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MIRGMSNLKESSDFVASSYVRLGGLMDDPAATGGDNPHKVAMLGLTFDDVLLLPAASDVVPATADISSQL TKKIRLKVPLVSSAMDTVTEARMAIAMARAGGMGVLHRNLPVGEQAGQVETVKRSEAGMVTDPVTCRPDN TLAQVGALCARFRISGLPVVDDSGALAGIITNRDMRFEVDQSKQVAEVMTKTPLITAAEGVSADAALGLL RRNKIEKLPVVDGHGRLTGLITVKDFVKTEQHPLATKDNDGRLLVGAAVGVGGDAWVRAMMLVDAGVDVL IVDTAHAHNRLVLDMVGKLKVEIGDRVQVIGGNVATRSAAAALVEAGADAVKVGVGPGSTCTTRVVAGVG APQITAILEAVAACGPAGVPVIADGGLQYSGDIAKALAAGASTTMLGSLLAGTAEAPGELIFVNGKQFKS YRGMGSLGAMQGRGGDKSYSKDRYFADDALSEDKLVPEGIEGRVPFRGPLSSVIHQLVGGLRAAMGYTGS PTIEVLQQAQFVRITPAGLKESHPHDVAMTVEAPNYYPR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. leprae Br4923 | MLBr_00387 | guaB2 | - | 100% (529) | inosine 5'-monophosphate dehydrogenase |
| M. leprae Br4923 | MLBr_02066 | guaB1 | 2e-62 | 34.39% (474) | inosine 5-monophosphate dehydrogenase |
| M. leprae Br4923 | MLBr_00388 | guaB3 | 2e-13 | 36.54% (156) | inosine 5-monophosphate dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3445c | guaB2 | 0.0 | 92.44% (529) | inosine 5'-monophosphate dehydrogenase |
| M. gilvum PYR-GCK | Mflv_4909 | - | 0.0 | 86.14% (505) | inositol-5-monophosphate dehydrogenase |
| M. tuberculosis H37Rv | Rv3411c | guaB2 | 0.0 | 92.44% (529) | inosine 5'-monophosphate dehydrogenase |
| M. abscessus ATCC 19977 | MAB_3721c | - | 0.0 | 87.35% (498) | inosine 5'-monophosphate dehydrogenase |
| M. marinum M | MMAR_1137 | guaB2 | 0.0 | 90.41% (532) | inosine-5'-monophosphate (imp) dehydrogenase, GuaB2 |
| M. avium 104 | MAV_4356 | guaB | 0.0 | 91.71% (531) | inositol-5-monophosphate dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_1602 | guaB | 0.0 | 88.22% (501) | inositol-5-monophosphate dehydrogenase |
| M. thermoresistible (build 8) | TH_1679 | guaB2 | 1e-110 | 87.83% (230) | PROBABLE INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE GUAB2 (IMP |
| M. ulcerans Agy99 | MUL_0900 | guaB2 | 0.0 | 90.04% (532) | inosine 5'-monophosphate dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_1511 | - | 0.0 | 87.13% (505) | inositol-5-monophosphate dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_4909|M.gilvum_PYR-GCK MSIAESSIP-------------------IAVPVPTGGDDPTKIAMLGLTF
Mvan_1511|M.vanbaalenii_PYR-1 MSIAESSIP-------------------IAVPVPTGGDDPTKVAMLGLTF
MSMEG_1602|M.smegmatis_MC2_155 MSIAESSVP-------------------IAVPVPTGGDDPTKVAMLGLTF
Mb3445c|M.bovis_AF2122/97 MSRGMSGLEDSSDLVVSPYVR---MGGLTTDPVPTGGDDPHKVAMLGLTF
Rv3411c|M.tuberculosis_H37Rv MSRGMSGLEDSSDLVVSPYVR---MGGLTTDPVPTGGDDPHKVAMLGLTF
MMAR_1137|M.marinum_M MSRGMSHLEDSSDLVDSPYMRDARVGDLSGDSVPTGGDDPHKVAMLGLTF
MUL_0900|M.ulcerans_Agy99 MSRGMSHLEDSSDLVDTPYMRDARVGDLSGDSVPTGGDDPHKVAMLGLTF
MAV_4356|M.avium_104 MTRGTSHLEDSSDLVGSAYVR---VGGLVDDPVPTGGDNPHKIAMLGLTF
MLBr_00387|M.leprae_Br4923 MIRGMSNLKESSDFVASSYVR---LGGLMDDPAATGGDNPHKVAMLGLTF
MAB_3721c|M.abscessus_ATCC_199 MT-------------------------IAAGSVHTGGDDPHKVAMLGLTF
TH_1679|M.thermoresistible__bu MDVYFCTPDGDPPMSIAERSVP------IAVPVPTGGDDPTKIAMLGLTF
* .. ****:* *:*******
Mflv_4909|M.gilvum_PYR-GCK DDVLLLPAASDVIPATADTSSQLTRRIRLKVPLVSSAMDTVTESRMAIAM
Mvan_1511|M.vanbaalenii_PYR-1 DDVLLLPAASDVIPATADTSSQLTRKIRLKVPLVSSAMDTVTESRMAIAM
MSMEG_1602|M.smegmatis_MC2_155 DDVLLLPAASDVVPATADTSSQLTKRIRLRVPLVSSAMDTVTESRMAIAM
Mb3445c|M.bovis_AF2122/97 DDVLLLPAASDVVPATADTSSQLTKKIRLKVPLVSSAMDTVTESRMAIAM
Rv3411c|M.tuberculosis_H37Rv DDVLLLPAASDVVPATADTSSQLTKKIRLKVPLVSSAMDTVTESRMAIAM
MMAR_1137|M.marinum_M DDVLLLPAASDVVPSTADTSSQLTKKIRLKVPLVSSAMDTVTESRMAIAM
MUL_0900|M.ulcerans_Agy99 DDVLLLPAASDVVPSTADTSSQLTKKIRLKVPLVSSAMDTVTESRMAIAM
MAV_4356|M.avium_104 DDVLLLPAASDVVPATADTSSQLTKKIRLKVPLVSSAMDTVTESRMAIAM
MLBr_00387|M.leprae_Br4923 DDVLLLPAASDVVPATADISSQLTKKIRLKVPLVSSAMDTVTEARMAIAM
MAB_3721c|M.abscessus_ATCC_199 DDVLLLPAASDVLPAGADTSSQLTKRIRLNVPLVSSAMDTVTEARMAIAM
TH_1679|M.thermoresistible__bu DDVLLLPAASDVLPANADTSSQLTKKIRLKVPLVSSAMDTVTEARMAIAM
************:*: ** *****::***.*************:******
Mflv_4909|M.gilvum_PYR-GCK ARAGGMGVLHRNLPVAEQAGQVETVKRSEAGMVTDPVTCSPENTLAEVDA
Mvan_1511|M.vanbaalenii_PYR-1 ARAGGMGVLHRNLPVAEQAGQVETVKRSEAGMVTDPVTCSPDNTLAEVDA
MSMEG_1602|M.smegmatis_MC2_155 ARAGGMGVLHRNLPVAEQAGQVETVKRSEAGMVTDPVTCSPDNTLAEVDA
Mb3445c|M.bovis_AF2122/97 ARAGGMGVLHRNLPVAEQAGQVEMVKRSEAGMVTDPVTCRPDNTLAQVDA
Rv3411c|M.tuberculosis_H37Rv ARAGGMGVLHRNLPVAEQAGQVEMVKRSEAGMVTDPVTCRPDNTLAQVDA
MMAR_1137|M.marinum_M ARAGGMGVLHRNLPVAEQASQVETVKRSEAGMVTDPVTCRPDNTLAQVDA
MUL_0900|M.ulcerans_Agy99 ARAGGMGVLHRNLPVAEQASQVETVKRSEAGMVTDPVTCRPDNTLAQVDA
MAV_4356|M.avium_104 ARAGGMGVLHRNLPVAEQAGQVEMVKRSEAGMVTDPVTCRPDNTLAQVDA
MLBr_00387|M.leprae_Br4923 ARAGGMGVLHRNLPVGEQAGQVETVKRSEAGMVTDPVTCRPDNTLAQVGA
MAB_3721c|M.abscessus_ATCC_199 ARAGGMGVLHRNLSVEDQAGQVETVKRSEAGMVTNPVTCSPANTLAEVDA
TH_1679|M.thermoresistible__bu ARAGGMGVLHRNLPVAEQAAQVETVKRSEAGMVTDPVTCSPDNTLAEVDA
*************.* :**.*** **********:**** * ****:*.*
Mflv_4909|M.gilvum_PYR-GCK MCARFRISGLPVVDDKGSLVGIITNRDMRFEVDQSKPVAEVMTKAPLITA
Mvan_1511|M.vanbaalenii_PYR-1 MCARFRISGLPVVDDRGSLVGIITNRDMRFEVDLSKPVSEVMTKAPLITA
MSMEG_1602|M.smegmatis_MC2_155 MCARFRISGLPVVDDTGELVGIITNRDMRFEVDQSKPVSEVMTKAPLITA
Mb3445c|M.bovis_AF2122/97 LCARFRISGLPVVDDDGALVGIITNRDMRFEVDQSKQVAEVMTKAPLITA
Rv3411c|M.tuberculosis_H37Rv LCARFRISGLPVVDDDGALVGIITNRDMRFEVDQSKQVAEVMTKAPLITA
MMAR_1137|M.marinum_M LCARFRISGLPVVDDAGALVGIITNRDMRFEVDQSKQVAEVMTKAPLITA
MUL_0900|M.ulcerans_Agy99 LCARFRISGLPVVDDAGALVGIITNRDMRFEVDQSKQVAEVMTKAPLITA
MAV_4356|M.avium_104 LCARFRISGLPVVDDSGALVGIITNRDMRFEVDQTKKVAEVMTKAPLITA
MLBr_00387|M.leprae_Br4923 LCARFRISGLPVVDDSGALAGIITNRDMRFEVDQSKQVAEVMTKTPLITA
MAB_3721c|M.abscessus_ATCC_199 LCARFRISGLPVVDAQGALVGIITNRDMRFEADLSKPVAEVMTKAPLITA
TH_1679|M.thermoresistible__bu LCARFRISGLPVVDDEGHLVGIITNRDMRFEADQNKRVAEVMTKAPLVTA
:************* * *.***********.* .* *:*****:**:**
Mflv_4909|M.gilvum_PYR-GCK QEGVSAEAALGLLRRNKIEKLPIVDGHGKLTGLITVKDFVKTEQFPLSTK
Mvan_1511|M.vanbaalenii_PYR-1 QEGVSAEAALGLLRRNKIEKLPIVDGHGKLTGLITVKDFVKTEQFPLATK
MSMEG_1602|M.smegmatis_MC2_155 KEGVSAEAALGLLRRHKIEKLPIVDGHGKLTGLITVKDFVKTEQFPLSTK
Mb3445c|M.bovis_AF2122/97 QEGVSASAALGLLRRNKIEKLPVVDGRGRLTGLITVKDFVKTEQHPLATK
Rv3411c|M.tuberculosis_H37Rv QEGVSASAALGLLRRNKIEKLPVVDGRGRLTGLITVKDFVKTEQHPLATK
MMAR_1137|M.marinum_M QEGVSASAALGLLRRHKIEKLPVVDGSGRLTGLITVKDFVKTEQHPLATK
MUL_0900|M.ulcerans_Agy99 QEGVSASAALGLLRRHKIEKLPVVDGSGRLTGLITVKDFVKTEQHPLATK
MAV_4356|M.avium_104 QEGVSADAALGLLRRNKIEKLPIVDGHGRLTGLITVKDFVKTEQHPLATK
MLBr_00387|M.leprae_Br4923 AEGVSADAALGLLRRNKIEKLPVVDGHGRLTGLITVKDFVKTEQHPLATK
MAB_3721c|M.abscessus_ATCC_199 REGVTADAALGLLRRNKIEKLPIVDGEGRLTGLITVKDFAKTEQHPNATK
TH_1679|M.thermoresistible__bu HEGVSAEAALGLLRRNKIEKLPIVDGSGKLTGLITVKDFVKTEQFPLATK
***:*.********:******:*** *:**********.****.* :**
Mflv_4909|M.gilvum_PYR-GCK DSDGRLLVGAAVGVGEDAWTRAMTLADAGADVLIVDTAHAHNRGVLDMVH
Mvan_1511|M.vanbaalenii_PYR-1 DSDGRLLVGAAVGVGEDAWTRAMTLADAGVDVLIVDTAHAHNRGVLEMVN
MSMEG_1602|M.smegmatis_MC2_155 DSDGRLLVGAAVGVGDDAWTRAMTLVDAGVDVLIVDTAHAHNRGVLDMVS
Mb3445c|M.bovis_AF2122/97 DSDGRLLVGAAVGVGGDAWVRAMMLVDAGVDVLVVDTAHAHNRLVLDMVG
Rv3411c|M.tuberculosis_H37Rv DSDGRLLVGAAVGVGGDAWVRAMMLVDAGVDVLVVDTAHAHNRLVLDMVG
MMAR_1137|M.marinum_M DSDGRLLVGAAVGVGGDAWVRAMMLVDAGVDVLIVDTAHAHNRLVLDMVS
MUL_0900|M.ulcerans_Agy99 DSDGRLLVGAAVGVGGDAWVRAMMLVDAGVDVLIVDTAHAHNRLVLDMVS
MAV_4356|M.avium_104 DSDGRLLVGAAVGVGGDAWVRAMMLVDAGVDVLVVDTAHAHNRLVLDMVG
MLBr_00387|M.leprae_Br4923 DNDGRLLVGAAVGVGGDAWVRAMMLVDAGVDVLIVDTAHAHNRLVLDMVG
MAB_3721c|M.abscessus_ATCC_199 DSDGRLLVGAAVGVGEDAWTRAMSLVDAGVDVLIVDTAHAHNRKVLDMVG
TH_1679|M.thermoresistible__bu DHDGRLLVG-AAGRGRXXRRRAGPFLTA-------DPQSGGNR-------
* ******* *.* * ** : * *. . **
Mflv_4909|M.gilvum_PYR-GCK RLKRAVGERVDVVGGNVATRAAAAALVDAGADAVKVGVGPGSICTTRVVA
Mvan_1511|M.vanbaalenii_PYR-1 RLKVAVGDRVEVVGGNVATRAAAAALVQAGADAVKVGVGPGSICTTRVVA
MSMEG_1602|M.smegmatis_MC2_155 RLKQAVGERVDVVGGNVATRAAAAALVEAGADAVKVGVGPGSICTTRVVA
Mb3445c|M.bovis_AF2122/97 KLKSEVGDRVEVVGGNVATRSAAAALVDAGADAVKVGVGPGSICTTRVVA
Rv3411c|M.tuberculosis_H37Rv KLKSEVGDRVEVVGGNVATRSAAAALVDAGADAVKVGVGPGSICTTRVVA
MMAR_1137|M.marinum_M KLKLEVGERVEVVGGNVATRSAAAALVDAGADAVKVGVGPGSICTTRVVA
MUL_0900|M.ulcerans_Agy99 KLKLEVGERVEVVGGNVATRSAAAALVDAGADAVKVGVGPGSICTTRVVA
MAV_4356|M.avium_104 KLKAEVGERVEVIGGNVATRAAAAALVAAGADAVKVGVGPGSICTTRVVA
MLBr_00387|M.leprae_Br4923 KLKVEIGDRVQVIGGNVATRSAAAALVEAGADAVKVGVGPGSTCTTRVVA
MAB_3721c|M.abscessus_ATCC_199 KLKAEVGERVDVVGGNVATRSAAAALVEAGADAVKVGVGPGSICTTRVVA
TH_1679|M.thermoresistible__bu ----------------------RQQLLDPGIHTVCLTRSPGSAHYP----
*: .* .:* : .*** .
Mflv_4909|M.gilvum_PYR-GCK GVGAPQITAILEAVAACAPHGVPVIADGGLQYSGDIAKALAAGASTAMLG
Mvan_1511|M.vanbaalenii_PYR-1 GVGAPQITAILEAVAACAPHGVPVIADGGLQYSGDIAKALAAGASTAMLG
MSMEG_1602|M.smegmatis_MC2_155 GVGAPQITAILEAVAACKPYGVPVIADGGLQYSGDIAKALAAGASTAMLG
Mb3445c|M.bovis_AF2122/97 GVGAPQITAILEAVAACRPAGVPVIADGGLQYSGDIAKALAAGASTAMLG
Rv3411c|M.tuberculosis_H37Rv GVGAPQITAILEAVAACRPAGVPVIADGGLQYSGDIAKALAAGASTAMLG
MMAR_1137|M.marinum_M GVGAPQITAILEAVAVCRRAGIPVIADGGLQYSGDIAKALAAGASTAMLG
MUL_0900|M.ulcerans_Agy99 GVGAPQITAILEAVAVCRRAGIPVIADGGLQYSGDIAKALAAGASTAMLG
MAV_4356|M.avium_104 GVGAPQITAILEAVAACGPAGVPVIADGGLQYSGDIAKALAAGASTAMLG
MLBr_00387|M.leprae_Br4923 GVGAPQITAILEAVAACGPAGVPVIADGGLQYSGDIAKALAAGASTTMLG
MAB_3721c|M.abscessus_ATCC_199 GVGAPQITAILEAATVCHPAGVPVIADGGMQYSGDIAKALAAGASTTMLG
TH_1679|M.thermoresistible__bu -------------------------HRGELRFS-----------------
* :::*
Mflv_4909|M.gilvum_PYR-GCK SLLAGTAESPGDLIFVNGKQFKSYRGMGSLGAMQGRGATGNLRGSYSKDR
Mvan_1511|M.vanbaalenii_PYR-1 SLLAGTAESPGDLILVNGKQFKSYRGMGSLGAMQGRGAGGNLRGSYSKDR
MSMEG_1602|M.smegmatis_MC2_155 SLLAGTAESPGELIFVNGKQFKSYRGMGSLGAMQGRGAAK----SYSKDR
Mb3445c|M.bovis_AF2122/97 SLLAGTAEAPGELIFVNGKQYKSYRGMGSLGAMRGRG--GAT--SYSKDR
Rv3411c|M.tuberculosis_H37Rv SLLAGTAEAPGELIFVNGKQYKSYRGMGSLGAMRGRG--GAT--SYSKDR
MMAR_1137|M.marinum_M SLLAGTAEAPGELIFVNGKQYKSYRGMGSLGAMQGRG--GAK--SYSKDR
MUL_0900|M.ulcerans_Agy99 SLLAGTAEAPGELIFVNGKQYKSYRGMGSLGAMQGRG--GAK--SYSKDR
MAV_4356|M.avium_104 SLLAGTAEAPGELIFVNGKQFKSYRGMGSLGAMAGRGSGAGK--SYSKDR
MLBr_00387|M.leprae_Br4923 SLLAGTAEAPGELIFVNGKQFKSYRGMGSLGAMQGRG--GDK--SYSKDR
MAB_3721c|M.abscessus_ATCC_199 SLLAGTAESPGELIFVNGKQFKSYRGMGSMGAMQGRG--ATK--SYSKDR
TH_1679|M.thermoresistible__bu ---------------------ACFR--------------------YHRD-
.:* * :*
Mflv_4909|M.gilvum_PYR-GCK YFQDDVLSEDKLVPEGIEGRVPFRGPLSTVIHQLTGGLRAAMGYTGSASI
Mvan_1511|M.vanbaalenii_PYR-1 YFQDDVLSEDKLVPEGIEGRVPFRGPLSTVIHQLVGGLRAAMGYTGSATI
MSMEG_1602|M.smegmatis_MC2_155 YFQDDVLSEDKLVPEGIEGRVPFRGPLGTVIHQLTGGLRAAMGYTGSATI
Mb3445c|M.bovis_AF2122/97 YFADDALSEDKLVPEGIEGRVPFRGPLSSVIHQLTGGLRAAMGYTGSPTI
Rv3411c|M.tuberculosis_H37Rv YFADDALSEDKLVPEGIEGRVPFRGPLSSVIHQLTGGLRAAMGYTGSPTI
MMAR_1137|M.marinum_M YFADDALSEDKLVPEGIEGRVPFRGPLASVIHQLTGGLRAAMGYTGSPTI
MUL_0900|M.ulcerans_Agy99 YFADDALSEDKLVPEGIEGRVPFRGPLASVIHQLTGGLRAAMGYTGSPTI
MAV_4356|M.avium_104 YFADDALSEDKLVPEGIEGRVPFRGPLSSVIHQLTGGLRAAMGYTGSPTI
MLBr_00387|M.leprae_Br4923 YFADDALSEDKLVPEGIEGRVPFRGPLSSVIHQLVGGLRAAMGYTGSPTI
MAB_3721c|M.abscessus_ATCC_199 YFQDDVLSEDKLVPEGIEGRVPFRGPLSTVMHQLTGGLRAAMGYTGASSI
TH_1679|M.thermoresistible__bu --------------PGLAGPEPSSR-------------------------
*: * *
Mflv_4909|M.gilvum_PYR-GCK EALQQAQFVQITAAGLKESHPHDITMTVEAPNYTTR
Mvan_1511|M.vanbaalenii_PYR-1 EHLQQAQFVQITAAGLKESHPHDITMTVEAPNYTTR
MSMEG_1602|M.smegmatis_MC2_155 EQLQQAQFVQITAAGLKESHPHDITMTVEAPNYYTR
Mb3445c|M.bovis_AF2122/97 EVLQQAQFVRITPAGLKESHPHDVAMTVEAPNYYAR
Rv3411c|M.tuberculosis_H37Rv EVLQQAQFVRITPAGLKESHPHDVAMTVEAPNYYAR
MMAR_1137|M.marinum_M EVLQQAQFVRITPAGLKESHPHDVAMTVEAPNYYAR
MUL_0900|M.ulcerans_Agy99 EVLQQAQFVRITSAGLKESHPHDVAMTVEAPNYYAR
MAV_4356|M.avium_104 EALQQAQFVRITAAGLRESHPHDVAMTVEAPNYYAR
MLBr_00387|M.leprae_Br4923 EVLQQAQFVRITPAGLKESHPHDVAMTVEAPNYYPR
MAB_3721c|M.abscessus_ATCC_199 EELQRAQFVQITAAGLKESHPHDITMTAEAPNYYVR
TH_1679|M.thermoresistible__bu ------------------------------------