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RQDLNMDLYDVMRTTGAVRQFTGDPLPDDVLRRILDHARFAPSGGNRQGVHVIAVRDVATRRALAELSRT GARRYLAQKHNGEGPWNPLRPMKVTADEVAAIEVPEQMTAPLLTAAVVLVFSVDLDVVAAIDQDLDRIGL VAGASVYPFVWNVLLAARNEGFGGVLTTMAVAEEPRVKELLGLPDEHAVAAIVPMGRPLRQVTKLTRRPV AEFATRENFDGESL*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_2149 | - | - | 100% (225) | nitroreductase |
| M. gilvum PYR-GCK | Mflv_3382 | - | 8e-18 | 32.54% (209) | nitroreductase |
| M. gilvum PYR-GCK | Mflv_1262 | - | 1e-12 | 24.77% (222) | nitroreductase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3403c | - | 2e-14 | 27.73% (220) | oxidoreductase |
| M. tuberculosis H37Rv | Rv3368c | - | 2e-14 | 27.73% (220) | oxidoreductase |
| M. leprae Br4923 | MLBr_00418 | - | 1e-12 | 28.80% (191) | putative oxidoreductase |
| M. abscessus ATCC 19977 | MAB_4760 | - | 6e-43 | 66.10% (118) | nitroreductase |
| M. marinum M | MMAR_2938 | - | 1e-16 | 29.30% (215) | nitroreductase |
| M. avium 104 | MAV_1962 | - | 6e-15 | 32.88% (219) | NADPH nitroreductase |
| M. smegmatis MC2 155 | MSMEG_5155 | - | 3e-87 | 71.30% (216) | nitroreductase |
| M. thermoresistible (build 8) | TH_3507 | - | 2e-34 | 41.20% (216) | PUTATIVE putative nitroreductase |
| M. ulcerans Agy99 | MUL_2198 | - | 4e-17 | 29.30% (215) | nitroreductase |
| M. vanbaalenii PYR-1 | Mvan_4554 | - | 1e-101 | 81.28% (219) | nitroreductase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_2149|M.gilvum_PYR-GCK MRQDLNMDLYDVMRTTGAVR-QFTGD-PLPDDVLRRILDHARFAPSGGNR
Mvan_4554|M.vanbaalenii_PYR-1 ------MDLYDVMRTTGAVR-QFTGD-PLPDEVLVRILDNARFAPSGGNR
MSMEG_5155|M.smegmatis_MC2_155 ------MEFTDVVRTTAAIR-QFTGD-PLPDDVLRRILDNARFAPSGGNR
MAB_4760|M.abscessus_ATCC_1997 --------------------------------------------------
TH_3507|M.thermoresistible__bu ------VELVEAMRTTGTCR-YFRPD-PVPDEVLYQAFDHARFAPQGGNR
MMAR_2938|M.marinum_M ------MPLEDAMRTQRSIR-RLKSD-PVDDSLVLHLLELAMKAPTGSNA
MUL_2198|M.ulcerans_Agy99 ------MPLEDAMRTQRSIR-RLKSD-PVDDSLVLHLLELAMKAPTGSNA
MAV_1962|M.avium_104 -----MSDLRAVMQAQRACR-RFDPDGKVLDSDIEQMLQLAAHAPSAENT
Mb3403c|M.bovis_AF2122/97 --MTLNLSVDEVLTTTRSVRKRLDFDKPVPRDVLMECLELALQAPTGSNS
Rv3368c|M.tuberculosis_H37Rv --MTLNLSVDEVLTTTRSVRKRLDFDKPVPRDVLMECLELALQAPTGSNS
MLBr_00418|M.leprae_Br4923 ------MSVDEVLTTTRSVRKRLDFDKPVPRDVLMECLQLALQAPTGSNS
Mflv_2149|M.gilvum_PYR-GCK QGVHVIAVRDVATRRALAELSRTGARRYLAQKHNGEGPWNPLRPMKVTAD
Mvan_4554|M.vanbaalenii_PYR-1 QGVHVIAVRDRATREALGALSVTGARRYIAQQRNGEGPWNPLRPMQISAE
MSMEG_5155|M.smegmatis_MC2_155 QGTRVVVIRDRDTREALAELTITGSRRYIAQKRIGENPWNPLHPTAVTEA
MAB_4760|M.abscessus_ATCC_1997 --------------------------------------------------
TH_3507|M.thermoresistible__bu QPVRWIVVRDPARKAALQDLYLPLWKNYLSGIADGTVNVGALP-------
MMAR_2938|M.marinum_M QNWEFIVVKDREVVAKLGRLNRRAMQLFGPIYRRSIARRGDEK-------
MUL_2198|M.ulcerans_Agy99 QNWEFIVVKDREVVAKLGRLNRRAMQLFGPIYRRSIARRGDEK-------
MAV_1962|M.avium_104 QPWSFVVVRAEENRKLLADWWTETWNAGGGDFVR---QNLEDK-------
Mb3403c|M.bovis_AF2122/97 QGWQWVFVEDAAKKKAIADVYLANARGYLSGPAPEYPDGDTRG------E
Rv3368c|M.tuberculosis_H37Rv QGWQWVFVEDAAKKKAIADVYLANARGYLSGPAPEYPDGDTRG------E
MLBr_00418|M.leprae_Br4923 QGWHWVFVEDAEKRKAIGDIYLVNARCYLSQPAPEYPEGDTRG------E
Mflv_2149|M.gilvum_PYR-GCK EVAAIEVPEQMTAPLLTAAVVLVFSVDLDVVAAIDQDLDRIGLVAGASVY
Mvan_4554|M.vanbaalenii_PYR-1 QLAATEVPAELSAPLLTSAVVLVVCVDLAVVAAFDQDLDRVGLIAGASAY
MSMEG_5155|M.smegmatis_MC2_155 DLAAVDVPR--ATPLLDAAVVLVVCVDLGVVAAFDQDLDRIGVVSGASVY
MAB_4760|M.abscessus_ATCC_1997 -----MVPESVAAPLRTAGAVLVVCVDLRLVAAVDQDLERVGVVGGASIY
TH_3507|M.thermoresistible__bu --KTVRDADYFAEHLAEAPAIVVACAELDGLHPTDTDLGRLSIVGGASVY
MMAR_2938|M.marinum_M -MLRLQKAVQWQADHFEEIPVVVVACLRGVIAPWPR---ISTSSAYGSIY
MUL_2198|M.ulcerans_Agy99 -MLRLQKAVQWQADHFEEIPVVVVACLRGVIAPWPR---ISTSSAYGSIY
MAV_1962|M.avium_104 -ALVADLEFGFNKGGFAAAPVVVVVC-----ADTDR---VAEIYAPSSIY
Mb3403c|M.bovis_AF2122/97 RMGRVRDSATYLAEHMHRAPVLLIPCLKGREDESAVG----GVSFWASLF
Rv3368c|M.tuberculosis_H37Rv RMGRVRDSATYLAEHMHRAPVLLIPCLKGREDESAVG----GVSFWASLF
MLBr_00418|M.leprae_Br4923 RMRLVRDSATYLAEHMHEVPVLLIPCLLGRAEESPLG----AVSYWASLF
::: .* :
Mflv_2149|M.gilvum_PYR-GCK PFVWNVLLAARNEGFGGVLTT--MAVAEEPRVKELLGLP-DEHAVAAIVP
Mvan_4554|M.vanbaalenii_PYR-1 PFVWNVLLAARNEGFGGVLTT--MAVAEEPGVKALLGIP-DDHAVAAVLP
MSMEG_5155|M.smegmatis_MC2_155 PFVWNILLSARNEGFGGVLTT--MAIAEEPKVKELLAIP-DDYAVAAVLP
MAB_4760|M.abscessus_ATCC_1997 PLVWNILLAARAEGYGGALTT--MAVAEEPKVRELLGIP-DTYAVAAVLP
TH_3507|M.thermoresistible__bu PTVQNFCLALRNLGVGSALTT--LLCQVEPEVRELLAIP-EGVATAAHIA
MMAR_2938|M.marinum_M PAVQNLLLAARAAGLGAGLIT--VPLWSTVLARRALGLP-WNVTPCAVVP
MUL_2198|M.ulcerans_Agy99 PAVQNLLLAARAAGLGAGLIT--VPLWSTVLARRALGLP-RNVTPCAVVP
MAV_1962|M.avium_104 PAVQNLLLAAADLGYGSCLTTG-LTTFGVDRVRELLELP-PNLIPMAAVY
Mb3403c|M.bovis_AF2122/97 PAVWSFCLALRSRGLGSCWTTLHLLDNGEHKVADVLGIPYDEYSQGGLLP
Rv3368c|M.tuberculosis_H37Rv PAVWSFCLALRSRGLGSCWTTLHLLDNGEHKVADVLGIPYDEYSQGGLLP
MLBr_00418|M.leprae_Br4923 PAVWSFCLALRSRGLGTCWTSLHLLGDGEQRAAEVLGIPSDKYSQGGLFP
* * .. *: * * : : . * :* . .
Mflv_2149|M.gilvum_PYR-GCK MGRPLR-QVTKLTRRPVAEFATRENFDGESL------------------
Mvan_4554|M.vanbaalenii_PYR-1 LGRPQR-QVTKLTRRPVSQFATRERFDGESL------------------
MSMEG_5155|M.smegmatis_MC2_155 LGKPVH-QPTKLTRKPVSEIATRERFDGAPF------------------
MAB_4760|M.abscessus_ATCC_1997 IGKPVK-QLTRLRRNRAAEFVTRERFDGPPWRTTTGEHHSESPRYPRSH
TH_3507|M.thermoresistible__bu IGYPRDPFPAKLTRLPVEDVVAAETYDQPFFAPTTV-------------
MMAR_2938|M.marinum_M LGWPIG-KYGPTTRRPVAEIVSLDRYGNRAFR-----------------
MUL_2198|M.ulcerans_Agy99 LGWPIG-KYGPTTRRPVAEIVSLDRYGNRAFR-----------------
MAV_1962|M.avium_104 VGRPVK-KLSPPRRRPVSEVTYREKFG-TAW------------------
Mb3403c|M.bovis_AF2122/97 IAYTQGIDFRPAKRLPAESVTHWNGW-----------------------
Rv3368c|M.tuberculosis_H37Rv IAYTQGIDFRPAKRLPAESVTHWNGW-----------------------
MLBr_00418|M.leprae_Br4923 IAYTKGTDFRPANRLPAENVTHWDIW-----------------------
:. . * . ... : :