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MFETLTAIDPDAEEAALIERIAELERLKSAAAAGQARAAAAVDAARRAAEGAAGVPAARRGRGLASEIAL ARRDSPARGSRHLGFAKALVYEMPHTLAALDCGALSEWRATLIVRESACLDVADRRALDAELCGDPGDLE GMGDARVVAAARAIAYRLDPQAVVDRAANAENDRTVTIRPAPDTMTYLTALLPVAQGVSVYAALTRAADT RCDGRSRGQVMADTLVERVTGRDAAVPTPIAVNLVMSDETLLGAANTPAQLCGYGPIPAAVARTMVASAV TDQRSRATLRRLYAHPQAGALVSMESRARLFPRGLAAFIELRDQRCRTPYCDAPIRHRDHAHPWADGGPT SAHNGLGTCERCNYAKQAPGWRVSTSVDENHTHTAEFITPTGSRHRSGAPPHLPAVTVSELEVRIGIALA RYAA
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv3074 | - | - | 100% (424) | hypothetical protein Rv3074 |
| M. tuberculosis H37Rv | Rv1378c | - | e-172 | 73.35% (424) | hypothetical protein Rv1378c |
| M. tuberculosis H37Rv | Rv0515 | - | 2e-21 | 27.15% (383) | 13E12 repeat family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3101 | - | 0.0 | 100.00% (424) | hypothetical protein Mb3101 |
| M. gilvum PYR-GCK | Mflv_2586 | - | 1e-137 | 60.33% (426) | hypothetical protein Mflv_2586 |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_1907 | - | 1e-134 | 61.27% (395) | hypothetical protein MAB_1907 |
| M. marinum M | MMAR_1584 | - | 0.0 | 84.43% (424) | hypothetical protein MMAR_1584 |
| M. avium 104 | MAV_3980 | - | 0.0 | 80.38% (418) | hypothetical protein MAV_3980 |
| M. smegmatis MC2 155 | MSMEG_6025 | - | 1e-146 | 62.62% (428) | hypothetical protein MSMEG_6025 |
| M. thermoresistible (build 8) | TH_0334 | - | 2e-17 | 26.86% (376) | HNH endonuclease |
| M. ulcerans Agy99 | MUL_1813 | - | 1e-19 | 27.23% (382) | 13e12 repeat-containing protein |
| M. vanbaalenii PYR-1 | Mvan_4725 | - | 1e-139 | 61.50% (413) | hypothetical protein Mvan_4725 |
CLUSTAL 2.0.9 multiple sequence alignment
Rv3074|M.tuberculosis_H37Rv ----------MFETLTAIDPDAEEAALIERIAELERLKSAAAAGQARAAA
Mb3101|M.bovis_AF2122/97 ----------MFETLTAIDPDAEEAALIERIAELERLKSAAAAGQARAAA
MMAR_1584|M.marinum_M ----------MFESLAAVDPAADQAALVERIAELETVKSAAAAGQARAAA
MAV_3980|M.avium_104 ---------------MAVDPAAGESALIERISELETLKCAAAAAQARAAA
Mflv_2586|M.gilvum_PYR-GCK ----------MFESLFDIDEGASQAELRAVVERCERLKSAAAAAQARATA
Mvan_4725|M.vanbaalenii_PYR-1 ----------MFESMFDVDETASQAELRAAVERLERLKSQAAAAQARATA
MSMEG_6025|M.smegmatis_MC2_155 MSVRGCSVWHMFESLFDIDPQASEAELRDRIEQFERMKSAAAAAQATASV
MAB_1907|M.abscessus_ATCC_1997 --------------MLPLDPATRAAQLVDRIAELERVKAAAAAEQAHAAV
TH_0334|M.thermoresistible__bu -----------------MFESLDDGAVVDSIAAASREQSAACGREMLAIG
MUL_1813|M.ulcerans_Agy99 ---------------------------MERAREASRREAAAAAERLDVVG
. :. *.. . .
Rv3074|M.tuberculosis_H37Rv AVDAARRAAEGAAGVPAARRGRG-LASEIALARRDSPARGSRHLGFAKAL
Mb3101|M.bovis_AF2122/97 AVDAARRAAEGAAGVPAARRGRG-LASEIALARRDSPARGSRHLGFAKAL
MMAR_1584|M.marinum_M ALDTARRAAESAAGVPAARRGRG-LANEIALARRDSPARGSRHLGFAKAL
MAV_3980|M.avium_104 ALDAARRAAEAAAGVPAARRGRG-VASEVALARRDSPARGGRHLGFAKAL
Mflv_2586|M.gilvum_PYR-GCK LWAAKRAAAEEAAGVPVRRRGKG-LASEVALARRDAPVKGGQHLGFAKAL
Mvan_4725|M.vanbaalenii_PYR-1 LWAAKRQLAEESAGVRAHHRGKG-LASEVALARRDAPVKGNQHLGFAKAL
MSMEG_6025|M.smegmatis_MC2_155 LWEQKRRAAEAAAGIPASRRGRG-LATEVALARRESPNAGGRHLGLAHAL
MAB_1907|M.abscessus_ATCC_1997 LLDRARREEEAANGVPRRRQGAG-VATEIALARQDSPARGSRHLGFAKAL
TH_0334|M.thermoresistible__bu ELYARRAPEDDTERANWAIDGHANVVAEISAALNISRGRAAGRLQLAIDL
MUL_1813|M.ulcerans_Agy99 ALFVLRCRES-GDRAEWATDTWEAVGAQVAAALRTSVAMGSSYLRYAMAM
* . : ::: * . : . * * :
Rv3074|M.tuberculosis_H37Rv VYEMPHTLAALDCGALS-EWRATLIVRESACLDVADRRALDAELCGDPGD
Mb3101|M.bovis_AF2122/97 VYEMPHTLAALDCGALS-EWRATLIVRESACLDVADRRALDAELCGDPGD
MMAR_1584|M.marinum_M VHEMPHTLAALECGLLS-EWRATLIVRESACLDIEHRRELDAELCGDPSG
MAV_3980|M.avium_104 VHEMPHTLAALECGALS-EWRATLIVRESACLDAEDRRALDAELCADPAG
Mflv_2586|M.gilvum_PYR-GCK MGEMPHTWAALECGALS-EWRATLIVRESACLSVEDRRRLDEELCADVSR
Mvan_4725|M.vanbaalenii_PYR-1 VNEMPHTLAALESGVLS-EWRANLIVRESACLSVEHRRQLDAELCADASG
MSMEG_6025|M.smegmatis_MC2_155 VDELPHTLAALRCGALS-EWRATLIARESACLSPELRRELDAELSADPSR
MAB_1907|M.abscessus_ATCC_1997 VNEMPHTLAALECGALS-EWRATILVRETAYLAVEDRQKIDVEMCAETSR
TH_0334|M.thermoresistible__bu RERLPRVAAVFAAGDIDFRMVSALVNRSRNVVDPDLLARLDAALAAWSPK
MUL_1813|M.ulcerans_Agy99 RNRLPKVGQAFRAEDIDYRAFQTIVFRTDLITDAEVLAKVDAQLAALLAR
.:*:. .: . :. . :: * :* :..
Rv3074|M.tuberculosis_H37Rv LEGMGDARVVAAARAIAYRLDPQAVVDRAANAENDRTVTIRPAPDT--MT
Mb3101|M.bovis_AF2122/97 LEGMGDARVVAAARAIAYRLDPQAVVDRAANAENDRTVTIRPAPDT--MT
MMAR_1584|M.marinum_M LEGMGDARVAAAAKAIAYRLDPHAVVDRAAKAERERTVTIRPAPDT--MT
MAV_3980|M.avium_104 LSGMGDARVAAAAKAIAYRLDPHAVVERAAKAENDRTVTIRPAPDT--MT
Mflv_2586|M.gilvum_PYR-GCK FEGWGNKRVEAEAKKIAARLDVAAVVERVDRAAAQARVSCRPAPNG--MV
Mvan_4725|M.vanbaalenii_PYR-1 LEGWGNRRIEAEAKKIAARLDAAALVERARKAPEQRCVSCRPAPDN--ML
MSMEG_6025|M.smegmatis_MC2_155 FDGWGDARVAAEAKKIACRLNIDAVLDRSAKAEKDRRVTIRPAPDA--MT
MAB_1907|M.abscessus_ATCC_1997 LRGLGDTRLAAEAKRLAYRLDAQAVVRRARRAESERRVSLRPAPDT--MT
TH_0334|M.thermoresistible__bu WMKLSGPTLNERIDMWVERFDPTGVRE-PRSPGEDRYVVVTPAGQG--MV
MUL_1813|M.ulcerans_Agy99 CPAVTRGRLSVAVDQVVADVDRDVVRR-VAEAADGRFVDVDVIADGSGLA
: . .: : . * : :
Rv3074|M.tuberculosis_H37Rv YLTALLPVAQGVSVYAALTRAADTRCD--GRSRGQVMADTLVERVTGRD-
Mb3101|M.bovis_AF2122/97 YLTALLPVAQGVSVYAALTRAADTRCD--GRSRGQVMADTLVERVTGRD-
MMAR_1584|M.marinum_M YLTALLPVAQGISVYAALRRAADTRCD--GRSRGQVMADTLVERVTGRD-
MAV_3980|M.avium_104 YLTALLPVAQGVSVYAALRREADTRGD--GRPRGQVMADTLVERVTGRR-
Mflv_2586|M.gilvum_PYR-GCK YFTVLLPLAQGIGMYAALKHHADTTFD--GRSRGQVMADTAFERITGRS-
Mvan_4725|M.vanbaalenii_PYR-1 YVTVLLPMTHGVAVYAACNRAADTTFD--GRTRDQVMADTIYERVTGRS-
MSMEG_6025|M.smegmatis_MC2_155 KLTVLLPLKQGVAVYAALHQAAMVNAD--DRNRGQVMADTLVERVTGRP-
MAB_1907|M.abscessus_ATCC_1997 YLTALLPVKQGVAVYAALKRTADASMDP-VRGQGQIMADTLVERVTGVS-
TH_0334|M.thermoresistible__bu DVSARLTFEAGFAFXTRLDQIAATVCRDDPRTADQRRADAMAAMSEGQNR
MUL_1813|M.ulcerans_Agy99 ALAGSVLATAGRAFDRRLDELANTVCAADPRTREQRRADAVGALVAGSDR
.: : * .. . * . * * **: *
Rv3074|M.tuberculosis_H37Rv -----AAVPTPIAVNLVMSDETLLGAANTPAQLCGYGPIPAAVARTMVAS
Mb3101|M.bovis_AF2122/97 -----AAVPTPIAVNLVMSDETLLGAANTPAQLCGYGPIPAAVARTMVAS
MMAR_1584|M.marinum_M -----AAVPTPIAVNLVLTDESLLGADSAPADVCGYGPIPAAVARTMVAD
MAV_3980|M.avium_104 -----STVPTPVAVNLVLSDETLLGGADAPGEISGYGPIPAAVARRMVAN
Mflv_2586|M.gilvum_PYR-GCK -----AGTAVPVALNLVMADTTLAGDDDCPGWLDGYGPVPAGFCRALTGD
Mvan_4725|M.vanbaalenii_PYR-1 -----AAEPVSVALNLVMADTTLFGDDEAPGWAQGYGPVPAAVVRDLVSD
MSMEG_6025|M.smegmatis_MC2_155 -----AHAPVPVNLNLVMADTTLFGEDDQPGWVQGYGPVPAEVARRMVAD
MAB_1907|M.abscessus_ATCC_1997 -----AAAAVPVGVNITVSDEALLGGGDEPATITGHGLVPAAVARRLISE
TH_0334|M.thermoresistible__bu LVCGCGSEDCPADPADTAATRLVINVIAEQATVEGRSDNPGYLPGYG-AV
MUL_1813|M.ulcerans_Agy99 LACGCTSADCTAA-ARSAPSKVVIHVVADQSTVDGTGHTPAVLLGAEGLI
. . : . * . *. .
Rv3074|M.tuberculosis_H37Rv AVTDQRSRATLRRLYAHPQAGALVSMESRARLFPRGLAAFIELRDQRCRT
Mb3101|M.bovis_AF2122/97 AVTDQRSRATLRRLYAHPQAGALVSMESRARLFPRGLAAFIELRDQRCRT
MMAR_1584|M.marinum_M AVADGRSRATLRRLYAHPRAGALVAMESRARLFPRGLAAFIELRDQRCRT
MAV_3980|M.avium_104 AAADPRSRATLRRLYAHPRAGALVAMESRARLFPQGLARFIGLRDQRCRT
Mflv_2586|M.gilvum_PYR-GCK AVADKGARATLRRLYRHPRSGQLVAMESRARLFPKGLATLIDRRDQTCRT
Mvan_4725|M.vanbaalenii_PYR-1 AVTDAKAKATLRRLYRHPKSGQLVAMESRSWLFPKGLATFIGLRDQSCRT
MSMEG_6025|M.smegmatis_MC2_155 ATLDENTKAAVRRLFRHPKSGQLVAMESRSRIFPKGLATFIGLRDQTCRT
MAB_1907|M.abscessus_ATCC_1997 AVS-AEAKVLVRRLYRRCTTGALVKAESRSRLFPRGLAELIDLRDQTCRT
TH_0334|M.thermoresistible__bu PASILRAKAATATLRPVALPQPCAEAGYRP---SAALTRFIRCRDLTCRF
MUL_1813|M.ulcerans_Agy99 PASLIAELAKVATLRPLMRPSGRPESGYAP---SAGLAEFVRCRDLTCRA
.. . * . . . .*: :: ** **
Rv3074|M.tuberculosis_H37Rv PYCDAP--IRHRDHAHPWADGGPTSAHNGLGTCERCNYAKQAPGWR----
Mb3101|M.bovis_AF2122/97 PYCDAP--IRHRDHAHPWADGGPTSAHNGLGTCERCNYAKQAPGWR----
MMAR_1584|M.marinum_M PYCDAP--IRHRDHARPWAKGGPTTADNGLGSCERCNYAKEAYGWR----
MAV_3980|M.avium_104 PYCDAP--IRHRDHAQPWADGGATSAGNGLGLCEHCNYVKETSGWT----
Mflv_2586|M.gilvum_PYR-GCK PYCDAP--IRHHDHATPDRAGGKTSAENGLGECAACNYAKEAPGWQ----
Mvan_4725|M.vanbaalenii_PYR-1 PYCDAP--IRHHDHAVPDREGGPTSALNGLGECQACNYAKEAPGWH----
MSMEG_6025|M.smegmatis_MC2_155 PYCDAL--IRHRDHAVPHHDGGPTTAHNGLGTCEACNYAKEAPGWS----
MAB_1907|M.abscessus_ATCC_1997 PYCDAP--IRHHDHVVGSMRGGPTALDNGQGLCERCNYVKETAGWN----
TH_0334|M.thermoresistible__bu PGCDAPAAVCQIDHTIPYPAG-PTHPSNLKLLCVFHCRQAELR-------
MUL_1813|M.ulcerans_Agy99 RGCDQPAVCCDLDHTVAYGDGGHTHASNLKCLCRKHHLLKTFWGWRDLQL
** . **. * * * *
Rv3074|M.tuberculosis_H37Rv ----VSTSVDENHTHTAE---------FITPTGSRHRSGAPPHLP-----
Mb3101|M.bovis_AF2122/97 ----VSTSVDENHTHTAE---------FITPTGSRHRSGAPPHLP-----
MMAR_1584|M.marinum_M ----VETSMHETHTHTAE---------FTTPTGTSYRSGAPPRVQ-----
MAV_3980|M.avium_104 ----VSAGVDETHTHTAL---------FTTPTGQTYRSTAPPRAP-----
Mflv_2586|M.gilvum_PYR-GCK ----VSAGTQ-DGSHTAR---------WVTPTGAVHYSIAPALPGPP---
Mvan_4725|M.vanbaalenii_PYR-1 ----VTTTDT-DGEHTAT---------FCTPTGAKYFSIAPPAPGTP---
MSMEG_6025|M.smegmatis_MC2_155 ----VIITETSDGEHIAE---------YVTPTGAVYRSTAPPLPGRP---
MAB_1907|M.abscessus_ATCC_1997 ----VAPVPG-ADRHTVE---------FTTPTGTAYRSTAPPLP------
TH_0334|M.thermoresistible__bu -------FTHDQHKHQSS----------CLPAYFQRPHGPATRRPP----
MUL_1813|M.ulcerans_Agy99 PDGTVIWLLPDGHTYVTTPGSALLFPNLCVPTGELPPIVGTAGKPPRWPS
: *: ..
Rv3074|M.tuberculosis_H37Rv ----------------AVTVSELEVRIGIALARYAA--------------
Mb3101|M.bovis_AF2122/97 ----------------AVTVSELEVRIGIALARYAA--------------
MMAR_1584|M.marinum_M ----------------TVTASELEVRVGISLARHAA--------------
MAV_3980|M.avium_104 ----------------AITMSTVEVRVAVAFARHAA--------------
Mflv_2586|M.gilvum_PYR-GCK ---------------VRRRISDTEGRLSIDLITFDKPDAA----------
Mvan_4725|M.vanbaalenii_PYR-1 ---------------VSRR-SIVEGELSIDIVTFLAA-------------
MSMEG_6025|M.smegmatis_MC2_155 ---------------VRHTLSLVETGLTIDLVTFDAA-------------
MAB_1907|M.abscessus_ATCC_1997 --------------------------------------------------
TH_0334|M.thermoresistible__bu ---------------SARGLREAVPRQGVDPRRVSGQ-------------
MUL_1813|M.ulcerans_Agy99 GEDADPCPNPRTKPGESHRHRAPMQSQGTGSRRRRPRRPVRHPGAGNRSR
Rv3074|M.tuberculosis_H37Rv --------------------------------------------------
Mb3101|M.bovis_AF2122/97 --------------------------------------------------
MMAR_1584|M.marinum_M --------------------------------------------------
MAV_3980|M.avium_104 --------------------------------------------------
Mflv_2586|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4725|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_6025|M.smegmatis_MC2_155 --------------------------------------------------
MAB_1907|M.abscessus_ATCC_1997 --------------------------------------------------
TH_0334|M.thermoresistible__bu --------------------------------------------------
MUL_1813|M.ulcerans_Agy99 RAAALLAATSLGTCQIPRRIAPRPGPSRSSRGCTDSGTRMGESSMSARPR
Rv3074|M.tuberculosis_H37Rv -----
Mb3101|M.bovis_AF2122/97 -----
MMAR_1584|M.marinum_M -----
MAV_3980|M.avium_104 -----
Mflv_2586|M.gilvum_PYR-GCK -----
Mvan_4725|M.vanbaalenii_PYR-1 -----
MSMEG_6025|M.smegmatis_MC2_155 -----
MAB_1907|M.abscessus_ATCC_1997 -----
TH_0334|M.thermoresistible__bu -----
MUL_1813|M.ulcerans_Agy99 ACVAG