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TKPLTVLAVDDEVPALDELAYLLDRHPCIAEVFRAGDATSALRELNLRPIDAVFLDINMPGLSGIELAGV LANYAQRPAIVFVTAHDDKAVAAFDVGAVDYLLKPIREERLDEAVRRAAQAQAGPPPDDETPAPEPESDV VPAELGGVTHLIPRNSIGWIEAEGDYARLHSASGSHLVRIPLSTLETRWREHGFQRVHRSYLVALKLVTG LRTSDGAVLVRLRANGGSPAVELPVSRRQARELRDRLVRSPMRNLRPAGGSDDQ*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_2143 | - | - | 100% (265) | response regulator receiver protein |
| M. gilvum PYR-GCK | Mflv_0082 | - | 1e-09 | 33.86% (127) | two component transcriptional regulator |
| M. gilvum PYR-GCK | Mflv_0999 | - | 2e-09 | 35.24% (105) | response regulator receiver modulated diguanylate |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1055c | kdpE | 6e-10 | 34.01% (147) | transcriptional regulatory protein KdpE |
| M. tuberculosis H37Rv | Rv1027c | kdpE | 6e-10 | 34.01% (147) | transcriptional regulatory protein KdpE |
| M. leprae Br4923 | MLBr_00773 | mtrA | 6e-09 | 31.37% (153) | putative two-component response regulator |
| M. abscessus ATCC 19977 | MAB_4047c | - | 2e-09 | 34.21% (114) | sensory transduction protein RegX3 |
| M. marinum M | MMAR_0816 | regX3 | 1e-09 | 30.72% (153) | two-component sensory transduction protein RegX3 |
| M. avium 104 | MAV_4660 | - | 9e-10 | 30.72% (153) | DNA-binding response regulator |
| M. smegmatis MC2 155 | MSMEG_5159 | - | 1e-119 | 80.53% (262) | DNA-binding response regulator, putative |
| M. thermoresistible (build 8) | TH_4312 | - | 6e-09 | 33.33% (114) | PUTATIVE two component transcriptional regulator, winged helix |
| M. ulcerans Agy99 | MUL_4560 | regX3 | 8e-10 | 30.72% (153) | two component sensory transduction protein RegX3 |
| M. vanbaalenii PYR-1 | Mvan_4560 | - | 1e-129 | 86.19% (268) | response regulator receiver protein |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_0816|M.marinum_M ---MTS-VLIVEDEESLADPLAFLLRKEG--FEATVVTDGPAALAEFDRS
MUL_4560|M.ulcerans_Agy99 ---MTS-VLIVEDEESLADPLAFLLRKEG--FEATVVTDGPAALAEFDRS
MAV_4660|M.avium_104 ---MTS-VLIVEDEESLADPLAFLLRKEG--FEATVVTDGSAALAEFDRA
MAB_4047c|M.abscessus_ATCC_199 ---MTS-VLIVEDEDSLADPLAFLLRKEG--FEATIVNDGPSALAEFERA
TH_4312|M.thermoresistible__bu ---MTS-VLIVEDEESLADPLAFLLRKEG--FETTIVTDGPSALAEFERS
MLBr_00773|M.leprae_Br4923 MDIMRQRILVVDDDASLAEMLTIVLRGEG--FDTAVIGDGTQALTAVREL
Mb1055c|M.bovis_AF2122/97 ---MTL-VLVIDDEPQILRALRINLTVRG--YQVITASTGAGALRAAAEH
Rv1027c|M.tuberculosis_H37Rv ---MTL-VLVIDDEPQILRALRINLTVRG--YQVITASTGAGALRAAAEH
Mflv_2143|M.gilvum_PYR-GCK -MTKPLTVLAVDDEVPALDELAYLLDRHPCIAEVFRAGDATSALRELNLR
Mvan_4560|M.vanbaalenii_PYR-1 -MTRPLTVLAVDDEAPALDELAYLLGKHPCVAEVFRAGDATSALRELNRR
MSMEG_5159|M.smegmatis_MC2_155 MSTRALTVLAVDDEAPALDELAYLLGRNPDVAEVLTASDATSALRELNRH
:* ::*: * * . :. .. **
MMAR_0816|M.marinum_M GADIVLLDLMLPGMSGTDVCKQLRARSSVPVIMVTARDSEIDKVVGLELG
MUL_4560|M.ulcerans_Agy99 GADIVLLDLMLPGMSGTDVCKQLRARSSVPVIMVTARDSEIDKVVGLELG
MAV_4660|M.avium_104 GADIVLLDLMLPGMSGTDVCKQLRARSSVPVIMVTARDSEIDKVVGLELG
MAB_4047c|M.abscessus_ATCC_199 GADIVLLDLMLPGMSGTDVCKQLRAKSSVPVIMVTARDSEIDKVVGLELG
TH_4312|M.thermoresistible__bu GADIILLDLMLPGMSGTDVCRRLRAKSKVPVIMVTARDSEIDKVVGLELG
MLBr_00773|M.leprae_Br4923 RPDLVLLDLMLPGMNGIDVCRVLRADSGVPIVMLTAKTDTVDVVLGLESG
Mb1055c|M.bovis_AF2122/97 PPDVVILDLGLPDMSGIDVLGGLRGWLTAPVIVLSARTDSSDKVQALDAG
Rv1027c|M.tuberculosis_H37Rv PPDVVILDLGLPDMSGIDVLGGLRGWLTAPVIVLSARTDSSDKVQALDAG
Mflv_2143|M.gilvum_PYR-GCK PIDAVFLDINMPGLSGIELAGVLANYAQRPAIVFVTAHDD-KAVAAFDVG
Mvan_4560|M.vanbaalenii_PYR-1 TIDAVFLDINMPGLSGIELAGVLTNYTQRPAIVFVTAHDD-KAVAAFDVG
MSMEG_5159|M.smegmatis_MC2_155 TIDAVFLDINMPGLSGIELAGVLTNFAHRPAVVFVTAHDD-KAVAAFDVG
* ::**: :*.:.* :: * * ::. : . . * .:: *
MMAR_0816|M.marinum_M ADDYVTKPYSARELIARIRAVLRRGGDDDSEVS-----DGVLESGPVRMD
MUL_4560|M.ulcerans_Agy99 ADDYVTKPYSARELIARIRAVLRRGGDDDSEVS-----DGVLESGPVRMD
MAV_4660|M.avium_104 ADDYVTKPYSARELIARIRAVLRRGGDDDSEIS-----DGVLESGPVRMD
MAB_4047c|M.abscessus_ATCC_199 ADDYVTKPYSARELIARIRAVLRRGSDSEETASG----DGVLEAGPVRMD
TH_4312|M.thermoresistible__bu ADDYVTKPYSARELIARIRAVLRRGSDLDGADVD----DSVLEAGPVRMD
MLBr_00773|M.leprae_Br4923 ADDYIMKPFKPKELVARVRARLRRNDDEP---------AEMLSIADVDID
Mb1055c|M.bovis_AF2122/97 ADDYVTKPFGMDEFLARLRAAVRRNTAAAELEQ------PVIETDSFTVD
Rv1027c|M.tuberculosis_H37Rv ADDYVTKPFGMDEFLARLRAAVRRNTAAAELEQ------PVIETDSFTVD
Mflv_2143|M.gilvum_PYR-GCK AVDYLLKPIREERLDEAVRRAAQAQAGPPPDD---ETPAPEPESDVVPAE
Mvan_4560|M.vanbaalenii_PYR-1 AVDYLLKPIREDRLDEAVRRAATAHPATPAAASRTETGAAAPDSDVIPAE
MSMEG_5159|M.smegmatis_MC2_155 AVDYLLKPIRQNRLDEAVRRVG---AAPSPTT---ETPADDQDSAVIPAE
* **: ** .: :* . . :
MMAR_0816|M.marinum_M VERHVVSVNGDAITLPLKEFDLLEYLMRNSGRVLTRGQ-LIDRVWGADYV
MUL_4560|M.ulcerans_Agy99 VERHVVSVNGDAITLPLKEFDLLEYLMRNSGRVLTRGQ-LIDRVWGADYV
MAV_4660|M.avium_104 VERHVVSVNGDTITLPLKEFDLLEYLMRNSGRVLTRGQ-LIDRVWGADYV
MAB_4047c|M.abscessus_ATCC_199 VDRHTVSVNGEAITLPLKEFDLLEYLIRNSGRVLTRGQ-LIDRVWGADYV
TH_4312|M.thermoresistible__bu VDRHVVTVRGEPITLPLKEFELLEYLLRNSGRVLTRGQ-LIDRVWGADYV
MLBr_00773|M.leprae_Br4923 VPAHKVTRNGEHISLTPLEFDLLVALARKPRQVFTRDV-LLEQVWGYRHP
Mb1055c|M.bovis_AF2122/97 LAGKKVIKDGAEVHLTPTEWGMLEMLARNRGKLVGRGE-LLKEVWGPAYA
Rv1027c|M.tuberculosis_H37Rv LAGKKVIKDGAEVHLTPTEWGMLEMLARNRGKLVGRGE-LLKEVWGPAYA
Mflv_2143|M.gilvum_PYR-GCK LGGVTHLIPRNSIGWIEAEGDYARLHSASGSHLVRIPLSTLETRWREHGF
Mvan_4560|M.vanbaalenii_PYR-1 LGGVTHLIPRDSIGWVEAEGDYARLHSASGSHLVRIPLSTLETRWRDHGF
MSMEG_5159|M.smegmatis_MC2_155 LGGITHLVPRDSIGWVEAEGDYARLHSATGAHLVRIPLSTLETRWRDHGF
: : * . ::. :. *
MMAR_0816|M.marinum_M GDTKTLDVHVKRLRSKIEADPANPVHLVTVRGLGYKLEG-----------
MUL_4560|M.ulcerans_Agy99 GDTKTLDVHVKRLRSKIEADPANPVHLVTVRGLGYKLEG-----------
MAV_4660|M.avium_104 GDTKTLDVHVKRLRSKIEADPANPVHLVTVRGLGYKLEG-----------
MAB_4047c|M.abscessus_ATCC_199 GDTKTLDVHVKRLRSKIEADPANPVHLVTVRGLGYKLEG-----------
TH_4312|M.thermoresistible__bu GDTKTLDVHVKRLRSKIEEDPANPVHLVTVRGLGYKLEG-----------
MLBr_00773|M.leprae_Br4923 ADTRLVNVHVQRLRAKVEKDPENPTVVLTVRGVGYKAGPP----------
Mb1055c|M.bovis_AF2122/97 TETHYLRVYLAQLRRKLEDDPSHPKHLLTESGMGYRFEA-----------
Rv1027c|M.tuberculosis_H37Rv TETHYLRVYLAQLRRKLEDDPSHPKHLLTESGMGYRFEA-----------
Mflv_2143|M.gilvum_PYR-GCK QRVHRSYLVALKLVTGLRTSDGAVLVRLRANGGSPAVELPVSRRQARELR
Mvan_4560|M.vanbaalenii_PYR-1 QRVHRSYLVALRLVTGLRTTDGAVLVRLRANGSSPAVELPVSRRQARELR
MSMEG_5159|M.smegmatis_MC2_155 QRIHRSYLVSLKQVTGLRTADGAVLVRLRANGASPAVELPVSRRQARELR
: : : :. : * .
MMAR_0816|M.marinum_M ---------------------
MUL_4560|M.ulcerans_Agy99 ---------------------
MAV_4660|M.avium_104 ---------------------
MAB_4047c|M.abscessus_ATCC_199 ---------------------
TH_4312|M.thermoresistible__bu ---------------------
MLBr_00773|M.leprae_Br4923 ---------------------
Mb1055c|M.bovis_AF2122/97 ---------------------
Rv1027c|M.tuberculosis_H37Rv ---------------------
Mflv_2143|M.gilvum_PYR-GCK DRLVRSPMRNLRPAGGSDDQ-
Mvan_4560|M.vanbaalenii_PYR-1 DRVVRNPMRSLRPAGSTDDQQ
MSMEG_5159|M.smegmatis_MC2_155 DRLVRDPMRNLKPTGADD---