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TVAIKDDAAMDEASLGMLEASLRKTMSSASGPKLDAALTELGWADMLTEAPELAIPLYFRLLGETGSHAS ILVDVVLHATGNAIGDTVELPLPYAGNAWVVWDRGGASEATGEDRGPESLDPTLGGLPLRREEEGYPIRV AEARVAVGWWLVGSARAMLALARQHALDRVQFGKPIAGFQAVRHRLAETLVAIEGAEATLSLPSADNPDL SSLLAKAAAGKAALTAAKNCQQVLGGIGFTEEHGLQHHVKRTLVLDGLLGSSRELTRRAGAGLRARGSVP RLAQL*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_2434 | - | - | 100% (286) | acyl-CoA dehydrogenase domain-containing protein |
| M. gilvum PYR-GCK | Mflv_0345 | - | 3e-17 | 39.26% (135) | acyl-CoA dehydrogenase domain-containing protein |
| M. gilvum PYR-GCK | Mflv_1477 | - | 1e-15 | 40.17% (117) | acyl-CoA dehydrogenase domain-containing protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3087c | fadE22b | 2e-16 | 33.95% (215) | acyl-CoA dehydrogenase |
| M. tuberculosis H37Rv | Rv3061c | fadE22 | 2e-16 | 33.95% (215) | acyl-CoA dehydrogenase FADE22 |
| M. leprae Br4923 | MLBr_00737 | fadE25 | 1e-07 | 28.15% (135) | putative acyl-CoA dehydrogenase |
| M. abscessus ATCC 19977 | MAB_0580 | - | 4e-15 | 31.51% (219) | acyl-CoA dehydrogenase FadE |
| M. marinum M | MMAR_4749 | - | 4e-79 | 58.72% (281) | acyl-CoA dehydrogenase |
| M. avium 104 | MAV_0900 | - | 4e-83 | 57.50% (280) | putative acyl-CoA dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_4845 | - | 1e-105 | 69.93% (276) | putative acyl-CoA dehydrogenase |
| M. thermoresistible (build 8) | TH_2022 | - | 1e-101 | 69.57% (276) | putative acyl-CoA dehydrogenase |
| M. ulcerans Agy99 | MUL_4129 | fadE33 | 4e-16 | 28.98% (283) | acyl-CoA dehydrogenase FadE33 |
| M. vanbaalenii PYR-1 | Mvan_4218 | - | 1e-141 | 90.22% (276) | acyl-CoA dehydrogenase domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3087c|M.bovis_AF2122/97 --------------------------------------------------
Rv3061c|M.tuberculosis_H37Rv -------MGIALTDDHRELSGVARAFLTSQKVRWAARASLDAAGDARPPF
MAB_0580|M.abscessus_ATCC_1997 -MSVPSGLRASGSSEVQEAARDAVRQWARSAAVIESVRKMESEPDGWGPA
Mflv_2434|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4218|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_4845|M.smegmatis_MC2_155 --------------------------------------------------
TH_2022|M.thermoresistible__bu --------------------------------------------------
MMAR_4749|M.marinum_M --------------------------------------------------
MAV_0900|M.avium_104 --------------------------------------------------
MUL_4129|M.ulcerans_Agy99 -----------MTEEREMLRETVAALVNKHASPAAVRSAMESERGYDETL
MLBr_00737|M.leprae_Br4923 MVGWSGNPLFDLFKLPEEHNELRATIRALAEKEIAPHAADVDQRARFPEE
Mb3087c|M.bovis_AF2122/97 --------------------------------------------------
Rv3061c|M.tuberculosis_H37Rv WQNLAELG-WLGLHIDERHGGSGYGLSELVVVIEELGRAVAPGLFVPTV-
MAB_0580|M.abscessus_ATCC_1997 YVGLAELG-IFGVAVPEAAGGSGAGFDDMIAMVDEAAASLVPGPVATSA-
Mflv_2434|M.gilvum_PYR-GCK -------------MTVAIKDDAAMDEASLGMLEASLRKTMS---SASGP-
Mvan_4218|M.vanbaalenii_PYR-1 -------------------MAPGMDEASLDMLEASLRKTML---SSSGP-
MSMEG_4845|M.smegmatis_MC2_155 -----------------------MDAESLGLLEETLRKTML---SASGA-
TH_2022|M.thermoresistible__bu ------------VSVPDISGRSDLDAESLELLEDGLRKTML---SASGA-
MMAR_4749|M.marinum_M --------------------MDLTDPESLRLLADSLKTAVTQNPSPSGA-
MAV_0900|M.avium_104 -------------------MAPSADAESLRLLTDSLRTTMS---AASGA-
MUL_4129|M.ulcerans_Agy99 WRLLCEQVGAAALVIPEELGGAGGELADAAIVLQELGRALVPSPLLGTT-
MLBr_00737|M.leprae_Br4923 ALAALNASGFNAIHVPEEYGGQGADSVAACIVIEEVARVDASASLIPAVN
Mb3087c|M.bovis_AF2122/97 -------------------------------MGLDSQVQVTDGVADGEAG
Rv3061c|M.tuberculosis_H37Rv -IASAVVAKEGTDDQRARLLPALIDGTLTAGVGLDSQVQVTDGVADGEAG
MAB_0580|M.abscessus_ATCC_1997 -LVAVVLAADG----HEELVPPLAAGERTAGLALTGNLAIADGLASGVLP
Mflv_2434|M.gilvum_PYR-GCK -KLDAALTELG----WADMLTEAPELAIPLYFRLLGETGSHASILVDVVL
Mvan_4218|M.vanbaalenii_PYR-1 -ELDAALTEMG----WADMLSEVPELAVPLVFRLLGETGSHASVLVDVVL
MSMEG_4845|M.smegmatis_MC2_155 -KLDAALAELG----WAEMLSDMPEVAMPLVFRLLGETGSHASVLNDVLL
TH_2022|M.thermoresistible__bu -ELDAALGELG----WAQMLEDMPDTAIPLVFRLLGETGSHASVLNDIVL
MMAR_4749|M.marinum_M -GLDAALQALG----WLDMLDEIPGTAVPLVFAMLGENGVHAPLVNDVVA
MAV_0900|M.avium_104 -KLDAALTDVG----WRDMLDEMPDIAIPLVFTLLGETGAHAPLLNDVLL
MUL_4129|M.ulcerans_Agy99 -LAELALLAAAEP--DAKTLAGLAEGSSIGALVLDPDYVLNGDTADVVVA
MLBr_00737|M.leprae_Br4923 KLGTMGLILRGSEELKKQVLPSLAAEGAMASYALSEREAGSDAASMRTRA
:
Mb3087c|M.bovis_AF2122/97 IVLGAGL--------------------AELL---LVAAGDDVLVLERGRK
Rv3061c|M.tuberculosis_H37Rv IVLGAGL--------------------AELL---LVAAGDDVLVLERGRK
MAB_0580|M.abscessus_ATCC_1997 AVLGGTA--------------------DGVL---LAPVPDGWVLVDCAEA
Mflv_2434|M.gilvum_PYR-GCK HATGNAI--------------------GDTVELPLPYAGNAWVVWDRGGA
Mvan_4218|M.vanbaalenii_PYR-1 HATGNTI--------------------GDTVELPLPYAGNGWVVWDRGGA
MSMEG_4845|M.smegmatis_MC2_155 ETIGGLP--------------------GGTP--PMPYAGGGWVVWERRDS
TH_2022|M.thermoresistible__bu ETIGALP--------------------GGTP--PLPYAGGTWVVWERTPT
MMAR_4749|M.marinum_M RAAGCPG--------------------GGTV--PLPFAGGSWVIWSRGDQ
MAV_0900|M.avium_104 CAAGEAP--------------------GGTL--ALPFTGGSWVLWERRDS
MUL_4129|M.ulcerans_Agy99 STEGQLSRW------------------TR-------FSAHRVATMDPTR-
MLBr_00737|M.leprae_Br4923 KADGDDWILNGFKCWITNGGKSTWYTVMAVTDPDKGANGISAFIVHKDDE
. *
Mb3087c|M.bovis_AF2122/97 GVSVDVPEN--------FDPTRRSGRVRLDNVRVTTDDILLGAYESALAR
Rv3061c|M.tuberculosis_H37Rv GVSVDVPEN--------FDPTRRSGRVRLDNVRVTTDDILLGAYESALAR
MAB_0580|M.abscessus_ATCC_1997 GVAVEAKKA--------TDFSRPWVTVTLHGAAVRPVG-LPAAVIADLS-
Mflv_2434|M.gilvum_PYR-GCK SEATGE------------DRGPESLDPTLGGLPLRREEEGYPIR---VAE
Mvan_4218|M.vanbaalenii_PYR-1 SEATGD------------DRSPESLDPTLGGLPLRREEEGYPIR---LAE
MSMEG_4845|M.smegmatis_MC2_155 TDSA------------------DSANPTLGGLPLRKVPDGQLLR---ISE
TH_2022|M.thermoresistible__bu TEG------------------------SLGGLPLRRVPDGESMR---LGE
MMAR_4749|M.marinum_M AGS-----------------------VLDGELPILRVEPADPLPPAALAA
MAV_0900|M.avium_104 CDS-----------------------AIDELLPIHRVPQGDPLPAAALHA
MUL_4129|M.ulcerans_Agy99 ---------------------------RLAQLRAEETAFLGENP-GLADA
MLBr_00737|M.leprae_Br4923 GFSIGPKEKKLGIKGSPTTELYFDKCRIPGDRIIGEPGTGFKTALATLDH
Mb3087c|M.bovis_AF2122/97 ARTLLAAEAVGGAADCVDSAVAYAKVRQQFGRTIATFQAVKHHCANMLVA
Rv3061c|M.tuberculosis_H37Rv ARTLLAAEAVGGAADCVDSAVAYAKVRQQFGRTIATFQAVKHHCANMLVA
MAB_0580|M.abscessus_ATCC_1997 -VVTLSAEAVGVARWALQTAVEYAKVREQFGKQIGSFQAIKHMCAEMLCR
Mflv_2434|M.gilvum_PYR-GCK ARVAVGWWLVGSARAMLALARQHALDRVQFGKPIAGFQAVRHRLAETLVA
Mvan_4218|M.vanbaalenii_PYR-1 ARVAVGWWLVGSARAMLSLARQHALDRVQFGKPIASFQAVRHRLAETLVA
MSMEG_4845|M.smegmatis_MC2_155 ARRALGWWLVGSARAMLALARQHAMDRVQFGAPIATFQAVRHRLAETLVA
TH_2022|M.thermoresistible__bu ARKAVGWWLVGSARAMLTLARQHALDRVQFGKPIASFQAVRHRLAETLVA
MMAR_4749|M.marinum_M GRSAVGWWLAGASRAMLELARRHALDRNQFGHPIAAFQAVRHRLAEALVA
MAV_0900|M.avium_104 GWRALGWWLVGTSRAMLTLGRRHAVDRVQFGRHISSFQAIRHRLAEALVA
MUL_4129|M.ulcerans_Agy99 AGILLAAEQIGAAERCLELTVEYAKSRVQFGRPIGSFQALKHRMADLYVE
MLBr_00737|M.leprae_Br4923 TRPTIGAQAVGIAQGALDAAIVYTKDRKQFGESISTFQSIQFMLADMAMK
:. * : : :: * *** *. **:::. *:
Mb3087c|M.bovis_AF2122/97 AESAIAAVWDAARAAAE------DEEQFRLAAAVAAALAFPAYARNAELN
Rv3061c|M.tuberculosis_H37Rv AESAIAAVWDAARAAAE------DEEQFRLAAAVAAALAFPAYARNAELN
MAB_0580|M.abscessus_ATCC_1997 VEQADVAVWDAAGCAQDVLANKGDSQQLSLAAAVAAAVAVDAAVANTKDC
Mflv_2434|M.gilvum_PYR-GCK IEGAEATLSLPSADNPD------------LSSLLAKAAAGKAALTAAKNC
Mvan_4218|M.vanbaalenii_PYR-1 IEGAEATLSLPGADNPD------------LTALLAKAAAGKAALTAAMHC
MSMEG_4845|M.smegmatis_MC2_155 IEGAEATLSQPNADNVD------------LTSLLAKAAAGKAALTAARHC
TH_2022|M.thermoresistible__bu IEGAEAALRLPGTQSPD------------LTAMLAKAAAGKAALTAARNC
MMAR_4749|M.marinum_M IEGAEATLRAATDQPDE------------LACLLAKAAAGQAALTTARHC
MAV_0900|M.avium_104 VEGAEATLQAAAECDEDP----------GLAALLAKAAAGQAALTTARHC
MUL_4129|M.ulcerans_Agy99 VAAARAVVTEACTAPTP------------TSAATARLAACEALCAVAAEG
MLBr_00737|M.leprae_Br4923 VEAARLIVYAAAARAERG------EPDLGFISAASKCFASDIAMEVTTDA
* : . . : * :
Mb3087c|M.bovis_AF2122/97 IQVHGGIGFTWEHDAHLHLRRALVTVGLFGGDAPVR-DVFERTAAGVTRA
Rv3061c|M.tuberculosis_H37Rv IQVHGGIGFTWEHDAHLHLRRALVTVGLFGGDAPVR-DVFERTAAGVTRA
MAB_0580|M.abscessus_ATCC_1997 IQILGGIGFTWEHDAHLYLRRAYALQSFVGKPAVWRRKAAALTIGGIRRS
Mflv_2434|M.gilvum_PYR-GCK QQVLGGIGFTEEHGLQHHVKRTLVLDGLLG--------------------
Mvan_4218|M.vanbaalenii_PYR-1 QQVLGGIGFTEEHHLHRHVKRALVLDGLLG--------------------
MSMEG_4845|M.smegmatis_MC2_155 QQVLGGIGFTAEHELHTHVERVLVLDGLLG--------------------
TH_2022|M.thermoresistible__bu QQVLGGIGFTAEHDLHRHVQRVLVLDGLLG--------------------
MMAR_4749|M.marinum_M QQVLAGMGFTAEHQLHHHVKRSLVLDGLLG--------------------
MAV_0900|M.avium_104 QQVLGGIGFTAEHPLHHHIKRSLILDGLLG--------------------
MUL_4129|M.ulcerans_Agy99 IQLHGGIAITWEHDMHLYFKRAHGSTHLLAS-------------------
MLBr_00737|M.leprae_Br4923 VQLFGGAGYTSDFPVERFMRDAKITQIYEG--------------------
*: .* . * :. . ... .
Mb3087c|M.bovis_AF2122/97 ISLDLPAQAEELRARIRSDAAEIAALEKDAQRDKLIETGYVMPHWPRPWG
Rv3061c|M.tuberculosis_H37Rv ISLDLPAQAEELRARIRSDAAEIAALEKDAQRDKLIETGYVMPHWPRPWG
MAB_0580|M.abscessus_ATCC_1997 LTIDL-GEVESQRAEVAGQVAEIASAPKAEHQVRLAEAGFLAPHWPAPYG
Mflv_2434|M.gilvum_PYR-GCK -------SSRELTRRAGAGLRARGSVPRLAQL------------------
Mvan_4218|M.vanbaalenii_PYR-1 -------SSRELTRRAGAGLRARGSAPRLAQL------------------
MSMEG_4845|M.smegmatis_MC2_155 -------NARELTRKAGSGMRARGTAPRMAQV------------------
TH_2022|M.thermoresistible__bu -------SARELTLRVGAGLRARGSAPRLAYL------------------
MMAR_4749|M.marinum_M -------SSRELTREAGAVLRTKGFAPRLAQL------------------
MAV_0900|M.avium_104 -------SARELTRQAGKTLVTTGSAPRLAQL------------------
MUL_4129|M.ulcerans_Agy99 -------PPELLRRLESEALGAGPSIP-----------------------
MLBr_00737|M.leprae_Br4923 ------------TNQIQRVVMSRALLR-----------------------
Mb3087c|M.bovis_AF2122/97 RAAGAVEQLVIEEEFSAAGIERPDYSITGWVILTLIQHGTPWQIERFVEK
Rv3061c|M.tuberculosis_H37Rv RAAGAVEQLVIEEEFSAAGIERPDYSITGWVILTLIQHGTPWQIERFVEK
MAB_0580|M.abscessus_ATCC_1997 LGAGAAQQLLIDQELHAAGVNRPDLVIGWWAAPTILEHGTPEQIAQFVAP
Mflv_2434|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4218|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_4845|M.smegmatis_MC2_155 --------------------------------------------------
TH_2022|M.thermoresistible__bu --------------------------------------------------
MMAR_4749|M.marinum_M --------------------------------------------------
MAV_0900|M.avium_104 --------------------------------------------------
MUL_4129|M.ulcerans_Agy99 --------------------------------------------------
MLBr_00737|M.leprae_Br4923 --------------------------------------------------
Mb3087c|M.bovis_AF2122/97 ALRQQEIWCQLFSEPDAGSDAASVKTRATRVEGGWKINGQKVWTSGAQYC
Rv3061c|M.tuberculosis_H37Rv ALRQQEIWCQLFSEPDAGSDAASVKTRATRVEGGWKINGQKVWTSGAQYC
MAB_0580|M.abscessus_ATCC_1997 TLRGEIEWCQLFSEPGAGSDLAALRTKATRVDGGWKLDGQKVWNSKAQIA
Mflv_2434|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4218|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_4845|M.smegmatis_MC2_155 --------------------------------------------------
TH_2022|M.thermoresistible__bu --------------------------------------------------
MMAR_4749|M.marinum_M --------------------------------------------------
MAV_0900|M.avium_104 --------------------------------------------------
MUL_4129|M.ulcerans_Agy99 --------------------------------------------------
MLBr_00737|M.leprae_Br4923 --------------------------------------------------
Mb3087c|M.bovis_AF2122/97 ARGLATVRTDPDAPKHAGITTVIIDMLAPGVEVRPLRQITGDSEFNEVFF
Rv3061c|M.tuberculosis_H37Rv ARGLATVRTDPDAPKHAGITTVIIDMLAPGVEVRPLRQITGDSEFNEVFF
MAB_0580|M.abscessus_ATCC_1997 DWAICLARTNPDVPKHKGITYFLLDMKTPGITVRPLREITGEEMFNEVFL
Mflv_2434|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4218|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_4845|M.smegmatis_MC2_155 --------------------------------------------------
TH_2022|M.thermoresistible__bu --------------------------------------------------
MMAR_4749|M.marinum_M --------------------------------------------------
MAV_0900|M.avium_104 --------------------------------------------------
MUL_4129|M.ulcerans_Agy99 --------------------------------------------------
MLBr_00737|M.leprae_Br4923 --------------------------------------------------
Mb3087c|M.bovis_AF2122/97 NDVFVPDEDVVGAPNSGWTVARATLGNERVSIGGSGSYYEAMAAKLVQLV
Rv3061c|M.tuberculosis_H37Rv NDVFVPDEDVVGAPNSGWTVARATLGNERVSIGGSGSYYEAMAAKLVQLV
MAB_0580|M.abscessus_ATCC_1997 DGVIVPDENVVGSVDDGWRLARTTLANERVAMAGGGTLDEAMESLLALIG
Mflv_2434|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4218|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_4845|M.smegmatis_MC2_155 --------------------------------------------------
TH_2022|M.thermoresistible__bu --------------------------------------------------
MMAR_4749|M.marinum_M --------------------------------------------------
MAV_0900|M.avium_104 --------------------------------------------------
MUL_4129|M.ulcerans_Agy99 --------------------------------------------------
MLBr_00737|M.leprae_Br4923 --------------------------------------------------
Mb3087c|M.bovis_AF2122/97 QRRSDAFAGAPIRVGAFLAEDHALRLLNLRRAARSVEGAGPGPEGNITKL
Rv3061c|M.tuberculosis_H37Rv QRRSDAFAGAPIRVGAFLAEDHALRLLNLRRAARSVEGAGPGPEGNITKL
MAB_0580|M.abscessus_ATCC_1997 DTELDAAQLD--TLGAFVCSAQTGALLDLRTALRAIGGQDPGAASSVRKL
Mflv_2434|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4218|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_4845|M.smegmatis_MC2_155 --------------------------------------------------
TH_2022|M.thermoresistible__bu --------------------------------------------------
MMAR_4749|M.marinum_M --------------------------------------------------
MAV_0900|M.avium_104 --------------------------------------------------
MUL_4129|M.ulcerans_Agy99 --------------------------------------------------
MLBr_00737|M.leprae_Br4923 --------------------------------------------------
Mb3087c|M.bovis_AF2122/97 KVAEHMIEGAAIAAALWGPEIALLDGPGRVIGR---TVMGARGMAIAGGT
Rv3061c|M.tuberculosis_H37Rv KVAEHMIEGAAIAAALWGPEIALLDGPGRVIGR---TVMGARGMAIAGGT
MAB_0580|M.abscessus_ATCC_1997 VGVRHRQG-------LSEHILDYVDTHGAVESREMWLFMRDRCLSIAGGT
Mflv_2434|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4218|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_4845|M.smegmatis_MC2_155 --------------------------------------------------
TH_2022|M.thermoresistible__bu --------------------------------------------------
MMAR_4749|M.marinum_M --------------------------------------------------
MAV_0900|M.avium_104 --------------------------------------------------
MUL_4129|M.ulcerans_Agy99 --------------------------------------------------
MLBr_00737|M.leprae_Br4923 --------------------------------------------------
Mb3087c|M.bovis_AF2122/97 SEVTRNQIAERILGMPRDPLIS
Rv3061c|M.tuberculosis_H37Rv SEVTRNQIAERILGMPRDPLIS
MAB_0580|M.abscessus_ATCC_1997 TQILLSVAGERLLGLPR-----
Mflv_2434|M.gilvum_PYR-GCK ----------------------
Mvan_4218|M.vanbaalenii_PYR-1 ----------------------
MSMEG_4845|M.smegmatis_MC2_155 ----------------------
TH_2022|M.thermoresistible__bu ----------------------
MMAR_4749|M.marinum_M ----------------------
MAV_0900|M.avium_104 ----------------------
MUL_4129|M.ulcerans_Agy99 ----------------------
MLBr_00737|M.leprae_Br4923 ----------------------