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MPFDLRELTVPVLVAPMAGGPSTPELAAAGSAAGGLGFVAAGYLTADMFAEKLSAAMTLTREPVGANLFV PQPSAAMPDEIAAYARALAPEAQRYGVAVGEPKFDDDDWAAKIEVLLDLRPAVVSFTFGLPSAEERRRLT GAGITTVGTVTTVAEARAAADVGVDVLTVQGPSAGGHRGTFDATARPSDIALDDLIARVTAAVGLPVVAA GGIMDAADIRRVRDAGAVAAQLGTAFLLADEAGSTPVHRAALQSSQFTETVVTRAFSGRYARGLRNRFII EHESQAPFGYPEVHYLTSPLRKASANAGDPGAVNIWAGTGFRRARTGSVADIVGSLVGDG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_2277 | - | - | 100% (340) | 2-nitropropane dioxygenase, NPD |
| M. gilvum PYR-GCK | Mflv_5156 | - | 6e-20 | 30.95% (294) | 2-nitropropane dioxygenase, NPD |
| M. gilvum PYR-GCK | Mflv_3286 | - | 9e-17 | 26.60% (312) | 2-nitropropane dioxygenase, NPD |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2804c | - | 5e-94 | 52.99% (334) | alanine rich oxidoreductase |
| M. tuberculosis H37Rv | Rv2781c | - | 5e-94 | 52.99% (334) | alanine rich oxidoreductase |
| M. leprae Br4923 | MLBr_00387 | guaB2 | 6e-05 | 26.09% (184) | inosine 5'-monophosphate dehydrogenase |
| M. abscessus ATCC 19977 | MAB_1641 | - | 8e-67 | 46.69% (332) | putative oxidoreductase |
| M. marinum M | MMAR_1927 | - | 2e-91 | 51.80% (334) | hypothetical protein MMAR_1927 |
| M. avium 104 | MAV_3673 | - | 2e-79 | 46.57% (335) | dioxygenase |
| M. smegmatis MC2 155 | MSMEG_4971 | - | 1e-132 | 69.55% (335) | oxidoreductase |
| M. thermoresistible (build 8) | TH_1530 | - | 2e-41 | 62.20% (127) | POSSIBLE ALANINE RICH OXIDOREDUCTASE |
| M. ulcerans Agy99 | MUL_2153 | - | 1e-90 | 51.66% (331) | hypothetical protein MUL_2153 |
| M. vanbaalenii PYR-1 | Mvan_4389 | - | 1e-141 | 73.81% (336) | 2-nitropropane dioxygenase, NPD |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2804c|M.bovis_AF2122/97 --------------------------------------------------
Rv2781c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_1927|M.marinum_M --------------------------------------------------
MUL_2153|M.ulcerans_Agy99 --------------------------------------------------
MAV_3673|M.avium_104 --------------------------------------------------
Mflv_2277|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4389|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_4971|M.smegmatis_MC2_155 --------------------------------------------------
TH_1530|M.thermoresistible__bu --------------------------------------------------
MAB_1641|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_00387|M.leprae_Br4923 MIRGMSNLKESSDFVASSYVRLGGLMDDPAATGGDNPHKVAMLGLTFDDV
Mb2804c|M.bovis_AF2122/97 ------------------MVLGFWDIAVPIVGAPMAGGPSTPALAAAVSN
Rv2781c|M.tuberculosis_H37Rv ------------------MVLGFWDIAVPIVGAPMAGGPSTPALAAAVSN
MMAR_1927|M.marinum_M ------------------MVLGFWDIAVPIVGAPMAGGPGTPALAAAVSN
MUL_2153|M.ulcerans_Agy99 ------------------MVLGFWDIAVPIVGAPMAGGPGTPALAAAVSN
MAV_3673|M.avium_104 ------------------MVLGFWDITVPIVGAPMAGGPGTPALAAAVSN
Mflv_2277|M.gilvum_PYR-GCK ----------------MP--FDLRELTVPVLVAPMAGGPSTPELAAAGSA
Mvan_4389|M.vanbaalenii_PYR-1 ----------------MS--FDVRDLSVPVLVAPMAGGPSTPELAAAGTN
MSMEG_4971|M.smegmatis_MC2_155 ----------------MMGDFDLRGLTRPVIVAPMAGGPSTPALAAAGSN
TH_1530|M.thermoresistible__bu --------------------------------------------------
MAB_1641|M.abscessus_ATCC_1997 ------------------MSTVLAGLRLPVVGAPMAGGITVPALARGVSA
MLBr_00387|M.leprae_Br4923 LLLPAASDVVPATADISSQLTKKIRLKVPLVSSAMDT-VTEARMAIAMAR
Mb2804c|M.bovis_AF2122/97 AGGLGFVAGGYLSADRLADDIAAARAATTGPIGANLFVPQPSVADWAQLE
Rv2781c|M.tuberculosis_H37Rv AGGLGFVAGGYLSADRLADDIAAARAATTGPIGANLFVPQPSVADWAQLE
MMAR_1927|M.marinum_M AGGLGFVAGGYRTADQFADDISAARAATTGPIGANIFVPQPSVADWLQLE
MUL_2153|M.ulcerans_Agy99 AGGLGFVAGGYRTADQFADDISAARAATTGPIGANIFVPQPSVADWLQLE
MAV_3673|M.avium_104 AGGLGFVPGGYVSAEQFADDIAAARKATTGPLGVNLFVPQPSVADWVALD
Mflv_2277|M.gilvum_PYR-GCK AGGLGFVAAGYLTADMFAEKLSAAMTLTREPVGANLFVPQPSAAMPDEIA
Mvan_4389|M.vanbaalenii_PYR-1 AGGLGFVAAGYLTADVFAERVRAAQRLTSGPLGVNLFVPQPSAGTPAAVA
MSMEG_4971|M.smegmatis_MC2_155 AGGLGFIAAGYLTADALAERIKATRELTSEPIGVNLFAPQPSAGTPEQIA
TH_1530|M.thermoresistible__bu --------------------------------------------------
MAB_1641|M.abscessus_ATCC_1997 AGGFGLLPAGYRTITQLEQDREAMGEL---PFGFNVFVPTPDQG--ADLR
MLBr_00387|M.leprae_Br4923 AGGMGVLHRNLPVGEQAGQVETVKRSEAGMVTDPVTCRPDNTLAQVGALC
Mb2804c|M.bovis_AF2122/97 Y-----------YADELEEVAEYYHTEVGQPVYGDDDDWVRKLEVVADVR
Rv2781c|M.tuberculosis_H37Rv Y-----------YADELEEVAEYYHTEVGQPVYGDDDDWVRKLEVVADVR
MMAR_1927|M.marinum_M Y-----------YAEELAEVAEYYHVEVGQPIHGDDDEWERKLEVVADIR
MUL_2153|M.ulcerans_Agy99 Y-----------YAEELAEVAEYYHVEVGQPIHGDDDEWERKLEVVADIR
MAV_3673|M.avium_104 Y-----------YAAELEEIAEHYQVEVGHPRYGDDDGWEQKLEVVADVR
Mflv_2277|M.gilvum_PYR-GCK A-----------YARALAPEAQRYGVAVGEPKF-DDDDWAAKIEVLLDLR
Mvan_4389|M.vanbaalenii_PYR-1 A-----------YAERLAEEARRYGTELGAPRF-DDDHWNAKLEVVLDLR
MSMEG_4971|M.smegmatis_MC2_155 A-----------YAQALAGEAERYGVALGEPRY-DDDAWAAKLDVVADLR
TH_1530|M.thermoresistible__bu --------------------------------------------------
MAB_1641|M.abscessus_ATCC_1997 E-----------YLDKLKVWADKLEVAPGDPVW-HDDAYADKIEYLVANP
MLBr_00387|M.leprae_Br4923 ARFRISGLPVVDDSGALAGIITNRDMRFEVDQSKQVAEVMTKTPLITAAE
Mb2804c|M.bovis_AF2122/97 PEVVSFTFGAPPPDVVQRLSALG---------------------------
Rv2781c|M.tuberculosis_H37Rv PEVVSFTFGAPPPDVVQRLSALG---------------------------
MMAR_1927|M.marinum_M PELVSFTFGAPPPDVVRQLSALG---------------------------
MUL_2153|M.ulcerans_Agy99 PELVSFTFGAPPPDVVRQLSALG---------------------------
MAV_3673|M.avium_104 PELVSFTFGVPPPDVIRRLGALG---------------------------
Mflv_2277|M.gilvum_PYR-GCK PAVVSFTFGLPSAEERRRLTGAG---------------------------
Mvan_4389|M.vanbaalenii_PYR-1 PALASFTFGLPTVEERRRLSAAG---------------------------
MSMEG_4971|M.smegmatis_MC2_155 PEVVSFTFGLPDDDEVKRLRQAG---------------------------
TH_1530|M.thermoresistible__bu --------------------------------------------------
MAB_1641|M.abscessus_ATCC_1997 VPVVSFTFGVPTAPDAHRLREAG---------------------------
MLBr_00387|M.leprae_Br4923 GVSADAALGLLRRNKIEKLPVVDGHGRLTGLITVKDFVKTEQHPLATKDN
Mb2804c|M.bovis_AF2122/97 -------LLVSITVTSVYEAGVAIAAGADSLVVQGPAAG-----------
Rv2781c|M.tuberculosis_H37Rv -------LLVSITVTSVYEAGVAIAAGADSLVVQGPAAG-----------
MMAR_1927|M.marinum_M -------LLVSVTVTSAYEAGVAIAAGADNLVVQGPGAG-----------
MUL_2153|M.ulcerans_Agy99 -------LLVSVTVTSAYEAGVAIAAGADNLVVQGPGAG-----------
MAV_3673|M.avium_104 -------LLVMVTVTSAYEAGVAVAAGADSLVVQGPAAG-----------
Mflv_2277|M.gilvum_PYR-GCK -------ITTVGTVTTVAEARAAADVGVDVLTVQGPSAG-----------
Mvan_4389|M.vanbaalenii_PYR-1 -------IATAATVTTPAEARLAADCGVDILVAQGPSAG-----------
MSMEG_4971|M.smegmatis_MC2_155 -------ITTVATVTSYDEAEQADGRGVDALAVQGPNAG-----------
TH_1530|M.thermoresistible__bu --------------------------------------------------
MAB_1641|M.abscessus_ATCC_1997 -------SEVWITVTSAAEAKIAEGIGADALVVQGPEAG-----------
MLBr_00387|M.leprae_Br4923 DGRLLVGAAVGVGGDAWVRAMMLVDAGVDVLIVDTAHAHNRLVLDMVGKL
Mb2804c|M.bovis_AF2122/97 --------------------------------------GHRGTFAPDMEP
Rv2781c|M.tuberculosis_H37Rv --------------------------------------GHRGTFAPDMEP
MMAR_1927|M.marinum_M --------------------------------------GHRGTFAPDTEP
MUL_2153|M.ulcerans_Agy99 --------------------------------------GHRGTFAPDTEP
MAV_3673|M.avium_104 --------------------------------------GHRGTFAPDMEP
Mflv_2277|M.gilvum_PYR-GCK --------------------------------------GHRGTFDATARP
Mvan_4389|M.vanbaalenii_PYR-1 --------------------------------------GHRGTFDPTATP
MSMEG_4971|M.smegmatis_MC2_155 --------------------------------------GHRGTFDPAAAP
TH_1530|M.thermoresistible__bu --------------------------------------------------
MAB_1641|M.abscessus_ATCC_1997 --------------------------------------GHRSSFDAGAP-
MLBr_00387|M.leprae_Br4923 KVEIGDRVQVIGGNVATRSAAAALVEAGADAVKVGVGPGSTCTTRVVAGV
Mb2804c|M.bovis_AF2122/97 GTESLHQLLDRIGSA--HDVPLVAAGGLGTAEDVAAVLRRGAIAAQVGTA
Rv2781c|M.tuberculosis_H37Rv GTESLHQLLDRIGSA--HDVPLVAAGGLGTAEDVAAVLRRGAIAAQVGTA
MMAR_1927|M.marinum_M GEESLHQLLDHIGHT--HDVPLIAAGGLGTADEVAAVLRRGAVAAQVGTA
MUL_2153|M.ulcerans_Agy99 GEESLHQLLDHIGHT--HDVPLIGAGGLGTADEVAAVLRRGAVAAQVGTA
MAV_3673|M.avium_104 ANESLHQLIDRIRHT--HDIPIIAAGGLGTADEVGAALRRGAVAAQVGTA
Mflv_2277|M.gilvum_PYR-GCK SDIALDDLIARVTAA--VGLPVVAAGGIMDAADIRRVRDAGAVAAQLGTA
Mvan_4389|M.vanbaalenii_PYR-1 SGQPLDELLAAVTAD--HAIPVVAAGGLMTATDIRRVRQAGAAAAQLGTA
MSMEG_4971|M.smegmatis_MC2_155 ATQSLEELLDDVVAA--MDMPVIAAGGLVTADDVAGVLAAGAVAAQLGTA
TH_1530|M.thermoresistible__bu ---------------------------LVTAXGVAGAISAGAVAVQAGTA
MAB_1641|M.abscessus_ATCC_1997 -DEPLLDLIASVRSV--TALPVVAAGGIMDGADIARVLAAGAAAAQLGTA
MLBr_00387|M.leprae_Br4923 GAPQITAILEAVAACGPAGVPVIADGGLQYSGDIAKALAAGASTTMLGSL
: . : . ** :. *:
Mb2804c|M.bovis_AF2122/97 LLLADEAGTNAAHRAALKNPEFDATLVTRAFSGRYARGLANN--------
Rv2781c|M.tuberculosis_H37Rv LLLADEAGTNAAHRAALKNPEFDATLVTRAFSGRYARGLANN--------
MMAR_1927|M.marinum_M LLLADEAGTSSVHRVALKNPEFDSTLVTRAFSGRYARGLANN--------
MUL_2153|M.ulcerans_Agy99 LLLADEAGTSSVHRVALKNPEFDSTLVTRAFSGRYARGLANN--------
MAV_3673|M.avium_104 LLLADEAGTNAAHRTALKNPLFAT-----------ARGLEND--------
Mflv_2277|M.gilvum_PYR-GCK FLLADEAGSTPVHRAALQSSQFTETVVTRAFSGRYARGLRNR--------
Mvan_4389|M.vanbaalenii_PYR-1 FLLSDEAGSSPVHRAALIDPQFTETAVTKAFSGRYARGLRNR--------
MSMEG_4971|M.smegmatis_MC2_155 FLLAEEAGSSDVHRAALQNPEFTETVVTRAFSGRYARGLRNR--------
TH_1530|M.thermoresistible__bu FLLADEAGTGPTQRAALRDPQFTETALTRAFSGRYARGLRNR--------
MAB_1641|M.abscessus_ATCC_1997 LVVTDESGAKQVYKDALLQP--ADTVVTRVFSGRPARSISNA--------
MLBr_00387|M.leprae_Br4923 LAGTAEAPGELIFVNGKQFKSYRGMGSLGAMQGRGGDKSYSKDRYFADDA
: : *: . . .
Mb2804c|M.bovis_AF2122/97 ------FTRLLDHVAPLG---YPEVHQMTKPIRAAAVQADDPHGTNLWAG
Rv2781c|M.tuberculosis_H37Rv ------FTRLLDHVAPLG---YPEVHQMTKPIRAAAVQADDPHGTNLWAG
MMAR_1927|M.marinum_M ------FTRLLDRVAPLG---YPEVNQMTKPIRAAAIEADDPHGTNLWAG
MUL_2153|M.ulcerans_Agy99 ------FTRLLDRVAPLG---YPEVNQMTKPIRAAAIEADDPHGTNLWAG
MAV_3673|M.avium_104 ------FTRMLDHVAPLG---YPEVNQMTTPIVEAAAAIEDPNGIPLWAG
Mflv_2277|M.gilvum_PYR-GCK ------FIIEHESQAPFG---YPEVHYLTSPLRKASANAGDPGAVNIWAG
Mvan_4389|M.vanbaalenii_PYR-1 ------FIVEHEAEAPFG---YPEVHYLTSPLRAAAVRAGDPQAVNIWAG
MSMEG_4971|M.smegmatis_MC2_155 ------FVVDHEAQAPFG---YPEVHYLTSPVRKASVAAGDPHATNIWAG
TH_1530|M.thermoresistible__bu ------FIDEHEDAAPFG---YPQVHHLTSPVRAAAARAGDPHGTNVWAG
MAB_1641|M.abscessus_ATCC_1997 ------FQRDMEAVAPVS---FPALNSATKELRAS----GDPDVMSLWAG
MLBr_00387|M.leprae_Br4923 LSEDKLVPEGIEGRVPFRGPLSSVIHQLVGGLRAAMGYTGSPTIEVLQQA
. : .*. . :: . : : .* : .
Mb2804c|M.bovis_AF2122/97 SAHRKTRPGPAADIIASLTPDVCSA-----
Rv2781c|M.tuberculosis_H37Rv SAHRKTRPGPAADIIASLTPDVCSA-----
MMAR_1927|M.marinum_M TAYRAAQAGPAADIVAALAPDVWSL-----
MUL_2153|M.ulcerans_Agy99 TAYRAAQAGPAADIVAALAPNVWSL-----
MAV_3673|M.avium_104 AAFKHASAGPAADIIAGLAATG--------
Mflv_2277|M.gilvum_PYR-GCK TGFRRARTGSVADIVGSLVGDG--------
Mvan_4389|M.vanbaalenii_PYR-1 TGFRQAGGGSVRDIMDTLIGRD--------
MSMEG_4971|M.smegmatis_MC2_155 TGFRAIGPGTVAEIMGRLVP----------
TH_1530|M.thermoresistible__bu TGYRSITAGPAADILTGLAAELPARS----
MAB_1641|M.abscessus_ATCC_1997 TEHHRARALPVAELMATLATELSAAQG---
MLBr_00387|M.leprae_Br4923 QFVRITPAGLKESHPHDVAMTVEAPNYYPR
: . :