For questions or suggestions e-mail us at: ioerger@cs.tamu.edu

M. gilvum PYR-GCK Mflv_4615 (-)

annotation: acyl-CoA dehydrogenase domain-containing protein
coordinates: 4913510 - 4914664
length: 384

MELHETEERRALRKAVSEIAKDFGHDYYVAKSLGGEKSSELWHAVGEQGFLGINIAEEYGGGGGGIYDMQ
IVGEELAAAGCPLLMTVVSPTICGTIIQAFGSDELKARWLPGIASGEVIMAFAITEPDAGSNSHNISTYA
KRVGGDWILNGTKYYISGVDEAEAILVVTRTATDDRGRGRLSLLVVPTDAPGLTKTLIPVQAVTPEKQFT
LFFDDVRVPAENLIGAENDGLRQVFMGLNPERIMGAALGNGIGRYALDKASAYARERKVWDVPIGAHQGL
SHPLAHAKIQLELARLMTQRAASLHDADDPGSAEASNMAKYAAAEAGILALDQAIQTHGGNGLATEYGLA
TLWGPARLMRTAPISREMILNYVAQHSLNLPRSY

Operon Prediction Model: Genebank

Paralogs

species id gene e-value identity (len) annotation
M. gilvum PYR-GCK Mflv_4615 - - 100% (384) acyl-CoA dehydrogenase domain-containing protein
M. gilvum PYR-GCK Mflv_1881 - e-129 59.84% (381) acyl-CoA dehydrogenase domain-containing protein
M. gilvum PYR-GCK Mflv_2442 - 3e-70 39.44% (393) acyl-CoA dehydrogenase domain-containing protein

Closest Orthologs (e-value cutoff: 1e-4)

species id gene e-value identity (len) annotation
M. bovis AF2122 / 97 Mb0997c fadE12 1e-130 60.10% (381) acyl-CoA dehydrogenase FADE12
M. tuberculosis H37Rv Rv0972c fadE12 1e-131 60.37% (381) acyl-CoA dehydrogenase FADE12
M. leprae Br4923 MLBr_00737 fadE25 6e-32 29.16% (367) putative acyl-CoA dehydrogenase
M. abscessus ATCC 19977 MAB_2065c - 0.0 87.24% (384) acyl-CoA dehydrogenase FadE
M. marinum M MMAR_4535 fadE12 1e-132 60.10% (381) acyl-CoA dehydrogenase FadE12
M. avium 104 MAV_1088 - 1e-130 59.32% (381) acyl-CoA dehydrogenase fadE12
M. smegmatis MC2 155 MSMEG_5494 - 1e-131 59.06% (381) acyl-CoA dehydrogenase fadE12
M. thermoresistible (build 8) TH_3553 - 1e-130 59.90% (384) PUTATIVE acyl-CoA dehydrogenase domain protein
M. ulcerans Agy99 MUL_4707 fadE12 1e-131 59.84% (381) acyl-CoA dehydrogenase FadE12
M. vanbaalenii PYR-1 Mvan_4850 - 1e-131 59.22% (385) acyl-CoA dehydrogenase domain-containing protein

CLUSTAL 2.0.9 multiple sequence alignment


Mflv_4615|M.gilvum_PYR-GCK          ----------MELHETEERRALRKAVSEIAKDFGHDYYVAKSLGGEKSSE
MAB_2065c|M.abscessus_ATCC_199      ----------MELHETEERQDLRKAVAEIAKDFGHEYYLEKSLAGAKSTE
Mb0997c|M.bovis_AF2122/97           -------MTDTSFIESEERQALRKAVASWVANYGHEYYLDKARKHEHTSE
Rv0972c|M.tuberculosis_H37Rv        -------MTDTSFIESEERQALRKAVASWVANYGHEYYLDKARKHEHTSE
MMAR_4535|M.marinum_M               -------MTDTSFIENEDRRALRKAVSEWASNYGHEYYLKKARAHEHTTE
MUL_4707|M.ulcerans_Agy99           ------MMTGTSFIENEDRRALRKAVSEWASNYGHEYYLKKARAHEHTTE
MAV_1088|M.avium_104                -------MTDSSFIENEERQALRKAVAEWASNYGSEYYLRKARAHEHTNE
MSMEG_5494|M.smegmatis_MC2_155      ---------MSGFVETEEQQALRRAVAAMAANYGQDYYLEKARAGQHTTE
TH_3553|M.thermoresistible__bu      ---------VTGFVESEEQRALRRAAAELAAGYGQDYYLEKARAGEHTDE
Mvan_4850|M.vanbaalenii_PYR-1       ----------MSFIETDEQQALRKAVAAMAANYGQDYYLEKARAGQHTDE
MLBr_00737|M.leprae_Br4923          MVGWSGNPLFDLFKLPEEHNELRATIRALAEKEIAPHAADVDQRARFPEE
                                                :   :::. ** :    .      :          . *

Mflv_4615|M.gilvum_PYR-GCK          LWHAVGEQGFLGINIAEEYGGGGGGIYDMQIVGEELAAAGCPLLMTVVSP
MAB_2065c|M.abscessus_ATCC_199      LWQAVGKQGFLGVNLSEQYGGGGGGIYDMQIVGEELAAAGCPLLMTVVSP
Mb0997c|M.bovis_AF2122/97           LWAEAGKLGFLGVNLPEEYGGGGAGMYELSLVMEEMAAAGSALLLMVVSP
Rv0972c|M.tuberculosis_H37Rv        LWAEAGKLGFLGVNLPEEYGGGGAGMYELSLVMEEMAAAGSALLLMVVSP
MMAR_4535|M.marinum_M               LWSEAGKLGFIGVNLPEEYGGGGAGMYELSMVMEEMAAAGSALLLMVVSP
MUL_4707|M.ulcerans_Agy99           LWSEAGKLGFIGVNLPEEYGGGGAGMYELSMVMEEMAAAGSALLLMVVSP
MAV_1088|M.avium_104                LWSEAGKLGFLGVNLPEEYGGGGAGMYELSLVMEEMAAAGSALLLMVVSP
MSMEG_5494|M.smegmatis_MC2_155      LWNEAGKLGFIGVNLPEEYGGGGAGMYELSLVMEEMAATGCALLMMVVSP
TH_3553|M.thermoresistible__bu      LWAEAGKLGFLGVNLPEEYGGGGAGMYELSLVMEELSAAGCGLLMMVVSP
Mvan_4850|M.vanbaalenii_PYR-1       LWSEAGKLGFIGVNLPEEYGGGGAGMYELSLVMEEMAAAGSSLLMMVVSP
MLBr_00737|M.leprae_Br4923          ALAALNASGFNAIHVPEEYGGQGADSVAACIVIEEVARVDASASLIPAVN
                                         .  ** .:::.*:*** *..     :* **:: ...   :  .  

Mflv_4615|M.gilvum_PYR-GCK          TICGTIIQAFGSDELKARWLPGIASGEVIMAFAITEPDAGSNSHNISTYA
MAB_2065c|M.abscessus_ATCC_199      TICGTIIQAFGSEELKQQWLPGIASGETIMAFAITEPDAGSNSHNISTTA
Mb0997c|M.bovis_AF2122/97           AINGTIIAKFGTDDQKKRWLPGIADGSLTMAFAITEPDAGSNSHKITTTA
Rv0972c|M.tuberculosis_H37Rv        AINGTIIAKFGTDDQKKRWLPGIADGSLTMAFAITEPDAGSNSHKITTTA
MMAR_4535|M.marinum_M               AINGTIISKFGTDEQKQRWLPGIADGTLTMAFAITEPDAGSNSHKITTTA
MUL_4707|M.ulcerans_Agy99           AINGTIISKFGTDEQKQRWLPGIADGTLTMAFAITEPEAGSNSHKITTTA
MAV_1088|M.avium_104                AINGTIISKFGTEEQKKRWLPGIADGTLTMAFAITEPDAGSNSHKITTTA
MSMEG_5494|M.smegmatis_MC2_155      AINGTIISKFGTEEQKRRWLPGIADGSITMAFAITEPDAGSNSHRITTTA
TH_3553|M.thermoresistible__bu      AINGTIISRFGTEDQKRRWLPGIADGSITMAFAITEPDAGSNSHRITTTA
Mvan_4850|M.vanbaalenii_PYR-1       AINGTIISKFGTEEQKKRWIPGIADGSLTMAFAITEPDAGSNSHKITTTA
MLBr_00737|M.leprae_Br4923          KLGTMGLILRGSEELKKQVLPSLAAEGAMASYALSEREAGSDAASMRTRA
                                     :    :   *::: * : :*.:*      ::*::* :***::  : * *

Mflv_4615|M.gilvum_PYR-GCK          KRVGGDWILNGTKYYISGVDEAEAILVVTRTATDDRG---RGRLSLLVVP
MAB_2065c|M.abscessus_ATCC_199      KRDGDDWVINGTKYYISGVDEAEAILVVTRTSTNDSG---RGLLSLLVVP
Mb0997c|M.bovis_AF2122/97           RRDGSDWIIKGQKVFISGIDQAQAVLVVGRSEEAKTG---KLRPALFVVP
Rv0972c|M.tuberculosis_H37Rv        RRDGSDWIIKGQKVFISGIDQAQAVLVVGRSEEAKTG---KLRPALFVVP
MMAR_4535|M.marinum_M               RRDGSDWIIKGQKVYISGIDQAQAVLVVGRTEEAKTG---KLRPALFVVP
MUL_4707|M.ulcerans_Agy99           RRDGSDWIIKGQKVYISGIDQAQAVLVVGRTEEAKTG---KLRPALFVVP
MAV_1088|M.avium_104                RRDGSDWILKGQKVFISGIDQAQAVLVVARTEEAKTG---KLRPALFVVP
MSMEG_5494|M.smegmatis_MC2_155      RRDGSDWILKGQKVFISGIDQAQAVLVVGRTEDHKTG---NLKPALFVIP
TH_3553|M.thermoresistible__bu      RRDGGDWILSGQKVFISGVDQAQAVLVVGRVQKDGTGRTKSLKPALFVVP
Mvan_4850|M.vanbaalenii_PYR-1       RRDGSDWVLSGQKVYISGVDQAQAVLVVGRTEDHKTG---SLKPALFVVP
MLBr_00737|M.leprae_Br4923          KADGDDWILNGFKCWITNGGKSTWYTVMAVTDPDKGAN----GISAFIVH
                                    :  *.**::.* * :*:. .::    *:        .       : ::: 

Mflv_4615|M.gilvum_PYR-GCK          TDAPGLTKTLIPVQA-VTPEKQFTLFFDDVRVPAENLIGAENDGLRQVFM
MAB_2065c|M.abscessus_ATCC_199      TDVPGLTKSLIPVQA-VTPEKQFTLFFDDVRVPAANLIGTENEGLRQVFM
Mb0997c|M.bovis_AF2122/97           TDAPGFSYTPIEMEL-VSPERQFQVFLDDVRLPADALVGAEDAAIAHLFA
Rv0972c|M.tuberculosis_H37Rv        TDAPGFSYTPIEMEL-VSPERQFQVFLDDVRLPADALVGAEDAAIAQLFA
MMAR_4535|M.marinum_M               TDTPGFTYTAIDMEL-VSPERQFQVFLDDVRLPADALVGAQDAAIAQLFA
MUL_4707|M.ulcerans_Agy99           TDTPGFTYTAIDMEL-VSPERQFQVFLDDVRLPADALVGAQDAAIAQLFA
MAV_1088|M.avium_104                TDAPGFSATPIEMEL-ISPERQFQVFLDDVRLPSDALVGAEDAAIAQLFA
MSMEG_5494|M.smegmatis_MC2_155      TDTPGLHWTKIEMEL-ISPESQFQVFLDDVRVPADALVGSEDAALAQLFA
TH_3553|M.thermoresistible__bu      TDAPGLSYTKIEMEL-ISPESQFQVFLDDVRLPADALVGDEDAALAQLFA
Mvan_4850|M.vanbaalenii_PYR-1       TDTPGFTYTKIPMEI-VSPEFQFQVFLDEVRLPADALVGSEDAAIAQLFA
MLBr_00737|M.leprae_Br4923          KDDEGFSIGPKEKKLGIKGSPTTELYFDKCRIPGDRIIGEPGTGFKTALA
                                    .*  *:       :  :. .    :::*. *:*.  ::*  . .:   : 

Mflv_4615|M.gilvum_PYR-GCK          GLNPERIMGAALGNGIGRYALDKASAYARERKVWDVPIGAHQGLSHPLAH
MAB_2065c|M.abscessus_ATCC_199      GLNPERIMGAALGNGIGRYALDKAADYARNRHVWGAPIGSHQGVSHPLAH
Mb0997c|M.bovis_AF2122/97           GLNPERIMGAASAVGMGRFALGRAVDYVKTRKVWSTPIGAHQGLAHPLAQ
Rv0972c|M.tuberculosis_H37Rv        GLNPERIMGAASAVGMGRFALGRAVDYVKTRKVWSTPIGAHQGLAHPLAQ
MMAR_4535|M.marinum_M               GLNPERIMGAASAVGMGRFALNRAVDYVKTRQVWSTPIGAHQGLAHPLAQ
MUL_4707|M.ulcerans_Agy99           GLNPERIMGAASAVGMGRFALNRAVDYVKTRQVWSTPIGAHQGLAHPLAQ
MAV_1088|M.avium_104                GLNPERIMGAASSVGMGRFALARAAEYVKTRQVWGTPVGAHQGLSHPLAQ
MSMEG_5494|M.smegmatis_MC2_155      GLNPERIMGAASAVGMGRFAIHKAVDYVKTRQVWKVPIGSHQGLSHPLAQ
TH_3553|M.thermoresistible__bu      GLNPERIMGAASAIGMGRFAIGRAVDYVKNRQVWRTPIGAHQGLAHPLAQ
Mvan_4850|M.vanbaalenii_PYR-1       GLNPERIMGAASAVGMGRFAIGRAVEYVKTRQVWKTPIGAHQGLSHPLAQ
MLBr_00737|M.leprae_Br4923          TLDHTRPTIGAQAVGIAQGALDAAIVYTKDRKQFGESISTFQSIQFMLAD
                                     *:  *   .* . *:.: *:  *  *.: *: :  .:.:.*.: . **.

Mflv_4615|M.gilvum_PYR-GCK          AKIQLELARLMTQRAASLHDADDP-GSAEASNMAKYAAAEAGILALDQAI
MAB_2065c|M.abscessus_ATCC_199      AKIQVELARLMTQRAAALHDAGDP-GSGEASNMAKYAAAEAGILALDQAI
Mb0997c|M.bovis_AF2122/97           CHIEVELAKLMTQKAATLYDHGDDFGAAEAANMAKYAAAEASSRAVDQAV
Rv0972c|M.tuberculosis_H37Rv        CHIEVELAKLMTQKAATLYDHGDDFGAAEAANMAKYAAAEASSRAVDQAV
MMAR_4535|M.marinum_M               CHIEVELAKLMMQKAATLYDHGDDGGAAEAANMAKYAAAEASARSVDQAV
MUL_4707|M.ulcerans_Agy99           CHIEVELAKLMMQKAATLYDHGDDGGAAEAANMAKYAAAEASARSVDQAV
MAV_1088|M.avium_104                CHIEVELAKLMMQKAATLYDAGNDMGAAEAANMAKYAAAEAATRSVDQAV
MSMEG_5494|M.smegmatis_MC2_155      NHIEIELAKLMMQKAAALYDAGDDLGAAEAANMAKYAAGEASVRAVDQAV
TH_3553|M.thermoresistible__bu      NHIEIELAKLMMQKAAALYDLGDGAGAAEAANMAKYAAGEASARAVDQAV
Mvan_4850|M.vanbaalenii_PYR-1       NHIEVELAKLMMQKAASLYDAGDDAGAAEAANMAKYAAGEASVRAVDQAV
MLBr_00737|M.leprae_Br4923          MAMKVEAARLIVYAAAARAERGEP-DLGFISAASKCFASDIAMEVTTDAV
                                      :::* *:*:   **:  : .:  . .  :  :*  *.: .     :*:

Mflv_4615|M.gilvum_PYR-GCK          QTHGGNGLATEYGLATLWGPARLMRTAPISREMILNYVAQHSLNLPRSY
MAB_2065c|M.abscessus_ATCC_199      QTHGGNGMATEYGLATLWGPARLMRTAPISREMILNFVAQHSLKLPASY
Mb0997c|M.bovis_AF2122/97           QSMGGNGLTKEYGVAAMMTSARLARIAPISREMVLNFVAQTSLGLPRSY
Rv0972c|M.tuberculosis_H37Rv        QSMGGNGLTKEYGVAAMMTSARLARIAPISREMVLNFVAQTSLGLPRSY
MMAR_4535|M.marinum_M               QSMGGNGLTQEYGVAAMLTSSRLARIAPISREMVLNFVAQTSLGLPRSY
MUL_4707|M.ulcerans_Agy99           QSMGGNGLTQEYGVAAMLTSSRLARIAPISREMVLNFVAQTSLGLPRSY
MAV_1088|M.avium_104                QSMGGNGLTKEYGVAAMLASARLGRIAPVSREMVLNFVAQTSLGLPRSY
MSMEG_5494|M.smegmatis_MC2_155      QSLGGNGLTKEYGIAAAVTASKLARIAPVSREMILNFVSQTSLGLPRSY
TH_3553|M.thermoresistible__bu      QSLGGNGLTKEYGIAAAITSSRLARIAPISREMILNFVAQTSLGLPRSY
Mvan_4850|M.vanbaalenii_PYR-1       QSLGGNGLTQEYGIASALTASRLARIAPVSREMILNFVAQTSLGLPRSY
MLBr_00737|M.leprae_Br4923          QLFGGAGYTSDFPVERFMRDAKITQIYEGTNQIQRVVMSRALLR-----
                                    *  ** * : :: :      ::: :    :.::    :::  *

species	id	gene	e-value	identity (len)	annotation
M. gilvum PYR-GCK	Mflv_4615	-	-	100% (384)	acyl-CoA dehydrogenase domain-containing protein
M. gilvum PYR-GCK	Mflv_1881	-	e-129	59.84% (381)	acyl-CoA dehydrogenase domain-containing protein
M. gilvum PYR-GCK	Mflv_2442	-	3e-70	39.44% (393)	acyl-CoA dehydrogenase domain-containing protein