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VSEPTALAFEDRCLSLADIDALAAGMAVELQRRGVGAGSRVALMSSNRPEFVVALRAIWRLGAAAVLLSP AWKQTEVGHAVALTEATHAVGDHPVLADAMPMLSLDDEIAPRDPEAAPDPDAGADAVFVFSSGTTGMPKA VRHTHASLAVAIRHWRDALGLTAADRMQVMTPPSHILGLLNIIMALDTGAWIRLHRRFDIDAMLRHIESD RITIEMAVAPIALALSAHPRLEDHDLSSLRYIMWCATPVTQSVAEAVTARTGVTWVTAYGASELPVISCN DLQHARLDTVGRAVTGVGIRIVSLQTGEVLGAGEEGEIQVRSDSAMAGYLPDQWTAQAFSDGWYRTGDVG TLDGEGWLRITDRAKEMIKVRGFQVAPAEVEAVLHGHPAVEDCAVFGIPAADGEAIVAAVTLGHPVDTDE LADLVADRLASYKRPSRVVVVDEIPRLPSGKVLRRVLRERAMGAGAKSGGF
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_2392 | - | - | 100% (471) | AMP-dependent synthetase and ligase |
| M. gilvum PYR-GCK | Mflv_4250 | - | 1e-57 | 32.72% (492) | AMP-dependent synthetase and ligase |
| M. gilvum PYR-GCK | Mflv_0027 | - | 2e-51 | 34.44% (482) | AMP-dependent synthetase and ligase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3116 | fadD13 | 1e-49 | 31.14% (472) | chain-fatty-acid-CoA ligase |
| M. tuberculosis H37Rv | Rv3089 | fadD13 | 2e-49 | 31.14% (472) | chain-fatty-acid-CoA ligase |
| M. leprae Br4923 | MLBr_02546 | fadD2 | 2e-39 | 30.18% (487) | acyl-CoA synthetase |
| M. abscessus ATCC 19977 | MAB_4055c | - | 2e-52 | 32.36% (479) | putative acyl-CoA synthetase |
| M. marinum M | MMAR_4793 | - | 1e-176 | 67.83% (460) | acyl-CoA synthetase |
| M. avium 104 | MAV_0863 | - | 1e-177 | 68.11% (461) | AMP-binding enzyme, putative |
| M. smegmatis MC2 155 | MSMEG_4876 | - | 1e-179 | 68.53% (464) | acyl-CoA synthase |
| M. thermoresistible (build 8) | TH_4258 | - | 0.0 | 74.68% (462) | PUTATIVE AMP-dependent synthetase and ligase |
| M. ulcerans Agy99 | MUL_0362 | - | 1e-175 | 67.17% (460) | acyl-CoA synthetase |
| M. vanbaalenii PYR-1 | Mvan_4256 | - | 0.0 | 85.38% (472) | AMP-dependent synthetase and ligase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3116|M.bovis_AF2122/97 --------------------------------------------MKNIGW
Rv3089|M.tuberculosis_H37Rv --------------------------------------------MKNIGW
Mflv_2392|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4256|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_4258|M.thermoresistible__bu --------------------------------------------------
MSMEG_4876|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_4793|M.marinum_M --------------------------------------------------
MUL_0362|M.ulcerans_Agy99 ------------MPGSAMTALPAPPLMYFRSSLLRILFASGDRIFSDCRD
MAV_0863|M.avium_104 --------------------------------------------------
MAB_4055c|M.abscessus_ATCC_199 -------------------------------MTFRSPLPDVSIPDCSVYE
MLBr_02546|M.leprae_Br4923 MTKLRHYLERGAAEVHYLRSIFESGALGFEPPLTYAAMAVAMRKWGDLAM
Mb3116|M.bovis_AF2122/97 MLRQRATVSPRLQAYVEPSTDVRMTYAQMNALANRCADVLTALGIAKGDR
Rv3089|M.tuberculosis_H37Rv MLRQRATVSPRLQAYVEPSTDVRMTYAQMNALANRCADVLTALGIAKGDR
Mflv_2392|M.gilvum_PYR-GCK ------MSEPTALAFED----RCLSLADIDALAAGMAVELQRRGVGAGSR
Mvan_4256|M.vanbaalenii_PYR-1 ------MSDPWALAFED----RQYSLADLDALAGGMAAELHRRGVAAGSR
TH_4258|M.thermoresistible__bu ------MADRVALTFED----RAYSAAELDALTGGTAAALAARGVCPGSR
MSMEG_4876|M.smegmatis_MC2_155 ---MRLMGESAVLAFGD----REYTLTELDALAGGMAATLAQRGVGPGDR
MMAR_4793|M.marinum_M ------MTEPAALVFED----RGFSLPGLGAMADGLAAALRKQGVVAGDR
MUL_0362|M.ulcerans_Agy99 RREGRDVTEPAALVFED----RGFSLPGLGAMADGLAAALRKQGVVAGDR
MAV_0863|M.avium_104 ------MTEPAALVFEE----RRFSVPELDALADGWAAALAKDGVTAGRR
MAB_4055c|M.abscessus_ATCC_199 YVFGDTGAEDSRIALIDGLTGAQTTLGELRSQIDATAAGLAERGFGIGDV
MLBr_02546|M.leprae_Br4923 LPAMPARRSPHRAALID--EEGTLTYKELDRAAHALANGLIAKGVRGGDG
. . : : : * * *. *
Mb3116|M.bovis_AF2122/97 VALLMPNSVEFCCLFYGAAKLGAVAVPINTRLAAPEVSFILSDSGSKVVI
Rv3089|M.tuberculosis_H37Rv VALLMPNSVEFCCLFYGAAKLGAVAVPINTRLAAPEVSFILSDSGSKVVI
Mflv_2392|M.gilvum_PYR-GCK VALMSSNRPEFVVALRAIWRLGAAAVLLSPAWKQTEVGHAVALTEATHAV
Mvan_4256|M.vanbaalenii_PYR-1 VAVMSSNRPEFVVALRAIWRLGASAVLLSPAWKQAEVGHALSLTEPTHAV
TH_4258|M.thermoresistible__bu VAIMSSNRPEFVVALRAIWSLGAAAVLLSPAWKRAEVDHALALTTPSHAV
MSMEG_4876|M.smegmatis_MC2_155 VAMMSSNRPEFVIALRAIWRLGAAAVLISPAWKTTEIAHALELTRANHAV
MMAR_4793|M.marinum_M VAVMSSNRPEFVAVLNAIWCLGASAVLISPAWKRAEVDHALALTGPAHAA
MUL_0362|M.ulcerans_Agy99 VAVMSSNRPEFVAVLNVIWCLGASAVLISPAWKRAEVDHALALTGPAHAA
MAV_0863|M.avium_104 VAVMTSNRPEFLAVLLAIWRLAATAVLISPAWKRDEVEHALALTDPGHAV
MAB_4055c|M.abscessus_ATCC_199 AAVFLPNCSAFAVVLHGILRAGGTASTVNVLYTAEELAKQLIDSKAQLIF
MLBr_02546|M.leprae_Br4923 IAILARNHRWFVIANYGCARVGARIILLNSEFSGPQIKEVSEREGAKVII
*:: * * .. :. :: .
Mb3116|M.bovis_AF2122/97 YGAPSAPVIDAIRAQADPPGTVTDWIG----ADSLAERLRSAAADEPAVE
Rv3089|M.tuberculosis_H37Rv YGAPSAPVIDAIRAQADPPGTVTDWIG----ADSLAERLRSAAADEPAVE
Mflv_2392|M.gilvum_PYR-GCK GDHPVLADAMP--------------------MLSLDDEIAPRDP-EAAPD
Mvan_4256|M.vanbaalenii_PYR-1 GDHPVLAGSMP--------------------MLSLDEEIAPVAHGAVQPA
TH_4258|M.thermoresistible__bu GDHPVLADLMP--------------------MLHLDEPVTADPDGAGRPV
MSMEG_4876|M.smegmatis_MC2_155 GDQPLLAEHLP--------------------MVHLDEPITPGER--PGPA
MMAR_4793|M.marinum_M GDHPVLAGLMP--------------------MLHLDEPITPAAP--LPGA
MUL_0362|M.ulcerans_Agy99 GDHPVLAGLMP--------------------MLHLDEPITPAAP--LPGA
MAV_0863|M.avium_104 GDHPVLAGLMP--------------------MLHLDEPVPPAQP--TAGA
MAB_4055c|M.abscessus_ATCC_199 TVSPLLSRALEAAEIAGIDAAGVITVDPVEGRLSLADIARPDLAPPQVTF
MLBr_02546|M.leprae_Br4923 YDDEYTKVVSKAEPALGKLRALGVNPDEEEPPGSTDETLAELIARSSSAP
:
Mb3116|M.bovis_AF2122/97 CGGDDN--LFIMYTSGTTGHPKGVVHTHESVHSAASSWASTIDVRYRDRL
Rv3089|M.tuberculosis_H37Rv CGGDDN--LFIMYTSGTTGHPKGVVHTHESVHSAASSWASTIDVRYRDRL
Mflv_2392|M.gilvum_PYR-GCK PDAGAD--AVFVFSSGTTGMPKAVRHTHASLAVAIRHWRDALGLTAADRM
Mvan_4256|M.vanbaalenii_PYR-1 PTPDAD--AVFVFSSGTTGMPKAVRHTHASLAVAVRHWRAALGLTSADRM
TH_4258|M.thermoresistible__bu PPEDAD--ALFVFSSGTTGMPKAVRHTHGALRTAVRHWRDALGLTAADRM
MSMEG_4876|M.smegmatis_MC2_155 VAPDAD--ALFVFSSGTTGMPKAVRHSHAGFAAAIEHWRDALGLTAADRM
MMAR_4793|M.marinum_M PRRAGD--ALLVFSSGTTGLPKAVRHTHASLNAAIGHWRDALGLTERDRI
MUL_0362|M.ulcerans_Agy99 PRRAGD--ALLVFSSGTTGLPKAVRHTHASLNAAIGHWRDALGLTERDRI
MAV_0863|M.avium_104 PPRAGD--AVLVFSSGTTGLPKAVRHTHASLDEAVRHWREALRLTRRDRI
MAB_4055c|M.abscessus_ATCC_199 DPATHL--AVLPYSSGTTGKAKGVMLTHHNLVANIAQAKHLYGVQRGDRV
MLBr_02546|M.leprae_Br4923 APKVRKRASIIILTSGTTGTPKGANRNTPASLAPLGGILSKVPFRAHEVT
.: :***** .*.. . . :
Mb3116|M.bovis_AF2122/97 LLPLPMFHVAALTTVIFSAMR-GVTLISMPQFDATKVWSLIVEERVCIGG
Rv3089|M.tuberculosis_H37Rv LLPLPMFHVAALTTVIFSAMR-GVTLISMPQFDATKVWSLIVEERVCIGG
Mflv_2392|M.gilvum_PYR-GCK QVMTPPSHILGLLNII-MALDTGAWIRLHRRFDIDAMLRHIESDRITIEM
Mvan_4256|M.vanbaalenii_PYR-1 QVMTPPSHILGLLNIV-MALDTGAWIRLHRRFDIDAMLRHIESDRITIEM
TH_4258|M.thermoresistible__bu QIMTPPSHILGLLNIV-MALDTGTWIRLHRRFDIDRMLHHIQADRITIEM
MSMEG_4876|M.smegmatis_MC2_155 QIMTPPSHILGLLNIA-MVLDTGAWMRLHPRFDVETMLRHIESDGITIEM
MMAR_4793|M.marinum_M QIVTPPSHILGLLNIV-TALRTGVRVRLHRRFDIDQMLAHIESDRITVEM
MUL_0362|M.ulcerans_Agy99 QIVTPPSHILGLLNIV-AALRTGVRVRLHRRFDIDQMLAHIESDRITVEM
MAV_0863|M.avium_104 QVATPPSHILGLLNLL-TALKTGACVRLHPRFDIDKVLHHIESDRVTVEM
MAB_4055c|M.abscessus_ATCC_199 LAVLPFFHIYGLVVLLNVQLKLGAELVILPRFELDTFLGSIANYRVDHVF
MLBr_02546|M.leprae_Br4923 LLPAPMFHALGYLHAT-LAMFLGSTLVLRRRFKPATVLEDIEKHQATAMV
* * . : * : :*. . *
Mb3116|M.bovis_AF2122/97 AVPAILNFMRQVPE--FAELDAPDFRYFITGGAPMPEALIKIYAAKN-IE
Rv3089|M.tuberculosis_H37Rv AVPAILNFMRQVPE--FAELDAPDFRYFITGGAPMPEALIKIYAAKN-IE
Mflv_2392|M.gilvum_PYR-GCK AVAPIALALSAHPR--LEDHDLSSLRYIMWCATPVTQSVAEAVTARTGVT
Mvan_4256|M.vanbaalenii_PYR-1 AVAPIALALSAHPG--LEEHDLSSLRYIMWCATPVTQTVAEAVSARTGAT
TH_4258|M.thermoresistible__bu AVAPIALALAGHPG--LESYDLSSLRYIMWCATPVTQSVADAVTARTGVG
MSMEG_4876|M.smegmatis_MC2_155 AVAPIALALAAHPG--LERFDLSSLRFVMWCATPVTRSVAEDITARAGIR
MMAR_4793|M.marinum_M AVAPIALAMASHPN--LESYDLSSLRFIMWGATPVSAGIAETVTNRTGIG
MUL_0362|M.ulcerans_Agy99 AVAPIALAMASHPN--LESYDLSSLRFIMWGATPVSAGIAETVTNRTGIG
MAV_0863|M.avium_104 AVAPIALAIASHPD--LESYDLSSLRYIVWGATPVNAEVAQTVTRRTGVG
MAB_4055c|M.abscessus_ATCC_199 VAPPVAVVLAKHPD--VDKYDVSCLRSVFSGAAPLDEQLGNAVAARLNCR
MLBr_02546|M.leprae_Br4923 VVPVMLSRILDTLENLETKSDLSSLRVVFVSGSQLGAELATRALEELGPV
... : : * . :* .. .: : : .
Mb3116|M.bovis_AF2122/97 VVQGYALTESCGGGTLLLSEDALRKAGSAGRATMFTDVAVRGDDGVIREH
Rv3089|M.tuberculosis_H37Rv VVQGYALTESCGGGTLLLSEDALRKAGSAGRATMFTDVAVRGDDGVIREH
Mflv_2392|M.gilvum_PYR-GCK WVTAYGASELPVISCNDLQHAR---LDTVGRAVTGVGIRIVSLQTGEVLG
Mvan_4256|M.vanbaalenii_PYR-1 WVTAYGASELPVISCNDLQDAR---LDTVGRAVAGVDIRIVSLESGAPLG
TH_4258|M.thermoresistible__bu WIAAYGTTELPVIACNPLQGGR---LDTVGRPVPGVQVRIVSLDTGAPVG
MSMEG_4876|M.smegmatis_MC2_155 WLTAYGTTELPVIACNPLDDTR---IETVGKPVRGVRVRIA---------
MMAR_4793|M.marinum_M WVPAYGTTELPVIACSPLRGAR---LDTVGRVLPGVDLRVVSIETGERVG
MUL_0362|M.ulcerans_Agy99 WVPAYGTTELPVIACSPLRGAR---LDTVGRVLPGVDLRVVSTETGERVG
MAV_0863|M.avium_104 WLPAYGTTELPVIACNPIEDAR---LDTVGRPVPGVEVRVVSLESGEPAG
MAB_4055c|M.abscessus_ATCC_199 VSQGYGMTELSPVSHLIPPDRPDIPLNSVGIPVPNSENKIIDTETGDEIE
MLBr_02546|M.leprae_Br4923 IYNMYGSTEIAFATIAGPKDLQIN-SATVGPVVKGVKVKILDDSGKEVPR
*. :* :.* :
Mb3116|M.bovis_AF2122/97 G-------EGEVVIKSDILLKEYWNRPEATRDAFD-NGWFRTGDIGEIDD
Rv3089|M.tuberculosis_H37Rv G-------EGEVVIKSDILLKEYWNRPEATRDAFD-NGWFRTGDIGEIDD
Mflv_2392|M.gilvum_PYR-GCK A-----GEEGEIQVRSDSAMAGYLPDQWTAQAFS--DGWYRTGDVGTLDG
Mvan_4256|M.vanbaalenii_PYR-1 P-----GDEGEIQVRSDSAMAGYLPDHWTADAFC--DGWYRTGDVGSLDA
TH_4258|M.thermoresistible__bu P-----GEEGEVQARSASVMAGYLPDQ--PGAFV--EGWYRTGDVGYLDT
MSMEG_4876|M.smegmatis_MC2_155 -------DTGEIQVCSPSAMCGYLPESATGGAFD--DGWYRTGDIGFLDD
MMAR_4793|M.marinum_M P-----GEVGEIQARSHSLMAGYLPAAATAEVMS--QGWYRTGDIGSLDA
MUL_0362|M.ulcerans_Agy99 P-----GEVGEIQARSHLLMAGYLPAAATAEVMS--QGWYRTGDIGSLDA
MAV_0863|M.avium_104 A-----GEVGEIQARSASLMAGYLPGEATGEAIR--DGWYRTGDAGWLDT
MAB_4055c|M.abscessus_ATCC_199 IPAEGESAPGELLVRGPNVMAGYLGNEEATAATIEPDGFLHTGDIAVVRA
MLBr_02546|M.leprae_Br4923 G------QVGRIFVGNAFPFEGYTGGGGKQIIDG----LLSSGDVGYFDE
*.: . : * :** . .
Mb3116|M.bovis_AF2122/97 EGYLYIKDRLKDMIISGGENVYPAEIESVIIGVPGVSEVAVIGLPDEKWG
Rv3089|M.tuberculosis_H37Rv EGYLYIKDRLKDMIISGGENVYPAEIESVIIGVPGVSEVAVIGLPDEKWG
Mflv_2392|M.gilvum_PYR-GCK EGWLRITDRAKEMIKVRGFQVAPAEVEAVLHGHPAVEDCAVFGIP-AADG
Mvan_4256|M.vanbaalenii_PYR-1 DGWLRITDRAKEMIKVRGFQVAPAEVEAVLHGHPAVEDCAVFGVP-AADG
TH_4258|M.thermoresistible__bu DGWLRLTDRAKDMVKVRGFQVAPAEVEAVLHEHPAVDDCAVFGVP-SPDG
MSMEG_4876|M.smegmatis_MC2_155 DGYLHVTDRAKEMVKVRGFQVAPAEVEAVLHGHPAVADCAVFGEPHDTDG
MMAR_4793|M.marinum_M AGWLRVTDRLKEMIKVRGFQVAPAEIEAVLHGHPAVRDCAVFGVPDGANG
MUL_0362|M.ulcerans_Agy99 AGWLRVTDRLKEMIKVRGFQVAPTEIEAVLHGHPAVRDCAVFGVPDGANG
MAV_0863|M.avium_104 GGWLRITDRLKEMIKVRGFQVAPAEIDAVLQGHPAVADCAVFGVPDGLNG
MAB_4055c|M.abscessus_ATCC_199 DGVVTIVDRLKELIKYKGYQVPPAELEALLLTHPGIGDAAVIGVPDPSSG
MLBr_02546|M.leprae_Br4923 HDLLYISGRDDEMIVSGGENVFPAEVEDLISGHPEVVEATAIGVDDKEWG
. : : .* .::: * :* *:*:: :: * : : :.:* *
Mb3116|M.bovis_AF2122/97 EIAAAIVVADQNE-VSEQQIVEYCGTRLARYKLPKKVIFAEAIPRNPTGK
Rv3089|M.tuberculosis_H37Rv EIAAAIVVADQNE-VSEQQIVEYCGTRLARYKLPKKVIFAEAIPRNPTGK
Mflv_2392|M.gilvum_PYR-GCK EAIVAAVTLGHP--VDTDELADLVADRLASYKRPSRVVVVDEIPRLPSGK
Mvan_4256|M.vanbaalenii_PYR-1 EAIVAAVAASGP--LDTDDLVALVAERLAGYKRLSQVFVVDEIPRLPSGK
TH_4258|M.thermoresistible__bu EALVAAVTRRGE--VSADELLALVGERLASYKRPSRVVFVPEIPRLPSGK
MSMEG_4876|M.smegmatis_MC2_155 EAVVAAVATCAE--VSAEELIDLVGARLASYKRPRRIEFVTEIPRLPSGK
MMAR_4793|M.marinum_M EAVVAAVAARTP--VGDAELRARVAASLASYKRLSRIVFVPDIPRLPSGK
MUL_0362|M.ulcerans_Agy99 EAVVVAVAARTP--VDAAELRARVAASLASYKRLSRIVFVPDIPRLPSGK
MAV_0863|M.avium_104 EAVVAAVAVSAP--VDVTELTALVRQKLASYKHLSRVVVVPEIPRLPSGK
MAB_4055c|M.abscessus_ATCC_199 EIPKAFVVRTDDD-LTDEAVMAFVEQKVAPHKRIRQVEFIDAIPKSAAGK
MLBr_02546|M.leprae_Br4923 ARLRAFVVKKQDATIDEDAIKAYVRDHLARYKVPREVIFLEELPRNPTGK
. *. : : :* :* .: . :*: .:**
Mb3116|M.bovis_AF2122/97 ILKTVLREQYSATVPK-----------
Rv3089|M.tuberculosis_H37Rv ILKTVLREQYSATVPK-----------
Mflv_2392|M.gilvum_PYR-GCK VLRRVLRERAMGAGAKSGGF-------
Mvan_4256|M.vanbaalenii_PYR-1 VLRRVLRERAMSARAESGGFGGRPSDQ
TH_4258|M.thermoresistible__bu VLRRVLKER---HGCPSDG--------
MSMEG_4876|M.smegmatis_MC2_155 VLRRVLKER---HGRPSDG--------
MMAR_4793|M.marinum_M VLRRALKEL---YGCASDS--------
MUL_0362|M.ulcerans_Agy99 VLRRALKEL---YGCTSDS--------
MAV_0863|M.avium_104 VLRRVLKER---HGCTSDS--------
MAB_4055c|M.abscessus_ATCC_199 ILRKDLRARI-----------------
MLBr_02546|M.leprae_Br4923 VLKRELRDFEVH---------------
:*: *: