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MSVRGCSVWHMFESLFDIDPQASEAELRDRIEQFERMKSAAAAAQATASVLWEQKRRAAEAAAGIPASRR GRGLATEVALARRESPNAGGRHLGLAHALVDELPHTLAALRCGALSEWRATLIARESACLSPELRRELDA ELSADPSRFDGWGDARVAAEAKKIACRLNIDAVLDRSAKAEKDRRVTIRPAPDAMTKLTVLLPLKQGVAV YAALHQAAMVNADDRNRGQVMADTLVERVTGRPAHAPVPVNLNLVMADTTLFGEDDQPGWVQGYGPVPAE VARRMVADATLDENTKAAVRRLFRHPKSGQLVAMESRSRIFPKGLATFIGLRDQTCRTPYCDALIRHRDH AVPHHDGGPTTAHNGLGTCEACNYAKEAPGWSVIITETSDGEHIAEYVTPTGAVYRSTAPPLPGRPVRHT LSLVETGLTIDLVTFDAA
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_6025 | - | - | 100% (438) | hypothetical protein MSMEG_6025 |
| M. smegmatis MC2 155 | MSMEG_5026 | - | 4e-12 | 24.70% (421) | hypothetical protein MSMEG_5026 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1413c | - | 1e-147 | 62.65% (431) | hypothetical protein Mb1413c |
| M. gilvum PYR-GCK | Mflv_2586 | - | 1e-156 | 65.49% (426) | hypothetical protein Mflv_2586 |
| M. tuberculosis H37Rv | Rv1378c | - | 1e-147 | 62.65% (431) | hypothetical protein Rv1378c |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_1907 | - | 1e-125 | 57.43% (397) | hypothetical protein MAB_1907 |
| M. marinum M | MMAR_1584 | - | 1e-146 | 65.34% (401) | hypothetical protein MMAR_1584 |
| M. avium 104 | MAV_3980 | - | 1e-144 | 63.68% (413) | hypothetical protein MAV_3980 |
| M. thermoresistible (build 8) | TH_0334 | - | 3e-16 | 26.86% (376) | HNH endonuclease |
| M. ulcerans Agy99 | MUL_2679 | - | 3e-18 | 25.91% (440) | 13e12 repeat-containing protein |
| M. vanbaalenii PYR-1 | Mvan_3614 | - | 1e-158 | 64.49% (445) | hypothetical protein Mvan_3614 |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_2586|M.gilvum_PYR-GCK ------------------------------------------------MF
Mvan_3614|M.vanbaalenii_PYR-1 ---------------------MSEAAAPVCRRRARLPLLSGTRCSVGFMF
MSMEG_6025|M.smegmatis_MC2_155 --------------------------------------MSVRGCSVWHMF
Mb1413c|M.bovis_AF2122/97 MGNLDLLLHLSGRIVKGCRPLGSVALARCGPAVRWPWWPRPAILEHMFDL
Rv1378c|M.tuberculosis_H37Rv MGNLDLLLRLSGRIVKGCRPLGSVALARCGPAVRWPRWPRPAILEHMFDL
MMAR_1584|M.marinum_M ------------------------------------------------MF
MAV_3980|M.avium_104 --------------------------------------------------
MAB_1907|M.abscessus_ATCC_1997 --------------------------------------------------
TH_0334|M.thermoresistible__bu --------------------------------------------------
MUL_2679|M.ulcerans_Agy99 ------------------------------------------------MD
Mflv_2586|M.gilvum_PYR-GCK ESLFDIDEGASQAELRAVVERCERLKSAAAAAQARATALWAAKRAAAEEA
Mvan_3614|M.vanbaalenii_PYR-1 ESLFDVGVGASEAELRAAVERCERLKSQAAAAQARATALWAAKRRAAEQA
MSMEG_6025|M.smegmatis_MC2_155 ESLFDIDPQASEAELRDRIEQFERMKSAAAAAQATASVLWEQKRRAAEAA
Mb1413c|M.bovis_AF2122/97 VSLAGVDSRDDEASLTARIAELERVKSAAAAGQARAAAALDKLRRCNEAD
Rv1378c|M.tuberculosis_H37Rv VSLAGVDSRDDEASLTARIAELERVKSAAAAGQARAAAALDKLRRCNEAD
MMAR_1584|M.marinum_M ESLAAVDPAADQAALVERIAELETVKSAAAAGQARAAAALDTARRAAESA
MAV_3980|M.avium_104 ---MAVDPAAGESALIERISELETLKCAAAAAQARAAAALDAARRAAEAA
MAB_1907|M.abscessus_ATCC_1997 --MLPLDPATRAAQLVDRIAELERVKAAAAAEQAHAAVLLDRARREEEAA
TH_0334|M.thermoresistible__bu -----MFESLDDGAVVDSIAAASREQSAACGREMLAIGELYARRAPEDDT
MUL_2679|M.ulcerans_Agy99 QHIIEYVFDTDDSAPLTRITAAARAEARAAAERLAAIGDLFRLRLSQHG-
. : :. *.. . * * .
Mflv_2586|M.gilvum_PYR-GCK AGVPVRRRGKG-LASEVALARRDAPVKGGQHLGFAKALMGEMPHTWAALE
Mvan_3614|M.vanbaalenii_PYR-1 GGVPAAKRGKG-LASEVALARHDAPVLGNRHLGFAQALVEEMPHTLAALE
MSMEG_6025|M.smegmatis_MC2_155 AGIPASRRGRG-LATEVALARRESPNAGGRHLGLAHALVDELPHTLAALR
Mb1413c|M.bovis_AF2122/97 AGVPARRRGRG-VASEVALARRDSPARGGRHLGFAKALVYEMPHTLAALE
Rv1378c|M.tuberculosis_H37Rv AGVPARRRGRG-VASEVALARRDSPARGGRHLGFAKALVYEMPHTLAALE
MMAR_1584|M.marinum_M AGVPAARRGRG-LANEIALARRDSPARGSRHLGFAKALVHEMPHTLAALE
MAV_3980|M.avium_104 AGVPAARRGRG-VASEVALARRDSPARGGRHLGFAKALVHEMPHTLAALE
MAB_1907|M.abscessus_ATCC_1997 NGVPRRRQGAG-VATEIALARQDSPARGSRHLGFAKALVNEMPHTLAALE
TH_0334|M.thermoresistible__bu ERANWAIDGHANVVAEISAALNISRGRAAGRLQLAIDLRERLPRVAAVFA
MUL_2679|M.ulcerans_Agy99 NREDWVADTCDAVAAEVAAALNTSVAMGHSNLRYARAMRERLPQLGAEFR
:. *:: * . : . .* * : .:*: * :
Mflv_2586|M.gilvum_PYR-GCK CGALS-EWRATLIVRESACLSVEDRRRLDEELCADVSRFEGWGNKRVEAE
Mvan_3614|M.vanbaalenii_PYR-1 CGALS-EWRATLIVRESACLSVEHRRALDEELCGDVSRLAGWGNKRIEAE
MSMEG_6025|M.smegmatis_MC2_155 CGALS-EWRATLIARESACLSPELRRELDAELSADPSRFDGWGDARVAAE
Mb1413c|M.bovis_AF2122/97 VGRLS-EWRATLIVRESACLDVEDRRALDAELCADMSALDGMGDARIAAA
Rv1378c|M.tuberculosis_H37Rv VGRLS-EWRATLIVRESACLDVEDRRALDAELCADMSALDGMGDARIAAA
MMAR_1584|M.marinum_M CGLLS-EWRATLIVRESACLDIEHRRELDAELCGDPSGLEGMGDARVAAA
MAV_3980|M.avium_104 CGALS-EWRATLIVRESACLDAEDRRALDAELCADPAGLSGMGDARVAAA
MAB_1907|M.abscessus_ATCC_1997 CGALS-EWRATILVRETAYLAVEDRQKIDVEMCAETSRLRGLGDTRLAAE
TH_0334|M.thermoresistible__bu AGDIDFRMVSALVNRSRNVVDPDLLARLDAALAAWSPKWMKLSGPTLNER
MUL_2679|M.ulcerans_Agy99 AGGIDFRLFRTIVFRTDLITESDALAAVDARLAIKAPRWPSMTSWKLATE
* :. . ::: * : :* :. . . :
Mflv_2586|M.gilvum_PYR-GCK AKKIAARLDVAAVVERVDRAAAQARVSCRPAPNGMVYFTVLLPLAQGIGM
Mvan_3614|M.vanbaalenii_PYR-1 AKTIAARLDAAAVVDHTEKAAADCAVTCRPAPNNMVYVTLRLPLTRGVGI
MSMEG_6025|M.smegmatis_MC2_155 AKKIACRLNIDAVLDRSAKAEKDRRVTIRPAPDAMTKLTVLLPLKQGVAV
Mb1413c|M.bovis_AF2122/97 ARAIAYRLDAQAVVERAARAETERTVTIRPAPDTMTWVTALLPVARGVSV
Rv1378c|M.tuberculosis_H37Rv ARAIAYRLDAQAVVERAARAETERTVTIRPAPDTMTWVTALLPVARGVSV
MMAR_1584|M.marinum_M AKAIAYRLDPHAVVDRAAKAERERTVTIRPAPDTMTYLTALLPVAQGISV
MAV_3980|M.avium_104 AKAIAYRLDPHAVVERAAKAENDRTVTIRPAPDTMTYLTALLPVAQGVSV
MAB_1907|M.abscessus_ATCC_1997 AKRLAYRLDAQAVVRRARRAESERRVSLRPAPDTMTYLTALLPVKQGVAV
TH_0334|M.thermoresistible__bu IDMWVERFDPTGVRE-PRSPGEDRYVVVTPAGQGMVDVSARLTFEAGFAF
MUL_2679|M.ulcerans_Agy99 VDRVVAKFDRDAVRR-SRRDAADRYVDCAPLEPGMALVNRQVFSATAEAL
. ::: .* : * * *. .. : . ..
Mflv_2586|M.gilvum_PYR-GCK YAALKHHADTTFD--GRSRGQVMADTAFERITGR----------------
Mvan_3614|M.vanbaalenii_PYR-1 YAACKRAADTTFD--GRPRGQVMTDTVYERVTGR----------------
MSMEG_6025|M.smegmatis_MC2_155 YAALHQAAMVNAD--DRNRGQVMADTLVERVTGR----------------
Mb1413c|M.bovis_AF2122/97 YAALKRAADTTFD--DRTRGQVMADTLVERVTGQ----------------
Rv1378c|M.tuberculosis_H37Rv YAALKRAADTTFD--DRTRGQVMADTLVERVTGQ----------------
MMAR_1584|M.marinum_M YAALRRAADTRCD--GRSRGQVMADTLVERVTGR----------------
MAV_3980|M.avium_104 YAALRREADTRGD--GRPRGQVMADTLVERVTGR----------------
MAB_1907|M.abscessus_ATCC_1997 YAALKRTADASMDP-VRGQGQIMADTLVERVTGV----------------
TH_0334|M.thermoresistible__bu XTRLDQIAATVCRDDPRTADQRRADAMAAMSEGQNRLVCGCGSEDCPADP
MUL_2679|M.ulcerans_Agy99 ARRLDELAKTVCADDPRTVVQRRADALGTLAAGQDRLICDCGRTDCPAAG
. * . * * :*: *
Mflv_2586|M.gilvum_PYR-GCK SAGTAVPVALNLVMADTTLAGDDDCPGWLDGYGPVPAGFCRALTGDAVAD
Mvan_3614|M.vanbaalenii_PYR-1 PADTPVPVALNLVMADTTLAGDDDELGWLDGYGPVPAGFCRALIGNAVAD
MSMEG_6025|M.smegmatis_MC2_155 PAHAPVPVNLNLVMADTTLFGEDDQPGWVQGYGPVPAEVARRMVADATLD
Mb1413c|M.bovis_AF2122/97 PAEAAQPVAVNLVLSDETLLAGDRAPAVVDGYGPIPAAVARNLVRDAVAD
Rv1378c|M.tuberculosis_H37Rv PAEAAQPVAVNLVLSDETLLAGDRAPAVVDGYGPIPAAVARNLVRDAVAD
MMAR_1584|M.marinum_M DAAVPTPIAVNLVLTDESLLGADSAPADVCGYGPIPAAVARTMVADAVAD
MAV_3980|M.avium_104 RSTVPTPVAVNLVLSDETLLGGADAPGEISGYGPIPAAVARRMVANAAAD
MAB_1907|M.abscessus_ATCC_1997 SAAAAVPVGVNITVSDEALLGGGDEPATITGHGLVPAAVARRLISEAVS-
TH_0334|M.thermoresistible__bu ADTAATRLVINVIAEQATVEGRSDNPGYLPGYGAVPASILRAKAATATLR
MUL_2679|M.ulcerans_Agy99 APQQPSRVVIHVVAGCQTVDGAGEAPGVLPGDGIIPAEIVRELAKSAKLQ
. : ::: :: . . : * * :** . * *
Mflv_2586|M.gilvum_PYR-GCK KGAR------------ATLRRLYRHPRSGQLVAMESRARLFPKGLATLID
Mvan_3614|M.vanbaalenii_PYR-1 AHAHADADAEVDAEVKATLRRLYRHPTSGQLVAMESRARIFPKGLGMLLQ
MSMEG_6025|M.smegmatis_MC2_155 ENTK------------AAVRRLFRHPKSGQLVAMESRSRIFPKGLATFIG
Mb1413c|M.bovis_AF2122/97 TRSR------------ATLRRLYRHPRSGALVAMESRARRFPKGLAAFIG
Rv1378c|M.tuberculosis_H37Rv TRSR------------ATLRRLYRHPRSGALVAMESRARRFPKGLAAFIG
MMAR_1584|M.marinum_M GRSR------------ATLRRLYAHPRAGALVAMESRARLFPRGLAAFIE
MAV_3980|M.avium_104 PRSR------------ATLRRLYAHPRAGALVAMESRARLFPQGLARFIG
MAB_1907|M.abscessus_ATCC_1997 AEAK------------VLVRRLYRRCTTGALVKAESRSRLFPRGLAELID
TH_0334|M.thermoresistible__bu PVALPQ--------------------------PCAEAGYRPSAALTRFIR
MUL_2679|M.ulcerans_Agy99 PMSTP---------------------------ILAETGYVPSPALMDFVR
: . . . .* ::
Mflv_2586|M.gilvum_PYR-GCK RRDQTCRTPYCDAPIRHH--DHATPDRAGGKTSAENGLGECAACNYAKEA
Mvan_3614|M.vanbaalenii_PYR-1 RRDRTCRTPYCDAPIRHH--DHATPDRAGGPTSALNGLGECEACNYAKEA
MSMEG_6025|M.smegmatis_MC2_155 LRDQTCRTPYCDALIRHR--DHAVPHHDGGPTTAHNGLGTCEACNYAKEA
Mb1413c|M.bovis_AF2122/97 LRDQRCRMPYCDAPIRHR--DHAQPHHRGGPTTATNGLGSCERCNYVKEA
Rv1378c|M.tuberculosis_H37Rv LRDQRCRMPYCDAPIRHR--DHAQPHHRGGPTTATNGLGSCERCNYVKEA
MMAR_1584|M.marinum_M LRDQRCRTPYCDAPIRHR--DHARPWAKGGPTTADNGLGSCERCNYAKEA
MAV_3980|M.avium_104 LRDQRCRTPYCDAPIRHR--DHAQPWADGGATSAGNGLGLCEHCNYVKET
MAB_1907|M.abscessus_ATCC_1997 LRDQTCRTPYCDAPIRHH--DHVVGSMRGGPTALDNGQGLCERCNYVKET
TH_0334|M.thermoresistible__bu CRDLTCRFPGCDAPAAVCQIDHTIPYPAG-PTHPSNLKLLCVFHCRQAEL
MUL_2679|M.ulcerans_Agy99 ARDLTCRAPGCDRPATQCDVDHTIPYSDGGATHPSNLKCLCRKHHLLKTF
** ** * ** **. * * * *
Mflv_2586|M.gilvum_PYR-GCK PGWQVSAGTQ-DGSHTAR-----WVTPTG----AVHYSIAPALPGPPVRR
Mvan_3614|M.vanbaalenii_PYR-1 PGWTVTTGDV-DGAHTAD-----FETPTG----AVYRSTAPPLPGPPVRR
MSMEG_6025|M.smegmatis_MC2_155 PGWSVIITETSDGEHIAE-----YVTPTG----AVYRSTAPPLPGRPVRH
Mb1413c|M.bovis_AF2122/97 PGWRVSTDTDETGRHTAE-----FTTPTG----MYYHCTAPPLPGPLEID
Rv1378c|M.tuberculosis_H37Rv PGWRVSTDTDETGRHTAE-----FTTPTG----MYYHCTAPPLPGPLEID
MMAR_1584|M.marinum_M YGWRVETSMHETHTHTAE-----FTTPTG----TSYRSGAP--PRVQTVT
MAV_3980|M.avium_104 SGWTVSAGVDETHTHTAL-----FTTPTG----QTYRSTAP--PRAPAIT
MAB_1907|M.abscessus_ATCC_1997 AGWNVAP-VPGADRHTVE-----FTTPTG----TAYRSTAPPLP------
TH_0334|M.thermoresistible__bu RFTHDQHKHQSS---CLP---AYFQRP---------HGPATRRPPSARG-
MUL_2679|M.ulcerans_Agy99 WGWHDEQLPDATVIWSLPDGQTYVTTPGSAWLLPGLFAPSPELPPPPRSE
* :. *
Mflv_2586|M.gilvum_PYR-GCK RISDTEGRLSIDLITFDKPDAA--------------
Mvan_3614|M.vanbaalenii_PYR-1 RLSLLEGRLSIDLVTFDAA-----------------
MSMEG_6025|M.smegmatis_MC2_155 TLSLVETGLTIDLVTFDAA-----------------
Mb1413c|M.bovis_AF2122/97 -VSQVEARIGVALTHLHAA-----------------
Rv1378c|M.tuberculosis_H37Rv -VSQVEARIGVALTHLHAA-----------------
MMAR_1584|M.marinum_M -ASELEVRVGISLAR-HAA-----------------
MAV_3980|M.avium_104 -MSTVEVRVAVAFAR-HAA-----------------
MAB_1907|M.abscessus_ATCC_1997 ------------------------------------
TH_0334|M.thermoresistible__bu ----LR-----EAVPRQGVDP-------RRVSGQ--
MUL_2679|M.ulcerans_Agy99 ATGSLRKPRRDDAQTRPNSRPKLGRTHCDRTQPQHD