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VFEVDEGASQAELRAVVEECERLKSRAAAAQARATVLWAAQRAAAERAAGVPASRRGKGLASEVALARRE APVKGNQHLGFAKALMQEMPHTLAALEGGVLSEWRATLIVRESACLSVEHRRQLDAELCGDPSRVAGWGN KRVEAEAKRIAARLDVAAVVERNDRAVKDRCVSTRPAPHNMVYVTLLMPLAQGIGMYAALRRHGEMTVDG RSLGQVMTDTAFERITGRSAAAPVPVELNLVMADTTLAGDDDCPGWLDGYGPVPAGFCRGLVGDAVADAE PKAALRRLYRHPRSGQLVAMESSARVFPKGLATLIDRRDQTCRTPYCDAPIRHHDHAVPDRAGGQTSADN GLGACAGCNYAKEAPGWKVTAGGEDGVHTARWVTPTGAVHYSIAPTLPGPPVYRRISSTESRLSIDLITF DRPDVA
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_2897 | - | - | 100% (426) | HNH nuclease |
| M. gilvum PYR-GCK | Mflv_2586 | - | 0.0 | 82.86% (426) | hypothetical protein Mflv_2586 |
| M. gilvum PYR-GCK | Mflv_3750 | - | e-172 | 71.73% (421) | HNH nuclease |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3101 | - | 1e-133 | 58.85% (418) | hypothetical protein Mb3101 |
| M. tuberculosis H37Rv | Rv3074 | - | 1e-133 | 58.85% (418) | hypothetical protein Rv3074 |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_1907 | - | 1e-114 | 52.88% (399) | hypothetical protein MAB_1907 |
| M. marinum M | MMAR_1584 | - | 1e-135 | 61.83% (393) | hypothetical protein MMAR_1584 |
| M. avium 104 | MAV_3980 | - | 1e-131 | 59.08% (413) | hypothetical protein MAV_3980 |
| M. smegmatis MC2 155 | MSMEG_6025 | - | 1e-152 | 63.98% (422) | hypothetical protein MSMEG_6025 |
| M. thermoresistible (build 8) | TH_0334 | - | 3e-09 | 23.96% (313) | HNH endonuclease |
| M. ulcerans Agy99 | MUL_2679 | - | 9e-14 | 25.29% (427) | 13e12 repeat-containing protein |
| M. vanbaalenii PYR-1 | Mvan_5297 | - | 0.0 | 75.24% (424) | hypothetical protein Mvan_5297 |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_2897|M.gilvum_PYR-GCK --------------MFEVDEGASQAELRAVVEECERLKSRAAAAQARATV
Mvan_5297|M.vanbaalenii_PYR-1 ----------MFESLFDVDVGASEAELRAAVERCERLKSQAAAAQARATA
MSMEG_6025|M.smegmatis_MC2_155 MSVRGCSVWHMFESLFDIDPQASEAELRDRIEQFERMKSAAAAAQATASV
Mb3101|M.bovis_AF2122/97 ----------MFETLTAIDPDAEEAALIERIAELERLKSAAAAGQARAAA
Rv3074|M.tuberculosis_H37Rv ----------MFETLTAIDPDAEEAALIERIAELERLKSAAAAGQARAAA
MMAR_1584|M.marinum_M ----------MFESLAAVDPAADQAALVERIAELETVKSAAAAGQARAAA
MAV_3980|M.avium_104 ---------------MAVDPAAGESALIERISELETLKCAAAAAQARAAA
MAB_1907|M.abscessus_ATCC_1997 --------------MLPLDPATRAAQLVDRIAELERVKAAAAAEQAHAAV
TH_0334|M.thermoresistible__bu -----------------MFESLDDGAVVDSIAAASREQSAACGREMLAIG
MUL_2679|M.ulcerans_Agy99 ----------MDQHIIEYVFDTDDSAPLTRITAAARAEARAAAERLAAIG
. : :. *.. . *
Mflv_2897|M.gilvum_PYR-GCK LWAAQRAAAERAAGVPASRRGKG-LASEVALARREAPVKGNQHLGFAKAL
Mvan_5297|M.vanbaalenii_PYR-1 LWAAKRRAAEQARGVPAARRGKG-LASEVALARHDAPVLGNRHLGFATAL
MSMEG_6025|M.smegmatis_MC2_155 LWEQKRRAAEAAAGIPASRRGRG-LATEVALARRESPNAGGRHLGLAHAL
Mb3101|M.bovis_AF2122/97 AVDAARRAAEGAAGVPAARRGRG-LASEIALARRDSPARGSRHLGFAKAL
Rv3074|M.tuberculosis_H37Rv AVDAARRAAEGAAGVPAARRGRG-LASEIALARRDSPARGSRHLGFAKAL
MMAR_1584|M.marinum_M ALDTARRAAESAAGVPAARRGRG-LANEIALARRDSPARGSRHLGFAKAL
MAV_3980|M.avium_104 ALDAARRAAEAAAGVPAARRGRG-VASEVALARRDSPARGGRHLGFAKAL
MAB_1907|M.abscessus_ATCC_1997 LLDRARREEEAANGVPRRRQGAG-VATEIALARQDSPARGSRHLGFAKAL
TH_0334|M.thermoresistible__bu ELYARRAPEDDTERANWAIDGHANVVAEISAALNISRGRAAGRLQLAIDL
MUL_2679|M.ulcerans_Agy99 DLFRLRLSQHG-NREDWVADTCDAVAAEVAAALNTSVAMGHSNLRYARAM
* . :. *:: * . : . .* * :
Mflv_2897|M.gilvum_PYR-GCK MQEMPHTLAALEGGVLS-EWRATLIVRESACLSVEHRRQLDAELCGDPSR
Mvan_5297|M.vanbaalenii_PYR-1 VEEMPHTLAALECGALS-EWRATLIVRESACLSVEHRRALDEELCGDVSR
MSMEG_6025|M.smegmatis_MC2_155 VDELPHTLAALRCGALS-EWRATLIARESACLSPELRRELDAELSADPSR
Mb3101|M.bovis_AF2122/97 VYEMPHTLAALDCGALS-EWRATLIVRESACLDVADRRALDAELCGDPGD
Rv3074|M.tuberculosis_H37Rv VYEMPHTLAALDCGALS-EWRATLIVRESACLDVADRRALDAELCGDPGD
MMAR_1584|M.marinum_M VHEMPHTLAALECGLLS-EWRATLIVRESACLDIEHRRELDAELCGDPSG
MAV_3980|M.avium_104 VHEMPHTLAALECGALS-EWRATLIVRESACLDAEDRRALDAELCADPAG
MAB_1907|M.abscessus_ATCC_1997 VNEMPHTLAALECGALS-EWRATILVRETAYLAVEDRQKIDVEMCAETSR
TH_0334|M.thermoresistible__bu RERLPRVAAVFAAGDIDFRMVSALVNRSRNVVDPDLLARLDAALAAWSPK
MUL_2679|M.ulcerans_Agy99 RERLPQLGAEFRAGGIDFRLFRTIVFRTDLITESDALAAVDARLAIKAPR
.:*: * : * :. . ::: * :* :.
Mflv_2897|M.gilvum_PYR-GCK VAGWGNKRVEAEAKRIAARLDVAAVVERNDRAVKDRCVSTRPAPHNMVYV
Mvan_5297|M.vanbaalenii_PYR-1 LAGWGNKRVEAEAKTIAARLDAAAIVERSEKAAADCAVTCRPAPNNMVYV
MSMEG_6025|M.smegmatis_MC2_155 FDGWGDARVAAEAKKIACRLNIDAVLDRSAKAEKDRRVTIRPAPDAMTKL
Mb3101|M.bovis_AF2122/97 LEGMGDARVVAAARAIAYRLDPQAVVDRAANAENDRTVTIRPAPDTMTYL
Rv3074|M.tuberculosis_H37Rv LEGMGDARVVAAARAIAYRLDPQAVVDRAANAENDRTVTIRPAPDTMTYL
MMAR_1584|M.marinum_M LEGMGDARVAAAAKAIAYRLDPHAVVDRAAKAERERTVTIRPAPDTMTYL
MAV_3980|M.avium_104 LSGMGDARVAAAAKAIAYRLDPHAVVERAAKAENDRTVTIRPAPDTMTYL
MAB_1907|M.abscessus_ATCC_1997 LRGLGDTRLAAEAKRLAYRLDAQAVVRRARRAESERRVSLRPAPDTMTYL
TH_0334|M.thermoresistible__bu WMKLSGPTLNERIDMWVERFDPTGVR-EPRSPGEDRYVVVTPAGQGMVDV
MUL_2679|M.ulcerans_Agy99 WPSMTSWKLATEVDRVVAKFDRDAVR-RSRRDAADRYVDCAPLEPGMALV
. : . ::: .: . : * * *. :
Mflv_2897|M.gilvum_PYR-GCK TLLMPLAQGIGMYAALRRHGEMTVD--GRSLGQVMTDTAFERITGR----
Mvan_5297|M.vanbaalenii_PYR-1 TLRLPLTRGVGIYAACKRAADTTFD--GRPRGQVMTDTVYERVTGR----
MSMEG_6025|M.smegmatis_MC2_155 TVLLPLKQGVAVYAALHQAAMVNAD--DRNRGQVMADTLVERVTGR----
Mb3101|M.bovis_AF2122/97 TALLPVAQGVSVYAALTRAADTRCD--GRSRGQVMADTLVERVTGR----
Rv3074|M.tuberculosis_H37Rv TALLPVAQGVSVYAALTRAADTRCD--GRSRGQVMADTLVERVTGR----
MMAR_1584|M.marinum_M TALLPVAQGISVYAALRRAADTRCD--GRSRGQVMADTLVERVTGR----
MAV_3980|M.avium_104 TALLPVAQGVSVYAALRREADTRGD--GRPRGQVMADTLVERVTGR----
MAB_1907|M.abscessus_ATCC_1997 TALLPVKQGVAVYAALKRTADASMDP-VRGQGQIMADTLVERVTGV----
TH_0334|M.thermoresistible__bu SARLTFEAGFAFXTRLDQIAATVCRDDPRTADQRRADAMAAMSEGQNRLV
MUL_2679|M.ulcerans_Agy99 NRQVFSATAEALARRLDELAKTVCADDPRTVVQRRADALGTLAAGQDRLI
. : . .. . . * * :*: *
Mflv_2897|M.gilvum_PYR-GCK ------------SAAAPVPVELNLVMADTTLAGDDDCPGWLDGYGPVPAG
Mvan_5297|M.vanbaalenii_PYR-1 ------------PADTPVPVALNLVMADTTLAGDDDELGWLDGYGPVPAG
MSMEG_6025|M.smegmatis_MC2_155 ------------PAHAPVPVNLNLVMADTTLFGEDDQPGWVQGYGPVPAE
Mb3101|M.bovis_AF2122/97 ------------DAAVPTPIAVNLVMSDETLLGAANTPAQLCGYGPIPAA
Rv3074|M.tuberculosis_H37Rv ------------DAAVPTPIAVNLVMSDETLLGAANTPAQLCGYGPIPAA
MMAR_1584|M.marinum_M ------------DAAVPTPIAVNLVLTDESLLGADSAPADVCGYGPIPAA
MAV_3980|M.avium_104 ------------RSTVPTPVAVNLVLSDETLLGGADAPGEISGYGPIPAA
MAB_1907|M.abscessus_ATCC_1997 ------------SAAAAVPVGVNITVSDEALLGGGDEPATITGHGLVPAA
TH_0334|M.thermoresistible__bu CGCGSEDCPADPADTAATRLVINVIAEQATVEGRSDNPGYLPGYGAVPAS
MUL_2679|M.ulcerans_Agy99 CDCGRTDCPAAGAPQQPSRVVIHVVAGCQTVDGAGEAPGVLPGDGIIPAE
. : ::: :: * . . : * * :**
Mflv_2897|M.gilvum_PYR-GCK FCRGLVG---DAVADAEPKAALRRLYRHPRSGQLVAMESSARVFPKGLAT
Mvan_5297|M.vanbaalenii_PYR-1 FCRTLIGNADDAEAEAEVKATLRRLYRHPTSGQLVAMESRARIFPKGLGM
MSMEG_6025|M.smegmatis_MC2_155 VARRMVA---DATLDENTKAAVRRLFRHPKSGQLVAMESRSRIFPKGLAT
Mb3101|M.bovis_AF2122/97 VARTMVA---SAVTDQRSRATLRRLYAHPQAGALVSMESRARLFPRGLAA
Rv3074|M.tuberculosis_H37Rv VARTMVA---SAVTDQRSRATLRRLYAHPQAGALVSMESRARLFPRGLAA
MMAR_1584|M.marinum_M VARTMVA---DAVADGRSRATLRRLYAHPRAGALVAMESRARLFPRGLAA
MAV_3980|M.avium_104 VARRMVA---NAAADPRSRATLRRLYAHPRAGALVAMESRARLFPQGLAR
MAB_1907|M.abscessus_ATCC_1997 VARRLIS----EAVSAEAKVLVRRLYRRCTTGALVKAESRSRLFPRGLAE
TH_0334|M.thermoresistible__bu ILRAKAA-----------TATLRPVALPQ------PCAEAGYRPSAALTR
MUL_2679|M.ulcerans_Agy99 IVRELAK-----------SAKLQPMSTP-------ILAETGYVPSPALMD
. * . :: : . . . .*
Mflv_2897|M.gilvum_PYR-GCK LIDRRDQTCRTPYCDAPIRHH--DHAVPDRAGGQTSADNGLGACAGCNYA
Mvan_5297|M.vanbaalenii_PYR-1 LLQRRDRTCRTPYCDAPIRHH--DHATPDRQGGPTSALNGLGECEACNYA
MSMEG_6025|M.smegmatis_MC2_155 FIGLRDQTCRTPYCDALIRHR--DHAVPHHDGGPTTAHNGLGTCEACNYA
Mb3101|M.bovis_AF2122/97 FIELRDQRCRTPYCDAPIRHR--DHAHPWADGGPTSAHNGLGTCERCNYA
Rv3074|M.tuberculosis_H37Rv FIELRDQRCRTPYCDAPIRHR--DHAHPWADGGPTSAHNGLGTCERCNYA
MMAR_1584|M.marinum_M FIELRDQRCRTPYCDAPIRHR--DHARPWAKGGPTTADNGLGSCERCNYA
MAV_3980|M.avium_104 FIGLRDQRCRTPYCDAPIRHR--DHAQPWADGGATSAGNGLGLCEHCNYV
MAB_1907|M.abscessus_ATCC_1997 LIDLRDQTCRTPYCDAPIRHH--DHVVGSMRGGPTALDNGQGLCERCNYV
TH_0334|M.thermoresistible__bu FIRCRDLTCRFPGCDAPAAVCQIDHTIPYPAG-PTHPSNLKLLCVFHCRQ
MUL_2679|M.ulcerans_Agy99 FVRARDLTCRAPGCDRPATQCDVDHTIPYSDGGATHPSNLKCLCRKHHLL
:: ** ** * ** **. * * * *
Mflv_2897|M.gilvum_PYR-GCK KEAPGWKVTAGGE-DGVHTAR----WVTPTG--------AVHYSIAPTLP
Mvan_5297|M.vanbaalenii_PYR-1 KEAPGWTVTTGDV-DGAHTAD----FETPTG--------AVYRSTAPPLP
MSMEG_6025|M.smegmatis_MC2_155 KEAPGWSVIITETSDGEHIAE----YVTPTG--------AVYRSTAPPLP
Mb3101|M.bovis_AF2122/97 KQAPGWRVSTSVDENHTHTAE----FITPTG--------SRHRSGAPPHL
Rv3074|M.tuberculosis_H37Rv KQAPGWRVSTSVDENHTHTAE----FITPTG--------SRHRSGAPPHL
MMAR_1584|M.marinum_M KEAYGWRVETSMHETHTHTAE----FTTPTG--------TSYRSGAPPRV
MAV_3980|M.avium_104 KETSGWTVSAGVDETHTHTAL----FTTPTG--------QTYRSTAPPRA
MAB_1907|M.abscessus_ATCC_1997 KETAGWNVAPVPG-ADRHTVE----FTTPTG--------TAYRSTAPPLP
TH_0334|M.thermoresistible__bu AELRFTHDQHKHQSS---CLP---AYFQRP---------HGPATRRPPSA
MUL_2679|M.ulcerans_Agy99 KTFWGWHDEQLPDATVIWSLPDGQTYVTTPGSAWLLPGLFAPSPELPPPP
: . . *.
Mflv_2897|M.gilvum_PYR-GCK GPPVYRRISSTESRLSIDLITFDRPDVA-----------
Mvan_5297|M.vanbaalenii_PYR-1 GPPVRRRLSLLEGRLSIDLVTFDAA--------------
MSMEG_6025|M.smegmatis_MC2_155 GRPVRHTLSLVETGLTIDLVTFDAA--------------
Mb3101|M.bovis_AF2122/97 P---AVTVSELEVRIGIALARYAA---------------
Rv3074|M.tuberculosis_H37Rv P---AVTVSELEVRIGIALARYAA---------------
MMAR_1584|M.marinum_M Q---TVTASELEVRVGISLARHAA---------------
MAV_3980|M.avium_104 P---AITMSTVEVRVAVAFARHAA---------------
MAB_1907|M.abscessus_ATCC_1997 ---------------------------------------
TH_0334|M.thermoresistible__bu RG-----LR-----EAVPRQGVDP-------RRVSGQ--
MUL_2679|M.ulcerans_Agy99 RSEATGSLRKPRRDDAQTRPNSRPKLGRTHCDRTQPQHD