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APSADAESLRLLTDSLRTTMSAASGAKLDAALTDVGWRDMLDEMPDIAIPLVFTLLGETGAHAPLLNDVL LCAAGEAPGGTLALPFTGGSWVLWERRDSCDSAIDELLPIHRVPQGDPLPAAALHAGWRALGWWLVGTSR AMLTLGRRHAVDRVQFGRHISSFQAIRHRLAEALVAVEGAEATLQAAAECDEDPGLAALLAKAAAGQAAL TTARHCQQVLGGIGFTAEHPLHHHIKRSLILDGLLGSARELTRQAGKTLVTTGSAPRLAQL*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_0900 | - | - | 100% (272) | putative acyl-CoA dehydrogenase |
| M. avium 104 | MAV_1631 | - | 2e-19 | 41.26% (143) | putative acyl-CoA dehydrogenase |
| M. avium 104 | MAV_2593 | - | 1e-18 | 44.44% (126) | acyl-CoA dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3593 | fadE32 | 3e-16 | 39.57% (139) | acyl-CoA dehydrogenase FADE32 |
| M. gilvum PYR-GCK | Mflv_2434 | - | 4e-83 | 57.50% (280) | acyl-CoA dehydrogenase domain-containing protein |
| M. tuberculosis H37Rv | Rv3563 | fadE32 | 4e-16 | 39.57% (139) | acyl-CoA dehydrogenase FADE32 |
| M. leprae Br4923 | MLBr_00737 | fadE25 | 2e-09 | 30.70% (114) | putative acyl-CoA dehydrogenase |
| M. abscessus ATCC 19977 | MAB_0580 | - | 2e-17 | 39.23% (130) | acyl-CoA dehydrogenase FadE |
| M. marinum M | MMAR_4749 | - | 2e-98 | 68.15% (270) | acyl-CoA dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_4845 | - | 2e-90 | 62.50% (272) | putative acyl-CoA dehydrogenase |
| M. thermoresistible (build 8) | TH_2022 | - | 1e-89 | 62.17% (267) | putative acyl-CoA dehydrogenase |
| M. ulcerans Agy99 | MUL_1194 | fadE6 | 3e-16 | 31.23% (285) | acyl-CoA dehydrogenase FadE6 |
| M. vanbaalenii PYR-1 | Mvan_4218 | - | 6e-85 | 57.54% (285) | acyl-CoA dehydrogenase domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3593|M.bovis_AF2122/97 ----MTMEFALNEQQRDFAASIDAALGAADLPGVVRAWAAGDVAPG--RK
Rv3563|M.tuberculosis_H37Rv ----MTMEFALNEQQRDFAASIDAALGAADLPGVVRAWAAGDVAPG--RK
MAV_0900|M.avium_104 ---------------------MAPSADAESLRLLTDSLRTTMS-------
MMAR_4749|M.marinum_M ----------------------MDLTDPESLRLLADSLKTAVTQNP----
MSMEG_4845|M.smegmatis_MC2_155 -------------------------MDAESLGLLEETLRKTML-------
TH_2022|M.thermoresistible__bu --------------VSVPDISGRSDLDAESLELLEDGLRKTML-------
Mflv_2434|M.gilvum_PYR-GCK ---------------MTVAIKDDAAMDEASLGMLEASLRKTMS-------
Mvan_4218|M.vanbaalenii_PYR-1 ---------------------MAPGMDEASLDMLEASLRKTML-------
MAB_0580|M.abscessus_ATCC_1997 --MSVPSGLRASGSSEVQEAARDAVRQWARSAAVIESVRKMESEPDGWGP
MUL_1194|M.ulcerans_Agy99 ----MPIAITPEHR-DLADSVRSLVARVAPSEVLHAAMETPVENPP---P
MLBr_00737|M.leprae_Br4923 MVGWSGNPLFDLFKLPEEHNELRATIRALAEKEIAPHAADVDQRARFPEE
:
Mb3593|M.bovis_AF2122/97 VWQQLANLGVTALGVAEKFDGLGASPVDLVVALERLG-------------
Rv3563|M.tuberculosis_H37Rv VWQQLANLGVTALGVAEKFDGLGASPVDLVVALERLG-------------
MAV_0900|M.avium_104 -----------------AASGA-----KLDAALTDVG-------------
MMAR_4749|M.marinum_M -----------------SPSGA-----GLDAALQALG-------------
MSMEG_4845|M.smegmatis_MC2_155 -----------------SASGA-----KLDAALAELG-------------
TH_2022|M.thermoresistible__bu -----------------SASGA-----ELDAALGELG-------------
Mflv_2434|M.gilvum_PYR-GCK -----------------SASGP-----KLDAALTELG-------------
Mvan_4218|M.vanbaalenii_PYR-1 -----------------SSSGP-----ELDAALTEMG-------------
MAB_0580|M.abscessus_ATCC_1997 AYVGLAELGIFGVAVPEAAGGSGAGFDDMIAMVDEAA-------------
MUL_1194|M.ulcerans_Agy99 YWQAAAEQGLQGVHLAESVGGQGYGILQLAVALAEFG-------------
MLBr_00737|M.leprae_Br4923 ALAALNASGFNAIHVPEEYGGQGADSVAACIVIEEVARVDASASLIPAVN
.* : .
Mb3593|M.bovis_AF2122/97 ----------------RWCVPGPVTESIAVAPILLAHDDRAERSHG----
Rv3563|M.tuberculosis_H37Rv ----------------RWCVPGPVTESIAVAPILLAHDDQAERSHG----
MAV_0900|M.avium_104 ----------------WRDMLDEMPDIAIPLVFTLLGETGAHAP------
MMAR_4749|M.marinum_M ----------------WLDMLDEIPGTAVPLVFAMLGENGVHAP------
MSMEG_4845|M.smegmatis_MC2_155 ----------------WAEMLSDMPEVAMPLVFRLLGETGSHAS------
TH_2022|M.thermoresistible__bu ----------------WAQMLEDMPDTAIPLVFRLLGETGSHAS------
Mflv_2434|M.gilvum_PYR-GCK ----------------WADMLTEAPELAIPLYFRLLGETGSHAS------
Mvan_4218|M.vanbaalenii_PYR-1 ----------------WADMLSEVPELAVPLVFRLLGETGSHAS------
MAB_0580|M.abscessus_ATCC_1997 ----------------ASLVPGPVATSALVAVVLAADGHEELVP-PLAAG
MUL_1194|M.ulcerans_Agy99 ----------------YGAVPGPFVPSAIASALISVHDPEAKVLSELASG
MLBr_00737|M.leprae_Br4923 KLGTMGLILRGSEELKKQVLPSLAAEGAMASYALSEREAGSDAASMRTRA
:
Mb3593|M.bovis_AF2122/97 -------------------------LASGELIATVAMPPRVPR--AVDAD
Rv3563|M.tuberculosis_H37Rv -------------------------LASGELIATVAMPPRVPR--AVDAD
MAV_0900|M.avium_104 -------------------------LLNDVLLCAAGEAPGGTL--ALPFT
MMAR_4749|M.marinum_M -------------------------LVNDVVARAAGCPGGGTV--PLPFA
MSMEG_4845|M.smegmatis_MC2_155 -------------------------VLNDVLLETIGGLPGGTP--PMPYA
TH_2022|M.thermoresistible__bu -------------------------VLNDIVLETIGALPGGTP--PLPYA
Mflv_2434|M.gilvum_PYR-GCK -------------------------ILVDVVLHATGNAIGDTVELPLPYA
Mvan_4218|M.vanbaalenii_PYR-1 -------------------------VLVDVVLHATGNTIGDTVELPLPYA
MAB_0580|M.abscessus_ATCC_1997 ERTAGLALTG-----NLAIADG---LASGVLPAVLGGTADGVLLAPVP--
MUL_1194|M.ulcerans_Agy99 AAISAYALDSGLTATRQGLEDGGVLVIRGEVRAVPAAAQASTLVLPVAID
MLBr_00737|M.leprae_Br4923 KADGDDWILNG----FKCWITNGGKSTWYTVMAVTDPDKGANGISAFIVH
: . ..
Mb3593|M.bovis_AF2122/97 TAGLVLLAGDGSVTEGTPGDCHRSVDPSRRLYEVAASGQAWRAPKDVVAR
Rv3563|M.tuberculosis_H37Rv TAGLVLLAGDGSVTEGTPGDCHRSVDPSRRLYEVAASGQAWRAPKDVVAR
MAV_0900|M.avium_104 GGSWVLWERRDSCDS-----------AIDELLPIHRVPQ----GDPLPAA
MMAR_4749|M.marinum_M GGSWVIWSRGDQAGS-----------VLDGELPILRVEP----ADPLPPA
MSMEG_4845|M.smegmatis_MC2_155 GGGWVVWERRDSTDSA------DSANPTLGGLPLRKVPD----GQLLR--
TH_2022|M.thermoresistible__bu GGTWVVWERTPTTEG------------SLGGLPLRRVPD----GESMR--
Mflv_2434|M.gilvum_PYR-GCK GNAWVVWDRGGASEATGEDRGPESLDPTLGGLPLRREEE----GYPIR--
Mvan_4218|M.vanbaalenii_PYR-1 GNGWVVWDRGGASEATGDDRSPESLDPTLGGLPLRREEE----GYPIR--
MAB_0580|M.abscessus_ATCC_1997 DGWVLVDCAEAGVAVEAKKATDFSRPWVTVTLHGAAVRP----VGLPAAV
MUL_1194|M.ulcerans_Agy99 SGGEWVVLRAEQLEIEPVRSLDPLRPVAHVRANAVEVGDDVVLSNLSMTT
MLBr_00737|M.leprae_Br4923 KDDEGFSIGPKEKKLGIKGSPTTELYFDKCRIPGDRIIGEPGTGFKTALA
.
Mb3593|M.bovis_AF2122/97 AYEFGALATAAQLVGAGQALLEAAVNYAKQRTQFGRAIGSYQAIKHKLAD
Rv3563|M.tuberculosis_H37Rv AYEFGALATAAQLVGAGQALLEAAVNYAKQRTQFGRAIGSYQAIKHKLAD
MAV_0900|M.avium_104 ALHAGWRALGWWLVGTSRAMLTLGRRHAVDRVQFGRHISSFQAIRHRLAE
MMAR_4749|M.marinum_M ALAAGRSAVGWWLAGASRAMLELARRHALDRNQFGHPIAAFQAVRHRLAE
MSMEG_4845|M.smegmatis_MC2_155 -ISEARRALGWWLVGSARAMLALARQHAMDRVQFGAPIATFQAVRHRLAE
TH_2022|M.thermoresistible__bu -LGEARKAVGWWLVGSARAMLTLARQHALDRVQFGKPIASFQAVRHRLAE
Mflv_2434|M.gilvum_PYR-GCK -VAEARVAVGWWLVGSARAMLALARQHALDRVQFGKPIAGFQAVRHRLAE
Mvan_4218|M.vanbaalenii_PYR-1 -LAEARVAVGWWLVGSARAMLSLARQHALDRVQFGKPIASFQAVRHRLAE
MAB_0580|M.abscessus_ATCC_1997 IADLSVVTLSAEAVGVARWALQTAVEYAKVREQFGKQIGSFQAIKHMCAE
MUL_1194|M.ulcerans_Agy99 AHALMSTLLSAEAVGVARWATDAASGYAKIREQFGRPIGQFQAIKHKCAE
MLBr_00737|M.leprae_Br4923 TLDHTRPTIGAQAVGIAQGALDAAIVYTKDRKQFGESISTFQSIQFMLAD
. .* .: . :: * *** *. :*:::. *:
Mb3593|M.bovis_AF2122/97 VHIAIELACPLVYGAAVSLEP------------RDVSAAKAAASEAALLA
Rv3563|M.tuberculosis_H37Rv VHIAIELACPLVYGAAVSLEP------------RDVSAAKAAASEAALLA
MAV_0900|M.avium_104 ALVAVEGAEATLQAAAECDEDP----------GLAALLAKAAAGQAALTT
MMAR_4749|M.marinum_M ALVAIEGAEATLRAATDQPDE------------LACLLAKAAAGQAALTT
MSMEG_4845|M.smegmatis_MC2_155 TLVAIEGAEATLSQPNADNVD------------LTSLLAKAAAGKAALTA
TH_2022|M.thermoresistible__bu TLVAIEGAEAALRLPGTQSPD------------LTAMLAKAAAGKAALTA
Mflv_2434|M.gilvum_PYR-GCK TLVAIEGAEATLSLPSADNPD------------LSSLLAKAAAGKAALTA
Mvan_4218|M.vanbaalenii_PYR-1 TLVAIEGAEATLSLPGADNPD------------LTALLAKAAAGKAALTA
MAB_0580|M.abscessus_ATCC_1997 MLCRVEQADVAVWDAAGCAQDVLANKGDSQQLSLAAAVAAAVAVDAAVAN
MUL_1194|M.ulcerans_Agy99 MIADTERATAAVWDAARALDE------DSPHIEFAAAVAATLAPAAAQRC
MLBr_00737|M.leprae_Br4923 MAMKVEAARLIVYAAAARAERG------EPDLGFISAASKCFASDIAMEV
* * : . : * *
Mb3593|M.bovis_AF2122/97 ARSALQTHGAIGFTCEHDLSLWLLRVQALHSAWGTPQEHRRRVLEAL---
Rv3563|M.tuberculosis_H37Rv ARWALQTHGAIGFTCEHDLSLWLLRVQALHSAWGTPQEHRRRVLEAL---
MAV_0900|M.avium_104 ARHCQQVLGGIGFTAEHPLHHHIKRSLILDGLLGSARELTRQAGKTLVTT
MMAR_4749|M.marinum_M ARHCQQVLAGMGFTAEHQLHHHVKRSLVLDGLLGSSRELTREAGAVLRTK
MSMEG_4845|M.smegmatis_MC2_155 ARHCQQVLGGIGFTAEHELHTHVERVLVLDGLLGNARELTRKAGSGMRAR
TH_2022|M.thermoresistible__bu ARNCQQVLGGIGFTAEHDLHRHVQRVLVLDGLLGSARELTLRVGAGLRAR
Mflv_2434|M.gilvum_PYR-GCK AKNCQQVLGGIGFTEEHGLQHHVKRTLVLDGLLGSSRELTRRAGAGLRAR
Mvan_4218|M.vanbaalenii_PYR-1 AMHCQQVLGGIGFTEEHHLHRHVKRALVLDGLLGSSRELTRRAGAGLRAR
MAB_0580|M.abscessus_ATCC_1997 TKDCIQILGGIGFTWEHDAHLYLRRAYALQSFVGKPAVWRRKAAALTIGG
MUL_1194|M.ulcerans_Agy99 TQDCIQVHGGIGYTWEHDTNVYYRRALMLAACFGRSVEYPQRVVDTATTT
MLBr_00737|M.leprae_Br4923 TTDAVQLFGGAGYTSDFPVERFMRDAKITQIYEGTNQIQRVVMSRALLR-
: . * .. *:* :. *
Mb3593|M.bovis_AF2122/97 --------------------------------------------------
Rv3563|M.tuberculosis_H37Rv --------------------------------------------------
MAV_0900|M.avium_104 GSAPRLAQL-----------------------------------------
MMAR_4749|M.marinum_M GFAPRLAQL-----------------------------------------
MSMEG_4845|M.smegmatis_MC2_155 GTAPRMAQV-----------------------------------------
TH_2022|M.thermoresistible__bu GSAPRLAYL-----------------------------------------
Mflv_2434|M.gilvum_PYR-GCK GSVPRLAQL-----------------------------------------
Mvan_4218|M.vanbaalenii_PYR-1 GSAPRLAQL-----------------------------------------
MAB_0580|M.abscessus_ATCC_1997 IRRSLTIDLG-EVESQRAEVAGQVAEIASAPKAEHQVRLAEAGFLAPHWP
MUL_1194|M.ulcerans_Agy99 GMRAVDIDLDPDTEKLRAEIRADVEALKRMDREPRKAAIAEGGWVLPYLP
MLBr_00737|M.leprae_Br4923 --------------------------------------------------
Mb3593|M.bovis_AF2122/97 --------------------------------------------------
Rv3563|M.tuberculosis_H37Rv --------------------------------------------------
MAV_0900|M.avium_104 --------------------------------------------------
MMAR_4749|M.marinum_M --------------------------------------------------
MSMEG_4845|M.smegmatis_MC2_155 --------------------------------------------------
TH_2022|M.thermoresistible__bu --------------------------------------------------
Mflv_2434|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4218|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_0580|M.abscessus_ATCC_1997 APYGLGAGAAQQLLIDQELHAAGVNRPDLVIGWWAAPTILEHGTPEQIAQ
MUL_1194|M.ulcerans_Agy99 KPWGRASSPVEQVIIAQEFSTGRVKRPQVGIAAWILPSIVAFGTEEQKQR
MLBr_00737|M.leprae_Br4923 --------------------------------------------------
Mb3593|M.bovis_AF2122/97 --------------------------------------------------
Rv3563|M.tuberculosis_H37Rv --------------------------------------------------
MAV_0900|M.avium_104 --------------------------------------------------
MMAR_4749|M.marinum_M --------------------------------------------------
MSMEG_4845|M.smegmatis_MC2_155 --------------------------------------------------
TH_2022|M.thermoresistible__bu --------------------------------------------------
Mflv_2434|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4218|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_0580|M.abscessus_ATCC_1997 FVAPTLRGEIEWCQLFSEPGAGSDLAALRTKATRVDGGWKLDGQKVWNSK
MUL_1194|M.ulcerans_Agy99 FLPPTFRGEMIWCQLFSEPGAGSDLAGLSTKATRVDGGWRITGQKIWTTA
MLBr_00737|M.leprae_Br4923 --------------------------------------------------
Mb3593|M.bovis_AF2122/97 --------------------------------------------------
Rv3563|M.tuberculosis_H37Rv --------------------------------------------------
MAV_0900|M.avium_104 --------------------------------------------------
MMAR_4749|M.marinum_M --------------------------------------------------
MSMEG_4845|M.smegmatis_MC2_155 --------------------------------------------------
TH_2022|M.thermoresistible__bu --------------------------------------------------
Mflv_2434|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4218|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_0580|M.abscessus_ATCC_1997 AQIADWAICLARTNPDVPKHKGITYFLLDMKTPGITVRPLREITGEEMFN
MUL_1194|M.ulcerans_Agy99 AQYSQWGALLARTDPNAPKHNGITYFLLDMKTEGVQVKPLRDLTGHEMFN
MLBr_00737|M.leprae_Br4923 --------------------------------------------------
Mb3593|M.bovis_AF2122/97 --------------------------------------------------
Rv3563|M.tuberculosis_H37Rv --------------------------------------------------
MAV_0900|M.avium_104 --------------------------------------------------
MMAR_4749|M.marinum_M --------------------------------------------------
MSMEG_4845|M.smegmatis_MC2_155 --------------------------------------------------
TH_2022|M.thermoresistible__bu --------------------------------------------------
Mflv_2434|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4218|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_0580|M.abscessus_ATCC_1997 EVFLDGVIVPDENVVGSVDDGWRLARTTLANERVAMAGGG-TLDEAMESL
MUL_1194|M.ulcerans_Agy99 TVYIDDVFVPDECVLGEVNRGWEVSRNTLTAERVSIGSTDNNFLATLPQF
MLBr_00737|M.leprae_Br4923 --------------------------------------------------
Mb3593|M.bovis_AF2122/97 --------------------------------------------------
Rv3563|M.tuberculosis_H37Rv --------------------------------------------------
MAV_0900|M.avium_104 --------------------------------------------------
MMAR_4749|M.marinum_M --------------------------------------------------
MSMEG_4845|M.smegmatis_MC2_155 --------------------------------------------------
TH_2022|M.thermoresistible__bu --------------------------------------------------
Mflv_2434|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4218|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_0580|M.abscessus_ATCC_1997 LALIGDTELDAAQLDTLGAFVCSAQTGALLDLRTALRAIGGQDPGAASSV
MUL_1194|M.ulcerans_Agy99 VEFVRDGQFDQVAQHRAGHLIAEGHAAKVLNLRSTLLTLSGGDAMPSAAI
MLBr_00737|M.leprae_Br4923 --------------------------------------------------
Mb3593|M.bovis_AF2122/97 --------------------------------------------------
Rv3563|M.tuberculosis_H37Rv --------------------------------------------------
MAV_0900|M.avium_104 --------------------------------------------------
MMAR_4749|M.marinum_M --------------------------------------------------
MSMEG_4845|M.smegmatis_MC2_155 --------------------------------------------------
TH_2022|M.thermoresistible__bu --------------------------------------------------
Mflv_2434|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4218|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_0580|M.abscessus_ATCC_1997 RKLVGVRHRQGLSEHILDYVDTHGAVESREMWL------FMRDRCLSIAG
MUL_1194|M.ulcerans_Agy99 SKLLSMRTGQGYAEFAVSSFGTDAAIGDTDELAGKWGEYLLSSRATTIYG
MLBr_00737|M.leprae_Br4923 --------------------------------------------------
Mb3593|M.bovis_AF2122/97 ---------------------
Rv3563|M.tuberculosis_H37Rv ---------------------
MAV_0900|M.avium_104 ---------------------
MMAR_4749|M.marinum_M ---------------------
MSMEG_4845|M.smegmatis_MC2_155 ---------------------
TH_2022|M.thermoresistible__bu ---------------------
Mflv_2434|M.gilvum_PYR-GCK ---------------------
Mvan_4218|M.vanbaalenii_PYR-1 ---------------------
MAB_0580|M.abscessus_ATCC_1997 GTTQILLSVAGERLLGLPR--
MUL_1194|M.ulcerans_Agy99 GTSKVQLNIIAERLLGLPRDP
MLBr_00737|M.leprae_Br4923 ---------------------