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M. tuberculosis H37Rv Rv0981 (mprA)

annotation: MYCOBACTERIAL PERSISTENCE REGULATOR MRPA (TWO COMPONENT RESPONSE TRANSCRIPTIONAL REGULATORY PROTEIN)
coordinates: 1096816 - 1097508
length: 230

VSVRILVVDDDRAVRESLRRSLSFNGYSVELAHDGVEALDMIASDRPDALVLDVMMPRLDGLEVCRQLRG
TGDDLPILVLTARDSVSERVAGLDAGADDYLPKPFALEELLARMRALLRRTKPEDAAESMAMRFSDLTLD
PVTREVNRGQRRISLTRTEFALLEMLIANPRRVLTRSRILEEVWGFDFPTSGNALEVYVGYLRRKTEADG
EPRLIHTVRGVGYVLRETPP

Operon Prediction Model: Genebank

Paralogs

species id gene e-value identity (len) annotation
M. tuberculosis H37Rv Rv0981 mprA - 100% (230) MYCOBACTERIAL PERSISTENCE REGULATOR MRPA (TWO COMPONENT RESPONSE TRANSCRIPTIONAL REGULATORY PROTEIN)
M. tuberculosis H37Rv Rv1033c trcR 4e-60 50.00% (228) two component transcriptional regulator TRCR
M. tuberculosis H37Rv Rv0903c prrA 4e-57 50.67% (225) two component response transcriptional regulatory protein

Closest Orthologs (e-value cutoff: 1e-4)

species id gene e-value identity (len) annotation
M. bovis AF2122 / 97 Mb1007 mprA 1e-126 99.57% (230) two component response transcriptional regulatory protein
M. gilvum PYR-GCK Mflv_1887 - 1e-115 91.77% (231) two component transcriptional regulator
M. leprae Br4923 MLBr_00174 - 1e-119 94.30% (228) putative two-component response regulator
M. abscessus ATCC 19977 MAB_1076 - 1e-112 87.83% (230) two component response transcriptional regulatory protein MprA
M. marinum M MMAR_4529 mprA 1e-120 94.40% (232) two component response transcriptional regulatory protein
M. avium 104 MAV_1094 - 1e-123 97.81% (228) two component response transcriptional regulatory protein MprA
M. smegmatis MC2 155 MSMEG_5488 - 1e-115 90.00% (230) DNA-binding response regulator
M. thermoresistible (build 8) TH_1732 phoP 1e-117 90.43% (230) DNA-binding response regulator PhoP
M. ulcerans Agy99 MUL_4701 mprA 1e-119 93.97% (232) two component response transcriptional regulatory protein
M. vanbaalenii PYR-1 Mvan_4844 - 1e-116 92.21% (231) two component transcriptional regulator

CLUSTAL 2.0.9 multiple sequence alignment


Mflv_1887|M.gilvum_PYR-GCK          MPVRILVVDDDRAVRESLRRSLSFNGYSVELAQDGREALDLIASDRPDAV
Mvan_4844|M.vanbaalenii_PYR-1       MPVRILVVDDDRAVRESLRRSLSFNGYSVELAQDGREALDLIASDRPDAV
Rv0981|M.tuberculosis_H37Rv         MSVRILVVDDDRAVRESLRRSLSFNGYSVELAHDGVEALDMIASDRPDAL
Mb1007|M.bovis_AF2122/97            MSVRILVVDDDRAVRESLRRSLSFNGYSVELAHDGVEALDMIASDRPDAL
MAV_1094|M.avium_104                --MRILVVDDDRAVRESLRRSLSFNGYSVELAHDGVEALDMIASDRPDAL
MLBr_00174|M.leprae_Br4923          --MRILAVDDDRAVRESLRRSLSFNGYSVELANDGVEALEMVARDRPDAL
MMAR_4529|M.marinum_M               MSVRILVVDDDRAVRESLRRSLSFNGYTVELAHDGVEALEMIASDRPDAL
MUL_4701|M.ulcerans_Agy99           MSVRILVVDDDRAVRESLRRSLSFNGYTVELAHDGVEALEMIASDRPDAL
MSMEG_5488|M.smegmatis_MC2_155      MAVRILVVDDDRAVRESLRRSLSFNGYSVELAQDGVEALDAITNNRPDAL
TH_1732|M.thermoresistible__bu      VAVRILVVDDDRAVRESLRRSLSFNGYSVELAEDGVEALDLIANDRPDAV
MAB_1076|M.abscessus_ATCC_1997      MPVRILVVDDDRAVRESLRRSLSFNGYSVDLAEDGVDALNVIANDRPDAL
                                      :***.********************:*:**.** :**: :: :****:

Mflv_1887|M.gilvum_PYR-GCK          VLDVMMPRLDGLEVCRQLRSTGDDLPILVLTARDSVSERVAGLDAGADDY
Mvan_4844|M.vanbaalenii_PYR-1       VLDVMMPRLDGLEVCRQLRSTGDDLPILVLTARDSVSERVAGLDAGADDY
Rv0981|M.tuberculosis_H37Rv         VLDVMMPRLDGLEVCRQLRGTGDDLPILVLTARDSVSERVAGLDAGADDY
Mb1007|M.bovis_AF2122/97            VLDVMMPRLDGLEVCRQLRSTGDDLPILVLTARDSVSERVAGLDAGADDY
MAV_1094|M.avium_104                VLDVMMPRLDGLEVCRQLRSTGDDLPILVLTARDSVSERVAGLDAGADDY
MLBr_00174|M.leprae_Br4923          VLDVMMPRLDGLEVCRQLRSTGDDLPILVLTARDSVSERVAGLDAGADDY
MMAR_4529|M.marinum_M               VLDVMMPRLDGLEVCRQLRSTGDDLPILVLTARDSVSERVAGLDAGADDY
MUL_4701|M.ulcerans_Agy99           VLDVMMPRLDGLEVCRQLRSTGDDLPILVLTARDSVSERVAGLDAGADDY
MSMEG_5488|M.smegmatis_MC2_155      ILDVMMPRLDGLEVCRQLRSTGDDLPILVLTARDSVSERVAGLDAGADDY
TH_1732|M.thermoresistible__bu      VLDVMMPRLDGLEVCRQLRSTGDDLPILVLTARDSVSERVAGLDAGADDY
MAB_1076|M.abscessus_ATCC_1997      VLDVMMPKLDGLEVCRRLRSTGDDLPILVLTARDSVSERVAGLDAGADDY
                                    :******:********:**.******************************

Mflv_1887|M.gilvum_PYR-GCK          LPKPFALEELLARMRALLRRTSPVDG-DGESAAMTFSDLTLDPVTREVTR
Mvan_4844|M.vanbaalenii_PYR-1       LPKPFALEELLARMRALLRRTTPDDG-AGESAAMTFSDLSLDPVTREVTR
Rv0981|M.tuberculosis_H37Rv         LPKPFALEELLARMRALLRRTKPED--AAESMAMRFSDLTLDPVTREVNR
Mb1007|M.bovis_AF2122/97            LPKPFALEELLARMRALLRRTKPED--AAESMAMRFSDLTLDPVTREVNR
MAV_1094|M.avium_104                LPKPFALEELLARMRALLRRTKPED--DAESVAMTFSDLTLDPVTREVTR
MLBr_00174|M.leprae_Br4923          LPKPFALEELLARIRALLRRTKPDD--AAESVAMSFSDLTLDPVTREVAR
MMAR_4529|M.marinum_M               LPKPFALEELLARMRALLRRTKPEDDEAADSVAMTFSDLSLDPVTREVTR
MUL_4701|M.ulcerans_Agy99           LPKPFALEELLARMRALLRRTKLEDDEAADSVAMTFSDLSLDPVTREVTR
MSMEG_5488|M.smegmatis_MC2_155      LPKPFALEELLARMRALLRRTVSDD--SGDSQKMTFSDLTLDPVTREVTR
TH_1732|M.thermoresistible__bu      LPKPFALEELLARLRALLRRTTPDD--AADSQKLTFADLTLDPVTREVTR
MAB_1076|M.abscessus_ATCC_1997      LPKPFALEELLARMRALLRRTTIDE--SADAATLSFGDLTLDPVTREVHR
                                    *************:*******   :   .::  : *.**:******** *

Mflv_1887|M.gilvum_PYR-GCK          GNRSISLTRTEFSLLEMLITNPRRVLTRSRILEEVWGFDFPTSGNALEVY
Mvan_4844|M.vanbaalenii_PYR-1       GDRPISLTRTEFSLLEMLIANPRRVLTRSRILEEVWGFDFPTSGNALEVY
Rv0981|M.tuberculosis_H37Rv         GQRRISLTRTEFALLEMLIANPRRVLTRSRILEEVWGFDFPTSGNALEVY
Mb1007|M.bovis_AF2122/97            GQRRISLTRTEFALLEMLIANPRRVLTRSRILEEVWGFDFPTSGNALEVY
MAV_1094|M.avium_104                GQRRISLTRTEFALLEMLIANPRRVLTRSRILEEVWGFDFPTSGNALEVY
MLBr_00174|M.leprae_Br4923          GQRWISLTRTEFALLEMLIANPRRVLTRSRILEEVWGFDFPTSGNALEVY
MMAR_4529|M.marinum_M               GARRISLTRTEFALLEMLIANPRRVLTRSRILEEVWGFDFPTSGNALEVY
MUL_4701|M.ulcerans_Agy99           GARRISLTRTEFALLEMLIANPRRVLTRSRILEEVWGFDFPTSGNALEVY
MSMEG_5488|M.smegmatis_MC2_155      GGRQISLTRTEFSLLEMLIANPRRVLTRSRILEEVWGFDFPTSGNALEVY
TH_1732|M.thermoresistible__bu      GNRQISLTRTEFALLELLIANPRRVLSRSRILEEVWGFDFPTSGNALEVY
MAB_1076|M.abscessus_ATCC_1997      GTRSISLTRTEFALLEMLMANPRRVLTRSRILEEVWGFDFPTSGNALEVY
                                    * * ********:***:*::******:***********************

Mflv_1887|M.gilvum_PYR-GCK          VGYLRRKTEAEGEPRLIHTVRGVGYVLRETPP
Mvan_4844|M.vanbaalenii_PYR-1       VGYLRRKTEAEGEPRLIHTVRGVGYVLRETPP
Rv0981|M.tuberculosis_H37Rv         VGYLRRKTEADGEPRLIHTVRGVGYVLRETPP
Mb1007|M.bovis_AF2122/97            VGYLRRKTEADGEPRLIHTVRGVGYVLRETPP
MAV_1094|M.avium_104                VGYLRRKTEADGEPRLIHTVRGVGYVLRETPP
MLBr_00174|M.leprae_Br4923          VGYLRRKTEADGESRLIHTVRGVGYVLRETPP
MMAR_4529|M.marinum_M               VGYLRRKTEAEGEPRLIHTVRGVGYVLRETPP
MUL_4701|M.ulcerans_Agy99           VGYLRRKTEAEGEPRLIHTVRGVGYVLRETPP
MSMEG_5488|M.smegmatis_MC2_155      IGYLRRKTEAEGEPRLIHTVRGVGYVLRETPP
TH_1732|M.thermoresistible__bu      IGYLRRKTEAEGEPRLIHTVRGVGYVLRETPP
MAB_1076|M.abscessus_ATCC_1997      VGYLRRKTEAEGELRLIHTVRGVGYVLRETPP
                                    :*********:** ******************

species	id	gene	e-value	identity (len)	annotation
M. tuberculosis H37Rv	Rv0981	mprA	-	100% (230)	MYCOBACTERIAL PERSISTENCE REGULATOR MRPA (TWO COMPONENT RESPONSE TRANSCRIPTIONAL REGULATORY PROTEIN)
M. tuberculosis H37Rv	Rv1033c	trcR	4e-60	50.00% (228)	two component transcriptional regulator TRCR
M. tuberculosis H37Rv	Rv0903c	prrA	4e-57	50.67% (225)	two component response transcriptional regulatory protein