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TDTSFIESEERQALRKAVASWVANYGHEYYLDKARKHEHTSELWAEAGKLGFLGVNLPEEYGGGGAGMYE LSLVMEEMAAAGSALLLMVVSPAINGTIIAKFGTDDQKKRWLPGIADGSLTMAFAITEPDAGSNSHKITT TARRDGSDWIIKGQKVFISGIDQAQAVLVVGRSEEAKTGKLRPALFVVPTDAPGFSYTPIEMELVSPERQ FQVFLDDVRLPADALVGAEDAAIAQLFAGLNPERIMGAASAVGMGRFALGRAVDYVKTRKVWSTPIGAHQ GLAHPLAQCHIEVELAKLMTQKAATLYDHGDDFGAAEAANMAKYAAAEASSRAVDQAVQSMGGNGLTKEY GVAAMMTSARLARIAPISREMVLNFVAQTSLGLPRSY*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv0972c | fadE12 | - | 100% (388) | PROBABLE ACYL-CoA DEHYDROGENASE FADE12 |
| M. tuberculosis H37Rv | Rv2500c | fadE19 | 3e-44 | 31.15% (382) | acyl-CoA dehydrogenase |
| M. tuberculosis H37Rv | Rv2724c | fadE20 | 5e-37 | 28.88% (374) | acyl-CoA dehydrogenase FADE20 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0997c | fadE12 | 0.0 | 99.74% (388) | acyl-CoA dehydrogenase FADE12 |
| M. gilvum PYR-GCK | Mflv_1881 | - | 0.0 | 82.86% (385) | acyl-CoA dehydrogenase domain-containing protein |
| M. leprae Br4923 | MLBr_00737 | fadE25 | 6e-37 | 29.64% (361) | putative acyl-CoA dehydrogenase |
| M. abscessus ATCC 19977 | MAB_1070c | - | 1e-168 | 74.15% (383) | acyl-CoA dehydrogenase |
| M. marinum M | MMAR_4535 | fadE12 | 0.0 | 91.24% (388) | acyl-CoA dehydrogenase FadE12 |
| M. avium 104 | MAV_1088 | - | 0.0 | 89.95% (388) | acyl-CoA dehydrogenase fadE12 |
| M. smegmatis MC2 155 | MSMEG_5494 | - | 0.0 | 81.82% (385) | acyl-CoA dehydrogenase fadE12 |
| M. thermoresistible (build 8) | TH_3553 | - | 0.0 | 82.73% (388) | PUTATIVE acyl-CoA dehydrogenase domain protein |
| M. ulcerans Agy99 | MUL_4707 | fadE12 | 0.0 | 90.72% (388) | acyl-CoA dehydrogenase FadE12 |
| M. vanbaalenii PYR-1 | Mvan_4850 | - | 0.0 | 84.11% (384) | acyl-CoA dehydrogenase domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
Rv0972c|M.tuberculosis_H37Rv -------MTDTSFIESEERQALRKAVASWVANYGHEYYLDKARKHEHTSE
Mb0997c|M.bovis_AF2122/97 -------MTDTSFIESEERQALRKAVASWVANYGHEYYLDKARKHEHTSE
MMAR_4535|M.marinum_M -------MTDTSFIENEDRRALRKAVSEWASNYGHEYYLKKARAHEHTTE
MUL_4707|M.ulcerans_Agy99 ------MMTGTSFIENEDRRALRKAVSEWASNYGHEYYLKKARAHEHTTE
MAV_1088|M.avium_104 -------MTDSSFIENEERQALRKAVAEWASNYGSEYYLRKARAHEHTNE
MSMEG_5494|M.smegmatis_MC2_155 ---------MSGFVETEEQQALRRAVAAMAANYGQDYYLEKARAGQHTTE
TH_3553|M.thermoresistible__bu ---------VTGFVESEEQRALRRAAAELAAGYGQDYYLEKARAGEHTDE
Mflv_1881|M.gilvum_PYR-GCK ---------MSGFIETEEQQALRSAVAAMVAGYGQDYYLEKSRAGEHTDE
Mvan_4850|M.vanbaalenii_PYR-1 ---------MS-FIETDEQQALRKAVAAMAANYGQDYYLEKARAGQHTDE
MAB_1070c|M.abscessus_ATCC_199 ------MTQPNPYVESDERKALRQAVASLAASYGHEYYLEKSKTHEPLAE
MLBr_00737|M.leprae_Br4923 MVGWSGNPLFDLFKLPEEHNELRATIRALAEKEIAPHAADVDQRARFPEE
: :::. ** : . : : . *
Rv0972c|M.tuberculosis_H37Rv LWAEAGKLGFLGVNLPEEYGGGGAGMYELSLVMEEMAAAGSALLLMVVSP
Mb0997c|M.bovis_AF2122/97 LWAEAGKLGFLGVNLPEEYGGGGAGMYELSLVMEEMAAAGSALLLMVVSP
MMAR_4535|M.marinum_M LWSEAGKLGFIGVNLPEEYGGGGAGMYELSMVMEEMAAAGSALLLMVVSP
MUL_4707|M.ulcerans_Agy99 LWSEAGKLGFIGVNLPEEYGGGGAGMYELSMVMEEMAAAGSALLLMVVSP
MAV_1088|M.avium_104 LWSEAGKLGFLGVNLPEEYGGGGAGMYELSLVMEEMAAAGSALLLMVVSP
MSMEG_5494|M.smegmatis_MC2_155 LWNEAGKLGFIGVNLPEEYGGGGAGMYELSLVMEEMAATGCALLMMVVSP
TH_3553|M.thermoresistible__bu LWAEAGKLGFLGVNLPEEYGGGGAGMYELSLVMEELSAAGCGLLMMVVSP
Mflv_1881|M.gilvum_PYR-GCK LWSEAGKLGFIGVNLPEEYGGGGAGMYELSLVMEEMAAGGASLLMMVVSP
Mvan_4850|M.vanbaalenii_PYR-1 LWSEAGKLGFIGVNLPEEYGGGGAGMYELSLVMEEMAAAGSSLLMMVVSP
MAB_1070c|M.abscessus_ATCC_199 LWDEAGKLGFLGVNIPEEYGGGGAGMYELGLVFEELSAAGCPLLLMVVSP
MLBr_00737|M.leprae_Br4923 ALAALNASGFNAIHVPEEYGGQGADSVAACIVIEEVARVDASASLIPAVN
. ** .:::****** **. :*:**:: .. :: .
Rv0972c|M.tuberculosis_H37Rv AINGTIIAKFGTDDQKKRWLPGIADGSLTMAFAITEPDAGSNSHKITTTA
Mb0997c|M.bovis_AF2122/97 AINGTIIAKFGTDDQKKRWLPGIADGSLTMAFAITEPDAGSNSHKITTTA
MMAR_4535|M.marinum_M AINGTIISKFGTDEQKQRWLPGIADGTLTMAFAITEPDAGSNSHKITTTA
MUL_4707|M.ulcerans_Agy99 AINGTIISKFGTDEQKQRWLPGIADGTLTMAFAITEPEAGSNSHKITTTA
MAV_1088|M.avium_104 AINGTIISKFGTEEQKKRWLPGIADGTLTMAFAITEPDAGSNSHKITTTA
MSMEG_5494|M.smegmatis_MC2_155 AINGTIISKFGTEEQKRRWLPGIADGSITMAFAITEPDAGSNSHRITTTA
TH_3553|M.thermoresistible__bu AINGTIISRFGTEDQKRRWLPGIADGSITMAFAITEPDAGSNSHRITTTA
Mflv_1881|M.gilvum_PYR-GCK AINGTIIAKFGTEEQKKRWLPGIADGTLTMAFAITEPDAGSNSHRITTTA
Mvan_4850|M.vanbaalenii_PYR-1 AINGTIISKFGTEEQKKRWIPGIADGSLTMAFAITEPDAGSNSHKITTTA
MAB_1070c|M.abscessus_ATCC_199 AINATIIARYGTDAQKKSWLPAMAEGSFKMAFAITEPDAGSNSHNIITTA
MLBr_00737|M.leprae_Br4923 KLGTMGLILRGSEELKKQVLPSLAAEGAMASYALSEREAGSDAASMRTRA
:. : *:: *: :*.:* ::*::* :***:: : * *
Rv0972c|M.tuberculosis_H37Rv RRDGSDWIIKGQKVFISGIDQAQAVLVVGRSEEAKTG---KLRPALFVVP
Mb0997c|M.bovis_AF2122/97 RRDGSDWIIKGQKVFISGIDQAQAVLVVGRSEEAKTG---KLRPALFVVP
MMAR_4535|M.marinum_M RRDGSDWIIKGQKVYISGIDQAQAVLVVGRTEEAKTG---KLRPALFVVP
MUL_4707|M.ulcerans_Agy99 RRDGSDWIIKGQKVYISGIDQAQAVLVVGRTEEAKTG---KLRPALFVVP
MAV_1088|M.avium_104 RRDGSDWILKGQKVFISGIDQAQAVLVVARTEEAKTG---KLRPALFVVP
MSMEG_5494|M.smegmatis_MC2_155 RRDGSDWILKGQKVFISGIDQAQAVLVVGRTEDHKTG---NLKPALFVIP
TH_3553|M.thermoresistible__bu RRDGGDWILSGQKVFISGVDQAQAVLVVGRVQKDGTGRTKSLKPALFVVP
Mflv_1881|M.gilvum_PYR-GCK RRDGSDWILSGQKVYISGVDQAQAVLIVGRTEDHKTG---NLKPALFVVP
Mvan_4850|M.vanbaalenii_PYR-1 RRDGSDWVLSGQKVYISGVDQAQAVLVVGRTEDHKTG---SLKPALFVVP
MAB_1070c|M.abscessus_ATCC_199 KRDGGDWILNGRKVFISGVNEANAVLVVARTEEAKTG---KLKPALFVVP
MLBr_00737|M.leprae_Br4923 KADGDDWILNGFKCWITNGGKSTWYTVMAVTDPDKGAN----GISAFIVH
: **.**::.* * :*:. .:: ::. : . : *::
Rv0972c|M.tuberculosis_H37Rv TDAPGFSYTPIEMEL-VSPERQFQVFLDDVRLPADALVGAEDAAIAQLFA
Mb0997c|M.bovis_AF2122/97 TDAPGFSYTPIEMEL-VSPERQFQVFLDDVRLPADALVGAEDAAIAHLFA
MMAR_4535|M.marinum_M TDTPGFTYTAIDMEL-VSPERQFQVFLDDVRLPADALVGAQDAAIAQLFA
MUL_4707|M.ulcerans_Agy99 TDTPGFTYTAIDMEL-VSPERQFQVFLDDVRLPADALVGAQDAAIAQLFA
MAV_1088|M.avium_104 TDAPGFSATPIEMEL-ISPERQFQVFLDDVRLPSDALVGAEDAAIAQLFA
MSMEG_5494|M.smegmatis_MC2_155 TDTPGLHWTKIEMEL-ISPESQFQVFLDDVRVPADALVGSEDAALAQLFA
TH_3553|M.thermoresistible__bu TDAPGLSYTKIEMEL-ISPESQFQVFLDDVRLPADALVGDEDAALAQLFA
Mflv_1881|M.gilvum_PYR-GCK TDTPGLTYTKIPMEI-VSPEFQFQVFLDEVRLPADALVGSEDAAIAQLFA
Mvan_4850|M.vanbaalenii_PYR-1 TDTPGFTYTKIPMEI-VSPEFQFQVFLDEVRLPADALVGSEDAAIAQLFA
MAB_1070c|M.abscessus_ATCC_199 TNTKGFEYTPIDMQL-TLPEQQFQVFLDDVRVPGDALVGSEDAALMQLFA
MLBr_00737|M.leprae_Br4923 KDDEGFSIGPKEKKLGIKGSPTTELYFDKCRIPGDRIIGEPGTGFKTALA
.: *: :: . ::::*. *:*.* ::* .:.: :*
Rv0972c|M.tuberculosis_H37Rv GLNPERIMGAASAVGMGRFALGRAVDYVKTRKVWSTPIGAHQGLAHPLAQ
Mb0997c|M.bovis_AF2122/97 GLNPERIMGAASAVGMGRFALGRAVDYVKTRKVWSTPIGAHQGLAHPLAQ
MMAR_4535|M.marinum_M GLNPERIMGAASAVGMGRFALNRAVDYVKTRQVWSTPIGAHQGLAHPLAQ
MUL_4707|M.ulcerans_Agy99 GLNPERIMGAASAVGMGRFALNRAVDYVKTRQVWSTPIGAHQGLAHPLAQ
MAV_1088|M.avium_104 GLNPERIMGAASSVGMGRFALARAAEYVKTRQVWGTPVGAHQGLSHPLAQ
MSMEG_5494|M.smegmatis_MC2_155 GLNPERIMGAASAVGMGRFAIHKAVDYVKTRQVWKVPIGSHQGLSHPLAQ
TH_3553|M.thermoresistible__bu GLNPERIMGAASAIGMGRFAIGRAVDYVKNRQVWRTPIGAHQGLAHPLAQ
Mflv_1881|M.gilvum_PYR-GCK GLNPERIMGAASAVGMGRFALAKAVEYVKGRQVWKTPIGAHQGLSHPLAQ
Mvan_4850|M.vanbaalenii_PYR-1 GLNPERIMGAASAVGMGRFAIGRAVEYVKTRQVWKTPIGAHQGLSHPLAQ
MAB_1070c|M.abscessus_ATCC_199 GLNPERIMGAASGVGLTRLALNKATEYVKTRQVWKTPIGAHQAIAHPLAE
MLBr_00737|M.leprae_Br4923 TLDHTRPTIGAQAVGIAQGALDAAIVYTKDRKQFGESISTFQSIQFMLAD
*: * .*..:*: : *: * *.* *: : .:.:.*.: . **:
Rv0972c|M.tuberculosis_H37Rv CHIEVELAKLMTQKAATLYDHGDDFGAAEAANMAKYAAAEASSRAVDQAV
Mb0997c|M.bovis_AF2122/97 CHIEVELAKLMTQKAATLYDHGDDFGAAEAANMAKYAAAEASSRAVDQAV
MMAR_4535|M.marinum_M CHIEVELAKLMMQKAATLYDHGDDGGAAEAANMAKYAAAEASARSVDQAV
MUL_4707|M.ulcerans_Agy99 CHIEVELAKLMMQKAATLYDHGDDGGAAEAANMAKYAAAEASARSVDQAV
MAV_1088|M.avium_104 CHIEVELAKLMMQKAATLYDAGNDMGAAEAANMAKYAAAEAATRSVDQAV
MSMEG_5494|M.smegmatis_MC2_155 NHIEIELAKLMMQKAAALYDAGDDLGAAEAANMAKYAAGEASVRAVDQAV
TH_3553|M.thermoresistible__bu NHIEIELAKLMMQKAAALYDLGDGAGAAEAANMAKYAAGEASARAVDQAV
Mflv_1881|M.gilvum_PYR-GCK NHIEVELAKLMMQKAAALYDAGADEAAAEAANMAKYAAGEASVRAVDQAV
Mvan_4850|M.vanbaalenii_PYR-1 NHIEVELAKLMMQKAASLYDAGDDAGAAEAANMAKYAAGEASVRAVDQAV
MAB_1070c|M.abscessus_ATCC_199 IKVELELAKLMMQKAATLYDCGDDWGAAEAANMAKYAAADVACRAADRAV
MLBr_00737|M.leprae_Br4923 MAMKVEAARLIVYAAAARAERGEP-DLGFISAASKCFASDIAMEVTTDAV
:::* *:*: **: : * . : :* *.: : . . **
Rv0972c|M.tuberculosis_H37Rv QSMGGNGLTKEYGVAAMMTSARLARIAPISREMVLNFVAQTSLGLPRSY
Mb0997c|M.bovis_AF2122/97 QSMGGNGLTKEYGVAAMMTSARLARIAPISREMVLNFVAQTSLGLPRSY
MMAR_4535|M.marinum_M QSMGGNGLTQEYGVAAMLTSSRLARIAPISREMVLNFVAQTSLGLPRSY
MUL_4707|M.ulcerans_Agy99 QSMGGNGLTQEYGVAAMLTSSRLARIAPISREMVLNFVAQTSLGLPRSY
MAV_1088|M.avium_104 QSMGGNGLTKEYGVAAMLASARLGRIAPVSREMVLNFVAQTSLGLPRSY
MSMEG_5494|M.smegmatis_MC2_155 QSLGGNGLTKEYGIAAAVTASKLARIAPVSREMILNFVSQTSLGLPRSY
TH_3553|M.thermoresistible__bu QSLGGNGLTKEYGIAAAITSSRLARIAPISREMILNFVAQTSLGLPRSY
Mflv_1881|M.gilvum_PYR-GCK QSLGGNGLTKEYGVAAMLTASRLARIAPVSREMILNFVAQTSLGLPRSY
Mvan_4850|M.vanbaalenii_PYR-1 QSLGGNGLTQEYGIASALTASRLARIAPVSREMILNFVAQTSLGLPRSY
MAB_1070c|M.abscessus_ATCC_199 QSLGGNGLTTEYGVAPLLNLSRFGRIAPVSREMILNFVAQTSLGLPRSY
MLBr_00737|M.leprae_Br4923 QLFGGAGYTSDFPVERFMRDAKITQIYEGTNQIQRVVMSRALLR-----
* :** * * :: : : ::: :* :.:: .:::: *