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M. ulcerans Agy99 MUL_4707 (fadE12)

annotation: acyl-CoA dehydrogenase FadE12
coordinates: 5212621 - 5213790
length: 389

VMTGTSFIENEDRRALRKAVSEWASNYGHEYYLKKARAHEHTTELWSEAGKLGFIGVNLPEEYGGGGAGM
YELSMVMEEMAAAGSALLLMVVSPAINGTIISKFGTDEQKQRWLPGIADGTLTMAFAITEPEAGSNSHKI
TTTARRDGSDWIIKGQKVYISGIDQAQAVLVVGRTEEAKTGKLRPALFVVPTDTPGFTYTAIDMELVSPE
RQFQVFLDDVRLPADALVGAQDAAIAQLFAGLNPERIMGAASAVGMGRFALNRAVDYVKTRQVWSTPIGA
HQGLAHPLAQCHIEVELAKLMMQKAATLYDHGDDGGAAEAANMAKYAAAEASARSVDQAVQSMGGNGLTQ
EYGVAAMLTSSRLARIAPISREMVLNFVAQTSLGLPRSY

Operon Prediction Model: Genebank

Paralogs

species id gene e-value identity (len) annotation
M. ulcerans Agy99 MUL_4707 fadE12 - 100% (389) acyl-CoA dehydrogenase FadE12
M. ulcerans Agy99 MUL_3778 fadE19 1e-44 29.82% (389) acyl-CoA dehydrogenase FadE19
M. ulcerans Agy99 MUL_2825 fadE7 4e-36 33.23% (313) acyl-CoA dehydrogenase FadE7

Closest Orthologs (e-value cutoff: 1e-4)

species id gene e-value identity (len) annotation
M. bovis AF2122 / 97 Mb0997c fadE12 0.0 90.46% (388) acyl-CoA dehydrogenase FADE12
M. gilvum PYR-GCK Mflv_1881 - 0.0 83.12% (385) acyl-CoA dehydrogenase domain-containing protein
M. tuberculosis H37Rv Rv0972c fadE12 0.0 90.72% (388) acyl-CoA dehydrogenase FADE12
M. leprae Br4923 MLBr_00737 fadE25 3e-33 30.09% (319) putative acyl-CoA dehydrogenase
M. abscessus ATCC 19977 MAB_1070c - 1e-166 72.58% (383) acyl-CoA dehydrogenase
M. marinum M MMAR_4535 fadE12 0.0 99.48% (388) acyl-CoA dehydrogenase FadE12
M. avium 104 MAV_1088 - 0.0 89.18% (388) acyl-CoA dehydrogenase fadE12
M. smegmatis MC2 155 MSMEG_5494 - 0.0 81.56% (385) acyl-CoA dehydrogenase fadE12
M. thermoresistible (build 8) TH_3553 - 0.0 80.41% (388) PUTATIVE acyl-CoA dehydrogenase domain protein
M. vanbaalenii PYR-1 Mvan_4850 - 0.0 85.16% (384) acyl-CoA dehydrogenase domain-containing protein

CLUSTAL 2.0.9 multiple sequence alignment


MUL_4707|M.ulcerans_Agy99           ------MMTGTSFIENEDRRALRKAVSEWASNYGHEYYLKKARAHEHTTE
MMAR_4535|M.marinum_M               -------MTDTSFIENEDRRALRKAVSEWASNYGHEYYLKKARAHEHTTE
Mb0997c|M.bovis_AF2122/97           -------MTDTSFIESEERQALRKAVASWVANYGHEYYLDKARKHEHTSE
Rv0972c|M.tuberculosis_H37Rv        -------MTDTSFIESEERQALRKAVASWVANYGHEYYLDKARKHEHTSE
MAV_1088|M.avium_104                -------MTDSSFIENEERQALRKAVAEWASNYGSEYYLRKARAHEHTNE
MSMEG_5494|M.smegmatis_MC2_155      ---------MSGFVETEEQQALRRAVAAMAANYGQDYYLEKARAGQHTTE
TH_3553|M.thermoresistible__bu      ---------VTGFVESEEQRALRRAAAELAAGYGQDYYLEKARAGEHTDE
Mflv_1881|M.gilvum_PYR-GCK          ---------MSGFIETEEQQALRSAVAAMVAGYGQDYYLEKSRAGEHTDE
Mvan_4850|M.vanbaalenii_PYR-1       ---------MS-FIETDEQQALRKAVAAMAANYGQDYYLEKARAGQHTDE
MAB_1070c|M.abscessus_ATCC_199      ------MTQPNPYVESDERKALRQAVASLAASYGHEYYLEKSKTHEPLAE
MLBr_00737|M.leprae_Br4923          MVGWSGNPLFDLFKLPEEHNELRATIRALAEKEIAPHAADVDQRARFPEE
                                                :   :::. ** :    .      :     :  .   *

MUL_4707|M.ulcerans_Agy99           LWSEAGKLGFIGVNLPEEYGGGGAGMYELSMVMEEMAAAGSALLLMVVSP
MMAR_4535|M.marinum_M               LWSEAGKLGFIGVNLPEEYGGGGAGMYELSMVMEEMAAAGSALLLMVVSP
Mb0997c|M.bovis_AF2122/97           LWAEAGKLGFLGVNLPEEYGGGGAGMYELSLVMEEMAAAGSALLLMVVSP
Rv0972c|M.tuberculosis_H37Rv        LWAEAGKLGFLGVNLPEEYGGGGAGMYELSLVMEEMAAAGSALLLMVVSP
MAV_1088|M.avium_104                LWSEAGKLGFLGVNLPEEYGGGGAGMYELSLVMEEMAAAGSALLLMVVSP
MSMEG_5494|M.smegmatis_MC2_155      LWNEAGKLGFIGVNLPEEYGGGGAGMYELSLVMEEMAATGCALLMMVVSP
TH_3553|M.thermoresistible__bu      LWAEAGKLGFLGVNLPEEYGGGGAGMYELSLVMEELSAAGCGLLMMVVSP
Mflv_1881|M.gilvum_PYR-GCK          LWSEAGKLGFIGVNLPEEYGGGGAGMYELSLVMEEMAAGGASLLMMVVSP
Mvan_4850|M.vanbaalenii_PYR-1       LWSEAGKLGFIGVNLPEEYGGGGAGMYELSLVMEEMAAAGSSLLMMVVSP
MAB_1070c|M.abscessus_ATCC_199      LWDEAGKLGFLGVNIPEEYGGGGAGMYELGLVFEELSAAGCPLLLMVVSP
MLBr_00737|M.leprae_Br4923          ALAALNASGFNAIHVPEEYGGQGADSVAACIVIEEVARVDASASLIPAVN
                                         .  ** .:::****** **.     :*:**::  ..   :: .  

MUL_4707|M.ulcerans_Agy99           AINGTIISKFGTDEQKQRWLPGIADGTLTMAFAITEPEAGSNSHKITTTA
MMAR_4535|M.marinum_M               AINGTIISKFGTDEQKQRWLPGIADGTLTMAFAITEPDAGSNSHKITTTA
Mb0997c|M.bovis_AF2122/97           AINGTIIAKFGTDDQKKRWLPGIADGSLTMAFAITEPDAGSNSHKITTTA
Rv0972c|M.tuberculosis_H37Rv        AINGTIIAKFGTDDQKKRWLPGIADGSLTMAFAITEPDAGSNSHKITTTA
MAV_1088|M.avium_104                AINGTIISKFGTEEQKKRWLPGIADGTLTMAFAITEPDAGSNSHKITTTA
MSMEG_5494|M.smegmatis_MC2_155      AINGTIISKFGTEEQKRRWLPGIADGSITMAFAITEPDAGSNSHRITTTA
TH_3553|M.thermoresistible__bu      AINGTIISRFGTEDQKRRWLPGIADGSITMAFAITEPDAGSNSHRITTTA
Mflv_1881|M.gilvum_PYR-GCK          AINGTIIAKFGTEEQKKRWLPGIADGTLTMAFAITEPDAGSNSHRITTTA
Mvan_4850|M.vanbaalenii_PYR-1       AINGTIISKFGTEEQKKRWIPGIADGSLTMAFAITEPDAGSNSHKITTTA
MAB_1070c|M.abscessus_ATCC_199      AINATIIARYGTDAQKKSWLPAMAEGSFKMAFAITEPDAGSNSHNIITTA
MLBr_00737|M.leprae_Br4923          KLGTMGLILRGSEELKKQVLPSLAAEGAMASYALSEREAGSDAASMRTRA
                                     :.   :   *::  *:  :*.:*      ::*::* :***::  : * *

MUL_4707|M.ulcerans_Agy99           RRDGSDWIIKGQKVYISGIDQAQAVLVVGRTEEAKTG---KLRPALFVVP
MMAR_4535|M.marinum_M               RRDGSDWIIKGQKVYISGIDQAQAVLVVGRTEEAKTG---KLRPALFVVP
Mb0997c|M.bovis_AF2122/97           RRDGSDWIIKGQKVFISGIDQAQAVLVVGRSEEAKTG---KLRPALFVVP
Rv0972c|M.tuberculosis_H37Rv        RRDGSDWIIKGQKVFISGIDQAQAVLVVGRSEEAKTG---KLRPALFVVP
MAV_1088|M.avium_104                RRDGSDWILKGQKVFISGIDQAQAVLVVARTEEAKTG---KLRPALFVVP
MSMEG_5494|M.smegmatis_MC2_155      RRDGSDWILKGQKVFISGIDQAQAVLVVGRTEDHKTG---NLKPALFVIP
TH_3553|M.thermoresistible__bu      RRDGGDWILSGQKVFISGVDQAQAVLVVGRVQKDGTGRTKSLKPALFVVP
Mflv_1881|M.gilvum_PYR-GCK          RRDGSDWILSGQKVYISGVDQAQAVLIVGRTEDHKTG---NLKPALFVVP
Mvan_4850|M.vanbaalenii_PYR-1       RRDGSDWVLSGQKVYISGVDQAQAVLVVGRTEDHKTG---SLKPALFVVP
MAB_1070c|M.abscessus_ATCC_199      KRDGGDWILNGRKVFISGVNEANAVLVVARTEEAKTG---KLKPALFVVP
MLBr_00737|M.leprae_Br4923          KADGDDWILNGFKCWITNGGKSTWYTVMAVTDPDKGAN----GISAFIVH
                                    : **.**::.* * :*:. .::    ::.  :    .       : *:: 

MUL_4707|M.ulcerans_Agy99           TDTPGFTYTAIDMEL-VSPERQFQVFLDDVRLPADALVGAQDAAIAQLFA
MMAR_4535|M.marinum_M               TDTPGFTYTAIDMEL-VSPERQFQVFLDDVRLPADALVGAQDAAIAQLFA
Mb0997c|M.bovis_AF2122/97           TDAPGFSYTPIEMEL-VSPERQFQVFLDDVRLPADALVGAEDAAIAHLFA
Rv0972c|M.tuberculosis_H37Rv        TDAPGFSYTPIEMEL-VSPERQFQVFLDDVRLPADALVGAEDAAIAQLFA
MAV_1088|M.avium_104                TDAPGFSATPIEMEL-ISPERQFQVFLDDVRLPSDALVGAEDAAIAQLFA
MSMEG_5494|M.smegmatis_MC2_155      TDTPGLHWTKIEMEL-ISPESQFQVFLDDVRVPADALVGSEDAALAQLFA
TH_3553|M.thermoresistible__bu      TDAPGLSYTKIEMEL-ISPESQFQVFLDDVRLPADALVGDEDAALAQLFA
Mflv_1881|M.gilvum_PYR-GCK          TDTPGLTYTKIPMEI-VSPEFQFQVFLDEVRLPADALVGSEDAAIAQLFA
Mvan_4850|M.vanbaalenii_PYR-1       TDTPGFTYTKIPMEI-VSPEFQFQVFLDEVRLPADALVGSEDAAIAQLFA
MAB_1070c|M.abscessus_ATCC_199      TNTKGFEYTPIDMQL-TLPEQQFQVFLDDVRVPGDALVGSEDAALMQLFA
MLBr_00737|M.leprae_Br4923          KDDEGFSIGPKEKKLGIKGSPTTELYFDKCRIPGDRIIGEPGTGFKTALA
                                    .:  *:       ::    .   ::::*. *:*.* ::*  .:.:   :*

MUL_4707|M.ulcerans_Agy99           GLNPERIMGAASAVGMGRFALNRAVDYVKTRQVWSTPIGAHQGLAHPLAQ
MMAR_4535|M.marinum_M               GLNPERIMGAASAVGMGRFALNRAVDYVKTRQVWSTPIGAHQGLAHPLAQ
Mb0997c|M.bovis_AF2122/97           GLNPERIMGAASAVGMGRFALGRAVDYVKTRKVWSTPIGAHQGLAHPLAQ
Rv0972c|M.tuberculosis_H37Rv        GLNPERIMGAASAVGMGRFALGRAVDYVKTRKVWSTPIGAHQGLAHPLAQ
MAV_1088|M.avium_104                GLNPERIMGAASSVGMGRFALARAAEYVKTRQVWGTPVGAHQGLSHPLAQ
MSMEG_5494|M.smegmatis_MC2_155      GLNPERIMGAASAVGMGRFAIHKAVDYVKTRQVWKVPIGSHQGLSHPLAQ
TH_3553|M.thermoresistible__bu      GLNPERIMGAASAIGMGRFAIGRAVDYVKNRQVWRTPIGAHQGLAHPLAQ
Mflv_1881|M.gilvum_PYR-GCK          GLNPERIMGAASAVGMGRFALAKAVEYVKGRQVWKTPIGAHQGLSHPLAQ
Mvan_4850|M.vanbaalenii_PYR-1       GLNPERIMGAASAVGMGRFAIGRAVEYVKTRQVWKTPIGAHQGLSHPLAQ
MAB_1070c|M.abscessus_ATCC_199      GLNPERIMGAASGVGLTRLALNKATEYVKTRQVWKTPIGAHQAIAHPLAE
MLBr_00737|M.leprae_Br4923          TLDHTRPTIGAQAVGIAQGALDAAIVYTKDRKQFGESISTFQSIQFMLAD
                                     *:  *   .*..:*: : *:  *  *.* *: :  .:.:.*.: . **:

MUL_4707|M.ulcerans_Agy99           CHIEVELAKLMMQKAATLYDHGDDGGAAEAANMAKYAAAEASARSVDQAV
MMAR_4535|M.marinum_M               CHIEVELAKLMMQKAATLYDHGDDGGAAEAANMAKYAAAEASARSVDQAV
Mb0997c|M.bovis_AF2122/97           CHIEVELAKLMTQKAATLYDHGDDFGAAEAANMAKYAAAEASSRAVDQAV
Rv0972c|M.tuberculosis_H37Rv        CHIEVELAKLMTQKAATLYDHGDDFGAAEAANMAKYAAAEASSRAVDQAV
MAV_1088|M.avium_104                CHIEVELAKLMMQKAATLYDAGNDMGAAEAANMAKYAAAEAATRSVDQAV
MSMEG_5494|M.smegmatis_MC2_155      NHIEIELAKLMMQKAAALYDAGDDLGAAEAANMAKYAAGEASVRAVDQAV
TH_3553|M.thermoresistible__bu      NHIEIELAKLMMQKAAALYDLGDGAGAAEAANMAKYAAGEASARAVDQAV
Mflv_1881|M.gilvum_PYR-GCK          NHIEVELAKLMMQKAAALYDAGADEAAAEAANMAKYAAGEASVRAVDQAV
Mvan_4850|M.vanbaalenii_PYR-1       NHIEVELAKLMMQKAASLYDAGDDAGAAEAANMAKYAAGEASVRAVDQAV
MAB_1070c|M.abscessus_ATCC_199      IKVELELAKLMMQKAATLYDCGDDWGAAEAANMAKYAAADVACRAADRAV
MLBr_00737|M.leprae_Br4923          MAMKVEAARLIVYAAAARAERGEP-DLGFISAASKCFASDIAMEVTTDAV
                                      :::* *:*:   **:  : *     .  :  :*  *.: : . .  **

MUL_4707|M.ulcerans_Agy99           QSMGGNGLTQEYGVAAMLTSSRLARIAPISREMVLNFVAQTSLGLPRSY
MMAR_4535|M.marinum_M               QSMGGNGLTQEYGVAAMLTSSRLARIAPISREMVLNFVAQTSLGLPRSY
Mb0997c|M.bovis_AF2122/97           QSMGGNGLTKEYGVAAMMTSARLARIAPISREMVLNFVAQTSLGLPRSY
Rv0972c|M.tuberculosis_H37Rv        QSMGGNGLTKEYGVAAMMTSARLARIAPISREMVLNFVAQTSLGLPRSY
MAV_1088|M.avium_104                QSMGGNGLTKEYGVAAMLASARLGRIAPVSREMVLNFVAQTSLGLPRSY
MSMEG_5494|M.smegmatis_MC2_155      QSLGGNGLTKEYGIAAAVTASKLARIAPVSREMILNFVSQTSLGLPRSY
TH_3553|M.thermoresistible__bu      QSLGGNGLTKEYGIAAAITSSRLARIAPISREMILNFVAQTSLGLPRSY
Mflv_1881|M.gilvum_PYR-GCK          QSLGGNGLTKEYGVAAMLTASRLARIAPVSREMILNFVAQTSLGLPRSY
Mvan_4850|M.vanbaalenii_PYR-1       QSLGGNGLTQEYGIASALTASRLARIAPVSREMILNFVAQTSLGLPRSY
MAB_1070c|M.abscessus_ATCC_199      QSLGGNGLTTEYGVAPLLNLSRFGRIAPVSREMILNFVAQTSLGLPRSY
MLBr_00737|M.leprae_Br4923          QLFGGAGYTSDFPVERFMRDAKITQIYEGTNQIQRVVMSRALLR-----
                                    * :** * * :: :   :  ::: :*   :.::   .:::: *

species	id	gene	e-value	identity (len)	annotation
M. ulcerans Agy99	MUL_4707	fadE12	-	100% (389)	acyl-CoA dehydrogenase FadE12
M. ulcerans Agy99	MUL_3778	fadE19	1e-44	29.82% (389)	acyl-CoA dehydrogenase FadE19
M. ulcerans Agy99	MUL_2825	fadE7	4e-36	33.23% (313)	acyl-CoA dehydrogenase FadE7