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MTMITAYRGPLRSTDLHVDDSGGDGRPVVLIHGWPLHSDSWAHQVDALRDAGYRVITYDRRGFGRSDKPL IGYTYESLSDDLSAVLEELDLTDVTLVGFSMGGGEVAAYCARKGVERIRSVVFASSVTPFMSARKDNPEG PLGKLEAARMAASLTTDQDAFFEQFMTDVFSADGELQVTEQERQEALSMCGDADKPATLACMAAFGGTDF REDLPKVTVPSLVIHGDSDATVPFEGSGKRTYELLPDGRLHVIAGGPHGIPVSHADEFNAVLLEFLEQDF ADGRGR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_2561 | - | - | 100% (286) | alpha/beta hydrolase fold |
| M. gilvum PYR-GCK | Mflv_3146 | - | 2e-43 | 40.31% (258) | alpha/beta hydrolase fold |
| M. gilvum PYR-GCK | Mflv_1348 | - | 1e-19 | 27.51% (269) | 3-oxoadipate enol-lactonase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3600c | bphD | 4e-13 | 27.60% (279) | 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase BphD |
| M. tuberculosis H37Rv | Rv3569c | bphD | 4e-13 | 27.60% (279) | 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase BphD |
| M. leprae Br4923 | MLBr_02297 | - | 5e-10 | 24.69% (320) | putative hydrolase |
| M. abscessus ATCC 19977 | MAB_0528c | - | 4e-18 | 29.37% (303) | epoxide hydrolase EphA |
| M. marinum M | MMAR_2050 | - | 4e-17 | 29.70% (266) | hypothetical protein MMAR_2050 |
| M. avium 104 | MAV_5175 | - | 2e-92 | 58.70% (276) | non-haem bromoperoxidase BPO-A2 |
| M. smegmatis MC2 155 | MSMEG_4707 | - | 1e-113 | 68.68% (281) | non-heme bromoperoxidase BPO-A2 |
| M. thermoresistible (build 8) | TH_3727 | - | 4e-45 | 41.76% (261) | PUTATIVE Chloride peroxidase |
| M. ulcerans Agy99 | MUL_3195 | - | 3e-14 | 28.41% (271) | hydrolase |
| M. vanbaalenii PYR-1 | Mvan_1567 | - | 5e-45 | 40.22% (271) | chloride peroxidase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_2561|M.gilvum_PYR-GCK -------------------------------------------MTMITAY
MSMEG_4707|M.smegmatis_MC2_155 -------------------------------------------MAAITAY
MAV_5175|M.avium_104 -------------------------------------------MPDVIAH
TH_3727|M.thermoresistible__bu -------------------------------------------MATITTS
Mvan_1567|M.vanbaalenii_PYR-1 -------------------------------------------MSIFTTT
Mb3600c|M.bovis_AF2122/97 ---------------------------------MTATEELTFESTSRFAE
Rv3569c|M.tuberculosis_H37Rv ---------------------------------MTATEELTFESTSRFAE
MMAR_2050|M.marinum_M ------------------MRPTLAAAALAGASGLVGWGGARALARRIERN
MAB_0528c|M.abscessus_ATCC_199 ---------------------------------------MTDAAVDIRER
MLBr_02297|M.leprae_Br4923 --------------------------------MAMSNPSVTRIAGPWHHL
MUL_3195|M.ulcerans_Agy99 MKYPRRRPHKRRRDVHTAHRYPSRPALARMCGERRSQEIHPVERISALGS
Mflv_2561|M.gilvum_PYR-GCK RGPLRSTDLHVDDSGG------------------DGRPVVLIHGWPLHSD
MSMEG_4707|M.smegmatis_MC2_155 RGLLRSIELHVEDTGG------------------AGRPVVLVHGWPLTGE
MAV_5175|M.avium_104 HGLLKDTRLHVDDTGG------------------PGRPVLLMHPWPLSGQ
TH_3727|M.thermoresistible__bu DG----VEIFYRDWG-------------------SGQPIVFSHGWPLTAD
Mvan_1567|M.vanbaalenii_PYR-1 DG----TDIFYKDWG-------------------SGQPIVFSHGWPLSSD
Mb3600c|M.bovis_AF2122/97 VDVDGPLKLHYHEAGV-----------------GNDQTVVLLHGGGPGAA
Rv3569c|M.tuberculosis_H37Rv VDVDGPLKLHYHEAGV-----------------GNDQTVVLLHGGGPGAA
MMAR_2050|M.marinum_M PDPFPRERLLAEPQGERVAITRPDGTVLHALVAGRGTPVILVHGYCASLT
MAB_0528c|M.abscessus_ATCC_199 DIATNGVHLRIVEAGE-----------------PGQPAVILSHGFPELAY
MLBr_02297|M.leprae_Br4923 DVHANGIRFHVVEAVPTQPAG-----QDCAPSATARPLVMLLHGFGSFWW
MUL_3195|M.ulcerans_Agy99 KPMESAAQPHRIEVGETVCNDG---TVIGHTAAGEGPALALLPGWSLTAQ
: :
Mflv_2561|M.gilvum_PYR-GCK SWA--HQVDALRDAGYRVITYDRRGFGRSDK--PLIGYTYESLSDDLSAV
MSMEG_4707|M.smegmatis_MC2_155 SWG--AQVEALTAAGHRVITYDRRGFGRSDT--SLVGYTYEALSDDLAAV
MAV_5175|M.avium_104 SWS--AQVPVLHAAGYRVVTYDRRGFGRSDK--PLTGYSYSQLTQDLHTL
TH_3727|M.thermoresistible__bu DWD--PQMLFFLNAGYRVIAHDRRGHGRSSP--VPDGHDMDHYADDLAAL
Mvan_1567|M.vanbaalenii_PYR-1 DWD--TQMLFFLQRGYRVIAHDRRGHGRSTQ--TPDGHDLDHYADDLAEL
Mb3600c|M.bovis_AF2122/97 SWTNFSRNIAVLARHFHVLAVDQPGYGHSDKR-AEHGQFNRYAAMALKGL
Rv3569c|M.tuberculosis_H37Rv SWTNFSRNIAVLARHFHVLAVDQPGYGHSDKR-AEHGQFNRYAAMALKGL
MMAR_2050|M.marinum_M EWN--FVWDELLARGLRVIAFDQRGHGRSTL--GAEGIGSEPMADDLAAV
MAB_0528c|M.abscessus_ATCC_199 SWR--HQIPALAAAGYHVIAPDQRGYGRSSMPAHIDDYNIEALSDDLLGI
MLBr_02297|M.leprae_Br4923 SWR--HQLRGLTEA--RLVAVDLRGYGGSDK--PPRGYDGWTLAGDTAGL
MUL_3195|M.ulcerans_Agy99 IFR---HQLAGLSHTWRVLAIDHRGHGRSST--PQLGYHIHRLAADLRTV
: :::: * *.* * . : :
Mflv_2561|M.gilvum_PYR-GCK LEELDLTDVTLVGFSMGGGEVAAYCARKGVERIRSVVFAS---------S
MSMEG_4707|M.smegmatis_MC2_155 LDELDVRDATLVGFSMGTGEVAAYCARKGTERLRSVVLAA---------P
MAV_5175|M.avium_104 VESLDLRDLTLVGSSMGGGEVARYLSTYGPERVRSVVFAS---------S
TH_3727|M.thermoresistible__bu VEHLGLRDAVHVGHSTGGGVVVRYLARHGEERTAKAVLIA---------A
Mvan_1567|M.vanbaalenii_PYR-1 TAHLDLRDAIHVGHSTGGGEVVRYLGRHGESRVAKAALIS---------A
Mb3600c|M.bovis_AF2122/97 FDQLGLGRVPLVGNSLGGGTAVRFALDYPARAGRLVLMGP---------G
Rv3569c|M.tuberculosis_H37Rv FDQLGLGRVPLVGNSLGGGTAVRFALDYPARAGRLVLMGP---------G
MMAR_2050|M.marinum_M LQHFDIRDGVLVGHSMGGFVSIRALLDHGALAQRLRAVVL---------F
MAB_0528c|M.abscessus_ATCC_199 LDDVGAGKATFVGHDWGAVVTWHTALAVPERVSGVVGLSVPFTRRSQVPP
MLBr_02297|M.leprae_Br4923 IRALGHSSATLVGHAEGGLACWATALLHPRLVRAIALINSP------HPA
MUL_3195|M.ulcerans_Agy99 LQTHQLDQVHLLGHSMGCAVIWSYLELFGTDRLASLLLVD----------
:* * .
Mflv_2561|M.gilvum_PYR-GCK VTPFMSARKDNPEGPLGKLEA---------ARMAASLTTDQDAFFEQFMT
MSMEG_4707|M.smegmatis_MC2_155 VTPYMLNTADNPEGPLSKTQA---------AQMAAALTTNSDAFYREMMT
MAV_5175|M.avium_104 VTPYLLQTTDNPDGPLTMKDA---------ARATASFVKDQDAFYDHQMT
TH_3727|M.thermoresistible__bu VPPLMVRTDANPGG-LPKSVF---------DDFQAQLAANRSEFYRALAS
Mvan_1567|M.vanbaalenii_PYR-1 VPPLMVRTEDNPEG-TPKEVF---------DDLQAQLAANRSVFYRSLPA
Mb3600c|M.bovis_AF2122/97 GLSINLFAPDPTEG--VKRLS---------KFSVAPTRENLEAFLRVMVY
Rv3569c|M.tuberculosis_H37Rv GLSINLFAPDPTEG--VKRLS---------KFSVAPTRENLEAFLRVMVY
MMAR_2050|M.marinum_M ATWAGRVLDGAPQNRLQIPLL---------ERGILQRLLRSRTIAVLFGA
MAB_0528c|M.abscessus_ATCC_199 TQAWNKLFGDNFFYILYFQEP---------GVADADLNRDPATTMRRMMA
MLBr_02297|M.leprae_Br4923 ALRRSMLTHRNQGYALLPTLLRYQLPIWPERLLTRNNAAEIERLVRSRSS
MUL_3195|M.ulcerans_Agy99 -QMPCALRNPAWTGAQALEAG---------ATMDPTGLFAFTDRLRADGD
Mflv_2561|M.gilvum_PYR-GCK DVFSADG--ELQVTEQ----------ERQEALSMCGDADKPATLACMAAF
MSMEG_4707|M.smegmatis_MC2_155 GVFSADG--VLTISED----------ALQQVLDMCGQASKNAALACMAAF
MAV_5175|M.avium_104 EFFSANG--QLRVSPA----------TRAEALRLCKQAGKEASLACMAAW
TH_3727|M.thermoresistible__bu GPFYGFNRDGVEPSEA----------LIANWWRQGMMGDAKAHYDGIVAF
Mvan_1567|M.vanbaalenii_PYR-1 GPFYGFNRPGVEPQEA----------IIENWWRQGMMGDAYSHYDGIVAF
Mb3600c|M.bovis_AF2122/97 DKNLITP--ELVDQRF----------ALASTPESLTATRAMGKSFAGADF
Rv3569c|M.tuberculosis_H37Rv DKNLITP--ELVDQRF----------ALASTPESLTATRAMGKSFAGADF
MMAR_2050|M.marinum_M AQCGARP----SPAMI----------SVFLEWFHQHLDRHGPHLPIVRAF
MAB_0528c|M.abscessus_ATCC_199 GMARIDGATMIAPGPAGFVERMPDPGELPEWLSQDELDHYITEFARTGFT
MLBr_02297|M.leprae_Br4923 AKWQACEDFAVTIDHLR-------IAIQIPAAAHCALEYQRWAVRSQLRN
MUL_3195|M.ulcerans_Agy99 DPRPDFVTEVVSEGIG--------ADELAWPVEQGQTLDRRCAADLIFDV
Mflv_2561|M.gilvum_PYR-GCK GGTDFREDLPK------------VTVPSLVIHGDSDATVPFEGSGKRTYE
MSMEG_4707|M.smegmatis_MC2_155 SNTDFREDLPR------------VTVPALVIHGDADATTPLQNCGERTHA
MAV_5175|M.avium_104 ANTDFRPDLTR------------VSVPALIIHGEGDESVPLAGSARRTHR
TH_3727|M.thermoresistible__bu SQTDFTEDLTK------------ITVPVLVMHGDDDQVVPYANSGPLTAE
Mvan_1567|M.vanbaalenii_PYR-1 SQTDFTEDLKK------------ITVPVLVMHSEADQIVPYVASGPKSAA
Mb3600c|M.bovis_AF2122/97 EAGMMWREVYR------------LRQPVLLIWGREDRVNPLDG-ALVALK
Rv3569c|M.tuberculosis_H37Rv EAGMMWREVYR------------LRQPVLLIWGREDRVNPLDG-ALVALK
MMAR_2050|M.marinum_M SREDRYPRLAE------------ISVPAVVMVGSSDRTTPPSHSHRLAAG
MAB_0528c|M.abscessus_ATCC_199 GGLNWYRNFDRNWALTERLAGANVVVPSLFIAGAADPVLGFTDHAGSAKY
MLBr_02297|M.leprae_Br4923 EGRKFMKSMSR-----------PFSVPLLHVRGDADP-YLLADSVDRTRR
MUL_3195|M.ulcerans_Agy99 ATHDWRGLMAH------------IGLPTLVLAG--DSVNVPIASQRWMWQ
. . . * : : . *
Mflv_2561|M.gilvum_PYR-GCK LLPDGRLHVIAG---GPHGIPVSHADEFNAVLLEFLEQDFADGRGR
MSMEG_4707|M.smegmatis_MC2_155 ALPNSRLHVISG---GPHGIPVSHTEEFNRVLLDFLAEDLAAAR--
MAV_5175|M.avium_104 AIPGSRLCVIAD---GPHGCHISHAQEFNAALLDFLAA--------
TH_3727|M.thermoresistible__bu LLRNAKLKTYQG---FPHGMMTTHAEVVNADILEFLRS--------
Mvan_1567|M.vanbaalenii_PYR-1 LLKNGVLKTYKD---FPHGMPTTHADVVNADLLEFLKG--------
Mb3600c|M.bovis_AF2122/97 TIPRAQLHVFGQ---CGHWVQVEKFDEFNKLTIEFLGGGR------
Rv3569c|M.tuberculosis_H37Rv TIPRAQLHVFGQ---CGHWVQVEKFDEFNKLTIEFLGGGR------
MMAR_2050|M.marinum_M -IPGARLVTVPG---AGHLLNWEAVDELAEVVESFAAQR-------
MAB_0528c|M.abscessus_ATCC_199 RTDNRGDLLIDG---AGHWIQQERPLEVNAALLAFLREVVH-----
MLBr_02297|M.leprae_Br4923 YAPHGRYVSVSD---AGHFSHEEAPEEINRYLTRFLKQVHGPRLS-
MUL_3195|M.ulcerans_Agy99 QIPGAQFARVPGRRGGTHFPFLENPQTFNDVVSQHLCAHRPG----
* . .