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MAPGMDEASLDMLEASLRKTMLSSSGPELDAALTEMGWADMLSEVPELAVPLVFRLLGETGSHASVLVDV VLHATGNTIGDTVELPLPYAGNGWVVWDRGGASEATGDDRSPESLDPTLGGLPLRREEEGYPIRLAEARV AVGWWLVGSARAMLSLARQHALDRVQFGKPIASFQAVRHRLAETLVAIEGAEATLSLPGADNPDLTALLA KAAAGKAALTAAMHCQQVLGGIGFTEEHHLHRHVKRALVLDGLLGSSRELTRRAGAGLRARGSAPRLAQL
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_4218 | - | - | 100% (280) | acyl-CoA dehydrogenase domain-containing protein |
| M. vanbaalenii PYR-1 | Mvan_0393 | - | 7e-21 | 41.84% (141) | acyl-CoA dehydrogenase domain-containing protein |
| M. vanbaalenii PYR-1 | Mvan_5311 | - | 3e-17 | 31.12% (286) | acyl-CoA dehydrogenase domain-containing protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3087c | fadE22b | 8e-18 | 35.29% (204) | acyl-CoA dehydrogenase |
| M. gilvum PYR-GCK | Mflv_2434 | - | 1e-141 | 90.22% (276) | acyl-CoA dehydrogenase domain-containing protein |
| M. tuberculosis H37Rv | Rv3061c | fadE22 | 8e-18 | 35.29% (204) | acyl-CoA dehydrogenase FADE22 |
| M. leprae Br4923 | MLBr_00737 | fadE25 | 2e-08 | 28.93% (121) | putative acyl-CoA dehydrogenase |
| M. abscessus ATCC 19977 | MAB_0580 | - | 3e-17 | 32.39% (247) | acyl-CoA dehydrogenase FadE |
| M. marinum M | MMAR_4749 | - | 3e-81 | 60.99% (282) | acyl-CoA dehydrogenase |
| M. avium 104 | MAV_0900 | - | 5e-85 | 57.54% (285) | putative acyl-CoA dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_4845 | - | 1e-108 | 71.38% (276) | putative acyl-CoA dehydrogenase |
| M. thermoresistible (build 8) | TH_2022 | - | 1e-106 | 72.46% (276) | putative acyl-CoA dehydrogenase |
| M. ulcerans Agy99 | MUL_2893 | fadE18 | 2e-18 | 42.40% (125) | acyl-CoA dehydrogenase FadE18 |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3087c|M.bovis_AF2122/97 --------------------------------------------------
Rv3061c|M.tuberculosis_H37Rv ----------MGIALTDDHRELSGVARAFLTSQKVRWAARASLDAAGDAR
MAB_0580|M.abscessus_ATCC_1997 ----MSVPSGLRASGSSEVQEAARDAVRQWARSAAVIESVRKMESEPDGW
Mvan_4218|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_2434|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_4845|M.smegmatis_MC2_155 --------------------------------------------------
TH_2022|M.thermoresistible__bu --------------------------------------------------
MMAR_4749|M.marinum_M --------------------------------------------------
MAV_0900|M.avium_104 --------------------------------------------------
MUL_2893|M.ulcerans_Agy99 ----------MDFRYSTEQDDFRESLRGFLRDQAPPARVRQVAAVGGHDK
MLBr_00737|M.leprae_Br4923 MVGWSGNPLFDLFKLPEEHNELRATIRALAEKEIAPHAADVDQRARFPEE
Mb3087c|M.bovis_AF2122/97 --------------------------------------------------
Rv3061c|M.tuberculosis_H37Rv PPFWQNLAELGWLGLHIDERHGGSGYGLSELVVVIEELGRAVAPGLFVPT
MAB_0580|M.abscessus_ATCC_1997 GPAYVGLAELGIFGVAVPEAAGGSGAGFDDMIAMVDEAAASLVPGPVATS
Mvan_4218|M.vanbaalenii_PYR-1 ---------------------MAPGMDEASLDMLEASLRKTML---SSSG
Mflv_2434|M.gilvum_PYR-GCK ---------------MTVAIKDDAAMDEASLGMLEASLRKTMS---SASG
MSMEG_4845|M.smegmatis_MC2_155 -------------------------MDAESLGLLEETLRKTML---SASG
TH_2022|M.thermoresistible__bu --------------VSVPDISGRSDLDAESLELLEDGLRKTML---SASG
MMAR_4749|M.marinum_M ----------------------MDLTDPESLRLLADSLKTAVTQNPSPSG
MAV_0900|M.avium_104 ---------------------MAPSADAESLRLLTDSLRTTMS---AASG
MUL_2893|M.ulcerans_Agy99 KLWHRLCAELELPALHAPPEYGGAGGTLVETAIAFGELGRALTPVPFAAT
MLBr_00737|M.leprae_Br4923 ALAALNASGFN--AIHVPEEYGGQGADSVAACIVIEEVARVDASASLIPA
Mb3087c|M.bovis_AF2122/97 ---------------------------------MGLDSQVQVTDGVADG-
Rv3061c|M.tuberculosis_H37Rv V--IASAVVAKEGTDDQRARLLPALIDGTLTAGVGLDSQVQVTDGVADG-
MAB_0580|M.abscessus_ATCC_1997 A--LVAVVLAADG----HEELVPPLAAGERTAGLALTGNLAIADGLASG-
Mvan_4218|M.vanbaalenii_PYR-1 P--ELDAALTEMG----WADMLSEVPELAVPLVFRLLGETGSHASVLVD-
Mflv_2434|M.gilvum_PYR-GCK P--KLDAALTELG----WADMLTEAPELAIPLYFRLLGETGSHASILVD-
MSMEG_4845|M.smegmatis_MC2_155 A--KLDAALAELG----WAEMLSDMPEVAMPLVFRLLGETGSHASVLND-
TH_2022|M.thermoresistible__bu A--ELDAALGELG----WAQMLEDMPDTAIPLVFRLLGETGSHASVLND-
MMAR_4749|M.marinum_M A--GLDAALQALG----WLDMLDEIPGTAVPLVFAMLGENGVHAPLVND-
MAV_0900|M.avium_104 A--KLDAALTDVG----WRDMLDEMPDIAIPLVFTLLGETGAHAPLLND-
MUL_2893|M.ulcerans_Agy99 I--LAIEAILRMGDSEQRKGLLSGLLSGDRIGALAAAGPDLSVTSVRAGR
MLBr_00737|M.leprae_Br4923 VNKLGTMGLILRGSEELKKQVLPSLAAEGAMASYALSEREAGSDAASMRT
Mb3087c|M.bovis_AF2122/97 --------------EAGIVLGAGLAELL---LVAAGDD-----VLVLERG
Rv3061c|M.tuberculosis_H37Rv --------------EAGIVLGAGLAELL---LVAAGDD-----VLVLERG
MAB_0580|M.abscessus_ATCC_1997 --------------VLPAVLGGTADGVL---LAPVPDG-----WVLVDCA
Mvan_4218|M.vanbaalenii_PYR-1 --------------VVLHATGNTIGDTVELPLPYAGNG-----WVVWDRG
Mflv_2434|M.gilvum_PYR-GCK --------------VVLHATGNAIGDTVELPLPYAGNA-----WVVWDRG
MSMEG_4845|M.smegmatis_MC2_155 --------------VLLETIGGLPGGTP--PMPYAGGG-----WVVWERR
TH_2022|M.thermoresistible__bu --------------IVLETIGALPGGTP--PLPYAGGT-----WVVWERT
MMAR_4749|M.marinum_M --------------VVARAAGCPGGGTV--PLPFAGGS-----WVIWSRG
MAV_0900|M.avium_104 --------------VLLCAAGEAPGGTL--ALPFTGGS-----WVLWERR
MUL_2893|M.ulcerans_Agy99 RDGRP---------VLTGECAPVLHGHVADLFVVPAESDGAVILYVVDAA
MLBr_00737|M.leprae_Br4923 RAKADGDDWILNGFKCWITNGGKSTWYTVMAVTDPDKGANGISAFIVHKD
. . :
Mb3087c|M.bovis_AF2122/97 RKGVSVDVPE-------NFDPTRRSGRVRLDNVRVTTDDILLGAYES-AL
Rv3061c|M.tuberculosis_H37Rv RKGVSVDVPE-------NFDPTRRSGRVRLDNVRVTTDDILLGAYES-AL
MAB_0580|M.abscessus_ATCC_1997 EAGVAVEAKK-------ATDFSRPWVTVTLHGAAVRPVG-LPAAVIA-DL
Mvan_4218|M.vanbaalenii_PYR-1 GASEATGD-----------DRSPESLDPTLGGLPLRREEEGYPIR----L
Mflv_2434|M.gilvum_PYR-GCK GASEATGE-----------DRGPESLDPTLGGLPLRREEEGYPIR----V
MSMEG_4845|M.smegmatis_MC2_155 DSTDSA-----------------DSANPTLGGLPLRKVPDGQLLR----I
TH_2022|M.thermoresistible__bu PTTEG-----------------------SLGGLPLRRVPDGESMR----L
MMAR_4749|M.marinum_M DQAGS----------------------VLDGELPILRVEPADPLPPA-AL
MAV_0900|M.avium_104 DSCDS----------------------AIDELLPIHRVPQGDPLPAA-AL
MUL_2893|M.ulcerans_Agy99 APGVAVVGLP-------SFDITRPVAKLRLVRAPAEALAASSADEVARLL
MLBr_00737|M.leprae_Br4923 DEGFSIGPKEKKLGIKGSPTTELYFDKCRIPGDRIIGEPGTGFKTALATL
. :
Mb3087c|M.bovis_AF2122/97 ARARTLLAAEAVGGAADCVDSAVAYAKVRQQFGRTIATFQAVKHHCANML
Rv3061c|M.tuberculosis_H37Rv ARARTLLAAEAVGGAADCVDSAVAYAKVRQQFGRTIATFQAVKHHCANML
MAB_0580|M.abscessus_ATCC_1997 S--VVTLSAEAVGVARWALQTAVEYAKVREQFGKQIGSFQAIKHMCAEML
Mvan_4218|M.vanbaalenii_PYR-1 AEARVAVGWWLVGSARAMLSLARQHALDRVQFGKPIASFQAVRHRLAETL
Mflv_2434|M.gilvum_PYR-GCK AEARVAVGWWLVGSARAMLALARQHALDRVQFGKPIAGFQAVRHRLAETL
MSMEG_4845|M.smegmatis_MC2_155 SEARRALGWWLVGSARAMLALARQHAMDRVQFGAPIATFQAVRHRLAETL
TH_2022|M.thermoresistible__bu GEARKAVGWWLVGSARAMLTLARQHALDRVQFGKPIASFQAVRHRLAETL
MMAR_4749|M.marinum_M AAGRSAVGWWLAGASRAMLELARRHALDRNQFGHPIAAFQAVRHRLAEAL
MAV_0900|M.avium_104 HAGWRALGWWLVGTSRAMLTLGRRHAVDRVQFGRHISSFQAIRHRLAEAL
MUL_2893|M.ulcerans_Agy99 DVARVLLAAEMLGGAEACLDLAIEYACSRKQFDRPIGSFQAVKHRCADMM
MLBr_00737|M.leprae_Br4923 DHTRPTIGAQAVGIAQGALDAAIVYTKDRKQFGESISTFQSIQFMLADMA
:. * : : . :: * **. *. **:::. *:
Mb3087c|M.bovis_AF2122/97 VAAESAIAAVWDAARAAAE------DEEQFRLAAAVAAALAFPAYARNAE
Rv3061c|M.tuberculosis_H37Rv VAAESAIAAVWDAARAAAE------DEEQFRLAAAVAAALAFPAYARNAE
MAB_0580|M.abscessus_ATCC_1997 CRVEQADVAVWDAAGCAQDVLANKGDSQQLSLAAAVAAAVAVDAAVANTK
Mvan_4218|M.vanbaalenii_PYR-1 VAIEGAEATLSLPGADNPD------------LTALLAKAAAGKAALTAAM
Mflv_2434|M.gilvum_PYR-GCK VAIEGAEATLSLPSADNPD------------LSSLLAKAAAGKAALTAAK
MSMEG_4845|M.smegmatis_MC2_155 VAIEGAEATLSQPNADNVD------------LTSLLAKAAAGKAALTAAR
TH_2022|M.thermoresistible__bu VAIEGAEAALRLPGTQSPD------------LTAMLAKAAAGKAALTAAR
MMAR_4749|M.marinum_M VAIEGAEATLRAATDQPDE------------LACLLAKAAAGQAALTTAR
MAV_0900|M.avium_104 VAVEGAEATLQAAAECDEDP----------GLAALLAKAAAGQAALTTAR
MUL_2893|M.ulcerans_Agy99 IEIDATRAAVMFAQLCAAGG-------DELHATAPLAKAQAAGTYVLCAG
MLBr_00737|M.leprae_Br4923 MKVEAARLIVYAAAARAERG------EPDLGFISAASKCFASDIAMEVTT
: : : . . : . * :
Mb3087c|M.bovis_AF2122/97 LNIQVHGGIGFTWEHDAHLHLRRALVTVGLFGGDAPVR-DVFERTAAGVT
Rv3061c|M.tuberculosis_H37Rv LNIQVHGGIGFTWEHDAHLHLRRALVTVGLFGGDAPVR-DVFERTAAGVT
MAB_0580|M.abscessus_ATCC_1997 DCIQILGGIGFTWEHDAHLYLRRAYALQSFVGKPAVWRRKAAALTIGGIR
Mvan_4218|M.vanbaalenii_PYR-1 HCQQVLGGIGFTEEHHLHRHVKRALVLDGLLG------------------
Mflv_2434|M.gilvum_PYR-GCK NCQQVLGGIGFTEEHGLQHHVKRTLVLDGLLG------------------
MSMEG_4845|M.smegmatis_MC2_155 HCQQVLGGIGFTAEHELHTHVERVLVLDGLLG------------------
TH_2022|M.thermoresistible__bu NCQQVLGGIGFTAEHDLHRHVQRVLVLDGLLG------------------
MMAR_4749|M.marinum_M HCQQVLAGMGFTAEHQLHHHVKRSLVLDGLLG------------------
MAV_0900|M.avium_104 HCQQVLGGIGFTAEHPLHHHIKRSLILDGLLG------------------
MUL_2893|M.ulcerans_Agy99 SAIQVHGGIAFTWEHDLHLYFRRAKTTEALFG------------------
MLBr_00737|M.leprae_Br4923 DAVQLFGGAGYTSDFPVERFMRDAKITQIYEG------------------
*: .* .:* :. . ... *
Mb3087c|M.bovis_AF2122/97 RAISLDLPAQAEELRARIRSDAAEIAALEKDAQRDKLIETGYVMPHWPRP
Rv3061c|M.tuberculosis_H37Rv RAISLDLPAQAEELRARIRSDAAEIAALEKDAQRDKLIETGYVMPHWPRP
MAB_0580|M.abscessus_ATCC_1997 RSLTIDL-GEVESQRAEVAGQVAEIASAPKAEHQVRLAEAGFLAPHWPAP
Mvan_4218|M.vanbaalenii_PYR-1 ---------SSRELTRRAGAGLRARGSAPRLAQL----------------
Mflv_2434|M.gilvum_PYR-GCK ---------SSRELTRRAGAGLRARGSVPRLAQL----------------
MSMEG_4845|M.smegmatis_MC2_155 ---------NARELTRKAGSGMRARGTAPRMAQV----------------
TH_2022|M.thermoresistible__bu ---------SARELTLRVGAGLRARGSAPRLAYL----------------
MMAR_4749|M.marinum_M ---------SSRELTREAGAVLRTKGFAPRLAQL----------------
MAV_0900|M.avium_104 ---------SARELTRQAGKTLVTTGSAPRLAQL----------------
MUL_2893|M.ulcerans_Agy99 -------------SSAHHRSLLADRVGL----------------------
MLBr_00737|M.leprae_Br4923 --------------TNQIQRVVMSRALLR---------------------
.
Mb3087c|M.bovis_AF2122/97 WGRAAGAVEQLVIEEEFSAAGIERPDYSITGWVILTLIQHGTPWQIERFV
Rv3061c|M.tuberculosis_H37Rv WGRAAGAVEQLVIEEEFSAAGIERPDYSITGWVILTLIQHGTPWQIERFV
MAB_0580|M.abscessus_ATCC_1997 YGLGAGAAQQLLIDQELHAAGVNRPDLVIGWWAAPTILEHGTPEQIAQFV
Mvan_4218|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_2434|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_4845|M.smegmatis_MC2_155 --------------------------------------------------
TH_2022|M.thermoresistible__bu --------------------------------------------------
MMAR_4749|M.marinum_M --------------------------------------------------
MAV_0900|M.avium_104 --------------------------------------------------
MUL_2893|M.ulcerans_Agy99 --------------------------------------------------
MLBr_00737|M.leprae_Br4923 --------------------------------------------------
Mb3087c|M.bovis_AF2122/97 EKALRQQEIWCQLFSEPDAGSDAASVKTRATRVEGGWKINGQKVWTSGAQ
Rv3061c|M.tuberculosis_H37Rv EKALRQQEIWCQLFSEPDAGSDAASVKTRATRVEGGWKINGQKVWTSGAQ
MAB_0580|M.abscessus_ATCC_1997 APTLRGEIEWCQLFSEPGAGSDLAALRTKATRVDGGWKLDGQKVWNSKAQ
Mvan_4218|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_2434|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_4845|M.smegmatis_MC2_155 --------------------------------------------------
TH_2022|M.thermoresistible__bu --------------------------------------------------
MMAR_4749|M.marinum_M --------------------------------------------------
MAV_0900|M.avium_104 --------------------------------------------------
MUL_2893|M.ulcerans_Agy99 --------------------------------------------------
MLBr_00737|M.leprae_Br4923 --------------------------------------------------
Mb3087c|M.bovis_AF2122/97 YCARGLATVRTDPDAPKHAGITTVIIDMLAPGVEVRPLRQITGDSEFNEV
Rv3061c|M.tuberculosis_H37Rv YCARGLATVRTDPDAPKHAGITTVIIDMLAPGVEVRPLRQITGDSEFNEV
MAB_0580|M.abscessus_ATCC_1997 IADWAICLARTNPDVPKHKGITYFLLDMKTPGITVRPLREITGEEMFNEV
Mvan_4218|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_2434|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_4845|M.smegmatis_MC2_155 --------------------------------------------------
TH_2022|M.thermoresistible__bu --------------------------------------------------
MMAR_4749|M.marinum_M --------------------------------------------------
MAV_0900|M.avium_104 --------------------------------------------------
MUL_2893|M.ulcerans_Agy99 --------------------------------------------------
MLBr_00737|M.leprae_Br4923 --------------------------------------------------
Mb3087c|M.bovis_AF2122/97 FFNDVFVPDEDVVGAPNSGWTVARATLGNERVSIGGSGSYYEAMAAKLVQ
Rv3061c|M.tuberculosis_H37Rv FFNDVFVPDEDVVGAPNSGWTVARATLGNERVSIGGSGSYYEAMAAKLVQ
MAB_0580|M.abscessus_ATCC_1997 FLDGVIVPDENVVGSVDDGWRLARTTLANERVAMAGGGTLDEAMESLLAL
Mvan_4218|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_2434|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_4845|M.smegmatis_MC2_155 --------------------------------------------------
TH_2022|M.thermoresistible__bu --------------------------------------------------
MMAR_4749|M.marinum_M --------------------------------------------------
MAV_0900|M.avium_104 --------------------------------------------------
MUL_2893|M.ulcerans_Agy99 --------------------------------------------------
MLBr_00737|M.leprae_Br4923 --------------------------------------------------
Mb3087c|M.bovis_AF2122/97 LVQRRSDAFAGAPIRVGAFLAEDHALRLLNLRRAARSVEGAGPGPEGNIT
Rv3061c|M.tuberculosis_H37Rv LVQRRSDAFAGAPIRVGAFLAEDHALRLLNLRRAARSVEGAGPGPEGNIT
MAB_0580|M.abscessus_ATCC_1997 IGDTELDAAQLD--TLGAFVCSAQTGALLDLRTALRAIGGQDPGAASSVR
Mvan_4218|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_2434|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_4845|M.smegmatis_MC2_155 --------------------------------------------------
TH_2022|M.thermoresistible__bu --------------------------------------------------
MMAR_4749|M.marinum_M --------------------------------------------------
MAV_0900|M.avium_104 --------------------------------------------------
MUL_2893|M.ulcerans_Agy99 --------------------------------------------------
MLBr_00737|M.leprae_Br4923 --------------------------------------------------
Mb3087c|M.bovis_AF2122/97 KLKVAEHMIEGAAIAAALWGPEIALLDGPGRVIGR---TVMGARGMAIAG
Rv3061c|M.tuberculosis_H37Rv KLKVAEHMIEGAAIAAALWGPEIALLDGPGRVIGR---TVMGARGMAIAG
MAB_0580|M.abscessus_ATCC_1997 KLVGVRHRQG-------LSEHILDYVDTHGAVESREMWLFMRDRCLSIAG
Mvan_4218|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_2434|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_4845|M.smegmatis_MC2_155 --------------------------------------------------
TH_2022|M.thermoresistible__bu --------------------------------------------------
MMAR_4749|M.marinum_M --------------------------------------------------
MAV_0900|M.avium_104 --------------------------------------------------
MUL_2893|M.ulcerans_Agy99 --------------------------------------------------
MLBr_00737|M.leprae_Br4923 --------------------------------------------------
Mb3087c|M.bovis_AF2122/97 GTSEVTRNQIAERILGMPRDPLIS
Rv3061c|M.tuberculosis_H37Rv GTSEVTRNQIAERILGMPRDPLIS
MAB_0580|M.abscessus_ATCC_1997 GTTQILLSVAGERLLGLPR-----
Mvan_4218|M.vanbaalenii_PYR-1 ------------------------
Mflv_2434|M.gilvum_PYR-GCK ------------------------
MSMEG_4845|M.smegmatis_MC2_155 ------------------------
TH_2022|M.thermoresistible__bu ------------------------
MMAR_4749|M.marinum_M ------------------------
MAV_0900|M.avium_104 ------------------------
MUL_2893|M.ulcerans_Agy99 ------------------------
MLBr_00737|M.leprae_Br4923 ------------------------