRARLRRN---DDEPAE
MAB_3591c|M.abscessus_ATCC_199 TAKTDTVDVVLGLESGADDYIMKPFKPKELVARIRARLRRN---DDEPAE
Mflv_3002|M.gilvum_PYR-GCK TAARELDTVRGALDGGAADYLIKPFEFSQLETKLTAYAARADALQSARGA
Mvan_3504|M.vanbaalenii_PYR-1 TAARELDTVRGALDGGAADYLIKPFEFAQLQAKLQAFAARADALQSASGV
MSMEG_4212|M.smegmatis_MC2_155 TAARELDTVRGALDGGAADYLIKPFEFDQLRAKLVAFAARADALAADGGA
** .* .*. **: *** :: :: * * .
Mb3791c|M.bovis_AF2122/97 QLVVGDLVLDEDSHEVMRAGEPVSLTSTEFELLRFMMHNSKRVLSKAQIL
Rv3765c|M.tuberculosis_H37Rv QLVVGDLVLDEDSHEVMRAGEPVSLTSTEFELLRFMMHNSKRVLSKAQIL
MAV_0304|M.avium_104 QLVVGDLVLDEDSHEVTRAGEPISLTSTEFELLRFMMRNSKRVLSKAQIL
MMAR_5317|M.marinum_M QLVVGDLVLDEDSHEVTRAGEPISLTSTEFELLRFMMRNSKRVLSKAQIL
MUL_4391|M.ulcerans_Agy99 QLVVGDLVLDEDSHEVTRAGEPISLTSTEFELLRFMMRNSKRVLSNAQIL
TH_1732|M.thermoresistible__bu KLTFADLTLDPVTREVTRGNRQISLTRTEFALLELLIANPRRVLSRSRIL
MLBr_00773|M.leprae_Br4923 MLSIADVDIDVPAHKVTRNGEHISLTPLEFDLLVALARKPRQVFTRDVLL
MAB_3591c|M.abscessus_ATCC_199 LLNIAGIDIDVPAHKVTREGEQISLTPLEFDLLVALARKPRQVFTRDVLL
Mflv_3002|M.gilvum_PYR-GCK DQDLIDALFGGPSVAPAKT-MPKGLGAETGELVLDAVRTAGEVS--AAEC
Mvan_3504|M.vanbaalenii_PYR-1 DQTLIDTLFGGPAVTPAKV-LPKGLGAETGELVLAAVRGAGEVS--AAEC
MSMEG_4212|M.smegmatis_MC2_155 DQSMIDALFGGSAPTATAA-LPKGLGAETGRLVMDAVRNAGEVS--AAQC
. . :. : .* *: . .*
Mb3791c|M.bovis_AF2122/97 DRVWSYDFGGRSNIVELYISY--LRKKIDNG-REP-MIHTLRGAGYVLKP
Rv3765c|M.tuberculosis_H37Rv DRVWSYDFGGRSNIVELYISY--LRKKIDNG-REP-MIHTLRGAGYVLKP
MAV_0304|M.avium_104 DRVWSYDFGGRSNIVELYISY--LRKKIDNG-REP-MIHTLRGAGYVLKP
MMAR_5317|M.marinum_M DRVWSYDFGGRSNIVELYISY--LRKKIDNG-REP-MIHTLRGAGYVLKP
MUL_4391|M.ulcerans_Agy99 DRVWSYDFGGRSNIVELYISY--LRKKIDNG-REP-MIHTLRGAGYVLKP
TH_1732|M.thermoresistible__bu EEVWGFDFPTSGNALEVYIGY--LRRKTEAE-GEPRLIHTVRGVGYVLRE
MLBr_00773|M.leprae_Br4923 EQVWGYRHPADTRLVNVHVQR--LRAKVEKDPENPTVVLTVRGVGYKAGP
MAB_3591c|M.abscessus_ATCC_199 EQVWGYRHPADTRLVNVHVQR--LRAKVEKDPENPTVVLTVRGVGYKAGP
Mflv_3002|M.gilvum_PYR-GCK ADLVGISRVSARRYLEHYLGTGTLELRLQYGVGRPERRYRIAG-------
Mvan_3504|M.vanbaalenii_PYR-1 ADAVGISRVSARRYLEHYLSVGALELRLQYGVGRPERRYRIAG-------
MSMEG_4212|M.smegmatis_MC2_155 AELVGISRVSARRYLEHFLSTGALELRLQYGTGRPERRYRIP--------
. . :: .: *. : : .* :
Mb3791c|M.bovis_AF2122/97 AR-
Rv3765c|M.tuberculosis_H37Rv AR-
MAV_0304|M.avium_104 AR-
MMAR_5317|M.marinum_M AR-
MUL_4391|M.ulcerans_Agy99 AR-
TH_1732|M.thermoresistible__bu TPP
MLBr_00773|M.leprae_Br4923 P--
MAB_3591c|M.abscessus_ATCC_199 P--
Mflv_3002|M.gilvum_PYR-GCK ---
Mvan_3504|M.vanbaalenii_PYR-1 ---
MSMEG_4212|M.smegmatis_MC2_155 ---