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PSAGPLSGVKVVDLTAVVAGPYCTQIMADMGADVVKVEAPQGDNARYISVGPEPGLSGVFTNVNRGKRSV VLDLQTDAGKDALRTLVARADVFIHSMRAAAIAKLGFDYAAVADLNPSIVYTNCYGYGRTGPYAARPAYD DTIQAECGLAAVQEELTGTAGYVGSIMADKICGLTAVNATMMALFHRERTGEGQEVEVPMFETMAAFMLV EHANGAMFDPPLGPALYPRTVARNRRPYQTSDGHIAALIYNDKQWQAFIDAVKPAWATDRYATMAGRAAD IDTVYGLIGDALRERTTAEWLALFDELGIPASPLRSTGDLFTDPHLDAVGFFETVQTGHGPVRFPGVPTG FSRTPGRVRGGAPRLGEHTAEVLADWGQEPVK*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_5186 | - | - | 100% (383) | L-carnitine dehydratase/bile acid-inducible protein F |
| M. gilvum PYR-GCK | Mflv_1791 | - | e-165 | 73.82% (382) | L-carnitine dehydratase/bile acid-inducible protein F |
| M. gilvum PYR-GCK | Mflv_4116 | - | 7e-50 | 36.06% (391) | L-carnitine dehydratase/bile acid-inducible protein F |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3300 | - | 2e-41 | 30.75% (387) | hypothetical protein Mb3300 |
| M. tuberculosis H37Rv | Rv3272 | - | 2e-41 | 31.88% (389) | hypothetical protein Rv3272 |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0824 | - | 7e-48 | 33.51% (382) | putative L-carnitine dehydratase |
| M. marinum M | MMAR_0311 | - | 1e-158 | 70.59% (374) | hypothetical protein MMAR_0311 |
| M. avium 104 | MAV_5204 | - | 1e-166 | 75.54% (372) | L-carnitine dehydratase/bile acid-inducible protein F |
| M. smegmatis MC2 155 | MSMEG_5623 | - | 1e-165 | 75.13% (374) | L-carnitine dehydratase/bile acid-inducible protein F |
| M. thermoresistible (build 8) | TH_3725 | - | 1e-161 | 74.67% (375) | PUTATIVE L-carnitine dehydratase/bile acid-inducible protein F |
| M. ulcerans Agy99 | MUL_4811 | - | 1e-158 | 70.59% (374) | hypothetical protein MUL_4811 |
| M. vanbaalenii PYR-1 | Mvan_1126 | - | 0.0 | 90.55% (381) | L-carnitine dehydratase/bile acid-inducible protein F |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_5186|M.gilvum_PYR-GCK ----------------MPSAGPLSGVKVVDLTAVVAGPYCTQIMADMGAD
Mvan_1126|M.vanbaalenii_PYR-1 ----------------MSSAGPLSGVNVVDLTAVVAGPYCTQIMADMGAD
MSMEG_5623|M.smegmatis_MC2_155 -----------------MTGGPLQGVRVIDLTAMVMGPYCTQIMADMGAD
TH_3725|M.thermoresistible__bu -------------------------VRVVDLTAMVMGPYCTQIMADMGAE
MMAR_0311|M.marinum_M MSNCGSDCDSSLGAGAGKRTGPLSGVRVVDLTAMVMGPYCTQIMADMGAD
MUL_4811|M.ulcerans_Agy99 -----------MGAGAGNRTGPLSGVRVVDLTAMVMGPYCTQIMADMGAD
MAV_5204|M.avium_104 ----------------------MAGVRVIDLTAMVMGPYCTQIMADMGAD
Mb3300|M.bovis_AF2122/97 -------------MPTSNPAKPLDGFRVLDFTQNVAGPLAGQVLVDLGAE
Rv3272|M.tuberculosis_H37Rv -------------MPTSNPAKPLDGFRVLDFTQNVAGPLAGQVLVDLGAE
MAB_0824|M.abscessus_ATCC_1997 -----------------MTAAALDGLLVVDFSRVLAGPYATMMLGDFGAE
. *:*:: : ** . :: *:**:
Mflv_5186|M.gilvum_PYR-GCK VVKVEAPQGDNARYISVGP--EPGLSGVFTNVNRGKRSVVLDLQTDAGKD
Mvan_1126|M.vanbaalenii_PYR-1 VVKVEPPQGDNARYISVGP--EPGLSGVFTNVNRGKRSAVLDLQTDEGKR
MSMEG_5623|M.smegmatis_MC2_155 VIKVEPPQGDDTRYVSVGP--APGLSGVFVNVNRGKRSIVLDLRTASGKA
TH_3725|M.thermoresistible__bu VIKVEPPAGDNTRFISVGP--RSGMSGVFVNVNRGKRSVVLDLRSEDGAG
MMAR_0311|M.marinum_M VIKIEPPQGDDTRYVSVGP--AAGMSGVFVNVNRGKRSAVIDLKSDSGQA
MUL_4811|M.ulcerans_Agy99 VIKIEPPQGDDTRYVSVGP--AAGMSGVFVNVNRGKRSAVIDLKSDSGQA
MAV_5204|M.avium_104 VIKVEPPQGDNTRYISVGP--APGMSGVFVNVNRGKRSVVLDLQTDAGAR
Mb3300|M.bovis_AF2122/97 VIKVEAPGGEAARQITSVLPGRPPLATYFLPNNRGKKSVTVDLTTEQAKQ
Rv3272|M.tuberculosis_H37Rv VIKVEAPGGEAARQITSVLPGRPPLATYFLPNNRGKKSVTVDLTTEQAKQ
MAB_0824|M.abscessus_ATCC_1997 VIKIERPVLGDDTRQWGPPYDSDGQATYFNSVNRNKQSVVLDLTSPDGQH
*:*:* * : * **.*:* .:** : .
Mflv_5186|M.gilvum_PYR-GCK ALRTLVARADVFIHSMRAAAIAKLGFDYAAVADLNPSIVYTNCYGYGRTG
Mvan_1126|M.vanbaalenii_PYR-1 ALRALVGQADVFIHSMRAAAIAKLGFDYQTVAALNPSIVYTNCYGYGRTG
MSMEG_5623|M.smegmatis_MC2_155 DLRDLIADADVFIHSMRAKAIAKLGFGYDDVAAINPRIVYTNCYGYGRRG
TH_3725|M.thermoresistible__bu ALRALIARADVFIHSMRAKAIAKLGFGYPDVAAINPAIVYTNCYGYGRRG
MMAR_0311|M.marinum_M AVRALIEGADVFIHSMRAKAIARLGLSYPEVAAINPAIVYTNCYGYGRRG
MUL_4811|M.ulcerans_Agy99 AVRALIEGADVFIHSMRAKAIARLGLSYPEVAAINPAIVYTNCYGYGRRG
MAV_5204|M.avium_104 ALRGLVETADVFIHSMRAKAIARLGFGYDDVAAINPAVVYTNCYGYGRRG
Mb3300|M.bovis_AF2122/97 QMLRLADTADVVLEAFRPGTMEKLGLGPDDLRSRNPNLIYARLTAYGGNG
Rv3272|M.tuberculosis_H37Rv QMLRLADTADVVLEAFRPGTMEKLGLGPDDLRSRNPNLIYARLTAYGGNG
MAB_0824|M.abscessus_ATCC_1997 RARELAGRADVVVENFRAGTMEKFGLGYQSLKQLNPGLIYCAITGFG-RG
* ***.:. :*. :: ::*:. : ** ::* .:* *
Mflv_5186|M.gilvum_PYR-GCK PYAARPAYDDTIQAECGLAAVQEELTGTAGYVGSIMADKICGLTAVNATM
Mvan_1126|M.vanbaalenii_PYR-1 PYAARPAYDDTIQAECGLAAVQEELTGTAGYVGSIMADKVCGLSALNATM
MSMEG_5623|M.smegmatis_MC2_155 PDADRPAYDDTIQAECGLPAVQKQLTGEAAYVGTIMADKVAGLTALYSTM
TH_3725|M.thermoresistible__bu PDADRPAYDDTIQAECGLPAVQEQLTGEANYVGTIMADKVAGLTALYATM
MMAR_0311|M.marinum_M PNRDLPAYDDTIQAACGLPSVQEQLTGEPSYVGTIMADKVAGLTALYATM
MUL_4811|M.ulcerans_Agy99 PNRDLPAYDDTIQAACGLPSVQEQLTGEPSYVGTIMADKVAGLTALYATM
MAV_5204|M.avium_104 PDRDRPAYDDTIQAECGLPAVQQQLTGQADYVGTIMADKIAGLTALYATT
Mb3300|M.bovis_AF2122/97 PHGSRPGIDLVVAAEAGMTTGMPTPEGKPQIIPFQLVDNASGHVLAQAVL
Rv3272|M.tuberculosis_H37Rv PHGSRPGIDLVVAAEAGMTTGMPTPEGKPQIIPFQLVDNASGHVLAQAVL
MAB_0824|M.abscessus_ATCC_1997 AGADLPGYDLLVQAVGGLMSVTGPDAAHPSKVGVALVDVLTALHALSGIL
. *. * : * *: : . . : :.* . .
Mflv_5186|M.gilvum_PYR-GCK MALFHRERTGEGQEVEVPMFETMAAFMLVEHANGAMFDPPLGPALYPRT-
Mvan_1126|M.vanbaalenii_PYR-1 MALFHRARTGEGQEVEVPMFETMAAFMLVEHANGAMFDPPLGPALYPRT-
MSMEG_5623|M.smegmatis_MC2_155 MALFHRERTGEGQEVEVSMFETMAAFMLVEHANGAMFDPPLGPAVYPRT-
TH_3725|M.thermoresistible__bu MALFHRERTGEGQEVEVAMFETMASFMLVEHANGAMFDPPLGPAVYPRT-
MMAR_0311|M.marinum_M MALFHRERTGQGQEVEIGMFEAVASFMLVEHANGAMFDPPLGPAVYPRT-
MUL_4811|M.ulcerans_Agy99 MALFHRERTGQGQEVEIGMFEAVASFMLVEHANGAMFDPPLGPAVYPRT-
MAV_5204|M.avium_104 MALFHRERTGQGQEVEVAMFETMASFMLVEHANGALFDPPLGPAVYPRT-
Mb3300|M.bovis_AF2122/97 AALLHRERNGVADVVQVAMYDVAVGLQANQLMMHLNRAASDQPKPEPAPK
Rv3272|M.tuberculosis_H37Rv AALLHRERNGVADVVQVAMYDVAVGLQANQLMMHLNRAASDQPKPEPAPK
MAB_0824|M.abscessus_ATCC_1997 AALSYRDRTGQGQRVDTDLMSVLLSSLVNQASGYLGAGVVPEALGNRHP-
** :* *.* .: *: : .. . : . .
Mflv_5186|M.gilvum_PYR-GCK ---------VARNRRPYQTSDGHIAALIYNDKQWQAFIDAVKPAWAT---
Mvan_1126|M.vanbaalenii_PYR-1 ---------VARNRRPYPTLDGHIAVLIYNDKQWHAFIDAVKPAWAS---
MSMEG_5623|M.smegmatis_MC2_155 ---------VAPNRRPYETKDGHIAALIYNDKHWNAFIDAVQPPWN---R
TH_3725|M.thermoresistible__bu ---------VAPNRRPYETKDGHIAALIYNDKHWQAFVDAVAPAWYEENR
MMAR_0311|M.marinum_M ---------VAPNRRPYRTSDGYLAALIYNDKHWAAFVDAVRPPWAS---
MUL_4811|M.ulcerans_Agy99 ---------VAPNRRPYRTSDGYLAALIYNDKHWAAFVDAVRPPWAS---
MAV_5204|M.avium_104 ---------VAPNRRPYRTSDGYIAALIYNDKHWNAFMNAVRPPWAS---
Mb3300|M.bovis_AF2122/97 AKRRKGVGFATQPSDAFRTADGYIVISAYVPKHWQKLCYLIGRPDLVE-D
Rv3272|M.tuberculosis_H37Rv AKRRKGVGFATQPSDAFRTADGYIVISAYVPKHWQKLCYLIGRPDLVE-D
MAB_0824|M.abscessus_ATCC_1997 ---------SIAPYQTFETADRPIAIAVGNDKQFRLLVQALEMPRLAR-D
.: * * :. *:: : : .
Mflv_5186|M.gilvum_PYR-GCK DRYATMAGRAADIDTVYGLIGDALRERTTAEWLALFDELGIPASPLRSTG
Mvan_1126|M.vanbaalenii_PYR-1 DRYATMAGRAADIDTVYGLVGDTLREQTTADWLALFDKLGIPASPLRTTD
MSMEG_5623|M.smegmatis_MC2_155 PEYATLEARARQIDTVYGLLAQTLKERTTAEWLDLFDDLEIPAAPIHTPD
TH_3725|M.thermoresistible__bu TRYATLENRARHIDTVYSLIAETLKERTTDEWLTLFRELEIPAAPINTPD
MMAR_0311|M.marinum_M EQYATLEGRARQIDTVYALLAETFAARTTQEWLDLLEELEIPASALSSPA
MUL_4811|M.ulcerans_Agy99 EQYATLEGRARQIDTVYALLAETFAARTTQEWLDLLEELEIPASALSSPA
MAV_5204|M.avium_104 ELYATLEQRAAQIDTVYGLVAETMKERSTAEWLELLGELEIPAAPLNSPG
Mb3300|M.bovis_AF2122/97 QRFAEQRSRSINYAELTAELELALASKTATEWVQLLQANGLMACLAHTWK
Rv3272|M.tuberculosis_H37Rv QRFAEQRSRSINYAELTAELELALASKTATEWVQLLQANGLMACLAHTWK
MAB_0824|M.abscessus_ATCC_1997 DRFATNPLRVRHRGELVRVLEQRLREKNADDWYDTLTAVGVPAGPINDIA
:* * . : : : :.: :* : : *
Mflv_5186|M.gilvum_PYR-GCK DLFTDPHLDAVGFFETVQTGHGPVRFPGVPTGFSRTPGRVRGGAPRLGEH
Mvan_1126|M.vanbaalenii_PYR-1 ELFTDAHLEAVGFFETVQTAHGPVRFPGVPTGFSRTPGRVRGGAPRLGEH
MSMEG_5623|M.smegmatis_MC2_155 ALFDNPHLNAVGLFETVDTQYGPVRFPGVPTWFSKTPGRVRGFAPELGAD
TH_3725|M.thermoresistible__bu ALFDNEHLNAVGLFETVDTPHGPVRFPGVPTWFSRTPGRVGGTAPELGAD
MMAR_0311|M.marinum_M ELFDNQHLNAVGFFETIDTAHGPVRFPGVPTWFSRTPGRVSGPAPQLGAD
MUL_4811|M.ulcerans_Agy99 ELFDNQHLNAVGFFETIDTAHGPVRFPGVPTWFSRTPGRVLGPAPQLGAD
MAV_5204|M.avium_104 ALFDDPHLNAVGMFQTVDTPHGPVRFPGVPTWFSQTPGRVAGPAPELGAH
Mb3300|M.bovis_AF2122/97 QVVDTPLFAESDLTLEVGRGADTITVIRTPARYASFRAVVTDPPPTAGEH
Rv3272|M.tuberculosis_H37Rv QVVDTPLFAENDLTLEVGRGADTITVIRTPARYASFRAVVTDPPPTAGEH
MAB_0824|M.abscessus_ATCC_1997 EAFRFAERLGLDVAVTVPGSPE--PQVANPISMSKTPVVYRNGPPRLGQS
. .. : * : . .* *
Mflv_5186|M.gilvum_PYR-GCK TAEVLADWGQEPVK---------
Mvan_1126|M.vanbaalenii_PYR-1 TAEVLAEVGIAPPD---------
MSMEG_5623|M.smegmatis_MC2_155 TDDVLAEVRPQNKAG--------
TH_3725|M.thermoresistible__bu TEAVLAELGLTPQAGREPAQGMS
MMAR_0311|M.marinum_M TSAVLEELGINAADAQPAGPA--
MUL_4811|M.ulcerans_Agy99 TSAVLEELGINAADAQPAGPA--
MAV_5204|M.avium_104 TDEVLAEIGAREGKEL-------
Mb3300|M.bovis_AF2122/97 NAVFLARP---------------
Rv3272|M.tuberculosis_H37Rv NAVFLARP---------------
MAB_0824|M.abscessus_ATCC_1997 RA---------------------