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TDAATITGGWRELLGARYLRTSILLAGGVALYATNEFLTTSLLPNTIAEIGGSRLYAWVTTLYLVGSVVA ATMVNPMLLRVGARASYLLGLAVFGVASLVCGAAPDMHVLIAGRAMQGVAGGLLAGLGYAVINSALPRWL WTRGSALVSAMWGVATVVGPATGGLFAQLGIWRWAFVVMAVLTALMALLVPVALARVDPAPAIPRMKVPV WSLLIIGVASLAVSVAQIPHNTAATFGLLAAGIMLVGLFVIVDWRMHAAILPPSVFSPGPLKWIYLTMGV LMAAAMVNTYVPLFGQRLAHLTPIAAGFLGAALALGWTVSEIVSASPENPRTVGRVVMVAPLVAASGLAL GAVARHGDGSAWTAALWAVALLVAGTGIGMAWPHLSARAMASVNDPAEGGAASAAINTVQLTSAAIGAGL AGVVVNTATGGDEMAAHLLFTVFTALSAAGVAVSYAATRATRQAQPVGNVG*
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. avium 104 | MAV_3140 | - | - | 100% (472) | drug efflux membrane protein |
M. avium 104 | MAV_2832 | - | 7e-33 | 23.70% (405) | drug transporter |
M. avium 104 | MAV_0729 | - | 1e-22 | 24.74% (392) | EmrB efflux protein |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb1660 | - | 0.0 | 71.22% (469) | drug efflux membrane protein |
M. gilvum PYR-GCK | Mflv_3321 | - | 1e-30 | 25.31% (403) | EmrB/QacA family drug resistance transporter |
M. tuberculosis H37Rv | Rv1634 | - | 0.0 | 71.00% (469) | drug efflux membrane protein |
M. leprae Br4923 | MLBr_00556 | - | 3e-18 | 25.68% (444) | putative integral membrane drug transport protein |
M. abscessus ATCC 19977 | MAB_2310 | - | 1e-137 | 54.84% (465) | drug efflux membrane protein |
M. marinum M | MMAR_2438 | - | 0.0 | 69.51% (469) | drug efflux membrane protein |
M. smegmatis MC2 155 | MSMEG_3815 | - | 1e-158 | 61.44% (459) | drug efflux membrane protein |
M. thermoresistible (build 8) | TH_3965 | - | 4e-23 | 29.69% (384) | PUTATIVE drug transporter |
M. ulcerans Agy99 | MUL_1617 | - | 1e-179 | 69.30% (469) | drug efflux membrane protein |
M. vanbaalenii PYR-1 | Mvan_3349 | - | 1e-159 | 61.85% (464) | major facilitator superfamily transporter |
CLUSTAL 2.0.9 multiple sequence alignment Mb1660|M.bovis_AF2122/97 ---MTETAS-----ETGSWRELLSR-YLGTSIVLAGGVALYATNEFLTIS Rv1634|M.tuberculosis_H37Rv ---MTETAS-----ETGSWRELLSR-YLGTSIVLAGGVALYATNEFLTIS MMAR_2438|M.marinum_M ---MTETAR-----ETGSWRELLSG-HLGTATLLAGGVAMYATNEFLTVS MUL_1617|M.ulcerans_Agy99 ---MTETAR-----ETGSWRELLRG-HLGTATLLAGGVAMYATNEFLTVS MAV_3140|M.avium_104 ---MTDAAT-----ITGGWRELLGARYLRTSILLAGGVALYATNEFLTTS MSMEG_3815|M.smegmatis_MC2_155 ---MTETAA---AEAAGTWRQLLGRRYLGASTVLAGGVLLYATNEFITIS Mvan_3349|M.vanbaalenii_PYR-1 ---MTHTEAGSAAVATGSWRELLGPKYLGASTVLAGGVALYATNEFLTIS MAB_2310|M.abscessus_ATCC_1997 ---MVRELG------AGGWRDLLDGRQLGIVTVLAGGVALYATNVYLTTS Mflv_3321|M.gilvum_PYR-GCK -------------------------------------MLLAALDQTIVAT MLBr_00556|M.leprae_Br4923 ---MSTRAG-----------------RRVAISAGSLAVLLGALDTYVVVT TH_3965|M.thermoresistible__bu VTSVDAGRSTMSEVFTAYAPRSAAANPWHALWAMLIGFFMILVDATIVPV . : : :. Mb1660|M.bovis_AF2122/97 LLPSTIADIGG----SRLYAWVTTLYLVGSVVAATTVNTMLLRVGARSSY Rv1634|M.tuberculosis_H37Rv LLPSTIADIGG----SRLYAWVTTLYLVGSVVAATTVNTMLLRVGARSSY MMAR_2438|M.marinum_M LLPSTIAEIGG----SRLYAWVTTLYLVGSVVSATTVNAMLLKVGARMSY MUL_1617|M.ulcerans_Agy99 LLPSTIAEIGG----SRLYAWVTTLYLVGSVVSATTVNAMLLKVGARMSY MAV_3140|M.avium_104 LLPNTIAEIGG----SRLYAWVTTLYLVGSVVAATMVNPMLLRVGARASY MSMEG_3815|M.smegmatis_MC2_155 LLPSAVADIGG----QRFYAWVTTVYLVASVVAATTVHSVLMRLGPRVAY Mvan_3349|M.vanbaalenii_PYR-1 LMPSAVADIGG----HRFYAWVTTVYLVGSVMAATTVHSVLTRLGPRWAY MAB_2310|M.abscessus_ATCC_1997 LLPSAVVEIGG----ERFYAWVTTVYLIASVSAATVVSPLLGWAGPRGAY Mflv_3321|M.gilvum_PYR-GCK ALPTVVADLGG----AGHQSWVVTSYLLASTIATAIVGKLGDLFGRKMIF MLBr_00556|M.leprae_Br4923 IMRDIMHDVGIPVNQMQRITWIVTMYLLGYIAAMPLLSRASDRFGRKLLL TH_3965|M.thermoresistible__bu ANLEIMADLGAD---YTAVIWVTSAYLLAYAVPLLIAGRLGDRFGPRTMY : ::* *:.: **:. . * : Mb1660|M.bovis_AF2122/97 LMGLAVFGLASLVCAAA---PSMQILVAGRTLQGIAGGLLAGLGYALINS Rv1634|M.tuberculosis_H37Rv LMGLAVFGLASLVCAAA---PSMQILVAGRTLQGIAGGLLAGLGYALINS MMAR_2438|M.marinum_M LMGLTVFGFASLVCAAA---QNMEMLVAGRTLQGVAGGLLAGLGYALINA MUL_1617|M.ulcerans_Agy99 LMGLTVFGFASLVCAAA---QNMEMLVAGRTLQGVAGGLLAGLGYALINA MAV_3140|M.avium_104 LLGLAVFGVASLVCGAA---PDMHVLIAGRAMQGVAGGLLAGLGYAVINS MSMEG_3815|M.smegmatis_MC2_155 LVALTVFGAGSLGCALA---PSMQLLLAGRLVQGFAGGLLAGLGYAVINT Mvan_3349|M.vanbaalenii_PYR-1 LLGLTVFGLGSLVCAVA---PSMEILLAGRTVQGAAGGLLAGLGYAVINT MAB_2310|M.abscessus_ATCC_1997 LLAFGAFAVGTLVCAVA---PGMHVLLAGRAVQGAAGGLLAGLAYAVINL Mflv_3321|M.gilvum_PYR-GCK GVAILFFLAGSVLCGIA---STMEMLVASRALQGIGGGALMVTATALIGE MLBr_00556|M.leprae_Br4923 QVSLAGFAIGSVMTALAGQFGDFHMLIAGRTIQGVASGALLPITLALGAD TH_3965|M.thermoresistible__bu LIGLAIFTAASLWCGLAG---TIGMLIAARVLQGLGAALLTPQTLSMITR :.: * .:: . * : :*:*.* :** ... * :: Mb1660|M.bovis_AF2122/97 TLPKSLWTRGSALVSAMWGVATLIGPATGGLFAQLG-LWRWAFGVMTLLT Rv1634|M.tuberculosis_H37Rv TLPKSLWTRGSALVSAMWGVATLIGPATGGLFAQLG-LWRWAFGVMTLLT MMAR_2438|M.marinum_M ALPHNLWTRGSALVSAMWGVATLIGPATGGLFAQFG-LWRWAFGVMATMA MUL_1617|M.ulcerans_Agy99 ALPHNLWTCGSALVSAMWGVATLIGPATGGLFAQFG-LWRWAFGVMATMA MAV_3140|M.avium_104 ALPRWLWTRGSALVSAMWGVATVVGPATGGLFAQLG-IWRWAFVVMAVLT MSMEG_3815|M.smegmatis_MC2_155 ALPNTLWTKASALVSAMWGVGTVVGPASGGLFAQYG-SWRWAFGVLVILT Mvan_3349|M.vanbaalenii_PYR-1 VLPSVLWKKASALVSAMWGVGTLVGPAAGGLFAQYS-SWRWAFGILVVMT MAB_2310|M.abscessus_ATCC_1997 ALPQGLWTRASALTSAMWGVGTFVGPAAGGLFAQWG-LWRWAFGMLAVIT Mflv_3321|M.gilvum_PYR-GCK VIPLRDRGRYQGALGAVFGVTTVIGPLLGGYFTDHL-TWRWAFWINVPIG MLBr_00556|M.leprae_Br4923 LWAQRNRAGVLGGIGAAQELGSVLGPLYGIFIVWLFSDWRYVFWINIPLT TH_3965|M.thermoresistible__bu IFPADRRGVPMGVWGATAGVATLIGPLAGGVLVDGL-GWQWIFIVNVPIG . . .* : :.:** * :. *:: * : : Mb1660|M.bovis_AF2122/97 ALMAMLVPVALGAGRVGPGGETPVGSTHKVPVWSLLLMGAAALAISVAA- Rv1634|M.tuberculosis_H37Rv ALMAMLVPVALGAGGVGPGGETPVGSTHKVPVWSLLLMGAAALAISVAA- MMAR_2438|M.marinum_M GLMTLLVLVVLSNG-VAVGGEKPVAPAHKVPVWSLLLMGAAALAVSVAE- MUL_1617|M.ulcerans_Agy99 GLMTLLVLVVLSNG-VAVGGEKPAAPAHKVPVWSLLLMGAAALAVSVAE- MAV_3140|M.avium_104 ALMALLVPVALARV-----DPAPAIPRMKVPVWSLLIIGVASLAVSVAQ- MSMEG_3815|M.smegmatis_MC2_155 AAMAVLVPLALPGRG-----SDTLVPPG-IPVWSLVLLGSAAMAVSVAG- Mvan_3349|M.vanbaalenii_PYR-1 TAMSALVPMALPARARAA-HLGSGAPPGRIPFWSLLLLGAAALLVSVAG- MAB_2310|M.abscessus_ATCC_1997 AGIAAMVPYVLTRAQ----KPNAARAGNQVPVWSLLVLTAAASLVAAAG- Mflv_3321|M.gilvum_PYR-GCK IVVLIVALATIPALS------RRGKPVIDYAGIVLIGLGASALTLATSWG MLBr_00556|M.leprae_Br4923 AIAMLMIQVSLSAHD-----RGDELEKVDVVGGVLLAIALGLVVIGLYNP TH_3965|M.thermoresistible__bu IAGLVLGARLMPRLP-------RQDQGFDVLGMVLSAVGLFLIVFALQEA : : * : .. Mb1660|M.bovis_AF2122/97 ---LPNYLVQT-AGLLAAAALLVAVFVVVDWRIHAAVLPPSVFGSGPLKW Rv1634|M.tuberculosis_H37Rv ---LPNYLVQT-AGLLAAAALLVAVFVVVDWRIHAAVLPPSVFGSGPLKW MMAR_2438|M.marinum_M ---IPQYLVAT-AGLLVAGALLVGIFVIVDWRMHVAVLPHSVFGSGPLKW MUL_1617|M.ulcerans_Agy99 ---IPQYLVAT-AGLLVAGALLVGIFVIVDWRMHVAVLPHSVFGSGPLKW MAV_3140|M.avium_104 ---IPHNTAAT-FGLLAAGIMLVGLFVIVDWRMHAAILPPSVFSPGPLKW MSMEG_3815|M.smegmatis_MC2_155 ---IPHDPRGT-AALLLVGVALVVAFIVVDRRAGASVLPPSTFGPGPLKW Mvan_3349|M.vanbaalenii_PYR-1 ---IPHDVRAT-AGLVVAGFVLVAVFVVVDRRVAASVLPPSAFGRGPLKW MAB_2310|M.abscessus_ATCC_1997 ---LQSTLPFM-ATLLAAAVVLVILFVALDRRSRASVLPKAVFARNPLKW Mflv_3321|M.gilvum_PYR-GCK GSTYAWSSPMI-IGLFVGSAVALAVFVRVELRATEPVLPIRLFAS-PVFT MLBr_00556|M.leprae_Br4923 QPDSKQVLPSYGVPVLVGGIVATVAFAVWERCARTRLIDPAGVHIRPFLS TH_3965|M.thermoresistible__bu ---QTHRWAPWIWGTLAGGAGVMAMFVIWQSANRRHPLVPLQIFADRNFM . . * : : . Mb1660|M.bovis_AF2122/97 IYLTMSVQMIAAMV--DTYVPLFGQRLGHLTPVAAGFLGAALAVGWTVGE Rv1634|M.tuberculosis_H37Rv IYLTMSVQMIAAMV--DTYVPLFGQRLGHLTPVAAGFLGAALAVGWTVGE MMAR_2438|M.marinum_M IYLTMSVQMVAAMV--TTYVPLFGQGLGHLTPVAAGFLGAALAFGWTAGE MUL_1617|M.ulcerans_Agy99 IYLTMSVQMVAAMV--TTYVPLFGQGLGHLTPVAAGLLGAALAFGWTAGE MAV_3140|M.avium_104 IYLTMGVLMAAAMV--NTYVPLFGQRLAHLTPIAAGFLGAALALGWTVSE MSMEG_3815|M.smegmatis_MC2_155 IYMSLGVLMAATMV--DMYVPLFGQRLAHMTPVVAGFFGAVLSVGWTFGE Mvan_3349|M.vanbaalenii_PYR-1 IYLTLGGLMAATMV--DMYVPLFGQRLAHLTPVAAGFLGAGLAIGWTVGE MAB_2310|M.abscessus_ATCC_1997 IYLTIAVLAVASMA--ETYIPFFGQRLGHLSPVAAGFLGATLAFGWTVGE Mflv_3321|M.gilvum_PYR-GCK VCCVLSFIVGFAMLGALTFLPTFMQFVDGVSATESGLRTLPMVGGLLLTS MLBr_00556|M.leprae_Br4923 ALGASVAAGAALMVT-LVNVELFGQGVLGMDQTQAAGLLVWFLIALPIGA TH_3965|M.thermoresistible__bu LANVGVATIGFVVTAMVLPAMFFAQAVCGLSPTGSALLIAPMAVASGVLA : * * : : :. : . Mb1660|M.bovis_AF2122/97 VASASLNSARVIGHVVAAAPLVMASGLALG-------AVTQRADAPVGII Rv1634|M.tuberculosis_H37Rv VASASLNSARVIGHVVAAAPLVMASGLALG-------AVTQRADAPVGII MMAR_2438|M.marinum_M IVSASLTNPRLIGYIIAAAPLVMASGLALG-------AVTQRADASLPTV MUL_1617|M.ulcerans_Agy99 IVSASLTNSRLIGYIIAVAPLVMASGLALG-------AVTQRADASLPTV MAV_3140|M.avium_104 IVSASPENPRTVGRVVMVAPLVAASGLALG-------AVARHGDGSAWTA MSMEG_3815|M.smegmatis_MC2_155 IASASLQNRKVIRRMVAVAPLVMALGLAAG-------AVLVRNGMPVWLV Mvan_3349|M.vanbaalenii_PYR-1 IGSASLTRHRVVVRTVAVAPAVMATGLTIG-------ALTQHRDAGPMLV MAB_2310|M.abscessus_ATCC_1997 MISAS-AQVRTVSRVVSVAPAVVAAGLFLA-------GVLQRDGATVLEI Mflv_3321|M.gilvum_PYR-GCK MGSGVLVSRTGR---YKIFPVLGTAVMTVG-------FVLLSQMDATTPV MLBr_00556|M.leprae_Br4923 VLGGWGATKAGDRTMTFVGLLITAGGYWLISHWPVDLLNYRRSIFGLFSV TH_3965|M.thermoresistible__bu PMAGRIVDRSHPTPVVGFGFSVVAVGLTWL----------AVEMAPTTPI .. : : Mb1660|M.bovis_AF2122/97 ALWALALLIIGTGIGIAWPHLTVRAMDSVADPAESSAAAAAINVVQLISG Rv1634|M.tuberculosis_H37Rv ALWALALLIIGTGIGIAWPHLTVRAMDSVADPAESSAAAAAINVVQLISG MMAR_2438|M.marinum_M ALWALALLITGAGIGIAWPHLTVRAMDCVDDPAESSSAAAAINIVQLVSA MUL_1617|M.ulcerans_Agy99 ALWALALLITGAGIGIAWPHLTVRAMDCVDDPAESSSAAAAINIVQLVSA MAV_3140|M.avium_104 ALWAVALLVAGTGIGMAWPHLSARAMASVNDPAEGGAASAAINTVQLTSA MSMEG_3815|M.smegmatis_MC2_155 VLWALALLVTGAGIGIAWPHLSAWAMSSVDDPAEGPAAAAAINTVQLICG Mvan_3349|M.vanbaalenii_PYR-1 ALWAVGLIITGAGVGIAWPHLSAWAMSKVDDPAEGPAAAAAINTVQVISA MAB_2310|M.abscessus_ATCC_1997 GCWALGFVVTGAGIGMAWPHLAAAAMSVSDDGSESGTGAAAISTVQLIAG Mflv_3321|M.gilvum_PYR-GCK WQQSAYLFVLGTGIGMCMQVLVLIVQSTAN-FSDLGVATSGVTFFRTIGS MLBr_00556|M.leprae_Br4923 PTMYADLLVAGLGLGLVIGPLSSATLRVVP-TAQHGIASAAVVVARMTGM TH_3965|M.thermoresistible__bu WRLVLPFVAVGVGMAFIWSPLATTATRQLP-LHLSGAGSGVYNTTRQIGS :. * *:.: * . .:. : Mb1660|M.bovis_AF2122/97 AFGAGLAG----VVVNTAKGGEVAA------------------------- Rv1634|M.tuberculosis_H37Rv AFGAGLAG----VVVNTAKGGEVAA------------------------- MMAR_2438|M.marinum_M AFGAGLAG----VVVNTATGGEVAA------------------------- MUL_1617|M.ulcerans_Agy99 AFGAGLAG----VVVNTATGGEVAA------------------------- MAV_3140|M.avium_104 AIGAGLAG----VVVNTATGGDEMA------------------------- MSMEG_3815|M.smegmatis_MC2_155 AFGAGLAG----VVVNLVNVGNPSS------------------------- Mvan_3349|M.vanbaalenii_PYR-1 AFGAALAG----VIVNLSHTGDVAA------------------------- MAB_2310|M.abscessus_ATCC_1997 ALGAGLAG----VFVNLG-GSARHG------------------------- Mflv_3321|M.gilvum_PYR-GCK SFGAAIFGSLFANFLDSRIGGALAASGAPPEAAQSPQVLHRLPDAVAAPI MLBr_00556|M.leprae_Br4923 LIGVAALTAWGLYRFNQILAGLSTAVPP---------------------- TH_3965|M.thermoresistible__bu VLGSAGMAAFLTGRLSAELPFGATAVPAG--------------------- :* . .. . Mb1660|M.bovis_AF2122/97 -------ARGLYMAFTVLAAAGVIASYQATHRDRRLPR------------ Rv1634|M.tuberculosis_H37Rv -------ARGLYMAFTVLAAAGVIASYQATHRDRRLPR------------ MMAR_2438|M.marinum_M -------ARWLYTVFTVLAAVGFIASYQATHHDRRSPG------------ MUL_1617|M.ulcerans_Agy99 -------ARWLYTVFTVLAAVGFIASYQATHHDRRSPG------------ MAV_3140|M.avium_104 -------AHLLFTVFTALSAAGVAVSYAATRATRQAQPVGNVG------- MSMEG_3815|M.smegmatis_MC2_155 -------ATWLFAAFAVLAVAGTLASIRAVR------------------- Mvan_3349|M.vanbaalenii_PYR-1 -------ARWLFASFAVLAVLATVASTRSGRLRSR--------------- MAB_2310|M.abscessus_ATCC_1997 -------AQLLFVGFAVMVLCGVVVSVRVFRTGSASEMTDRAGQQAVRIP Mflv_3321|M.gilvum_PYR-GCK VEAYSDSLGLVFLCAAPVAVIGFVVALTLKQVPLREIEATAALDMGEGFG MLBr_00556|M.leprae_Br4923 ------DATLIERAAAVADQAKRAYTMMYSDIFMITAIVCVIGALLGLLI TH_3965|M.thermoresistible__bu -----EQTRVLPEFLHAPYAAAMAQSMLLPAFVALFGVLAAIFLAGIVLS : : Mb1660|M.bovis_AF2122/97 -------------------------------------------------- Rv1634|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_2438|M.marinum_M -------------------------------------------------- MUL_1617|M.ulcerans_Agy99 -------------------------------------------------- MAV_3140|M.avium_104 -------------------------------------------------- MSMEG_3815|M.smegmatis_MC2_155 -------------------------------------------------- Mvan_3349|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_2310|M.abscessus_ATCC_1997 S------------------------------------------------- Mflv_3321|M.gilvum_PYR-GCK MPSDDSSERMMETAVGRLVRHSPEIRLRSIAGTHGCDPDVALLWALIQIY MLBr_00556|M.leprae_Br4923 SSRKEHASEPKVPE------------------------------------ TH_3965|M.thermoresistible__bu TPQPDADAQYLDEHDDYLVIELARPDPNPRTDIAVTAVIPALRPTLRPTL Mb1660|M.bovis_AF2122/97 -------------------------------------------------- Rv1634|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_2438|M.marinum_M -------------------------------------------------- MUL_1617|M.ulcerans_Agy99 -------------------------------------------------- MAV_3140|M.avium_104 -------------------------------------------------- MSMEG_3815|M.smegmatis_MC2_155 -------------------------------------------------- Mvan_3349|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_2310|M.abscessus_ATCC_1997 -------------------------------------------------- Mflv_3321|M.gilvum_PYR-GCK RQSQVFGSARLSEIAERLRVPPEVLAPTFDRLVATGRALRTDDQLWLTQS MLBr_00556|M.leprae_Br4923 -------------------------------------------------- TH_3965|M.thermoresistible__bu RPSLGPPGGPVVQPNNTAALR----------------------------- Mb1660|M.bovis_AF2122/97 -------------------------------------------------- Rv1634|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_2438|M.marinum_M -------------------------------------------------- MUL_1617|M.ulcerans_Agy99 -------------------------------------------------- MAV_3140|M.avium_104 -------------------------------------------------- MSMEG_3815|M.smegmatis_MC2_155 -------------------------------------------------- Mvan_3349|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_2310|M.abscessus_ATCC_1997 -------------------------------------------------- Mflv_3321|M.gilvum_PYR-GCK GAQQVSAATAALVSRIVEKLEKSPTFEGRPDWDEVEKALERIAQRLLVQR MLBr_00556|M.leprae_Br4923 -------------------------------------------------- TH_3965|M.thermoresistible__bu -------------------------------------------------- Mb1660|M.bovis_AF2122/97 -------------- Rv1634|M.tuberculosis_H37Rv -------------- MMAR_2438|M.marinum_M -------------- MUL_1617|M.ulcerans_Agy99 -------------- MAV_3140|M.avium_104 -------------- MSMEG_3815|M.smegmatis_MC2_155 -------------- Mvan_3349|M.vanbaalenii_PYR-1 -------------- MAB_2310|M.abscessus_ATCC_1997 -------------- Mflv_3321|M.gilvum_PYR-GCK EWEDDRTELAAAGK MLBr_00556|M.leprae_Br4923 -------------- TH_3965|M.thermoresistible__bu --------------