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VAEFESVWSDLQGVAFSQGYLDAGGVRTRYLHAGDPADPALVFLHGSGGHAEAYVRNLEAHAEHFSTWSI DMLGHGYTDKPGHPLEIPHYVDHLAAFLDAIGARRAHISGESLGGWVAARIAADRPERVDRLVLNTAGGS QADPEVMKRIITLSMAAAENPTWDTVQARIKWLMADKSKDYDDIVASRQRVYRQPGFANAMRDIMALQDP EIRQRNLLGPNEYGAITAPTLVVWTSDDPTADVEEGRRIASMIPGARFEVMPGCGHWPQYEDPKTFDRLH LDFLLGRA
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_2400 | - | - | 100% (288) | alpha/beta hydrolase fold |
| M. gilvum PYR-GCK | Mflv_0627 | - | 1e-49 | 38.27% (277) | alpha/beta hydrolase fold |
| M. gilvum PYR-GCK | Mflv_0545 | - | 1e-49 | 38.27% (277) | alpha/beta hydrolase fold |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3600c | bphD | 2e-23 | 29.30% (273) | 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase BphD |
| M. tuberculosis H37Rv | Rv3569c | bphD | 2e-23 | 29.30% (273) | 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase BphD |
| M. leprae Br4923 | MLBr_02269 | - | 5e-09 | 23.26% (258) | putative hydrolase |
| M. abscessus ATCC 19977 | MAB_4366c | - | 4e-22 | 32.58% (267) | putative hydrolase, alpha/beta fold |
| M. marinum M | MMAR_4778 | bphD_1 | 1e-139 | 82.93% (287) | 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase BphD_1 |
| M. avium 104 | MAV_0877 | - | 1e-145 | 84.67% (287) | 2-hydroxy-6-ketonona-2,4-dienedoic acid hydrolase |
| M. smegmatis MC2 155 | MSMEG_4867 | - | 1e-149 | 86.85% (289) | 2-hydroxy-6-ketonona-2,4-dienedoic acid hydrolase |
| M. thermoresistible (build 8) | TH_4528 | - | 1e-151 | 88.30% (282) | PUTATIVE alpha/beta hydrolase fold |
| M. ulcerans Agy99 | MUL_4140 | bphD | 4e-26 | 31.16% (276) | 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase BphD |
| M. vanbaalenii PYR-1 | Mvan_4246 | - | 1e-162 | 94.10% (288) | alpha/beta hydrolase fold |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3600c|M.bovis_AF2122/97 -----------------MTATEELTFESTSRFAEVDVDGPLKLHYHEAGV
Rv3569c|M.tuberculosis_H37Rv -----------------MTATEELTFESTSRFAEVDVDGPLKLHYHEAGV
MUL_4140|M.ulcerans_Agy99 -------------MTVTQSKTAEHTFESTSRYAEVDVDGPLKLHYHEAGV
MAB_4366c|M.abscessus_ATCC_199 -----------------MTIHTHLQSISTT-LGEIAVH-----DVPAAGG
Mflv_2400|M.gilvum_PYR-GCK -----------MAEFESVWSDLQGVAFSQGYLDAGG----VRTRYLHAGD
Mvan_4246|M.vanbaalenii_PYR-1 -----------MTEFESVWSDLQGVPFSQGYLDAGG----VRTRYLHAGD
TH_4528|M.thermoresistible__bu -----------------VWSDLQGVAFTQGYLDAGG----VRTRYLHAGE
MSMEG_4867|M.smegmatis_MC2_155 MTSTAAAGTASAVEFESIWSDLQGVAFSQGYLDVPVGDRKIRTRYLHAGN
MMAR_4778|M.marinum_M -----------MTDFESVWSDLQGVMFEQGYLTTAQG---VRTRYLRAGE
MAV_0877|M.avium_104 -----------MAEFESIWSDLQGVAFEQGYLD-AGG---IRTRYLRAGD
MLBr_02269|M.leprae_Br4923 -----------------------------------------MINLAYEDR
.
Mb3600c|M.bovis_AF2122/97 GNDQTVVLLHGGGPGAASWTNFSRNIAVLARHFHVLAVDQPGYGHSDK--
Rv3569c|M.tuberculosis_H37Rv GNDQTVVLLHGGGPGAASWTNFSRNIAVLARHFHVLAVDQPGYGHSDK--
MUL_4140|M.ulcerans_Agy99 GNDQTVVLLHGGGPGASSWSNFARNIEVLAQQFHVLAVDQPGYGHSDK--
MAB_4366c|M.abscessus_ATCC_199 ADAPTLVMLHGGGPGASGLSNYEQNIPALSRTFRILLPDQPGFGGSYRPT
Mflv_2400|M.gilvum_PYR-GCK PADPALVFLHGSG---GHAEAYVRNLEAHAEHFSTWSIDMLGHGYTDKP-
Mvan_4246|M.vanbaalenii_PYR-1 PGKPALVFLHGSG---GHAEAYVRNLEAHAEHFSTWSIDMLGHGYTDKP-
TH_4528|M.thermoresistible__bu ADKPVLIFLHGSG---GHAEAYVRNLEAHAEHFSTWSIDMLGHGYTDKP-
MSMEG_4867|M.smegmatis_MC2_155 PQAPALLFLHGSG---GHAEAYVRNLAAHAEHFSTWSIDMLGHGYTDKP-
MMAR_4778|M.marinum_M PDRPLLMLLHGSG---GHAEAYVRNLAAHAEHFWTWAIDMLGHGYTDKP-
MAV_0877|M.avium_104 PGKPVLVLLHGSG---GHAEAYVRNLAAHADHFWTWSIDMLGHGYTDKP-
MLBr_02269|M.leprae_Br4923 GTGEPVVFIAGRG-GAGRTWQPHQVPAFLAAGYRVITFDNRGIGATENT-
:::: * * . : : : * * * : .
Mb3600c|M.bovis_AF2122/97 --RAEHGQFNRYAAMALKGLFDQLGLGRVPLVGNSLGGGTAVRFALDYPA
Rv3569c|M.tuberculosis_H37Rv --RAEHGQFNRYAAMALKGLFDQLGLGRVPLVGNSLGGGTAVRFALDYPA
MUL_4140|M.ulcerans_Agy99 --RAEHGQFNHYAARALKELFDQLGLGRVLLVGNSLGGGTAVRFALDYPD
MAB_4366c|M.abscessus_ATCC_199 GADLDERSITEITVDALFQVLDDLAVGSFHLLGNSLGGAAAIRMAQLRPE
Mflv_2400|M.gilvum_PYR-GCK ----GHPLEIPHYVDHLAAFLDAIGARRAHISGESLGGWVAARIAADRPE
Mvan_4246|M.vanbaalenii_PYR-1 ----GHPLEIAHYVEHLAGFLDAIGASRAHISGESLGGWVAARFAADRPE
TH_4528|M.thermoresistible__bu ----GHPLEVRHYVEHLAAVLDAIGADRAHISGESLGGWVASRFAIDRPD
MSMEG_4867|M.smegmatis_MC2_155 ----GHPLEVAHYVDHVIAFLDTIGAQRAHISGESLGGWVAARVAVDHPD
MMAR_4778|M.marinum_M ----GHPLEIRHYVEHLMAVLRAIGAQRASISGESLGGWVAARAAVDHPE
MAV_0877|M.avium_104 ----GHPLEVRHYVEHLMTVLRTIGVERASISGESLGGWVAARAAIDHPD
MLBr_02269|M.leprae_Br4923 -----EGFTTQTMVADTAVLIESLGAVPARIVGVSMGSFIAQELMVARPE
. . .: :. : * *:*. * . *
Mb3600c|M.bovis_AF2122/97 RAGRLVLMGPGGLSINLFAPDPTEGVKRLSKFS--VAPTRENLEAFLRVM
Rv3569c|M.tuberculosis_H37Rv RAGRLVLMGPGGLSINLFAPDPTEGVKRLSKFS--VAPTRENLEAFLRVM
MUL_4140|M.ulcerans_Agy99 RAGRLVLMGPGGLSINLFAPDPTEGVKRLGKFS--VAPTRENLEAFLRVM
MAB_4366c|M.abscessus_ATCC_199 RVTRLVLMAPGGGWL-PFGPTPTEGQKEMFRYFNGEGPTEKKMAAFIRAM
Mflv_2400|M.gilvum_PYR-GCK RVDRLVLNTAGGSQADPEVMKRIITLSMAAAEN----PTWDTVQARIKWL
Mvan_4246|M.vanbaalenii_PYR-1 RVERLVLNTAGGSQADPEVMKRIVTLSMAAAEN----PTWETVQARIKWL
TH_4528|M.thermoresistible__bu RLDRLVLNTAGGSQADPEVMKRIITLSMAAAEN----PSWDTVQARITWL
MSMEG_4867|M.smegmatis_MC2_155 RVEKLVLNTAGGSQADPEVMKRIITLSMAAAEN----PTWDTVQARIKWL
MMAR_4778|M.marinum_M AVERLVLNTAGGSQADPEVMARIVTLSMAAAEN----PTWETVQARIKWL
MAV_0877|M.avium_104 VVDRLVLNTAGGSQADPVVMQRIIALSMAAAEN----PTWETVQARIKWL
MLBr_02269|M.leprae_Br4923 LVRAAVLMATRGRLDRTRQFFHAAEAEFHDSGIQ--LPSGYNAKVRLLEN
** . * . *: . . :
Mb3600c|M.bovis_AF2122/97 VYDKNLITPELVDQRFALASTPESLTATRAMGKSFAGADFEAGMMWREVY
Rv3569c|M.tuberculosis_H37Rv VYDKNLITPELVDQRFALASTPESLTATRAMGKSFAGADFEAGMMWREVY
MUL_4140|M.ulcerans_Agy99 VYDQKLITPELVDQRFELARTPESLAATRAMGKSFAAADFELGMMWREVY
MAB_4366c|M.abscessus_ATCC_199 VFDHKQFGRDVVSRRYQASLDEGHIEFYHHYNAAFAKRN-GMDPLWRDLH
Mflv_2400|M.gilvum_PYR-GCK MADKSKDYDDIVASRQRVYRQPGFANAMRDIMALQDPEIRQRNLLGPNEY
Mvan_4246|M.vanbaalenii_PYR-1 MADKTKDYDDIVASRQRVYRQPGFVNAMRDIMALQDPEIRARNLLGTNEY
TH_4528|M.thermoresistible__bu MADKSKGYDDIVASRQKIYRQPGFVDAMRNIMALQDPEIRARNLLGPEEY
MSMEG_4867|M.smegmatis_MC2_155 MADKSKDYDDIVASRQRVYRQPGFVAAMSDIMALQDPQIRARNLLGQAEY
MMAR_4778|M.marinum_M MADKSKDYDDLVASRQRIYRQPGFVAAMRDIMALQDPQIRARNLLGPAEY
MAV_0877|M.avium_104 MADKSRDYDDLVASRQRVYRQPGFVAAMRDIMALQDPEIRARNILGPAEY
MLBr_02269|M.leprae_Br4923 LSRKTLNDDVAVADWIAMFN----MWPIKSTPGLRCQTDVAPQNNRLPAY
: :. * :
Mb3600c|M.bovis_AF2122/97 -RLRQPVLLIWGREDRVNPLDGALVALKTIPRAQLHVFGQCGHWVQVEKF
Rv3569c|M.tuberculosis_H37Rv -RLRQPVLLIWGREDRVNPLDGALVALKTIPRAQLHVFGQCGHWVQVEKF
MUL_4140|M.ulcerans_Agy99 -KLRQPVLLIWGREDRVNPLDGALVALKTIPRAQLHVFGQCGHWAQVEKF
MAB_4366c|M.abscessus_ATCC_199 -TITAPTLLLWGRDDRTITLEGAQMMLKHISDVQLHVFGRCGHWVQLERQ
Mflv_2400|M.gilvum_PYR-GCK GAITAPTLVVWTSDDPTADVEEGRRIASMIPGARFEVMPGCGHWPQYEDP
Mvan_4246|M.vanbaalenii_PYR-1 GAITAPTLVVWTSDDPTADVKEGRRIASMIPGARFEVMPGCGHWPQYEDP
TH_4528|M.thermoresistible__bu GAITAPTLVVWTSDDPTADVDEGKRIASMIPGARFEVMPGCGHWPQYEDP
MSMEG_4867|M.smegmatis_MC2_155 GSITAPTLVVWTSDDPTADVAEGRRIASMIPGARFEVMPGCGHWPQYEDP
MMAR_4778|M.marinum_M GAIKAPTLVLWTSHDPTADVTEGRRIASMIPGARFEVMSGCGHWPQYEDA
MAV_0877|M.avium_104 GSIIAPTLVLWTSDDPTADVSEGRRIASMIPGARFEVMPGCGHWPQYEDA
MLBr_02269|M.leprae_Br4923 RSIAAPVLVIGFAEDVVTPPSLGREVADVLPNGRYLQIPDAGHLGFFERP
: *.*:: .* . . . :. : : .** *
Mb3600c|M.bovis_AF2122/97 DEFNKLTIEFLGGGR----
Rv3569c|M.tuberculosis_H37Rv DEFNKLTIEFLGGGR----
MUL_4140|M.ulcerans_Agy99 DEFNRLTIDFLGGAR----
MAB_4366c|M.abscessus_ATCC_199 AEFDRLVADFLGEPA----
Mflv_2400|M.gilvum_PYR-GCK KTFDRLHLDFLLGRA----
Mvan_4246|M.vanbaalenii_PYR-1 KTFDRLHLDFLLGRA----
TH_4528|M.thermoresistible__bu ATFNRLHIDFLLGRS----
MSMEG_4867|M.smegmatis_MC2_155 ATFNALHLDFLLGR-----
MMAR_4778|M.marinum_M KSFNRRHLDFLMGH-----
MAV_0877|M.avium_104 KTFNRLHLDFLLGR-----
MLBr_02269|M.leprae_Br4923 EAVNAAALQFFAGVKGEWP
.: :*: