For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
MPGMSFELTEDQELIRKSVAELCSKFDDHYWMEKDQNHEFPQEFYDAISKGGWLGMTIPEEYGGHGLGIT EATLLLEEVSRSGAAMNGASAIHLSIFGMQPVVKHGSDELKAATLPRIVDGDLHVCFGVTEPGAGLDTSR ITTFAKREGDHYRVNGRKVWISKALESEKILLLTRTETPEDLKQRGAKKTDGMTLFLTDLDRDHVDIRPI RKMGRNAVSSNELFIDDLMVPVEHRVGEEGQGFKYILDGLNPERMLIAAEALGIGRVALEKAVKYGNERV VFNRPIGMNQGLQFPLADSLARLDAAELVLRKATWLYDNGKPCGREANTAKYLCADAGFGAADRALQLHG GMGYSEEYHVSRYFRESRLMKIAPVSQEMILNFLGEHVLGLPRSY
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_2442 | - | - | 100% (395) | acyl-CoA dehydrogenase domain-containing protein |
| M. gilvum PYR-GCK | Mflv_4615 | - | 4e-70 | 39.44% (393) | acyl-CoA dehydrogenase domain-containing protein |
| M. gilvum PYR-GCK | Mflv_1881 | - | 2e-68 | 38.52% (392) | acyl-CoA dehydrogenase domain-containing protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0997c | fadE12 | 7e-71 | 38.13% (396) | acyl-CoA dehydrogenase FADE12 |
| M. tuberculosis H37Rv | Rv0972c | fadE12 | 2e-70 | 38.13% (396) | acyl-CoA dehydrogenase FADE12 |
| M. leprae Br4923 | MLBr_00737 | fadE25 | 3e-45 | 29.81% (369) | putative acyl-CoA dehydrogenase |
| M. abscessus ATCC 19977 | MAB_1070c | - | 1e-68 | 38.52% (392) | acyl-CoA dehydrogenase |
| M. marinum M | MMAR_4741 | fadE12_1 | 0.0 | 84.18% (392) | acyl-CoA dehydrogenase FadE12_1 |
| M. avium 104 | MAV_1088 | - | 3e-70 | 38.13% (396) | acyl-CoA dehydrogenase fadE12 |
| M. smegmatis MC2 155 | MSMEG_4836 | - | 0.0 | 85.14% (397) | FadE12_1 |
| M. thermoresistible (build 8) | TH_4562 | - | 0.0 | 85.20% (392) | PUTATIVE FadE12_1 |
| M. ulcerans Agy99 | MUL_4707 | fadE12 | 2e-71 | 38.27% (405) | acyl-CoA dehydrogenase FadE12 |
| M. vanbaalenii PYR-1 | Mvan_4210 | - | 0.0 | 95.93% (393) | acyl-CoA dehydrogenase domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0997c|M.bovis_AF2122/97 ------MTDTS-FIESEERQALRKAVASWVANYGHEYYLDKARKHEHTSE
Rv0972c|M.tuberculosis_H37Rv ------MTDTS-FIESEERQALRKAVASWVANYGHEYYLDKARKHEHTSE
MUL_4707|M.ulcerans_Agy99 -----MMTGTS-FIENEDRRALRKAVSEWASNYGHEYYLKKARAHEHTTE
MAV_1088|M.avium_104 ------MTDSS-FIENEERQALRKAVAEWASNYGSEYYLRKARAHEHTNE
MAB_1070c|M.abscessus_ATCC_199 ------MTQPNPYVESDERKALRQAVASLAASYGHEYYLEKSKTHEPLAE
Mflv_2442|M.gilvum_PYR-GCK ------MPG-MSFELTEDQELIRKSVAELCSKFDDHYWMEKDQNHEFPQE
Mvan_4210|M.vanbaalenii_PYR-1 ---MTSMPGGMSFELTEDQELIRKSVRELASRFDDHYWMEKDQAHEFPQE
MMAR_4741|M.marinum_M ----------MDFELTEDQELIRRSVAELASRFDDHYWMEKDQAHEFPAE
MSMEG_4836|M.smegmatis_MC2_155 ----MYVSGGMNFELTEDQQLIRSSVAELAAKFDDHYWMAKDQAHEFPQE
TH_4562|M.thermoresistible__bu ----------MHFELTEDQELIRASVRELAAKFDDTYWMEKDLNHEFPQE
MLBr_00737|M.leprae_Br4923 MVGWSGNPLFDLFKLPEEHNELRATIRALAEKEIAPHAADVDQRARFPEE
: :::. :* :: : . *
Mb0997c|M.bovis_AF2122/97 LWAEAGKLGFLGVNLPEEYGGGGAGMYELSLVMEEMAAAGSAL--LLMVV
Rv0972c|M.tuberculosis_H37Rv LWAEAGKLGFLGVNLPEEYGGGGAGMYELSLVMEEMAAAGSAL--LLMVV
MUL_4707|M.ulcerans_Agy99 LWSEAGKLGFIGVNLPEEYGGGGAGMYELSMVMEEMAAAGSAL--LLMVV
MAV_1088|M.avium_104 LWSEAGKLGFLGVNLPEEYGGGGAGMYELSLVMEEMAAAGSAL--LLMVV
MAB_1070c|M.abscessus_ATCC_199 LWDEAGKLGFLGVNIPEEYGGGGAGMYELGLVFEELSAAGCPL--LLMVV
Mflv_2442|M.gilvum_PYR-GCK FYDAISKGGWLGMTIPEEYGGHGLGITEATLLLEEVSRSGAAMNGASAIH
Mvan_4210|M.vanbaalenii_PYR-1 FYDAIANGGWLGMTIPEEYGGHGLGITEATLLLEEVSRSGAAMNGASAIH
MMAR_4741|M.marinum_M FYRAIADGGWLGMTIPTEYGGHGLGITEATILLEEVAKSGGAMNAASSIH
MSMEG_4836|M.smegmatis_MC2_155 FYDAIAGGGWLGMTIPEQYGGHGLGITEATILAEEVARSGGGMNAASAIH
TH_4562|M.thermoresistible__bu FYDAIAGGGWLGMTIPEEYGGHGLGITEATILAEEVARSGGGMNAASSIH
MLBr_00737|M.leprae_Br4923 ALAALNASGFNAIHVPEEYGGQGADSVAACIVIEEVARVDASAS--LIPA
*: .: :* :*** * . :: **:: .
Mb0997c|M.bovis_AF2122/97 SPAINGTIIAKFGTDDQKKRWLPGIADGSLTMAFAITEPDAGSNSHKITT
Rv0972c|M.tuberculosis_H37Rv SPAINGTIIAKFGTDDQKKRWLPGIADGSLTMAFAITEPDAGSNSHKITT
MUL_4707|M.ulcerans_Agy99 SPAINGTIISKFGTDEQKQRWLPGIADGTLTMAFAITEPEAGSNSHKITT
MAV_1088|M.avium_104 SPAINGTIISKFGTEEQKKRWLPGIADGTLTMAFAITEPDAGSNSHKITT
MAB_1070c|M.abscessus_ATCC_199 SPAINATIIARYGTDAQKKSWLPAMAEGSFKMAFAITEPDAGSNSHNIIT
Mflv_2442|M.gilvum_PYR-GCK LSIFGMQPVVKHGSDELKAATLPRIVDGDLHVCFGVTEPGAGLDTSRITT
Mvan_4210|M.vanbaalenii_PYR-1 LSIFGMQPVVKHGSDELKAATLPRIVNGDLHVCFGVTEPGAGLDTSRITT
MMAR_4741|M.marinum_M LSIFGMQPVVVHGSDELKARTLPSVATGETHVCFGVTEPGAGLDTSRITT
MSMEG_4836|M.smegmatis_MC2_155 MSIFGMQPVVVFGSDEMKAETLPRIVDGDLHVCFGVTEPGAGLDTSRITT
TH_4562|M.thermoresistible__bu LSIFGMQPVVLFGSDEMKAATLPRIVDGSLHVCFGVTEPGAGLDTTRITT
MLBr_00737|M.leprae_Br4923 VNKLGTMGLILRGSEELKKQVLPSLAAEGAMASYALSEREAGSDAASMRT
:. : *:: * ** :. .:.::* ** :: : *
Mb0997c|M.bovis_AF2122/97 TARRDGSD----WIIKGQKVFISGIDQAQAVLVVGRSE-----EAKTGKL
Rv0972c|M.tuberculosis_H37Rv TARRDGSD----WIIKGQKVFISGIDQAQAVLVVGRSE-----EAKTGKL
MUL_4707|M.ulcerans_Agy99 TARRDGSD----WIIKGQKVYISGIDQAQAVLVVGRTE-----EAKTGKL
MAV_1088|M.avium_104 TARRDGSD----WILKGQKVFISGIDQAQAVLVVARTE-----EAKTGKL
MAB_1070c|M.abscessus_ATCC_199 TAKRDGGD----WILNGRKVFISGVNEANAVLVVARTE-----EAKTGKL
Mflv_2442|M.gilvum_PYR-GCK FAKREGDH----YRVNGRKVWISKALESEKILLLTRTETPEDLKQRGAKK
Mvan_4210|M.vanbaalenii_PYR-1 FAKREGDK----YRVNGRKVWISKALESEKILLLTRTESPDDLEKRGAKK
MMAR_4741|M.marinum_M FAKRDGDR----YVVNGRKVWISKAVESDKILLLTRTQSYDEVK----KK
MSMEG_4836|M.smegmatis_MC2_155 FARRDGDHPDADYVVNGRKVWISKALESEKILLLTRTESREDVEKRGGKP
TH_4562|M.thermoresistible__bu FARREGDH----YVVNGRKVWISKAMESEKILLLARTEPLDAAERPGTKK
MLBr_00737|M.leprae_Br4923 RAKADGDD----WILNGFKCWITNGGKSTWYTVMAVTD--------PDKG
*: :*. : ::* * :*: :: :: :: *
Mb0997c|M.bovis_AF2122/97 RP--ALFVVPTDAPGFSYTP-IEMELVSPERQFQVFLDDVRLPADALVGA
Rv0972c|M.tuberculosis_H37Rv RP--ALFVVPTDAPGFSYTP-IEMELVSPERQFQVFLDDVRLPADALVGA
MUL_4707|M.ulcerans_Agy99 RP--ALFVVPTDTPGFTYTA-IDMELVSPERQFQVFLDDVRLPADALVGA
MAV_1088|M.avium_104 RP--ALFVVPTDAPGFSATP-IEMELISPERQFQVFLDDVRLPSDALVGA
MAB_1070c|M.abscessus_ATCC_199 KP--ALFVVPTNTKGFEYTP-IDMQLTLPEQQFQVFLDDVRVPGDALVGS
Mflv_2442|M.gilvum_PYR-GCK TDGMTLFLTDLDRDHVDIRP-IRKMGRNAVSSNELFIDDLMVPVEHRVGE
Mvan_4210|M.vanbaalenii_PYR-1 TDGMTLFLTDLDRNHVDIRP-IRKMGRNAVSSNEVFIDDLMVPVEHRVGE
MMAR_4741|M.marinum_M TDGMTLFITDLDRSRVEVRP-IRKMGRNAVSSNELFIDNLEIPVEDRIGE
MSMEG_4836|M.smegmatis_MC2_155 TEGLSLFLTDLDRDHVDIRP-INKMGRNAVSSNELFIDDLRVPVEHRIGE
TH_4562|M.thermoresistible__bu TDGLSLFLTDLDRDHVDIRP-IKKMGRNAVGSNELFIDDLRVPVEDRIGE
MLBr_00737|M.leprae_Br4923 ANGISAFIVHKDDEGFSIGPKEKKLGIKGSPTTELYFDKCRIPGDRIIGE
: *:. : . . ::::*. :* : :*
Mb0997c|M.bovis_AF2122/97 EDAAIAHLFAGLNPERIMGAASAVGMGRFALGRAVDYVKTRKVWSTPIGA
Rv0972c|M.tuberculosis_H37Rv EDAAIAQLFAGLNPERIMGAASAVGMGRFALGRAVDYVKTRKVWSTPIGA
MUL_4707|M.ulcerans_Agy99 QDAAIAQLFAGLNPERIMGAASAVGMGRFALNRAVDYVKTRQVWSTPIGA
MAV_1088|M.avium_104 EDAAIAQLFAGLNPERIMGAASSVGMGRFALARAAEYVKTRQVWGTPVGA
MAB_1070c|M.abscessus_ATCC_199 EDAALMQLFAGLNPERIMGAASGVGLTRLALNKATEYVKTRQVWKTPIGA
Mflv_2442|M.gilvum_PYR-GCK EGQGFKYILDGLNPERMLIAAEALGIGRVALEKAVKYGNERVVFNRPIGM
Mvan_4210|M.vanbaalenii_PYR-1 EGKGFKYILDGLNPERMLIAAEALGIGRVALEKAVKYGNERHVFNRPIGM
MMAR_4741|M.marinum_M EGNGFQYILDGLNPERMLIAAEALGIGRVALDKAVKYGNEREVFGRPIGM
MSMEG_4836|M.smegmatis_MC2_155 EGKGFGYILHGLNPERMLIAAEALGIGRVALDRAVKYANDRVVFDRPIGM
TH_4562|M.thermoresistible__bu EGKGFSYILHGLNPERMLIAAEALGIGRVALDRAVKYANERHVFDRPIGM
MLBr_00737|M.leprae_Br4923 PGTGFKTALATLDHTRPTIGAQAVGIAQGALDAAIVYTKDRKQFGESIST
. .: : *: * .*..:*: : ** * * : * : .:.
Mb0997c|M.bovis_AF2122/97 HQGLAHPLAQCHIEVELAKLMTQKAATLYDHGDDFGAAEAANMAKYAAAE
Rv0972c|M.tuberculosis_H37Rv HQGLAHPLAQCHIEVELAKLMTQKAATLYDHGDDFGAAEAANMAKYAAAE
MUL_4707|M.ulcerans_Agy99 HQGLAHPLAQCHIEVELAKLMMQKAATLYDHGDDGGAAEAANMAKYAAAE
MAV_1088|M.avium_104 HQGLSHPLAQCHIEVELAKLMMQKAATLYDAGNDMGAAEAANMAKYAAAE
MAB_1070c|M.abscessus_ATCC_199 HQAIAHPLAEIKVELELAKLMMQKAATLYDCGDDWGAAEAANMAKYAAAD
Mflv_2442|M.gilvum_PYR-GCK NQGLQFPLADSLARLDAAELVLRKATWLYDNGKPCG--REANTAKYLCAD
Mvan_4210|M.vanbaalenii_PYR-1 NQGLQFPLADSLARLDAAELVLRKATWLYDNGKPCG--REANTAKYLCAD
MMAR_4741|M.marinum_M NQGLQFPLADSLARLDAAELMLRKATWLYDNGKPCG--REANTAKYLCAD
MSMEG_4836|M.smegmatis_MC2_155 NQGIQFPLADSLARLDAAELVLRKATWLYDNGKPCG--REANMAKYLCAD
TH_4562|M.thermoresistible__bu NQGIQFPLADSLARLDAAELVLRKATWLYDNGKPCG--REANMAKYLCAD
MLBr_00737|M.leprae_Br4923 FQSIQFMLADMAMKVEAARLIVYAAAARAERGEPDLG-FISAASKCFASD
*.: . **: .:: *.*: *: : *. : :* .::
Mb0997c|M.bovis_AF2122/97 ASSRAVDQAVQSMGGNGLTKEYGVAAMMTSARLARIAPISREMVLNFVAQ
Rv0972c|M.tuberculosis_H37Rv ASSRAVDQAVQSMGGNGLTKEYGVAAMMTSARLARIAPISREMVLNFVAQ
MUL_4707|M.ulcerans_Agy99 ASARSVDQAVQSMGGNGLTQEYGVAAMLTSSRLARIAPISREMVLNFVAQ
MAV_1088|M.avium_104 AATRSVDQAVQSMGGNGLTKEYGVAAMLASARLGRIAPVSREMVLNFVAQ
MAB_1070c|M.abscessus_ATCC_199 VACRAADRAVQSLGGNGLTTEYGVAPLLNLSRFGRIAPVSREMILNFVAQ
Mflv_2442|M.gilvum_PYR-GCK AGFGAADRALQLHGGMGYSEEYHVSRYFRESRLMKIAPVSQEMILNFLGE
Mvan_4210|M.vanbaalenii_PYR-1 AGFGAADRALQLHGGMGYSEEYHVSRYFRESRLMKIAPVSQEMILNFLGE
MMAR_4741|M.marinum_M AGFAAADRALQTHGGMGYAEEYHVARYFREARLMKIAPVSQEMILNFLGS
MSMEG_4836|M.smegmatis_MC2_155 AGFAAADRALQTHGGMGYSEEYNISRFFRESRLMKIAPVSQEMILNFLGA
TH_4562|M.thermoresistible__bu AGFAAADRALQTHGGMGYSEEYSISRFFRESRLMKIAPVSQEMILNYLGS
MLBr_00737|M.leprae_Br4923 IAMEVTTDAVQLFGGAGYTSDFPVERFMRDAKITQIYEGTNQIQRVVMSR
. . *:* ** * : :: : : ::: :* :.:: :.
Mb0997c|M.bovis_AF2122/97 TSLGLPRSY
Rv0972c|M.tuberculosis_H37Rv TSLGLPRSY
MUL_4707|M.ulcerans_Agy99 TSLGLPRSY
MAV_1088|M.avium_104 TSLGLPRSY
MAB_1070c|M.abscessus_ATCC_199 TSLGLPRSY
Mflv_2442|M.gilvum_PYR-GCK HVLGLPRSY
Mvan_4210|M.vanbaalenii_PYR-1 HVLGLPRSY
MMAR_4741|M.marinum_M HVLKLPRSY
MSMEG_4836|M.smegmatis_MC2_155 NVLGLPKSY
TH_4562|M.thermoresistible__bu HVLGLPRSY
MLBr_00737|M.leprae_Br4923 ALLR-----
*