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RIHRRAVAVDGLATSYLEAGDGDPVVLLHGGEFGANAEIAWEHNIGVLGGRFRVLAPDLLGFGQSAKVVD FVDGRGMRIRHVARFCDVLGVGSAHFVGNSMGAIMLLTDTTSDAPMLPVRTMALICGGGQIQQNSHFDAL QSYDATLPAMRRIVAALFHDARYPADMDYVQRRYDSSIAPGAWEAVAAARFRRPGAPPSATPSSSRRYDR ITVPTMLVEGRNDKLLPSGWGEQIAGQIRNGHSQVVDRAGHCPQIEQAGTVNELMLDFLSR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_0342 | - | - | 100% (272) | hypothetical protein MUL_0342 |
| M. ulcerans Agy99 | MUL_4140 | bphD | 3e-13 | 28.21% (280) | 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase BphD |
| M. ulcerans Agy99 | MUL_4193 | ephA | 9e-09 | 26.22% (328) | epoxide hydrolase EphA |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3600c | bphD | 2e-12 | 27.70% (278) | 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase BphD |
| M. gilvum PYR-GCK | Mflv_2414 | - | 1e-106 | 67.66% (269) | alpha/beta hydrolase fold |
| M. tuberculosis H37Rv | Rv3569c | bphD | 2e-12 | 27.70% (278) | 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase BphD |
| M. leprae Br4923 | MLBr_02269 | - | 3e-06 | 21.61% (273) | putative hydrolase |
| M. abscessus ATCC 19977 | MAB_4366c | - | 3e-17 | 28.79% (264) | putative hydrolase, alpha/beta fold |
| M. marinum M | MMAR_4771 | - | 1e-155 | 98.16% (272) | hypothetical protein MMAR_4771 |
| M. avium 104 | MAV_0884 | - | 1e-117 | 73.06% (271) | hydrolase, alpha/beta fold family protein, putative |
| M. smegmatis MC2 155 | MSMEG_4860 | - | 1e-105 | 69.12% (272) | hydrolase, alpha/beta fold family protein, putative |
| M. thermoresistible (build 8) | TH_0899 | - | 1e-106 | 67.53% (271) | hydrolase, alpha/beta fold family protein, putative |
| M. vanbaalenii PYR-1 | Mvan_4238 | - | 1e-111 | 71.59% (264) | alpha/beta hydrolase fold |
CLUSTAL 2.0.9 multiple sequence alignment
MUL_0342|M.ulcerans_Agy99 ------MRIHRRA----VAVDG-LATSYLEAGD--GDPVVLLHGGEFGAN
MMAR_4771|M.marinum_M ------MRVHRRA----VAVDG-LPTSYLEAGD--GDPVVLLHGGEFGAN
MAV_0884|M.avium_104 ------MEIHRKT----MSVDG-LVTSYLEAGE--GDPVVLLHGGEFGAS
MSMEG_4860|M.smegmatis_MC2_155 ------MDFERKT----IVVDG-LTTAYLEAGDPARDAVVLLHGGEFGVS
TH_0899|M.thermoresistible__bu ------VTFDRRT----IVVDG-LATSYLEAGS--GDPLVLLHGGEFGAS
Mflv_2414|M.gilvum_PYR-GCK ----MGVTFERNT----VLVEG-LTTSYLEAGQ--GDPIVLLHGGEFGAD
Mvan_4238|M.vanbaalenii_PYR-1 ------MALEPKS----VLVDG-LRTSYLEAGH--GEPVVLLHGGEFGAS
Mb3600c|M.bovis_AF2122/97 MTATEELTFESTSRFAEVDVDGPLKLHYHEAGVGNDQTVVLLHGGGPGAA
Rv3569c|M.tuberculosis_H37Rv MTATEELTFESTSRFAEVDVDGPLKLHYHEAGVGNDQTVVLLHGGGPGAA
MAB_4366c|M.abscessus_ATCC_199 MTIHTHLQSISTT-LGEIAVH-----DVPAAGGADAPTLVMLHGGGPGAS
MLBr_02269|M.leprae_Br4923 ----------------------MINLAYEDRGT--GEPVVFIAGRG-GAG
* .:*:: * *.
MUL_0342|M.ulcerans_Agy99 AEIAWEHNIGVLGGRFRVLAPDLLGFGQSAK----VVDFVDGRGMRIRHV
MMAR_4771|M.marinum_M AEIAWEHNIGVLGGRFRVLAPDLLGFGQSAK----VVDFVDGRGMRIRHV
MAV_0884|M.avium_104 AELGWERNIAALAARYRVLAPDQLGFGGSAK----VIDFVDGRGMRIRHV
MSMEG_4860|M.smegmatis_MC2_155 AELGWERTIGALATDHHVLAPDMLGFGGSAK----VVDFTDGRGMRIRHI
TH_0899|M.thermoresistible__bu AELGWERNIDALAGYYRVIAPDMLGFGHSAK----VIDFVDGRGMRIRHI
Mflv_2414|M.gilvum_PYR-GCK AALGWEATIDALASRYRVLAPDMLGFGGSAK----VVDFTDGRGMRIRHI
Mvan_4238|M.vanbaalenii_PYR-1 ARIGWEHTIAPLAQRYRVLAPDMLGFGDSAK----VVDFTDGRGMRIRHI
Mb3600c|M.bovis_AF2122/97 SWTNFSRNIAVLARHFHVLAVDQPGYGHSDK----RAEHGQFNRYAAMAL
Rv3569c|M.tuberculosis_H37Rv SWTNFSRNIAVLARHFHVLAVDQPGYGHSDK----RAEHGQFNRYAAMAL
MAB_4366c|M.abscessus_ATCC_199 GLSNYEQNIPALSRTFRILLPDQPGFGGSYRPTGADLDERSITEITVDAL
MLBr_02269|M.leprae_Br4923 RTWQPHQVPAFLAAGYRVITFDNRGIGATEN------TEGFTTQTMVADT
*. .::: * * * : .
MUL_0342|M.ulcerans_Agy99 ARFCDVLGVGSAHFVGNSMGAIMLLTDTTSDAPMLPVRTMALICGGGQI-
MMAR_4771|M.marinum_M ARFCDVLGVDSAHFVGNSMGAIMLLTDTTSDAPMLPVQTMALICGGGQI-
MAV_0884|M.avium_104 ARFCELLGVESAHFVGNSMGAINLLTDATSDSPLWPVRSAVIICGGGEI-
MSMEG_4860|M.smegmatis_MC2_155 ARFCAQMGVKSAHFVGNSMGAINLLVDTTSDAPLLPVRSLVAICGGGEI-
TH_0899|M.thermoresistible__bu ARLCALLGIESAHFVGNSMGAINLLVDATSPAPRLPMRSLVAICGGGEI-
Mflv_2414|M.gilvum_PYR-GCK ARFCDVMGIAAAHFVGNSMGAINLLVDATSDTPVLPMRSLVAVCGGGDI-
Mvan_4238|M.vanbaalenii_PYR-1 ARFCEVMDVEAAHFVGNSMGAINLLVDVTSDAAVLPVRSLVLICGGGEI-
Mb3600c|M.bovis_AF2122/97 KGLFDQLGLGRVPLVGNSLGGG-TAVRFALDYPARAGRLVLMGPGGLSIN
Rv3569c|M.tuberculosis_H37Rv KGLFDQLGLGRVPLVGNSLGGG-TAVRFALDYPARAGRLVLMGPGGLSIN
MAB_4366c|M.abscessus_ATCC_199 FQVLDDLAVGSFHLLGNSLGGA-AAIRMAQLRPERVTRLVLMAPGGGWL-
MLBr_02269|M.leprae_Br4923 AVLIESLGAVPARIVGVSMGSFIAQELMVARPELVRAAVLMATRGRLDR-
. : ::* *:*. . *
MUL_0342|M.ulcerans_Agy99 ----QQNSHFDALQSYDATLPAMRRIVAALFHDARYP---ADMDYVQRRY
MMAR_4771|M.marinum_M ----QQNSHFDALQSYDATLPAMRRIVAALFHDARYP---ADMDYVQRRY
MAV_0884|M.avium_104 ----QQNEYFEALQNYDATLPAMRRIVEALFFDPAYP---ADDDYVRRRH
MSMEG_4860|M.smegmatis_MC2_155 ----QRNEHMAALYDYDATLEGMRRIVAALFADPSYP---ADEDYVRRRY
TH_0899|M.thermoresistible__bu ----QRNEHMAALYDYDATEPAMRRIVTALFFDPAFP---ADDAYVRRRY
Mflv_2414|M.gilvum_PYR-GCK ----QRNEHVSALYDYDATLEGMRRIVTALFADPSYP---ADDEYVRRRY
Mvan_4238|M.vanbaalenii_PYR-1 ----QRNEHVDALYDYDATFEGMRRIVAALFADPAYP---TDDEYVRRRY
Mb3600c|M.bovis_AF2122/97 LFAPDPTEGVKRLSKFS--VAPTRENLEAFLRVMVYDKNLITPELVDQRF
Rv3569c|M.tuberculosis_H37Rv LFAPDPTEGVKRLSKFS--VAPTRENLEAFLRVMVYDKNLITPELVDQRF
MAB_4366c|M.abscessus_ATCC_199 PFGPTPTEGQKEMFRYFNGEGPTEKKMAAFIRAMVFDHKQFGRDVVSRRY
MLBr_02269|M.leprae_Br4923 ---TRQFFHAAEAEFHDSGIQLPSGYNAKVRLLENLSRKTLNDDVAVADW
. . .
MUL_0342|M.ulcerans_Agy99 DSSIAPGAWEAVAAARFRRPGAPPSATPSSSRRYDRITVPTMLVEGRNDK
MMAR_4771|M.marinum_M DSSIAPGAWEAVAAARFRRPGAPPSATPSSSRRYDRITVPTMLVEGRNDK
MAV_0884|M.avium_104 ESSTAPGAWEAIAAARFRRPGATPSPTPSSARAYERIGVPTLVVEGRGDK
MSMEG_4860|M.smegmatis_MC2_155 ESSIAPGAWEALAAARFRRPGLEPPAAPSSARAYERIGVPVLIVEGERDK
TH_0899|M.thermoresistible__bu ESSILPGAWETLAAARFRRPGLEPPAAPSAARAYHRIGVPTLIVEGAGDK
Mflv_2414|M.gilvum_PYR-GCK ESSIAPGAWESLAAARFRRPGLEPPPTPSSSRAYERITVPTLVVEGGADK
Mvan_4238|M.vanbaalenii_PYR-1 ESSIAPGAWESLAAARFRRPGLDPPATPSSARAYDRITVPTLVLEGRDDK
Mb3600c|M.bovis_AF2122/97 ALASTPESLTATRAMGKSFAGADFEAGMMWREVYR-LRQPVLLIWGREDR
Rv3569c|M.tuberculosis_H37Rv ALASTPESLTATRAMGKSFAGADFEAGMMWREVYR-LRQPVLLIWGREDR
MAB_4366c|M.abscessus_ATCC_199 QASLDEGHIEFYHHYNAAFAKRN-GMDPLWRDLHT-ITAPTLLLWGRDDR
MLBr_02269|M.leprae_Br4923 IAMFNMWPIKSTPGLRCQT---DVAPQNNRLPAYRSIAAPVLVIGFAEDV
: : *.::: *
MUL_0342|M.ulcerans_Agy99 LLPSGWGEQIAGQIRNGHSQVVDRAGHCPQIEQAGTVNELMLDFLSR---
MMAR_4771|M.marinum_M LLPSGWGEQIAGQIRNGHSQVVDRAGHCPQIEQAGTVNELMLDFLTR---
MAV_0884|M.avium_104 LLPAGWSAQIAKQIDGARSVVVDDAGHCPQIEQPSVVNQLLMDFLATA--
MSMEG_4860|M.smegmatis_MC2_155 LLPSGWAAQIAAQISGATSTVVADAGHCPQIEQPDTVNRLLSDFLKEVS-
TH_0899|M.thermoresistible__bu LLPPGWAADIAAQIPDARSAVIADAGHCPQIEQPAAVNELLLDFLTTVNT
Mflv_2414|M.gilvum_PYR-GCK LLPRGWAAEIAGQIAGARSAVIDEAGHCPQIEQPEAVIGLLLTFFEEQR-
Mvan_4238|M.vanbaalenii_PYR-1 LLPTGWAAEIAGQIRHGRSAVIDDAGHCPQIEQPAAVNQELLDFFEEQT-
Mb3600c|M.bovis_AF2122/97 VNPLDGALVALKTIPRAQLHVFGQCGHWVQVEKFDEFNKLTIEFLGGGR-
Rv3569c|M.tuberculosis_H37Rv VNPLDGALVALKTIPRAQLHVFGQCGHWVQVEKFDEFNKLTIEFLGGGR-
MAB_4366c|M.abscessus_ATCC_199 TITLEGAQMMLKHISDVQLHVFGRCGHWVQLERQAEFDRLVADFLGEPA-
MLBr_02269|M.leprae_Br4923 VTPPSLGREVADVLPNGRYLQIPDAGHLGFFERPEAVNAAALQFFAGVKG
. . : . .** .*: . *:
MUL_0342|M.ulcerans_Agy99 --------
MMAR_4771|M.marinum_M --------
MAV_0884|M.avium_104 --------
MSMEG_4860|M.smegmatis_MC2_155 --------
TH_0899|M.thermoresistible__bu RDREVATR
Mflv_2414|M.gilvum_PYR-GCK --------
Mvan_4238|M.vanbaalenii_PYR-1 --------
Mb3600c|M.bovis_AF2122/97 --------
Rv3569c|M.tuberculosis_H37Rv --------
MAB_4366c|M.abscessus_ATCC_199 --------
MLBr_02269|M.leprae_Br4923 EWP-----