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VGVTFERNTVLVEGLTTSYLEAGQGDPIVLLHGGEFGADAALGWEATIDALASRYRVLAPDMLGFGGSAK VVDFTDGRGMRIRHIARFCDVMGIAAAHFVGNSMGAINLLVDATSDTPVLPMRSLVAVCGGGDIQRNEHV SALYDYDATLEGMRRIVTALFADPSYPADDEYVRRRYESSIAPGAWESLAAARFRRPGLEPPPTPSSSRA YERITVPTLVVEGGADKLLPRGWAAEIAGQIAGARSAVIDEAGHCPQIEQPEAVIGLLLTFFEEQR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_2414 | - | - | 100% (276) | alpha/beta hydrolase fold |
| M. gilvum PYR-GCK | Mflv_2400 | - | 8e-15 | 28.38% (296) | alpha/beta hydrolase fold |
| M. gilvum PYR-GCK | Mflv_0627 | - | 1e-14 | 25.95% (289) | alpha/beta hydrolase fold |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0569 | bpoC | 4e-12 | 27.01% (274) | peroxidase BpoC |
| M. tuberculosis H37Rv | Rv0554 | bpoC | 4e-12 | 27.01% (274) | peroxidase BpoC |
| M. leprae Br4923 | MLBr_02269 | - | 6e-10 | 25.55% (274) | putative hydrolase |
| M. abscessus ATCC 19977 | MAB_2946c | - | 2e-15 | 28.99% (276) | Alpha/beta hydrolase fold |
| M. marinum M | MMAR_4771 | - | 1e-105 | 67.29% (269) | hypothetical protein MMAR_4771 |
| M. avium 104 | MAV_0884 | - | 1e-116 | 73.96% (265) | hydrolase, alpha/beta fold family protein, putative |
| M. smegmatis MC2 155 | MSMEG_4860 | - | 1e-122 | 77.01% (274) | hydrolase, alpha/beta fold family protein, putative |
| M. thermoresistible (build 8) | TH_0899 | - | 1e-121 | 77.70% (269) | hydrolase, alpha/beta fold family protein, putative |
| M. ulcerans Agy99 | MUL_0342 | - | 1e-106 | 67.66% (269) | hypothetical protein MUL_0342 |
| M. vanbaalenii PYR-1 | Mvan_4238 | - | 1e-127 | 80.95% (273) | alpha/beta hydrolase fold |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0569|M.bovis_AF2122/97 -------------MINLAYDDNGT--GDPVVFIAG-RGGAGRTWHPHQVP
Rv0554|M.tuberculosis_H37Rv -------------MINLAYDDNGT--GDPVVFIAG-RGGAGRTWHPHQVP
MLBr_02269|M.leprae_Br4923 -------------MINLAYEDRGT--GEPVVFIAG-RGGAGRTWQPHQVP
Mflv_2414|M.gilvum_PYR-GCK MGVTFERNTVLVEGLTTSYLEAGQ--GDPIVLLHGGEFGADAALGWEATI
Mvan_4238|M.vanbaalenii_PYR-1 --MALEPKSVLVDGLRTSYLEAGH--GEPVVLLHGGEFGASARIGWEHTI
MSMEG_4860|M.smegmatis_MC2_155 --MDFERKTIVVDGLTTAYLEAGDPARDAVVLLHGGEFGVSAELGWERTI
TH_0899|M.thermoresistible__bu --VTFDRRTIVVDGLATSYLEAGS--GDPLVLLHGGEFGASAELGWERNI
MMAR_4771|M.marinum_M --MRVHRRAVAVDGLPTSYLEAGD--GDPVVLLHGGEFGANAEIAWEHNI
MUL_0342|M.ulcerans_Agy99 --MRIHRRAVAVDGLATSYLEAGD--GDPVVLLHGGEFGANAEIAWEHNI
MAV_0884|M.avium_104 --MEIHRKTMSVDGLVTSYLEAGE--GDPVVLLHGGEFGASAELGWERNI
MAB_2946c|M.abscessus_ATCC_199 --MIAESRAEYGGVVTRVLSVPGG--GPPIVLLHG---YSDSALTWRPVL
: * .:*:: * . .
Mb0569|M.bovis_AF2122/97 AFLAAG-YRCITFDNRGIGATENAEGFTTQT--MVADTAALIETLDIAPA
Rv0554|M.tuberculosis_H37Rv AFLAAG-YRCITFDNRGIGATENAEGFTTQT--MVADTAALIETLDIAPA
MLBr_02269|M.leprae_Br4923 AFLAAG-YRVITFDNRGIGATENTEGFTTQT--MVADTAVLIESLGAVPA
Mflv_2414|M.gilvum_PYR-GCK DALASR-YRVLAPDMLGFGGSAKVVDFTDGRGMRIRHIARFCDVMGIAAA
Mvan_4238|M.vanbaalenii_PYR-1 APLAQR-YRVLAPDMLGFGDSAKVVDFTDGRGMRIRHIARFCEVMDVEAA
MSMEG_4860|M.smegmatis_MC2_155 GALATD-HHVLAPDMLGFGGSAKVVDFTDGRGMRIRHIARFCAQMGVKSA
TH_0899|M.thermoresistible__bu DALAGY-YRVIAPDMLGFGHSAKVIDFVDGRGMRIRHIARLCALLGIESA
MMAR_4771|M.marinum_M GVLGGR-FRVLAPDLLGFGQSAKVVDFVDGRGMRIRHVARFCDVLGVDSA
MUL_0342|M.ulcerans_Agy99 GVLGGR-FRVLAPDLLGFGQSAKVVDFVDGRGMRIRHVARFCDVLGVGSA
MAV_0884|M.avium_104 AALAAR-YRVLAPDQLGFGGSAKVIDFVDGRGMRIRHVARFCELLGVESA
MAB_2946c|M.abscessus_ATCC_199 ARLASAGRAAIAVDLPGFGHAAPRP---PGPLLAQFDVFADAVLAAAGPA
*. :: * *:* : . .*
Mb0569|M.bovis_AF2122/97 RVVGVSMGAFIAQELMVV-----------APELVSSAVLMATRGRLDRAR
Rv0554|M.tuberculosis_H37Rv RVVGVSMGAFIAQELMVV-----------APELVSSAVLMATRGRLDRAR
MLBr_02269|M.leprae_Br4923 RIVGVSMGSFIAQELMVA-----------RPELVRAAVLMATRGRLDRTR
Mflv_2414|M.gilvum_PYR-GCK HFVGNSMGAINLLVDATS-----------DTPVLPMRSLVAVCGGGDIQR
Mvan_4238|M.vanbaalenii_PYR-1 HFVGNSMGAINLLVDVTS-----------DAAVLPVRSLVLICGGGEIQR
MSMEG_4860|M.smegmatis_MC2_155 HFVGNSMGAINLLVDTTS-----------DAPLLPVRSLVAICGGGEIQR
TH_0899|M.thermoresistible__bu HFVGNSMGAINLLVDATS-----------PAPRLPMRSLVAICGGGEIQR
MMAR_4771|M.marinum_M HFVGNSMGAIMLLTDTTS-----------DAPMLPVQTMALICGGGQIQQ
MUL_0342|M.ulcerans_Agy99 HFVGNSMGAIMLLTDTTS-----------DAPMLPVRTMALICGGGQIQQ
MAV_0884|M.avium_104 HFVGNSMGAINLLTDATS-----------DSPLWPVRSAVIICGGGEIQQ
MAB_2946c|M.abscessus_ATCC_199 VLVGNSLGAATAVRAAARRENEVKALIALDDPLNSRHLIARIVRRWSVPE
.** *:*: . . .
Mb0569|M.bovis_AF2122/97 QFFNKAEAELYDSGVQLPPTYDARARLLENFSRKTLNDDVAVGDWIAMFS
Rv0554|M.tuberculosis_H37Rv QFFNKAEAELYDSGVQLPPTYDARARLLENFSRKTLNDDVAVGDWIAMFS
MLBr_02269|M.leprae_Br4923 QFFHAAEAEFHDSGIQLPSGYNAKVRLLENLSRKTLNDDVAVADWIAMFN
Mflv_2414|M.gilvum_PYR-GCK ---NEHVSALYDYDATLEGMRRIVTALFADPSYPADDEYVRRRYESSIAP
Mvan_4238|M.vanbaalenii_PYR-1 ---NEHVDALYDYDATFEGMRRIVAALFADPAYPTDDEYVRRRYESSIAP
MSMEG_4860|M.smegmatis_MC2_155 ---NEHMAALYDYDATLEGMRRIVAALFADPSYPADEDYVRRRYESSIAP
TH_0899|M.thermoresistible__bu ---NEHMAALYDYDATEPAMRRIVTALFFDPAFPADDAYVRRRYESSILP
MMAR_4771|M.marinum_M ---NSHFDALQSYDATLPAMRRIVAALFHDARYPADMDYVQRRYDSSIAP
MUL_0342|M.ulcerans_Agy99 ---NSHFDALQSYDATLPAMRRIVAALFHDARYPADMDYVQRRYDSSIAP
MAV_0884|M.avium_104 ---NEYFEALQNYDATLPAMRRIVEALFFDPAYPADDDYVRRRHESSTAP
MAB_2946c|M.abscessus_ATCC_199 VFWAWVSRMPVPAGTLRRAARYFVPKMLYGPGVAADPEVVAYWCELISGP
. :: . : *
Mb0569|M.bovis_AF2122/97 -MWPIKSTPGLR-CQLDCAPQTNRLPAYRNIAAPVLVIGFADDVVTPPYL
Rv0554|M.tuberculosis_H37Rv -MWPIKSTPGLR-CQLDCAPQTNRLPAYRNIAAPVLVIGFADDVVTPPYL
MLBr_02269|M.leprae_Br4923 -MWPIKSTPGLR-CQTDVAPQNNRLPAYRSIAAPVLVIGFAEDVVTPPSL
Mflv_2414|M.gilvum_PYR-GCK GAWESLAAARFRRPGLEPPPTPSSSRAYERITVPTLVVEGGADKLLPRGW
Mvan_4238|M.vanbaalenii_PYR-1 GAWESLAAARFRRPGLDPPATPSSARAYDRITVPTLVLEGRDDKLLPTGW
MSMEG_4860|M.smegmatis_MC2_155 GAWEALAAARFRRPGLEPPAAPSSARAYERIGVPVLIVEGERDKLLPSGW
TH_0899|M.thermoresistible__bu GAWETLAAARFRRPGLEPPAAPSAARAYHRIGVPTLIVEGAGDKLLPPGW
MMAR_4771|M.marinum_M GAWEAVAAARFRRPGAPPSATPSSSRRYDRITVPTMLVEGRNDKLLPSGW
MUL_0342|M.ulcerans_Agy99 GAWEAVAAARFRRPGAPPSATPSSSRRYDRITVPTMLVEGRNDKLLPSGW
MAV_0884|M.avium_104 GAWEAIAAARFRRPGATPSPTPSSARAYERIGVPTLVVEGRGDKLLPAGW
MAB_2946c|M.abscessus_ATCC_199 -----SAVARLGRDACRYAHEALGSHSGIEVSCPTLVVHGGRDRIIPIHS
:.. : . : *.::: * : *
Mb0569|M.bovis_AF2122/97 GREVADALPNGRYLQIPDAGHLGFFERPEAVNTAMLKFFASVKA------
Rv0554|M.tuberculosis_H37Rv GREVADALPNGRYLQIPDAGHLGFFERPEAVNTAMLKFFASVKA------
MLBr_02269|M.leprae_Br4923 GREVADVLPNGRYLQIPDAGHLGFFERPEAVNAAALQFFAGVKGEWP---
Mflv_2414|M.gilvum_PYR-GCK AAEIAGQIAGARSAVIDEAGHCPQIEQPEAVIGLLLTFFEEQR-------
Mvan_4238|M.vanbaalenii_PYR-1 AAEIAGQIRHGRSAVIDDAGHCPQIEQPAAVNQELLDFFEEQT-------
MSMEG_4860|M.smegmatis_MC2_155 AAQIAAQISGATSTVVADAGHCPQIEQPDTVNRLLSDFLKEVS-------
TH_0899|M.thermoresistible__bu AADIAAQIPDARSAVIADAGHCPQIEQPAAVNELLLDFLTTVNTRDREVA
MMAR_4771|M.marinum_M GEQIAGQIRNGHSQVVDRAGHCPQIEQAGTVNELMLDFLTR---------
MUL_0342|M.ulcerans_Agy99 GEQIAGQIRNGHSQVVDRAGHCPQIEQAGTVNELMLDFLSR---------
MAV_0884|M.avium_104 SAQIAKQIDGARSVVVDDAGHCPQIEQPSVVNQLLMDFLATA--------
MAB_2946c|M.abscessus_ATCC_199 SGALQQQIPGSELVILPASGHCPQLDNPDEVTRLIVDFCDRISEPRQPDA
. : : . : :** ::.. * *
Mb0569|M.bovis_AF2122/97 ----
Rv0554|M.tuberculosis_H37Rv ----
MLBr_02269|M.leprae_Br4923 ----
Mflv_2414|M.gilvum_PYR-GCK ----
Mvan_4238|M.vanbaalenii_PYR-1 ----
MSMEG_4860|M.smegmatis_MC2_155 ----
TH_0899|M.thermoresistible__bu TR--
MMAR_4771|M.marinum_M ----
MUL_0342|M.ulcerans_Agy99 ----
MAV_0884|M.avium_104 ----
MAB_2946c|M.abscessus_ATCC_199 AHSG