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LSAPGCSVPDMFESLFDYDTEASEKELRVLVEQYEALKSRAAAAQARVTALWAAKRAAAERAAGIGTRKR GKGLASEIALARHDAPVKGNQHLGFANALVHEMPHTLAALECGVLSEYRATLIVRESACLSAEHRRRLDE ELCSDPSKLAGWGNNRVEAEAKRITARLDAAAVVERSAKAEQDRCVTTRPAPNCMVYVTVLLPVAQGVGM YAALKRAADTTFDERSRGQVMADTAYARITGKVATQPVSVSLNLVMADTTLAGDDTEPAWLDGYGPVPAG FACKLTGDAVADEDVKATLRRLYRHPGSGQLVAMESRSRAFPKGLAAFIGIRDRTCRTPYCNAPIRHHDH ATPDRDGGRTSAVNGLGLCEACNYAKEAPGWTVTTSVRAGEHRAEFVTPTHATYYSIAPPLPGTRISRRS IVEDRFSIDLVTFEAA
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_3750 | - | - | 100% (436) | HNH nuclease |
| M. gilvum PYR-GCK | Mflv_2586 | - | e-175 | 73.41% (425) | hypothetical protein Mflv_2586 |
| M. gilvum PYR-GCK | Mflv_2897 | - | e-172 | 71.73% (421) | HNH nuclease |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1413c | - | 1e-136 | 58.39% (435) | hypothetical protein Mb1413c |
| M. tuberculosis H37Rv | Rv1378c | - | 1e-136 | 58.39% (435) | hypothetical protein Rv1378c |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_1907 | - | 1e-112 | 53.26% (383) | hypothetical protein MAB_1907 |
| M. marinum M | MMAR_1584 | - | 1e-135 | 61.60% (401) | hypothetical protein MMAR_1584 |
| M. avium 104 | MAV_3980 | - | 1e-133 | 61.83% (393) | hypothetical protein MAV_3980 |
| M. smegmatis MC2 155 | MSMEG_6025 | - | 1e-156 | 63.93% (438) | hypothetical protein MSMEG_6025 |
| M. thermoresistible (build 8) | TH_0334 | - | 9e-09 | 25.17% (302) | HNH endonuclease |
| M. ulcerans Agy99 | MUL_2679 | - | 9e-14 | 25.59% (379) | 13e12 repeat-containing protein |
| M. vanbaalenii PYR-1 | Mvan_5297 | - | 1e-178 | 74.19% (430) | hypothetical protein Mvan_5297 |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_3750|M.gilvum_PYR-GCK --------------------------------------MSAPGCSVPDMF
Mvan_5297|M.vanbaalenii_PYR-1 ------------------------------------------------MF
MSMEG_6025|M.smegmatis_MC2_155 --------------------------------------MSVRGCSVWHMF
Mb1413c|M.bovis_AF2122/97 MGNLDLLLHLSGRIVKGCRPLGSVALARCGPAVRWPWWPRPAILEHMFDL
Rv1378c|M.tuberculosis_H37Rv MGNLDLLLRLSGRIVKGCRPLGSVALARCGPAVRWPRWPRPAILEHMFDL
MMAR_1584|M.marinum_M ------------------------------------------------MF
MAV_3980|M.avium_104 --------------------------------------------------
MAB_1907|M.abscessus_ATCC_1997 --------------------------------------------------
TH_0334|M.thermoresistible__bu --------------------------------------------------
MUL_2679|M.ulcerans_Agy99 ------------------------------------------------MD
Mflv_3750|M.gilvum_PYR-GCK ESLFDYDTEASEKELRVLVEQYEALKSRAAAAQARVTALWAAKRAAAERA
Mvan_5297|M.vanbaalenii_PYR-1 ESLFDVDVGASEAELRAAVERCERLKSQAAAAQARATALWAAKRRAAEQA
MSMEG_6025|M.smegmatis_MC2_155 ESLFDIDPQASEAELRDRIEQFERMKSAAAAAQATASVLWEQKRRAAEAA
Mb1413c|M.bovis_AF2122/97 VSLAGVDSRDDEASLTARIAELERVKSAAAAGQARAAAALDKLRRCNEAD
Rv1378c|M.tuberculosis_H37Rv VSLAGVDSRDDEASLTARIAELERVKSAAAAGQARAAAALDKLRRCNEAD
MMAR_1584|M.marinum_M ESLAAVDPAADQAALVERIAELETVKSAAAAGQARAAAALDTARRAAESA
MAV_3980|M.avium_104 ---MAVDPAAGESALIERISELETLKCAAAAAQARAAAALDAARRAAEAA
MAB_1907|M.abscessus_ATCC_1997 --MLPLDPATRAAQLVDRIAELERVKAAAAAEQAHAAVLLDRARREEEAA
TH_0334|M.thermoresistible__bu -----MFESLDDGAVVDSIAAASREQSAACGREMLAIGELYARRAPEDDT
MUL_2679|M.ulcerans_Agy99 QHIIEYVFDTDDSAPLTRITAAARAEARAAAERLAAIGDLFRLRLSQHG-
: :. *.. . . * .
Mflv_3750|M.gilvum_PYR-GCK AGIGTRKRGKG-LASEIALARHDAPVKGNQHLGFANALVHEMPHTLAALE
Mvan_5297|M.vanbaalenii_PYR-1 RGVPAARRGKG-LASEVALARHDAPVLGNRHLGFATALVEEMPHTLAALE
MSMEG_6025|M.smegmatis_MC2_155 AGIPASRRGRG-LATEVALARRESPNAGGRHLGLAHALVDELPHTLAALR
Mb1413c|M.bovis_AF2122/97 AGVPARRRGRG-VASEVALARRDSPARGGRHLGFAKALVYEMPHTLAALE
Rv1378c|M.tuberculosis_H37Rv AGVPARRRGRG-VASEVALARRDSPARGGRHLGFAKALVYEMPHTLAALE
MMAR_1584|M.marinum_M AGVPAARRGRG-LANEIALARRDSPARGSRHLGFAKALVHEMPHTLAALE
MAV_3980|M.avium_104 AGVPAARRGRG-VASEVALARRDSPARGGRHLGFAKALVHEMPHTLAALE
MAB_1907|M.abscessus_ATCC_1997 NGVPRRRQGAG-VATEIALARQDSPARGSRHLGFAKALVNEMPHTLAALE
TH_0334|M.thermoresistible__bu ERANWAIDGHANVVAEISAALNISRGRAAGRLQLAIDLRERLPRVAAVFA
MUL_2679|M.ulcerans_Agy99 NREDWVADTCDAVAAEVAAALNTSVAMGHSNLRYARAMRERLPQLGAEFR
:. *:: * . : . .* * : .:*: * :
Mflv_3750|M.gilvum_PYR-GCK CGVLS-EYRATLIVRESACLSAEHRRRLDEELCSDPSKLAGWGNNRVEAE
Mvan_5297|M.vanbaalenii_PYR-1 CGALS-EWRATLIVRESACLSVEHRRALDEELCGDVSRLAGWGNKRVEAE
MSMEG_6025|M.smegmatis_MC2_155 CGALS-EWRATLIARESACLSPELRRELDAELSADPSRFDGWGDARVAAE
Mb1413c|M.bovis_AF2122/97 VGRLS-EWRATLIVRESACLDVEDRRALDAELCADMSALDGMGDARIAAA
Rv1378c|M.tuberculosis_H37Rv VGRLS-EWRATLIVRESACLDVEDRRALDAELCADMSALDGMGDARIAAA
MMAR_1584|M.marinum_M CGLLS-EWRATLIVRESACLDIEHRRELDAELCGDPSGLEGMGDARVAAA
MAV_3980|M.avium_104 CGALS-EWRATLIVRESACLDAEDRRALDAELCADPAGLSGMGDARVAAA
MAB_1907|M.abscessus_ATCC_1997 CGALS-EWRATILVRETAYLAVEDRQKIDVEMCAETSRLRGLGDTRLAAE
TH_0334|M.thermoresistible__bu AGDIDFRMVSALVNRSRNVVDPDLLARLDAALAAWSPKWMKLSGPTLNER
MUL_2679|M.ulcerans_Agy99 AGGIDFRLFRTIVFRTDLITESDALAAVDARLAIKAPRWPSMTSWKLATE
* :. . ::: * : :* :. . . :
Mflv_3750|M.gilvum_PYR-GCK AKRITARLDAAAVVERSAKAEQDRCVTTRPAPNCMVYVTVLLPVAQGVGM
Mvan_5297|M.vanbaalenii_PYR-1 AKTIAARLDAAAIVERSEKAAADCAVTCRPAPNNMVYVTLRLPLTRGVGI
MSMEG_6025|M.smegmatis_MC2_155 AKKIACRLNIDAVLDRSAKAEKDRRVTIRPAPDAMTKLTVLLPLKQGVAV
Mb1413c|M.bovis_AF2122/97 ARAIAYRLDAQAVVERAARAETERTVTIRPAPDTMTWVTALLPVARGVSV
Rv1378c|M.tuberculosis_H37Rv ARAIAYRLDAQAVVERAARAETERTVTIRPAPDTMTWVTALLPVARGVSV
MMAR_1584|M.marinum_M AKAIAYRLDPHAVVDRAAKAERERTVTIRPAPDTMTYLTALLPVAQGISV
MAV_3980|M.avium_104 AKAIAYRLDPHAVVERAAKAENDRTVTIRPAPDTMTYLTALLPVAQGVSV
MAB_1907|M.abscessus_ATCC_1997 AKRLAYRLDAQAVVRRARRAESERRVSLRPAPDTMTYLTALLPVKQGVAV
TH_0334|M.thermoresistible__bu IDMWVERFDPTGVR-EPRSPGEDRYVVVTPAGQGMVDVSARLTFEAGFAF
MUL_2679|M.ulcerans_Agy99 VDRVVAKFDRDAVR-RSRRDAADRYVDCAPLEPGMALVNRQVFSATAEAL
. ::: .: .. : * * *. :. : . ..
Mflv_3750|M.gilvum_PYR-GCK YAALKRAADTTFD--ERSRGQVMADTAYARITGK----------------
Mvan_5297|M.vanbaalenii_PYR-1 YAACKRAADTTFD--GRPRGQVMTDTVYERVTGR----------------
MSMEG_6025|M.smegmatis_MC2_155 YAALHQAAMVNAD--DRNRGQVMADTLVERVTGR----------------
Mb1413c|M.bovis_AF2122/97 YAALKRAADTTFD--DRTRGQVMADTLVERVTGQ----------------
Rv1378c|M.tuberculosis_H37Rv YAALKRAADTTFD--DRTRGQVMADTLVERVTGQ----------------
MMAR_1584|M.marinum_M YAALRRAADTRCD--GRSRGQVMADTLVERVTGR----------------
MAV_3980|M.avium_104 YAALRREADTRGD--GRPRGQVMADTLVERVTGR----------------
MAB_1907|M.abscessus_ATCC_1997 YAALKRTADASMDP-VRGQGQIMADTLVERVTGV----------------
TH_0334|M.thermoresistible__bu XTRLDQIAATVCRDDPRTADQRRADAMAAMSEGQNRLVCGCGSEDCPADP
MUL_2679|M.ulcerans_Agy99 ARRLDELAKTVCADDPRTVVQRRADALGTLAAGQDRLICDCGRTDCPAAG
. * . * * :*: *
Mflv_3750|M.gilvum_PYR-GCK VATQPVSVSLNLVMADTTLAGDDTEPAWLDGYGPVPAGFACKLTG---DA
Mvan_5297|M.vanbaalenii_PYR-1 PADTPVPVALNLVMADTTLAGDDDELGWLDGYGPVPAGFCRTLIGNADDA
MSMEG_6025|M.smegmatis_MC2_155 PAHAPVPVNLNLVMADTTLFGEDDQPGWVQGYGPVPAEVARRMVA---DA
Mb1413c|M.bovis_AF2122/97 PAEAAQPVAVNLVLSDETLLAGDRAPAVVDGYGPIPAAVARNLVR---DA
Rv1378c|M.tuberculosis_H37Rv PAEAAQPVAVNLVLSDETLLAGDRAPAVVDGYGPIPAAVARNLVR---DA
MMAR_1584|M.marinum_M DAAVPTPIAVNLVLTDESLLGADSAPADVCGYGPIPAAVARTMVA---DA
MAV_3980|M.avium_104 RSTVPTPVAVNLVLSDETLLGGADAPGEISGYGPIPAAVARRMVA---NA
MAB_1907|M.abscessus_ATCC_1997 SAAAAVPVGVNITVSDEALLGGGDEPATITGHGLVPAAVARRLIS----E
TH_0334|M.thermoresistible__bu ADTAATRLVINVIAEQATVEGRSDNPGYLPGYGAVPASILRAKAA-----
MUL_2679|M.ulcerans_Agy99 APQQPSRVVIHVVAGCQTVDGAGEAPGVLPGDGIIPAEIVRELAK-----
. : ::: :: . . : * * :** .
Mflv_3750|M.gilvum_PYR-GCK VADEDVKATLRRLYRHPGSGQLVAMESRSRAFPKGLAAFIGIRDRTCRTP
Mvan_5297|M.vanbaalenii_PYR-1 EAEAEVKATLRRLYRHPTSGQLVAMESRARIFPKGLGMLLQRRDRTCRTP
MSMEG_6025|M.smegmatis_MC2_155 TLDENTKAAVRRLFRHPKSGQLVAMESRSRIFPKGLATFIGLRDQTCRTP
Mb1413c|M.bovis_AF2122/97 VADTRSRATLRRLYRHPRSGALVAMESRARRFPKGLAAFIGLRDQRCRMP
Rv1378c|M.tuberculosis_H37Rv VADTRSRATLRRLYRHPRSGALVAMESRARRFPKGLAAFIGLRDQRCRMP
MMAR_1584|M.marinum_M VADGRSRATLRRLYAHPRAGALVAMESRARLFPRGLAAFIELRDQRCRTP
MAV_3980|M.avium_104 AADPRSRATLRRLYAHPRAGALVAMESRARLFPQGLARFIGLRDQRCRTP
MAB_1907|M.abscessus_ATCC_1997 AVSAEAKVLVRRLYRRCTTGALVKAESRSRLFPRGLAELIDLRDQTCRTP
TH_0334|M.thermoresistible__bu ------TATLRPVALPQ------PCAEAGYRPSAALTRFIRCRDLTCRFP
MUL_2679|M.ulcerans_Agy99 ------SAKLQPMSTP-------ILAETGYVPSPALMDFVRARDLTCRAP
. :: : . . . .* :: ** ** *
Mflv_3750|M.gilvum_PYR-GCK YCNAPIRHH--DHATPDRDGGRTSAVNGLGLCEACNYAKEAPGWTVTTSV
Mvan_5297|M.vanbaalenii_PYR-1 YCDAPIRHH--DHATPDRQGGPTSALNGLGECEACNYAKEAPGWTVTTGD
MSMEG_6025|M.smegmatis_MC2_155 YCDALIRHR--DHAVPHHDGGPTTAHNGLGTCEACNYAKEAPGWSVIITE
Mb1413c|M.bovis_AF2122/97 YCDAPIRHR--DHAQPHHRGGPTTATNGLGSCERCNYVKEAPGWRVSTDT
Rv1378c|M.tuberculosis_H37Rv YCDAPIRHR--DHAQPHHRGGPTTATNGLGSCERCNYVKEAPGWRVSTDT
MMAR_1584|M.marinum_M YCDAPIRHR--DHARPWAKGGPTTADNGLGSCERCNYAKEAYGWRVETSM
MAV_3980|M.avium_104 YCDAPIRHR--DHAQPWADGGATSAGNGLGLCEHCNYVKETSGWTVSAGV
MAB_1907|M.abscessus_ATCC_1997 YCDAPIRHH--DHVVGSMRGGPTALDNGQGLCERCNYVKETAGWNVAPVP
TH_0334|M.thermoresistible__bu GCDAPAAVCQIDHTIPYPAG-PTHPSNLKLLCVFHCRQAELRFTHDQHKH
MUL_2679|M.ulcerans_Agy99 GCDRPATQCDVDHTIPYSDGGATHPSNLKCLCRKHHLLKTFWGWHDEQLP
*: **. * * * *
Mflv_3750|M.gilvum_PYR-GCK R-AGEHRAE-----FVTPTH----ATYYSIAPPLPGTRISRR-SIVEDRF
Mvan_5297|M.vanbaalenii_PYR-1 V-DGAHTAD-----FETPTG----AVYRSTAPPLPGPPVRRRLSLLEGRL
MSMEG_6025|M.smegmatis_MC2_155 TSDGEHIAE-----YVTPTG----AVYRSTAPPLPGRPVRHTLSLVETGL
Mb1413c|M.bovis_AF2122/97 DETGRHTAE-----FTTPTG----MYYHCTAPPLPGPLEIDV-SQVEARI
Rv1378c|M.tuberculosis_H37Rv DETGRHTAE-----FTTPTG----MYYHCTAPPLPGPLEIDV-SQVEARI
MMAR_1584|M.marinum_M HETHTHTAE-----FTTPTG----TSYRSGAP--PRVQTVTA-SELEVRV
MAV_3980|M.avium_104 DETHTHTAL-----FTTPTG----QTYRSTAP--PRAPAITM-STVEVRV
MAB_1907|M.abscessus_ATCC_1997 G-ADRHTVE-----FTTPTG----TAYRSTAPPLP---------------
TH_0334|M.thermoresistible__bu QSS---CLP---AYFQRP---------HGPATRRPPSARG-----LR---
MUL_2679|M.ulcerans_Agy99 DATVIWSLPDGQTYVTTPGSAWLLPGLFAPSPELPPPPRSEATGSLRKPR
* :. *
Mflv_3750|M.gilvum_PYR-GCK SIDLVTFEAA-----------------
Mvan_5297|M.vanbaalenii_PYR-1 SIDLVTFDAA-----------------
MSMEG_6025|M.smegmatis_MC2_155 TIDLVTFDAA-----------------
Mb1413c|M.bovis_AF2122/97 GVALTHLHAA-----------------
Rv1378c|M.tuberculosis_H37Rv GVALTHLHAA-----------------
MMAR_1584|M.marinum_M GISLAR-HAA-----------------
MAV_3980|M.avium_104 AVAFAR-HAA-----------------
MAB_1907|M.abscessus_ATCC_1997 ---------------------------
TH_0334|M.thermoresistible__bu --EAVPRQGVDP-------RRVSGQ--
MUL_2679|M.ulcerans_Agy99 RDDAQTRPNSRPKLGRTHCDRTQPQHD