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MGTDADLVADTARRVVAEHDPKTVPIQQFLGACFDAGLSWVHFPEGFGGLGVSRGLQAVADGILQGAGSP VPLGLNPMGYGMAAPTVREHAQTDDVRRQLLRPLATTEHIWCQLFSEPGAGSDLAGLATSAVLDGDTWVV NGQKVWTSLAHRAKWGLLLARTDPNMPKHKGLTYFVIDMHGEGVQTRPLRQLTGHAEFNEVYMTDARIPD TFRLGAVGDGWRVAMTTLMNERSALGGSGSRRGAGTISDAVALWTSRPDLHTPVLRDRLSSLWLRSEAQR LTSKRSRAAATVGGPGPEGSVGKLVGAELNQHIYEFCMDLLGPEGILYDGYGMGDGDAADWRGPIQQRFL RSRANTIEGGTSEVMRNILAERVLGLPGDLRADAGMAWKEIPRG
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. gilvum PYR-GCK | Mflv_0344 | - | - | 100% (394) | acyl-CoA dehydrogenase domain-containing protein |
M. gilvum PYR-GCK | Mflv_1481 | - | 3e-60 | 40.29% (350) | acyl-CoA dehydrogenase domain-containing protein |
M. gilvum PYR-GCK | Mflv_0441 | - | 4e-58 | 38.95% (362) | acyl-CoA dehydrogenase domain-containing protein |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb3590c | fadE30 | 3e-63 | 41.43% (350) | acyl-CoA dehydrogenase FADE30 |
M. tuberculosis H37Rv | Rv3560c | fadE30 | 3e-63 | 41.43% (350) | acyl-CoA dehydrogenase FADE30 |
M. leprae Br4923 | MLBr_00737 | fadE25 | 3e-22 | 23.48% (362) | putative acyl-CoA dehydrogenase |
M. abscessus ATCC 19977 | MAB_3122 | - | 1e-138 | 62.05% (390) | putative acyl-CoA dehydrogenase |
M. marinum M | MMAR_1953 | fadE34_1 | 1e-102 | 49.75% (398) | acyl-CoA dehydrogenase FadE34_1 |
M. avium 104 | MAV_0587 | - | 5e-63 | 39.52% (372) | putative acyl-CoA dehydrogenase |
M. smegmatis MC2 155 | MSMEG_6584 | - | 0.0 | 86.19% (391) | acyl-CoA dehydrogenase |
M. thermoresistible (build 8) | TH_0805 | - | 0.0 | 83.76% (394) | acyl-CoA dehydrogenase |
M. ulcerans Agy99 | MUL_4144 | fadE34 | 6e-63 | 40.32% (377) | acyl-CoA dehydrogenase FadE34 |
M. vanbaalenii PYR-1 | Mvan_0394 | - | 0.0 | 91.21% (398) | acyl-CoA dehydrogenase domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment Mb3590c|M.bovis_AF2122/97 -------------------------------------------------- Rv3560c|M.tuberculosis_H37Rv -------------------------------------------------- Mflv_0344|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_0394|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_6584|M.smegmatis_MC2_155 -------------------------------------------------- TH_0805|M.thermoresistible__bu -------------------------------------------------- MAB_3122|M.abscessus_ATCC_1997 -------------------------------------------------- MMAR_1953|M.marinum_M -------------------------------------------------- MAV_0587|M.avium_104 MVATVTDEQFAARALVRDWARNASTGPGGTAAIRDVEQGNPDAWRPVFAR MUL_4144|M.ulcerans_Agy99 MVAIVSDQQLAARELVRDWARTAAAGEIPTAASREIERGNADAWRPVFTG MLBr_00737|M.leprae_Br4923 -------------------------------------------------- Mb3590c|M.bovis_AF2122/97 -------------------------------------------------- Rv3560c|M.tuberculosis_H37Rv -------------------------------------------------- Mflv_0344|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_0394|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_6584|M.smegmatis_MC2_155 -------------------------------------------------- TH_0805|M.thermoresistible__bu -------------------------------------------------- MAB_3122|M.abscessus_ATCC_1997 -------------------------------------------------- MMAR_1953|M.marinum_M -------------------------------------------------- MAV_0587|M.avium_104 LAELGIFGVAVPEEAGGAGGSVEDLCAMVEEAAKALIPGPVATTALATLV MUL_4144|M.ulcerans_Agy99 LAELGLFGVAVPEDHGGAGGIIEDLCAMIEEAAKALVPGPVASTAVATAV MLBr_00737|M.leprae_Br4923 -------------------------------------------------- Mb3590c|M.bovis_AF2122/97 -------------------------------------------------- Rv3560c|M.tuberculosis_H37Rv -------------------------------------------------- Mflv_0344|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_0394|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_6584|M.smegmatis_MC2_155 -------------------------------------------------- TH_0805|M.thermoresistible__bu -------------------------------------------------- MAB_3122|M.abscessus_ATCC_1997 -------------------------------------------------- MMAR_1953|M.marinum_M -------------------------------------------------- MAV_0587|M.avium_104 LSDA----ELLAALAAGERFAGLALQGDITFDGAASTASGTLPFVLGAAD MUL_4144|M.ulcerans_Agy99 LAEAGAEPQLLAALASGDRFAGLALEGELQFDQNTSLASGSAPLVLGAIA MLBr_00737|M.leprae_Br4923 -------------------------------------------------- Mb3590c|M.bovis_AF2122/97 -------------------------------------------------- Rv3560c|M.tuberculosis_H37Rv -------------------------------------------------- Mflv_0344|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_0394|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_6584|M.smegmatis_MC2_155 -------------------------------------------------- TH_0805|M.thermoresistible__bu -------------------------------------------------- MAB_3122|M.abscessus_ATCC_1997 -------------------------------------------------- MMAR_1953|M.marinum_M -------------------------------------------------- MAV_0587|M.avium_104 GGVLLLPADGRWLVVDTASDGVHIEPLAATDFSRPLARVVLDSAPATVLA MUL_4144|M.ulcerans_Agy99 GGVVLLPAGASWLLVDTTAEGVAVEPLAATDFSRPLARVVLAAAPALSLG MLBr_00737|M.leprae_Br4923 -------------------------------------------------- Mb3590c|M.bovis_AF2122/97 -----------------------------------------------MQD Rv3560c|M.tuberculosis_H37Rv -----------------------------------------------MQD Mflv_0344|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_0394|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_6584|M.smegmatis_MC2_155 -------------------------------------------------- TH_0805|M.thermoresistible__bu -------------------------------------------------- MAB_3122|M.abscessus_ATCC_1997 ---------------------------------------MPVTSSEPSSA MMAR_1953|M.marinum_M -------------------------------------------------- MAV_0587|M.avium_104 QTPERVEELAATVLAAEAAGITRWSLQTAVDYAKVREQFGKPIGSFQAIK MUL_4144|M.ulcerans_Agy99 ELGQRVEDLTATVLAAEAAGVTRWALETAVAYAKVREQFGKPIGSFQAIK MLBr_00737|M.leprae_Br4923 ------------------------------------MVGWSGNPLFDLFK Mb3590c|M.bovis_AF2122/97 VEEFRAQVRGWLADNLAGEFAALKGLGGPGR------------EHEAFEE Rv3560c|M.tuberculosis_H37Rv VEEFRAQVRGWLADNLAGEFAALKGLGGPGR------------EHEAFEE Mflv_0344|M.gilvum_PYR-GCK --------MGTDADLVADTARRVVAEHDPK-----------------TVP Mvan_0394|M.vanbaalenii_PYR-1 --------MGTDADRVADAARRVVDEHDPK-----------------TVP MSMEG_6584|M.smegmatis_MC2_155 ------MSSVAEADLVAERARQVVSEHDPK-----------------SVP TH_0805|M.thermoresistible__bu --------MTTDADRVAELARRVVAEHDPN-----------------SVP MAB_3122|M.abscessus_ATCC_1997 GSNALHTSGSSQRDRVAAAAHEVLAKHPPA-----------------TTP MMAR_1953|M.marinum_M ---------MTAADDLQSRVQTLLDAHPPA-----------------TSD MAV_0587|M.avium_104 HLCAEMLCRAEQAEVAAADAARAAAEDDPAQFSLAAALAAATAITAVKAN MUL_4144|M.ulcerans_Agy99 HLCAEMLCRAEQADVAAADAARAAAESDDQQFALAAALAASIGISAAKAN MLBr_00737|M.leprae_Br4923 LPEEHNELRATIRALAEKEIAPHAADVDQR-----------------ARF Mb3590c|M.bovis_AF2122/97 RRAWNQRLAAAGLTCLGWP------------------------------- Rv3560c|M.tuberculosis_H37Rv RRAWNQRLAAAGLTCLGWP------------------------------- Mflv_0344|M.gilvum_PYR-GCK IQQFLGACFDAGLSWVHFP------------------------------- Mvan_0394|M.vanbaalenii_PYR-1 IPEFLGACFDAGLSWVHFP------------------------------- MSMEG_6584|M.smegmatis_MC2_155 IPQFLAACYDAGLSWVHFP------------------------------- TH_0805|M.thermoresistible__bu IPEFLGACYDAGLSWVHFP------------------------------- MAB_3122|M.abscessus_ATCC_1997 VTDLLGAVYDAGLAWVHFP------------------------------- MMAR_1953|M.marinum_M PREFLGARFDAGLAWVHFP------------------------------- MAV_0587|M.avium_104 VKDCIQVLGGIGCTWEHDAHLYLRRAHAIGRFLGGAERWLRRITALTQAG MUL_4144|M.ulcerans_Agy99 VKDCIQVLGGIGCTWEHDAHLYLRRAHSIGRFLGGAERWLRRVAALTQAG MLBr_00737|M.leprae_Br4923 PEEALAALNASGFNAIHVP------------------------------- * . Mb3590c|M.bovis_AF2122/97 -----------------------EEHGGRGLSTAHRVAFYEEYARADAPD Rv3560c|M.tuberculosis_H37Rv -----------------------EEHGGRGLSTAHRVAFYEEYARADAPD Mflv_0344|M.gilvum_PYR-GCK -----------------------EGFGGLGVSRGLQAVADGILQGAGSPV Mvan_0394|M.vanbaalenii_PYR-1 -----------------------EGFGGLGLSRGLQAVADRILQGAGGPV MSMEG_6584|M.smegmatis_MC2_155 -----------------------EGMGGLGVSRGLQAVVDRILQGAGGPV TH_0805|M.thermoresistible__bu -----------------------EGLGGLALPRGLQAVADRILQGAGGPV MAB_3122|M.abscessus_ATCC_1997 -----------------------VGLGGLDAPPALQAVSDTILRAAGVPD MMAR_1953|M.marinum_M -----------------------VGFGGLDLPHTYQAQVDKQLAAAGAPP MAV_0587|M.avium_104 VRRRLGIDLTEVEDQRPQIAEAVARIAALPAEQRQAALAEAGLQAPHWPA MUL_4144|M.ulcerans_Agy99 VRRRLDIDLSEVADLRPEIVAAVADVAALPEQKRQEALAEAGLLAPHWPA MLBr_00737|M.leprae_Br4923 -----------------------EEYGGQGADSVAACIVIEEVARVDASA .. . Mb3590c|M.bovis_AF2122/97 KVN------------------HFG------EELLGPTLIAFGTP-QQQRR Rv3560c|M.tuberculosis_H37Rv KVN------------------HFG------EELLGPTLIAFGTP-QQQRR Mflv_0344|M.gilvum_PYR-GCK PLG--------------LNPMGYG--------MAAPTVREHAQTDDVRRQ Mvan_0394|M.vanbaalenii_PYR-1 PLG--------------LNPMGYG--------MAAPTVREHAQTDEVRHR MSMEG_6584|M.smegmatis_MC2_155 PLG--------------LNPMGYG--------MAAPTIREHAQNDELKKS TH_0805|M.thermoresistible__bu PLG--------------LNPMGYG--------MAAPTIREHAQTDELKRF MAB_3122|M.abscessus_ATCC_1997 PLF--------------VNVIGYG--------MAAPTVLAHGQP-ELIRR MMAR_1953|M.marinum_M AGGG-------------RNIIGIG--------MAAPTIAAFGTA-EQKQK MAV_0587|M.avium_104 PYGRGASPAEQLLIDQELAAAGVARPDLVIGWWAAPTILEHGTP-EQIER MUL_4144|M.ulcerans_Agy99 PYGRGASPAEQLLIDQELAAAGVVRPDLVIGWWAAPTILEHGTP-EQIAR MLBr_00737|M.leprae_Br4923 SLIP--------------AVNKLG----------TMGLILRGSE-ELKKQ : . : Mb3590c|M.bovis_AF2122/97 FLPRIRDVTELWCQGYSEPGAGSDLASVATTAELDGD---QWVINGQKVW Rv3560c|M.tuberculosis_H37Rv FLPRIRDVTELWCQGYSEPGAGSDLASVATTAELDGD---QWVINGQKVW Mflv_0344|M.gilvum_PYR-GCK LLRPLATTEHIWCQLFSEPGAGSDLAGLATSAVLDGD---TWVVNGQKVW Mvan_0394|M.vanbaalenii_PYR-1 LLRPLATTEEIWCQLFSEPGAGSDLAGLATSAVLDGD---TWVVNGQKVW MSMEG_6584|M.smegmatis_MC2_155 WLRPLASTEHIWCQLFSEPGAGSDLAGLATSAVPDGD---DWVINGQKVW TH_0805|M.thermoresistible__bu WLRPLATTEDIWCQLFSEPGAGSDLAGLATSAVPDGD---DWIVNGQKVW MAB_3122|M.abscessus_ATCC_1997 ILRPLFTGEELWCQLFSEPGAGSDLAGLATRAVRDGD---EWVINGQKVW MMAR_1953|M.marinum_M FLRPLFTGEHLYCQLFSEPGAGSDLAAAATRAVRDPHRPLDWIVNGQKVW MAV_0587|M.avium_104 FVPGTLRGEFLWCQLFSEPGAGSDLASLRTKAVRTDG---GWLLTGQKVW MUL_4144|M.ulcerans_Agy99 FVPSTLRGDFLWCQLFSEPGAGSDLASLRTKAVRGDG---GWLLTGQKVW MLBr_00737|M.leprae_Br4923 VLPSLAAEGAMASYALSEREAGSDAASMRTRAKADGD---DWILNGFKCW : : . ** **** *. * * *::.* * * Mb3590c|M.bovis_AF2122/97 TSLAHLSQWCFVLARTEKGSQRHAGLSYLLVPLDQPGVQIRPIVQITGT- Rv3560c|M.tuberculosis_H37Rv TSLAHLSQWCFVLARTEKGSQRHAGLSYLLVPLDQPGVQIRPIVQITGT- Mflv_0344|M.gilvum_PYR-GCK TSLAHRAKWGLLLARTDPNMPKHKGLTYFVIDMHGEGVQTRPLRQLTGH- Mvan_0394|M.vanbaalenii_PYR-1 TSLAHRAKWGLLLARTDPDVPKHKGLTYFVIDMHADGVQTRPLRQLTGH- MSMEG_6584|M.smegmatis_MC2_155 TSLAHRARWGLLLARTNPDVPKHKGLTYFVIDMHGPGVETRPLRQMTGQ- TH_0805|M.thermoresistible__bu TSLAHRARWGLLLARTDPDAPKHKGLTYFVLDMHADGVETRPLRQMTGQ- MAB_3122|M.abscessus_ATCC_1997 TSGAHQARWALLVARSNPDVAKHRGLTYFVVDMTDPGVEVRPLRQMTGD- MMAR_1953|M.marinum_M TSMAQHAQMAILVARTDPDVPKHAGLTYFLCDMTQPGIDIRPLRQITGE- MAV_0587|M.avium_104 TSAAHKARWGVCLARTDPDAPKHKGITYFLVDMSAPGIEIRPLREITGD- MUL_4144|M.ulcerans_Agy99 TSAAHKARWGVCLARTDPDAPKHKGITYFLLDMTAPGIEIRPLREITGD- MLBr_00737|M.leprae_Br4923 ITNGGKSTWYTVMAVTDPD-KGANGISAFIVHKDDEGFSIGPKEKKLGIK : . : :* :: . *:: :: *.. * : * Mb3590c|M.bovis_AF2122/97 -AEFNEVFFDDARTDADLVVGAPGDGWRVAMATLTFER-GVSTLGQQIVY Rv3560c|M.tuberculosis_H37Rv -AEFNEVFFDDARTDADLVVGAPGDGWRVAMATLTFER-GVSTLGQQIVY Mflv_0344|M.gilvum_PYR-GCK -AEFNEVYMTDARIPDTFRLGAVGDGWRVAMTTLMNERSALGGSGSR-RG Mvan_0394|M.vanbaalenii_PYR-1 -AEFNEVYMTDARIPDAYRLGAVGDGWRVAMTTLMNERSALGGSGSR-RG MSMEG_6584|M.smegmatis_MC2_155 -AEFNEVYMTDARIPDAHRLGAVGDGWRVAMTTLMNERSALGGSGSR-RG TH_0805|M.thermoresistible__bu -AEFNEVYITDARIPDAHRLGAVGDGWRVAMTTLMNERSALGGSGNR-RG MAB_3122|M.abscessus_ATCC_1997 -AEFNEVYLTDVRIPDAHRLGNEGDGWRVSMTTLMNERSALGGAFDHGRG MMAR_1953|M.marinum_M -AEFNEVFLTDIRVPDANRLGPEGGGWRVATTTLNNERVAIGSRTGVPRE MAV_0587|M.avium_104 -SLFNEVFLDNVFVPDEMVVGEVNDGWRLARTTLANERVAMASGTALGNP MUL_4144|M.ulcerans_Agy99 -SLFNEVFLENVFIPDQMVVGAVNDGWRLARTTLANERVAMATGTALGNP MLBr_00737|M.leprae_Br4923 GSPTTELYFDKCRIPGDRIIGEPGTGFKTALATLDHTRPTIGAQAVG-IA : .*::: . :* . *:: : :** * :. Mb3590c|M.bovis_AF2122/97 ARELSNLVELARRTAAADDPLIRERLTRAWTGLRAMRSYALATMEGPAVE Rv3560c|M.tuberculosis_H37Rv ARELSNLVELARRTAAADDPLIRERLTRAWTGLRAMRSYALATMEGPAVE Mflv_0344|M.gilvum_PYR-GCK AGTISDAVALWTSRPDLHTPVLRDRLSSLWLRSEAQRLTSKRSRAAATVG Mvan_0394|M.vanbaalenii_PYR-1 AGTVSDAVALWASRPDLHTPVLRDRLTRLWLRAEAQRLTSERSRASATVG MSMEG_6584|M.smegmatis_MC2_155 AGTIADAVSLWASRPDLHTPVLRDRLTQLWLRSEAQRLTAERSRATATVG TH_0805|M.thermoresistible__bu SGTIADAVALWASRPDLHTPVMRDRLTRLWLRAEAQRLTAERSRATATVG MAB_3122|M.abscessus_ATCC_1997 GGSIGNALNLWKQRPDLHTPELRAKLTNLFVRSEGNRYGTQMRIAAQGDA MMAR_1953|M.marinum_M GGMIGKVTEAWRAEPALRNPAMHDDMMRLWVEAEVLRLAGERLRQQAASG MAV_0587|M.avium_104 MEELLELLSTLPLDS-----AQQDRLGRLIVTAQTGALLDQRIAQLAVGG MUL_4144|M.ulcerans_Agy99 MEELLEVLAEPELDT-----GQQDRLARLIVATQTGALLDQRIAQLVMGG MLBr_00737|M.leprae_Br4923 QGALDAAIVYTKDRKQFGESISTFQSIQFMLADMAMKVEAARLIVYAAAA : Mb3590c|M.bovis_AF2122/97 -QPGQD-NVSKLLWANWHRNLGELAMDVIGKPGMTMPDGEFDE------- Rv3560c|M.tuberculosis_H37Rv -QPGQD-NVSKLLWANWHRNLGELAMDVIGKPGMTMPDGEFDE------- Mflv_0344|M.gilvum_PYR-GCK -GPGPEGSVGKLVGAELNQHIYEFCMDLLGPEGILYDGYGMGD----GDA Mvan_0394|M.vanbaalenii_PYR-1 -GPGPEGSVGKLVGAELNQHIYEFCMDLLGPEGILYGSYGMQDTSSNGDA MSMEG_6584|M.smegmatis_MC2_155 -GPGPEGSIGKLVGAELNQHIYQWCMDFLGPEGLLYDGYGLGD----GDG TH_0805|M.thermoresistible__bu -GPGPEASIGKLVGAELNQEIYQFCMDLLGPEGVLYHSYDMDG----GSG MAB_3122|M.abscessus_ATCC_1997 -PMGPEGSIGKLMGAELNQQIYDFCVELLGIEATLYASYDMRR----VVE MMAR_1953|M.marinum_M -QPGPEGAGMKVAFARLAQQISGFELELHPESGLQYDDWTLRR----PDT MAV_0587|M.avium_104 QDPGAQSSVRKLIGVRYRQALAEYTMDVSEGGGLVHN------------- MUL_4144|M.ulcerans_Agy99 RDPGAQSSVRKLIGVRYRQALAEYMMDVSACGGLVEN------------- MLBr_00737|M.leprae_Br4923 RAERGEPDLGFIS-AASKCFASDIAMEVTTDAVQLFGGAGYTS------- : : . ::. Mb3590c|M.bovis_AF2122/97 -------WQRLYLFTRADTIYGGSNEIQRNIIAERVLGLPREAKG----- Rv3560c|M.tuberculosis_H37Rv -------WQRLYLFTRADTIYGGSNEIQRNIIAERVLGLPREAKG----- Mflv_0344|M.gilvum_PYR-GCK ADWRG-PIQQRFLRSRANTIEGGTSEVMRNILAERVLGLPGDLRADAGMA Mvan_0394|M.vanbaalenii_PYR-1 QDWRG-PIQQRFLRSRANTIEGGTSEVMRNILAERVLGLPGDLRADAGMP MSMEG_6584|M.smegmatis_MC2_155 ADWRG-PVQQRFLRSKANTIEGGTSEVMRNILGERILGLPGDLRADAGMA TH_0805|M.thermoresistible__bu DDWRG-PIQQRYLRSRANTIEGGTSEVMRNILGERVLGLPGDLRADAGMP MAB_3122|M.abscessus_ATCC_1997 DDRRA-DTMWAFLRSKANTIEGGTSDVMRNIIGERVLGLPGDIRVDTDKA MMAR_1953|M.marinum_M VDLTGRGPGYRYLRARGNSIEGGTSEILRNTISERVLGLPGEHRVDKTLA MAV_0587|M.avium_104 ------RAVYDFLNTRCLTIAGGTEQILLTVAAERLLGLPR--------- MUL_4144|M.ulcerans_Agy99 ------RAVFDFLNTRCLTIAGGTEQILLTVAAERLLGLPR--------- MLBr_00737|M.leprae_Br4923 ----DFPVERFMRDAKITQIYEGTNQIQRVVMSRALLR------------ :: * *:.:: .. :* Mb3590c|M.bovis_AF2122/97 ------- Rv3560c|M.tuberculosis_H37Rv ------- Mflv_0344|M.gilvum_PYR-GCK WKEIPRG Mvan_0394|M.vanbaalenii_PYR-1 WKEVPRG MSMEG_6584|M.smegmatis_MC2_155 WKEIPRG TH_0805|M.thermoresistible__bu WKEIPRG MAB_3122|M.abscessus_ATCC_1997 WKDVPRG MMAR_1953|M.marinum_M WKDLDR- MAV_0587|M.avium_104 ------- MUL_4144|M.ulcerans_Agy99 ------- MLBr_00737|M.leprae_Br4923 -------