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VQLTFDPDVEAFRAEFAAFLDENLPPASETLERPRSVSHMPQWARRWQRLLFDNGWLLPSQPPEYGGRNA TVLQQFVYLEELSRRRIYHSFNPQGVNIVAASLLSFGSDEQKQRWAVPILRAEITASLGMSEPSAGSDLA SLRTRAVLDGDHFVVNGQKVWTSGAHDADVLLTFVRTDPDAPKHKGISALVIPTDTPGLVRRPFPSICSI DDKDFNEVFFTDVRVPAENLVGGLNQGWLVANGSLGHERTMMWLGFADRLENMIADFQPGTEVERDQYAT TIMDRQALRLLGSAALARAARGEDDVAAISVLKLLGSEAELRAMELALTSAGADGLVHPGQTGPYAHMNL DHYFASWFERYARSFSGTIAGGTLEIQRNIIAQRVLGLPRG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_0935 | - | - | 100% (391) | putative acyl-CoA dehydrogenase |
| M. avium 104 | MAV_0898 | - | e-174 | 76.15% (390) | putative acyl-CoA dehydrogenase |
| M. avium 104 | MAV_1268 | - | 3e-66 | 40.10% (419) | acyl-CoA dehydrogenase domain-containing protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1969c | fadE17 | 8e-54 | 34.47% (412) | acyl-CoA dehydrogenase FADE17 |
| M. gilvum PYR-GCK | Mflv_2492 | - | 1e-180 | 78.72% (390) | acyl-CoA dehydrogenase domain-containing protein |
| M. tuberculosis H37Rv | Rv1934c | fadE17 | 8e-54 | 34.47% (412) | acyl-CoA dehydrogenase FADE17 |
| M. leprae Br4923 | MLBr_00737 | fadE25 | 2e-24 | 30.21% (341) | putative acyl-CoA dehydrogenase |
| M. abscessus ATCC 19977 | MAB_0595c | - | 1e-50 | 33.75% (397) | acyl-CoA dehydrogenase FadE |
| M. marinum M | MMAR_4718 | - | 0.0 | 86.70% (391) | acyl-CoA dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_4805 | - | 0.0 | 81.33% (391) | acyl-CoA dehydrogenase |
| M. thermoresistible (build 8) | TH_4023 | - | 0.0 | 81.98% (394) | PUTATIVE acyl-CoA dehydrogenase domain protein |
| M. ulcerans Agy99 | MUL_0322 | - | 1e-151 | 72.50% (360) | acyl-CoA dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_4162 | - | 1e-179 | 77.92% (394) | acyl-CoA dehydrogenase domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1969c|M.bovis_AF2122/97 ----------MDVSYPPEAEAFRDRIREFVAEHLPPGWPGPGALPPHERE
Rv1934c|M.tuberculosis_H37Rv ----------MDVSYPPEAEAFRDRIREFVAEHLPPGWPGPGALPPHERE
MAB_0595c|M.abscessus_ATCC_199 ----------MDLLLDDETEAFRAEVREFLVSNVPN--PPLPSYDSPEGA
MAV_0935|M.avium_104 ----------MQLTFDPDVEAFRAEFAAFLDENLPPASETLERPRSVSHM
MMAR_4718|M.marinum_M ----------MQLTFDPDVEAFRTEFATFLDEHLPPASETVERPRSVSHL
Mflv_2492|M.gilvum_PYR-GCK ----------MQLAFDSDVEEFRAEFSAFLDEHTPSAAETLERPRSVSHM
Mvan_4162|M.vanbaalenii_PYR-1 ----------MQLTFEPDVEEFRAEFSAFLDEHTPSAAETLERPRSVSHM
MSMEG_4805|M.smegmatis_MC2_155 ----------MQLTFDSDVEKFRAEFVAFLDANLPSEAATLERPRSVSHM
TH_4023|M.thermoresistible__bu ----------MQLTFDADVEEFRAEFIAFLEANLPDEAQTLERPRSVSHM
MUL_0322|M.ulcerans_Agy99 ----------MQLTFDADVEAFRDEFISFLDRNLPDQAAGMERPRSCSHV
MLBr_00737|M.leprae_Br4923 MVGWSGNPLFDLFKLPEEHNELRATIRALAEKEIAPHAADVDQRAR----
. : : :* . : . .
Mb1969c|M.bovis_AF2122/97 -EFARHWRRALAGAGLVAVSWPTEYGGGGLSPMEQVVLAEEFARAGAPER
Rv1934c|M.tuberculosis_H37Rv -EFARHWRRALAGAGLVAVSWPTEYGGGGLSPMEQVVLAEEFARAGAPER
MAB_0595c|M.abscessus_ATCC_199 -AAHRQWERTLYDAGFSAVSWPKEYGGRDVTPLQWVIFEEEYFKAGAPAR
MAV_0935|M.avium_104 PQWARRWQRLLFDNGWLLPSQPPEYGGRNATVLQQFVYLEELSRRRIYHS
MMAR_4718|M.marinum_M PQWARRWQRLLFDNGWLLPGQPPEFGGRNATVVQQFVHLEELCRRRIYHS
Mflv_2492|M.gilvum_PYR-GCK PQWARDWQRLLFDNGWLLPAQPPEFGGRNASVLQTFVHAEELCRRRIYHS
Mvan_4162|M.vanbaalenii_PYR-1 PQWAREWQRLLFDNGWLLPAQPPEFGGRNASVLQTFVHAEELCRRRIYHS
MSMEG_4805|M.smegmatis_MC2_155 PQWARDWQRLLFDNGWLLPAQPPEFGGRNANVVQQFVHLDELCRRRIYHS
TH_4023|M.thermoresistible__bu PQWARDWQRLLFDNGWLLPAQPPEFGGRNATVLQQYVHLEELCKRRIYHS
MUL_0322|M.ulcerans_Agy99 PEWARRWQRLLFDNGWLIPGNPPEFGGRNASLLQQYVHLQELARRRLYRS
MLBr_00737|M.leprae_Br4923 --FPEEALAALNASGFNAIHVPEEYGGQGADSVAACIVIEEVARVDASAS
. * * * *:** . : : :* :
Mb1969c|M.bovis_AF2122/97 AENDLLGIDLLGNTLIALGSEAQKRHFLPRILSGEHRWCQGFSEPEAGSD
Rv1934c|M.tuberculosis_H37Rv AENDLLGIDLLGNTLIALGSEAQKRHFLPRILSGEHRWCQGFSEPEAGSD
MAB_0595c|M.abscessus_ATCC_199 ISQN--GMFLLGPTLFAHGSKDQLDRVLPKMANGEEIWAQAWSEPESGSD
MAV_0935|M.avium_104 FNPQ--GVNIVAASLLSFGSDEQKQRWAVPILRAEITASLGMSEPSAGSD
MMAR_4718|M.marinum_M LNPQ--GVNIVAASILSFGTDEQKLRWAVPILRAQITASLGMSEPSAGSD
Mflv_2492|M.gilvum_PYR-GCK FNPQ--GVNIIAASLLTFGTDEQKHRWAVPVLRGERTASLGMSEPSAGSD
Mvan_4162|M.vanbaalenii_PYR-1 FNPQ--GVNIIAASLLTFGTDEQKHQWAVPVLRGERTASLGMSEPSAGSD
MSMEG_4805|M.smegmatis_MC2_155 FNPQ--GVNIIAASLLTFGTEEQKHRWAVPVLRGEKTASLGMSEPSAGSD
TH_4023|M.thermoresistible__bu FNPQ--GVNIIAASLLSFGSDEQKHRWAVPVLKAEMTASLGMSEPSAGSD
MUL_0322|M.ulcerans_Agy99 FNPQ--GVGIIAESLLSFGTPEQKRRWAVPILRAEMTASLGMSEPGAGSD
MLBr_00737|M.leprae_Br4923 LIPAVNKLGTMG--LILRGSEELKKQVLPSLAAEGAMASYALSEREAGSD
: :. :: *: : : . . ** :***
Mb1969c|M.bovis_AF2122/97 LASVRTRGVLD----GDEWVINGHKIWTSAGTTANWIFLLARTDPSAAKH
Rv1934c|M.tuberculosis_H37Rv LASVRTRGVLD----GDEWVINGHKIWTSAGTTANWIFLLARTDPSAAKH
MAB_0595c|M.abscessus_ATCC_199 LASLRSPARKV----DGGWRLSGQKIWSSRAPFADRAFGLFRSDPDAQRH
MAV_0935|M.avium_104 LASLRTRAVLD----GDHFVVNGQKVWTSGAHDADVLLTFVRTDPDAPKH
MMAR_4718|M.marinum_M LASLRTRAVLD----GDHFVVNGQKVWTSGAHDADVLLTFVRTDPDAPKH
Mflv_2492|M.gilvum_PYR-GCK LASLRTKAVRD----GDEFVVNGQKVWTSGAHDADFLLTFVRTDPDAPKH
Mvan_4162|M.vanbaalenii_PYR-1 LASLRTKAVLVSESGGSYFVVNGQKVWTSGAHDADFLLTFVRTDPDAPKH
MSMEG_4805|M.smegmatis_MC2_155 LASLRTRAVRD----GDEFVVNGQKVWTSGAHDADWLLTFVRTDPDAPKH
TH_4023|M.thermoresistible__bu LASLRTRAEFVSGDDGDHFVVNGQKVWTSGAHDADFLLTFVRTDPDAPKH
MUL_0322|M.ulcerans_Agy99 LASLKTRAVRYRDGEGDRFVVNGQKVWTSGAHDADVLLTFVRTYPDAPKH
MLBr_00737|M.leprae_Br4923 AASMRTRAKAD----GDDWILNGFKCWITNGGKSTWYTVMAVTDPDKGAN
**::: . .. : :.* * * : . : : : *. :
Mb1969c|M.bovis_AF2122/97 RGLSFLLVPMDQPGVVVRPIVNAAG--HSSFSEVFLTDARTSAGNVVGRV
Rv1934c|M.tuberculosis_H37Rv RGLSFLLVPMDQPGVVVRPIVNAAG--HSSFSEVFLTDARTSAGNVVGRV
MAB_0595c|M.abscessus_ATCC_199 QGLTYFMFDLKAEGITVRPIPQLDG--DPGFAEIFLDDVFVPDEDVIGAV
MAV_0935|M.avium_104 KGISALVIPTDTPGLVRRPFPSICSIDDKDFNEVFFTDVRVPAENLVGGL
MMAR_4718|M.marinum_M KGISALLIPTDTAGVVRRPFPSICSADDLDFNEVFFSDVLVPAANLVGAL
Mflv_2492|M.gilvum_PYR-GCK KGISVLLIPTDLDGVVCRPFADMTGIENLDFNEVFFTDVRVPAENLVGPL
Mvan_4162|M.vanbaalenii_PYR-1 KGISVLLIPTDLEGVVCRPFADMTGIDNLDFNEVFFTDVRVPVENLVGPL
MSMEG_4805|M.smegmatis_MC2_155 KGISVLIVPTDTPGVVCRPFADMTGQENLDFNEVFFTDARVPAENLVGPL
TH_4023|M.thermoresistible__bu KGISVLIIPTDLPGVVCRPFADICGPENKDFNEVFFTDVRVPAENLVGPL
MUL_0322|M.ulcerans_Agy99 KGISALLIPTDTPGVVRRPFASVCDHDDVDFNEVFFTDAAAPAENLVGEL
MLBr_00737|M.leprae_Br4923 -GISAFIVHKDDEGFSIGPKEKKLGIKGSPTTELYFDKCRIPGDRIIGEP
*:: ::. . *. * . . *::: . . ::*
Mb1969c|M.bovis_AF2122/97 GDGWSTAMTLLGFERGSHIATAAIDFERDLQRLCELARDR-----GLHTD
Rv1934c|M.tuberculosis_H37Rv GDGWSTAMTLLGFERGSHIATAAIDFERDLQRLCELARDR-----GLHTD
MAB_0595c|M.abscessus_ATCC_199 HDGWRVAMSTSSNERGMSLRSPGR-FLATADRLVELWKS-------VPEN
MAV_0935|M.avium_104 NQGWLVANGSLGHER-------TMMWLGFADRLENMIAD------FQPGT
MMAR_4718|M.marinum_M NGGWRVANGSLGHER-------TMMWLGFADRLDNLIAD------LHPVT
Mflv_2492|M.gilvum_PYR-GCK NGGWGVANGSLGHER-------TMMWLGFADRIANCIAD------FVPRT
Mvan_4162|M.vanbaalenii_PYR-1 NGGWGVANGSLGHER-------TMMWLGFADRIANCIAD------FKPKN
MSMEG_4805|M.smegmatis_MC2_155 NQGWKVANGSLGHER-------TMMWLGFADRIDNMLAD------FNPRT
TH_4023|M.thermoresistible__bu NGGWKVANGSLGHER-------TMMWLGFADRIDNIIAD------FTPRT
MUL_0322|M.ulcerans_Agy99 NGGWRVATGSLGHER-------TMLWLGYANLLGELATD------FTPAG
MLBr_00737|M.leprae_Br4923 GTGFKTALATLDHTRPTIGAQAVGIAQGALDAAIVYTKDRKQFGESISTF
*: .* . * : .
Mb1969c|M.bovis_AF2122/97 PRVRDGLAWCYARVQIMRYRGYRDLTLALTGRPPG-AEAAITKVIWSEYF
Rv1934c|M.tuberculosis_H37Rv PRVRDGLAWCYARVQIMRYRGYRDLTLALTGRPPG-AEAAITKVIWSEYF
MAB_0595c|M.abscessus_ATCC_199 EFASERVADAWIAAQAYRLHTFGTVTRLAGGGELG-AESSITKVFWSELD
MAV_0935|M.avium_104 EVERDQYATTIMDRQALRLLGSAALARAARGEDDV-AAISVLKLLGSEAE
MMAR_4718|M.marinum_M ELDHDRYATMVMDKQALRLLGSVALARASRGEDDT-SAISVLKLLGSEAE
Mflv_2492|M.gilvum_PYR-GCK PLERDALASSIMDYEALRLLGSVGIAKAARGEVDV-ASVSIPKLLGAEAE
Mvan_4162|M.vanbaalenii_PYR-1 PLERDALATSIMDYQALRLLGSVGIAKAARGEVDV-ASVSIPKLLGAEAE
MSMEG_4805|M.smegmatis_MC2_155 ELERDQYATTIMDYQALRALGSAALARAARGEQDT-ASVSVLKLLGSEAE
TH_4023|M.thermoresistible__bu PLERDQYATAIMDYQALRLIGSVGLAKAARGEMDT-ASVSVAKLLGSEAE
MUL_0322|M.ulcerans_Agy99 VLQRDHYATLVMDTQAMRLLGSATLASAARGQEDV-PAQSVLKLLGSEAL
MLBr_00737|M.leprae_Br4923 QSIQFMLADMAMKVEAARLIVYAAAARAERGEPDLGFISAASKCFASDIA
* : * : * : * : ::
Mb1969c|M.bovis_AF2122/97 RRYTDLAVEILGLEALGPRGPGNGGARLVPEAGTPNSPACWMDELLY-AR
Rv1934c|M.tuberculosis_H37Rv RRYTDLAVEILGLEALGPRGPGNGGARLVPEAGTPNSPACWMDELLY-AR
MAB_0595c|M.abscessus_ATCC_199 VALHETAIDLRGAEG--------------------ELTNAWTDGYLF-SL
MAV_0935|M.avium_104 LRAMELALTSAGADGLVHPGQTGPYAHMN----LDHYFASWFERYAR-SF
MMAR_4718|M.marinum_M LRASEHALAAAGSDGLIHPALTGPYAPMN----LDHYFASWFERYAR-SF
Mflv_2492|M.gilvum_PYR-GCK QRIEGLALEAAGLDGLVHPATSGPYEHMN----LDHYFASWFERYCR-SF
Mvan_4162|M.vanbaalenii_PYR-1 QRIEGLALEAAGPDGLVHPATSGPYEHMN----LDHYFASWFERYCR-SF
MSMEG_4805|M.smegmatis_MC2_155 RNAFENALAAAGPEGLIHPSTSGPYAHMN----LDHYFASWFERYAR-SF
TH_4023|M.thermoresistible__bu LRAAEMALTAAGSDGLIHPSTTGPYAHMN----LDHYFASWFERFAR-SF
MUL_0322|M.ulcerans_Agy99 QRACEDALDSAGGDGLVHPSITAPIAALN----LDNHYGS----------
MLBr_00737|M.leprae_Br4923 MEVTTDAVQLFGGAG--------------------YTSDFPVERFMRDAK
*: * .
Mb1969c|M.bovis_AF2122/97 AATIYAGSSQIQRNVIGERLLGLPKEPRPEVLC----
Rv1934c|M.tuberculosis_H37Rv AATIYAGSSQIQRNVIGERLLGLPKEPRPEVLC----
MAB_0595c|M.abscessus_ATCC_199 GGPIYAGTNEIQRNIIAERILGLPRESSASARTGGAK
MAV_0935|M.avium_104 SGTIAGGTLEIQRNIIAQRVLGLPRG-----------
MMAR_4718|M.marinum_M SGTIAGGTSEIQRNIIAQRVLGLPRG-----------
Mflv_2492|M.gilvum_PYR-GCK GGTIAGGTSEIQRNIIAQQVLGLPRR-----------
Mvan_4162|M.vanbaalenii_PYR-1 GGTIAGGTSEIQRNIIAQQVLGLPRR-----------
MSMEG_4805|M.smegmatis_MC2_155 GGTIAGGTSEIQRNIIATQVLGLPRG-----------
TH_4023|M.thermoresistible__bu SGTIAGGTSEIQRNIIAQQVLGLPRR-----------
MUL_0322|M.ulcerans_Agy99 -------------------------------------
MLBr_00737|M.leprae_Br4923 ITQIYEGTNQIQRVVMSRALLR---------------